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Aliases for C11orf70 Gene

Aliases for C11orf70 Gene

  • Chromosome 11 Open Reading Frame 70 2 3 5

External Ids for C11orf70 Gene

Previous GeneCards Identifiers for C11orf70 Gene

  • GC11P101424
  • GC11P101918
  • GC11P097844

Summaries for C11orf70 Gene

GeneCards Summary for C11orf70 Gene

C11orf70 (Chromosome 11 Open Reading Frame 70) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf70 Gene

Genomics for C11orf70 Gene

Regulatory Elements for C11orf70 Gene

Enhancers for C11orf70 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G102759 1.4 FANTOM5 Ensembl ENCODE 12 +714.6 714582 4.1 HDAC1 NFIB PLRG1 YY1 RFX5 RARA GATA2 ZNF366 ZNF350 RCOR1 DYNC2H1 C11orf70 MMP1 MMP8 MMP3 MMP27 MMP7 BIRC2 ENSG00000225678 LOC100421658
GH11G102169 1.4 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +124.2 124186 3.4 JUND GATA2 JUN STAT3 CEBPB FOS EP300 YAP1 C11orf70 TMEM123 ENSG00000254422 ENSG00000277459
GH11G102046 0.7 ENCODE 5.4 +0.2 230 1.6 SIN3A RBBP5 BMI1 POLR2A PATZ1 PRDM10 ZBTB20 MAZ RFX1 PHF8 C11orf70 ENSG00000274097
GH11G102010 1.4 FANTOM5 Ensembl ENCODE 0.3 -35.9 -35928 2.8 PKNOX1 ARID4B KLF17 SIN3A RAD21 BRCA1 GATA2 RCOR1 KLF7 FOS TRPC6 CEP126 ANGPTL5 GC11P102001 C11orf70
GH11G102006 1.2 Ensembl ENCODE 0.3 -40.0 -39955 1.8 ELF3 PKNOX1 FOXA2 ARID4B SIN3A RAD21 RARA RFX5 SLC30A9 CREM TRPC6 ANGPTL5 GC11P102001 C11orf70
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C11orf70 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf70 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000043955 189 1201 SIN3A RBBP5 BMI1 POLR2A PATZ1 PRDM10 ZBTB20 MAZ RFX1 PHF8

Transcription factor binding sites by QIAGEN in the C11orf70 gene promoter:

Genomic Location for C11orf70 Gene

Chromosome:
11
Start:
102,047,411 bp from pter
End:
102,084,560 bp from pter
Size:
37,150 bases
Orientation:
Plus strand

Genomic View for C11orf70 Gene

Genes around C11orf70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf70 Gene

Proteins for C11orf70 Gene

  • Protein details for C11orf70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRQ4-CK070_HUMAN
    Recommended name:
    Uncharacterized protein C11orf70
    Protein Accession:
    Q9BRQ4
    Secondary Accessions:
    • E9PJU1

    Protein attributes for C11orf70 Gene

    Size:
    267 amino acids
    Molecular mass:
    30859 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf70 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf70 Gene

Post-translational modifications for C11orf70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf70 Gene

No data available for DME Specific Peptides for C11orf70 Gene

Domains & Families for C11orf70 Gene

Protein Domains for C11orf70 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C11orf70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf70: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C11orf70 Gene

Function for C11orf70 Gene

Phenotypes for C11orf70 Gene

GenomeRNAi human phenotypes for C11orf70:
genes like me logo Genes that share phenotypes with C11orf70: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf70 Gene

Localization for C11orf70 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf70 gene
Compartment Confidence
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf70 Gene

Pathways & Interactions for C11orf70 Gene

SuperPathways for C11orf70 Gene

No Data Available

Interacting Proteins for C11orf70 Gene

Gene Ontology (GO) - Biological Process for C11orf70 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf70 Gene

Drugs & Compounds for C11orf70 Gene

No Compound Related Data Available

Transcripts for C11orf70 Gene

Unigene Clusters for C11orf70 Gene

Chromosome 11 open reading frame 70:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf70 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - - -
SP3:
SP4:

Relevant External Links for C11orf70 Gene

GeneLoc Exon Structure for
C11orf70
ECgene alternative splicing isoforms for
C11orf70

Expression for C11orf70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf70 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf70 Gene

This gene is overexpressed in Testis (x11.0).

Protein differential expression in normal tissues from HIPED for C11orf70 Gene

This gene is overexpressed in Testis (30.7), NK cells (22.3), and Ovary (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf70 Gene



Protein tissue co-expression partners for C11orf70 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf70 Gene:

C11orf70

SOURCE GeneReport for Unigene cluster for C11orf70 Gene:

Hs.98328
genes like me logo Genes that share expression patterns with C11orf70: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf70 Gene

Orthologs for C11orf70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11ORF70 35
  • 100 (a)
OneToOne
C11H11orf70 34
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia C5H11orf70 34
  • 90.48 (n)
C11orf70 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15H11orf70 34
  • 90.14 (n)
-- 35
  • 88 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 9230110C19Rik 34 16 35
  • 83.52 (n)
rat
(Rattus norvegicus)
Mammalia LOC654482 34
  • 82.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf70 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C11orf70 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H11ORF70 34 35
  • 67.68 (n)
lizard
(Anolis carolinensis)
Reptilia C11orf70 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf70 34
  • 66.14 (n)
Str.17259 34
zebrafish
(Danio rerio)
Actinopterygii si:rp71-1p14.7 34
  • 58.02 (n)
C21H11orf70 35
  • 49 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToOne
Species where no ortholog for C11orf70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf70 Gene

ENSEMBL:
Gene Tree for C11orf70 (if available)
TreeFam:
Gene Tree for C11orf70 (if available)

Paralogs for C11orf70 Gene

No data available for Paralogs for C11orf70 Gene

Variants for C11orf70 Gene

Sequence variations from dbSNP and Humsavar for C11orf70 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000104883 -- 102,065,263(+) TTTTT(A/G)GTAGA intron-variant
rs1000161701 -- 102,055,741(+) GATCT(C/T)GGCTC intron-variant
rs1000278527 -- 102,050,679(+) TTTTT(G/T)ACTGA intron-variant
rs1000328426 -- 102,072,638(+) CTCAT(A/T)AATTT intron-variant
rs1000411439 -- 102,084,227(+) TTTTT(G/T)GTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C11orf70 Gene

Variant ID Type Subtype PubMed ID
esv3580072 CNV gain 25503493

Variation tolerance for C11orf70 Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf70 Gene

Disorders for C11orf70 Gene

Relevant External Links for C11orf70

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf70

No disorders were found for C11orf70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf70 Gene

Publications for C11orf70 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64

Products for C11orf70 Gene

Sources for C11orf70 Gene

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