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Aliases for C11orf68 Gene

Aliases for C11orf68 Gene

  • Chromosome 11 Open Reading Frame 68 2 3 5
  • Basophilic Leukemia-Expressed Protein Bles03 3 4
  • Protein P5326 3 4
  • BLES03 3 4
  • Basophilic Leukemia Expressed Protein BLES03 3
  • Basophilic Leukemia-Expressed Protein 2
  • UPF0696 Protein C11orf68 3
  • P5326 3

External Ids for C11orf68 Gene

Previous GeneCards Identifiers for C11orf68 Gene

  • GC11M065441
  • GC11M065684
  • GC11M062010

Summaries for C11orf68 Gene

GeneCards Summary for C11orf68 Gene

C11orf68 (Chromosome 11 Open Reading Frame 68) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Additional gene information for C11orf68 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf68 Gene

Genomics for C11orf68 Gene

Regulatory Elements for C11orf68 Gene

Enhancers for C11orf68 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065940 1.2 Ensembl ENCODE 12.2 -22.3 -22252 2 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT NFRKB NFXL1 ZBTB40 RAD21 TCF12 SART1 C11orf68 DRAP1 FOSL1 CCDC85B FIBP CTSW EFEMP2 CFL1 BANF1
GH11H065945 0.8 Ensembl ENCODE 12.6 -26.7 -26679 1 GATAD2A RFX1 POLR2A FOXA3 SCRT2 CEBPG RARA C11orf68 DRAP1 FOSL1 BANF1 EIF1AD CST6 CTSW EFEMP2 CFL1 MUS81
GH11H065910 1.8 FANTOM5 ENCODE dbSUPER 3 +3.4 3390 11 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A ZBTB7B YY1 ZNF766 CBX5 LOC105369352 RBM14 ZFPL1 ENSG00000254461 ENSG00000258297 MUS81 EIF1AD KAT5 DPF2 SF3B2
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 1.8 +429.0 429034 39 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H065609 1.7 FANTOM5 ENCODE dbSUPER 2.8 +305.1 305119 8 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 MAP3K11 LOC105369352 EIF1AD MRPL11 SIPA1 RNASEH2C EHBP1L1 EFEMP2 SSSCA1 CTSF
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C11orf68 on UCSC Golden Path with GeneCards custom track

Genomic Location for C11orf68 Gene

Chromosome:
11
Start:
65,916,808 bp from pter
End:
65,919,117 bp from pter
Size:
2,310 bases
Orientation:
Minus strand

Genomic View for C11orf68 Gene

Genes around C11orf68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf68 Gene

Proteins for C11orf68 Gene

  • Protein details for C11orf68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3H3-CK068_HUMAN
    Recommended name:
    UPF0696 protein C11orf68
    Protein Accession:
    Q9H3H3
    Secondary Accessions:
    • J3KQG9
    • Q9BT13

    Protein attributes for C11orf68 Gene

    Size:
    251 amino acids
    Molecular mass:
    27355 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13185.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for C11orf68 Gene

    Alternative splice isoforms for C11orf68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf68 Gene

Post-translational modifications for C11orf68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf68 Gene

No data available for DME Specific Peptides for C11orf68 Gene

Domains & Families for C11orf68 Gene

Gene Families for C11orf68 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf68 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C11orf68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3H3

UniProtKB/Swiss-Prot:

CK068_HUMAN :
  • Belongs to the UPF0696 family.
Family:
  • Belongs to the UPF0696 family.
genes like me logo Genes that share domains with C11orf68: view

Function for C11orf68 Gene

Phenotypes From GWAS Catalog for C11orf68 Gene

Gene Ontology (GO) - Molecular Function for C11orf68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C11orf68: view
genes like me logo Genes that share phenotypes with C11orf68: view

Animal Model Products

CRISPR Products

miRNA for C11orf68 Gene

miRTarBase miRNAs that target C11orf68

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C11orf68
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf68 Gene

