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Aliases for C11orf68 Gene

Aliases for C11orf68 Gene

  • Chromosome 11 Open Reading Frame 68 2 3 5
  • Basophilic Leukemia-Expressed Protein Bles03 3 4
  • Protein P5326 3 4
  • BLES03 3 4
  • Basophilic Leukemia Expressed Protein BLES03 3
  • Basophilic Leukemia-Expressed Protein 2
  • UPF0696 Protein C11orf68 3
  • P5326 3

External Ids for C11orf68 Gene

Previous GeneCards Identifiers for C11orf68 Gene

  • GC11M065441
  • GC11M065684
  • GC11M062010

Summaries for C11orf68 Gene

GeneCards Summary for C11orf68 Gene

C11orf68 (Chromosome 11 Open Reading Frame 68) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf68 Gene

Genomics for C11orf68 Gene

Regulatory Elements for C11orf68 Gene

Enhancers for C11orf68 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G065940 1.2 Ensembl ENCODE 12.2 -22.3 -22252 2.0 PKNOX1 ATF1 ARNT TCF12 GATA2 ELK1 FOS ZNF263 NCOA1 RFX3 SART1 C11orf68 DRAP1 FOSL1 FIBP CCDC85B CTSW EFEMP2 CFL1 BANF1
GH11G065945 1.1 Ensembl ENCODE 12.6 -26.7 -26679 1.2 HDGF PKNOX1 ATF1 ZNF76 SIN3A RARA ZNF121 SCRT2 IKZF2 SP3 C11orf68 DRAP1 FOSL1 BANF1 EIF1AD CST6 CTSW EFEMP2 CFL1 MUS81
GH11G065910 1.8 FANTOM5 ENCODE dbSUPER 3 +3.4 3390 11.4 MLX AGO1 ZFP64 YY1 ZNF143 ZNF263 SP3 MEF2D SSRP1 GLIS1 LOC105369352 ZFPL1 ENSG00000258297 RBM14 MUS81 KAT5 DPF2 ENSG00000254461 RNASEH2C EIF1AD
GH11G065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 1.8 +429.0 429034 40.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 LOC105369352 ZFPL1 KAT5 ENSG00000254461 EIF1AD NEAT1 FRMD8 EHBP1L1 POLA2 LOC101927789
GH11G065609 1.7 FANTOM5 ENCODE dbSUPER 2.8 +305.1 305119 8.5 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 MAP3K11 SIPA1 RNASEH2C CTSF LOC105369352 EIF1AD MRPL11 ZFPL1 SNX32 CTSW
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C11orf68 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf68 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040907 -283 2001 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A ZBTB7B YY1 ZNF766 CBX5

Genomic Location for C11orf68 Gene

65,916,808 bp from pter
65,919,117 bp from pter
2,310 bases
Minus strand

Genomic View for C11orf68 Gene

Genes around C11orf68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf68 Gene

Proteins for C11orf68 Gene

  • Protein details for C11orf68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0696 protein C11orf68
    Protein Accession:
    Secondary Accessions:
    • J3KQG9
    • Q9BT13

    Protein attributes for C11orf68 Gene

    251 amino acids
    Molecular mass:
    27355 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH13185.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for C11orf68 Gene

    Alternative splice isoforms for C11orf68 Gene


neXtProt entry for C11orf68 Gene

Post-translational modifications for C11orf68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf68 Gene

No data available for DME Specific Peptides for C11orf68 Gene

Domains & Families for C11orf68 Gene

Protein Domains for C11orf68 Gene


Suggested Antigen Peptide Sequences for C11orf68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0696 family.
  • Belongs to the UPF0696 family.
genes like me logo Genes that share domains with C11orf68: view

No data available for Gene Families for C11orf68 Gene

Function for C11orf68 Gene

Gene Ontology (GO) - Molecular Function for C11orf68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C11orf68: view
genes like me logo Genes that share phenotypes with C11orf68: view

