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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C11orf65 Gene

protein-coding   GIFtS: 41
GCID: GC11M108179

Chromosome 11 Open Reading Frame 65

  Search for C11orf65
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 11 Open Reading Frame 651 2
Uncharacterized Protein C11orf652

External Ids:    HGNC: 285191   Entrez Gene: 1601402   Ensembl: ENSG000001663237   UniProtKB: Q8NCR33   

Export aliases for C11orf65 gene to outside databases

Previous GC identifers: GC11M107708 GC11M104179


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C11orf65 Gene: 
C11orf65 (chromosome 11 open reading frame 65) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C11orf65 gene promoter:
         HOXA9B   HOXA9   C/EBPbeta   Pbx1a   AML1a   E4BP4   Sox9   SEF-1 (1)   Pax-4a   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C11orf65

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf65


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.3

C11orf65 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf65 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M108179:  view genomic region     (about GC identifiers)

Start:
108,179,246 bp from pter      End:
108,338,258 bp from pter
Size:
159,013 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CK065_HUMAN, Q8NCR3 (See protein sequence)
Recommended Name: Uncharacterized protein C11orf65  
Size: 313 amino acids; 36720 Da
Secondary accessions: Q6PCA8

Explore the universe of human proteins at neXtProt for C11orf65: NX_Q8NCR3

Explore proteomics data for C11orf65 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NCR3

  • C11orf65 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C11orf65 Protein Expression
    REFSEQ proteins: NP_689800.3  
    ENSEMBL proteins: 
     ENSP00000433395   ENSP00000431706   ENSP00000432827   ENSP00000436400   ENSP00000434500  
     ENSP00000376799  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8NCR3


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C11orf65 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf65


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf65

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for C11orf65 (Q8NCR32, 3 ENSP000003767994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631652, 3, ENSP000003760764MINT-66561 I2D: score=4 STRING: ENSP00000376076
    SENP2ENSP000002962574STRING: ENSP00000296257
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    C11orf65 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C11orf65 (CK065)

    1 PharmGKB related drug/compound annotation for C11orf65 gene    About this table
    Drug/compound PharmGKB Annotation
    metforminCA  

    Search CenterWatch for drugs/clinical trials and news about C11orf65 / CK065

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C11orf65 gene: 
    NM_152587.3  

    Unigene Cluster for C11orf65:

    Chromosome 11 open reading frame 65
    Hs.653180  [show with all ESTs]
    Unigene Representative Sequence: AK303096
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525729(uc010rvx.1) ENST00000527531(uc009yxu.2) ENST00000524755
    ENST00000526725 ENST00000529391 ENST00000533583 ENST00000393084(uc001pkh.3)

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for C11orf65
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C11orf65
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    OriGene ORF clones in mouse, rat for C11orf65
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C11orf65
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf65
    Sirion Biotech Customized lentivirus for stable overexpression of C11orf65 
                         Customized lentivirus expression plasmids for stable overexpression of C11orf65 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for C11orf65
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C11orf65
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf65

    Additional mRNA sequence: 

    AK303096.1 BC029536.1 

    5 DOTS entries:

    DT.100015668  DT.95307173  DT.95222981  DT.120760464  DT.75179609 

    11 AceView cDNA sequences:

    AA382993 BX101217 AA412245 BC029536 BC059411 BP370017 AA960806 AA469976 
    NM_152587 AA912542 BI562544 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C11orf65 expression in normal human tissues (normalized intensities)      C11orf65 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTCTAGG
    C11orf65 Expression
    About this image


    C11orf65 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             sperm   
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See C11orf65 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C11orf65

    SOURCE GeneReport for Unigene cluster: Hs.653180
        SABiosciences Custom PCR Arrays for C11orf65
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf65
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf65

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C11orf65 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4930550C14Rik1 , 5 RIKEN cDNA 4930550C14 gene1, 5 77.35(n)1
    70.51(a)1
      9 (29.12 cM)5
    753111  NM_029247.31  NP_083523.11 
     534052865 
    lizard
    (Anolis carolinensis)
    Reptilia C11orf656
    chromosome 11 open reading frame 65
    43(a)
    1 ↔ 1
    5(124976226-124987065)
    zebrafish
    (Danio rerio)
    Actinopterygii C24H11orf656
    chromosome 11 open reading frame 65
    35(a)
    1 ↔ 1
    24(24584136-24590265)


    ENSEMBL Gene Tree for C11orf65 (if available)
    TreeFam Gene Tree for C11orf65 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C11orf65 gene

    C11orf65 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for C11orf65
    PGOHUM00000238677


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1851 SNPs in C11orf65 are shown (see all 1851)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2270771,2
    C,F,A,H--108253252(-) TTCTCG/AGTTTC 1 -- ds500127Minor allele frequency- A:0.46NS EA NA WA CSA 2776
    rs1383975281,2
    --108253268(+) AAGACA/CAACTA 1 -- ds50010--------
    rs1429892361,2
    C--108253308(+) GAAGAA/GAGAAA 1 -- ds50010--------
    rs1868476571,2
    --108253356(+) ATAAAC/TGTGGG 1 -- ds50010--------
    rs1451159171,2
    --108253357(+) TAAACA/GTGGGA 1 -- ds50010--------
    rs1152483901,2
    C,F--108253482(+) GCTTCT/CTGCAC 1 -- ds50011Minor allele frequency- C:0.08WA 118
    rs1921068111,2
    --108253529(+) AATACC/TACAGT 1 -- ds50010--------
    rs1821691131,2
    --108253546(+) GAATAC/TTAGGA 1 -- ds50010--------
    rs781727431,2
    C,F--108253645(+) GCCCAG/TAATAT 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs729921031,2
    C,F--108253700(+) ACTGAT/CGGATG 1 -- ds50011Minor allele frequency- C:0.04NA 120

    HapMap Linkage Disequilibrium report for C11orf65 (108179246 - 108338258 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for C11orf65:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1612880CNV Insertion17803354
    nsv832262CNV Loss17160897
    esv21753CNV Gain19812545
    nsv832263CNV Gain17160897


    Human Gene Mutation Database (HGMD): C11orf65
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for C11orf65

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C11orf65 for disorders           About MalaCards

    C11orf65 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C11orf65
    Human Genome Epidemiology (HuGE) Navigator: C11orf65 (1 document)

    Export disorders for C11orf65 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C11orf65 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C11orf65)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Does metformin work for everyone? A genome-wide associ ation study for metformin response. (PubMed id 21845381)1, 4 Florez J.C. (2011)
    2. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. (PubMed id 21186350)1  ....Pearson E.R. (2011)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 160140 HGNC: 28519 AceView: MGC33948 Ensembl:ENSG00000166323 euGenes: HUgn160140
    ECgene: C11orf65 H-InvDB: C11orf65

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C11orf65 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C11orf65 gene:
    Search GeneIP for patents involving C11orf65

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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