Localization for C11orf68 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf68 gene
Compartment Confidence
nucleus 3
mitochondrion 2
extracellular 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf68 Gene

Pathways & Interactions for C11orf68 Gene

SuperPathways for C11orf68 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf68 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf68 Gene

Drugs & Compounds for C11orf68 Gene

No Compound Related Data Available

Transcripts for C11orf68 Gene

mRNA/cDNA for C11orf68 Gene

Unigene Clusters for C11orf68 Gene

Chromosome 11 open reading frame 68:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C11orf68
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf68 Gene

ExUns: 1 ^ 2a · 2b
SP1:
SP2:

Relevant External Links for C11orf68 Gene

GeneLoc Exon Structure for
C11orf68
ECgene alternative splicing isoforms for
C11orf68

Expression for C11orf68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf68 Gene

Protein differential expression in normal tissues from HIPED for C11orf68 Gene

This gene is overexpressed in Bone marrow stromal cell (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C11orf68 Gene



Protein tissue co-expression partners for C11orf68 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf68 Gene:

C11orf68

SOURCE GeneReport for Unigene cluster for C11orf68 Gene:

Hs.433573

Evidence on tissue expression from TISSUES for C11orf68 Gene

  • Nervous system(4.4)
  • Adrenal gland(4.2)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with C11orf68: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf68 Gene

Orthologs for C11orf68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf68 33
  • 99.2 (n)
C11ORF68 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C11orf68 34
  • 92 (a)
OneToOne
C18H11orf68 33
  • 90.23 (n)
cow
(Bos Taurus)
Mammalia C29H11orf68 33 34
  • 91.21 (n)
rat
(Rattus norvegicus)
Mammalia Bles03 33
  • 90.23 (n)
mouse
(Mus musculus)
Mammalia AI837181 33 16 34
  • 89.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf68 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf68 33
  • 59.03 (n)
Str.20341 33
zebrafish
(Danio rerio)
Actinopterygii zgc:63470 33
  • 63.92 (n)
C7H11orf68 34
  • 56 (a)
OneToOne
zgc63470 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5323 33
Species where no ortholog for C11orf68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf68 Gene

ENSEMBL:
Gene Tree for C11orf68 (if available)
TreeFam:
Gene Tree for C11orf68 (if available)

Paralogs for C11orf68 Gene

No data available for Paralogs for C11orf68 Gene

Variants for C11orf68 Gene

Sequence variations from dbSNP and Humsavar for C11orf68 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000308235 -- 65,917,377(+) TGTGG(A/C/T)CTTCA upstream-variant-2KB, utr-variant-3-prime
rs1000349113 -- 65,917,129(+) GAAGG(A/G)GAGGT utr-variant-3-prime
rs1000443577 -- 65,917,144(+) CGGGG(C/G)ATGAG utr-variant-3-prime
rs1001663632 -- 65,917,485(+) GGCAC(A/G)GTCAA upstream-variant-2KB, reference, missense
rs1001859441 -- 65,916,448(+) CCTAA(C/G)GTGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C11orf68 Gene

Variant ID Type Subtype PubMed ID
esv2759834 CNV gain 17122850
nsv1159905 CNV duplication 26073780
nsv832191 CNV loss 17160897

Variation tolerance for C11orf68 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf68 Gene

Disorders for C11orf68 Gene

Relevant External Links for C11orf68

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf68

No disorders were found for C11orf68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf68 Gene

Publications for C11orf68 Gene

  1. The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03. (PMID: 16511166) Bitto E … Phillips GN (Acta crystallographica. Section F, Structural biology and crystallization communications 2005) 2 3 4 22 60
  2. Genome-wide search for eliminylating domains reveals novel function for BLES03-like proteins. (PMID: 25062915) Khater S … Mohanty D (Genome biology and evolution 2014) 2 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 60

Products for C11orf68 Gene

Sources for C11orf68 Gene

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