Animal Model Products

CRISPR Products

miRNA for C11orf68 Gene

miRTarBase miRNAs that target C11orf68

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf68 Gene

Localization for C11orf68 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf68 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf68 Gene

Pathways & Interactions for C11orf68 Gene

SuperPathways for C11orf68 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf68 Gene


No data available for Pathways by source and SIGNOR curated interactions for C11orf68 Gene

Drugs & Compounds for C11orf68 Gene

No Compound Related Data Available

Transcripts for C11orf68 Gene

mRNA/cDNA for C11orf68 Gene

Unigene Clusters for C11orf68 Gene

Chromosome 11 open reading frame 68:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf68 Gene

ExUns: 1 ^ 2a · 2b

Relevant External Links for C11orf68 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf68 Gene

Protein differential expression in normal tissues from HIPED for C11orf68 Gene

This gene is overexpressed in Bone marrow stromal cell (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C11orf68 Gene

Protein tissue co-expression partners for C11orf68 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf68 Gene:


SOURCE GeneReport for Unigene cluster for C11orf68 Gene:


Evidence on tissue expression from TISSUES for C11orf68 Gene

  • Nervous system(4.4)
  • Adrenal gland(4.2)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with C11orf68: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf68 Gene

Orthologs for C11orf68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf68 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11H11orf68 34
  • 99.2 (n)
C11ORF68 35
  • 99 (a)
(Canis familiaris)
Mammalia C11orf68 35
  • 92 (a)
C18H11orf68 34
  • 90.23 (n)
(Bos Taurus)
Mammalia C29H11orf68 34 35
  • 91.21 (n)
(Rattus norvegicus)
Mammalia Bles03 34
  • 90.23 (n)
(Mus musculus)
Mammalia AI837181 34 16 35
  • 89.74 (n)
(Ornithorhynchus anatinus)
Mammalia C11orf68 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf68 34
  • 59.03 (n)
Str.20341 34
(Danio rerio)
Actinopterygii zgc:63470 34
  • 63.92 (n)
C7H11orf68 35
  • 56 (a)
zgc63470 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5323 34
Species where no ortholog for C11orf68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf68 Gene

Gene Tree for C11orf68 (if available)
Gene Tree for C11orf68 (if available)

Paralogs for C11orf68 Gene

No data available for Paralogs for C11orf68 Gene

Variants for C11orf68 Gene

Sequence variations from dbSNP and Humsavar for C11orf68 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000308235 -- 65,917,377(+) TGTGG(A/C/T)CTTCA upstream-variant-2KB, utr-variant-3-prime
rs1000349113 -- 65,917,129(+) GAAGG(A/G)GAGGT utr-variant-3-prime
rs1000443577 -- 65,917,144(+) CGGGG(C/G)ATGAG utr-variant-3-prime
rs1001663632 -- 65,917,485(+) GGCAC(A/G)GTCAA upstream-variant-2KB, reference, missense
rs1001859441 -- 65,916,448(+) CCTAA(C/G)GTGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C11orf68 Gene

Variant ID Type Subtype PubMed ID
esv2759834 CNV gain 17122850
nsv1159905 CNV duplication 26073780
nsv832191 CNV loss 17160897

Variation tolerance for C11orf68 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf68 Gene

Disorders for C11orf68 Gene

Relevant External Links for C11orf68

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C11orf68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf68 Gene

Publications for C11orf68 Gene

  1. The structure at 2.5 A resolution of human basophilic leukemia- expressed protein BLES03. (PMID: 16511166) Bitto E. … Phillips G.N. Jr. (Acta Crystallogr. F 2005) 2 3 4 22 64
  2. Genome-wide search for eliminylating domains reveals novel function for BLES03-like proteins. (PMID: 25062915) Khater S. … Mohanty D. (Genome Biol Evol 2014) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for C11orf68 Gene

Sources for C11orf68 Gene

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