C11orf65 Gene
protein-coding GIFtS: 41
GCID: GC11M108179
|
|
chromosome 11 open reading frame 65
| |
Aliases
for C11orf65 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 11 Open Reading Frame 651 2 | | MGC339481 | | Uncharacterized Protein C11orf652 |
Export aliases for C11orf65 gene to outside databasesPrevious GC identifers: GC11M107708 GC11M104179 |
Summaries
for C11orf65 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C11orf65 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C11orf65 gene promoter:
HOXA9B HOXA9 C/EBPbeta Pbx1a AML1a E4BP4 Sox9 SEF-1 (1) Pax-4a RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for C11orf65
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf65 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22.3C11orf65 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M108179: view genomic region
(about GC identifiers)
Start:
|
108,179,246 bp from pter |
End:
|
108,338,258 bp from pter |
Size:
|
159,013 bases |
Orientation:
|
minus strand |
|
Proteins
for C11orf65 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CK065_HUMAN, Q8NCR3 (See
protein sequence)Recommended Name: Uncharacterized protein C11orf65 Size: 313 amino acids; 36720 Da
Secondary accessions: Q6PCA8Explore the universe of human proteins at neXtProt for C11orf65: NX_Q8NCR3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NCR3
C11orf65 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689800.3
ENSEMBL proteins: ENSP00000433395 ENSP00000431706 ENSP00000432827 ENSP00000436400 ENSP00000434500 ENSP00000376799
Human Recombinant Protein Products:
C11orf65 Antibody Products:
Assay Products for C11orf65: |
Protein
Domains /
Families
for C11orf65 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8NCR3 |
Function
for C11orf65 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf65 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf65 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C11orf65 (NM_152587) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C11orf65 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf65 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf65 |
|
Pathways & Interactions
for C11orf65 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf65
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for C11orf65 (Q8NCR32, 3 ENSP000003767994) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C11orf65 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
C11orf65 for compounds About GeneDecksing
 Browse Tocris compounds for C11orf65
1 PharmGKB related drug/compound annotation for C11orf65 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about C11orf65 / CK065
|
Transcripts
for C11orf65 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C11orf65 gene: NM_152587.3 Unigene Cluster for C11orf65: Chromosome 11 open reading frame 65 Hs.653180 [show with all ESTs]Unigene Representative Sequence: AK3030967 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000525729(uc010rvx.1) ENST00000527531(uc009yxu.2) ENST00000524755
ENST00000526725 ENST00000529391 ENST00000533583 ENST00000393084(uc001pkh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf65 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf65 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C11orf65 (NM_152587) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C11orf65 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf65 |
Additional cDNA sequence: AK303096.1 BC029536.1 5 DOTS entries: DT.100015668 DT.95307173 DT.95222981 DT.120760464 DT.75179609 11 AceView cDNA sequences: BX101217 AA382993 AA412245 BC029536 AA469976 NM_152587 AA960806 BP370017 BC059411 BI562544 AA912542
GeneLoc Exon Structure
|
Expression
for C11orf65 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C11orf65 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACTCTAGG
About this image
See C11orf65 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C11orf65
SOURCE GeneReport for Unigene cluster: Hs.653180
SABiosciences Custom PCR Arrays for C11orf65
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C11orf65
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C11orf65 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C11orf65 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf65 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf65 |
Orthologs
for C11orf65 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C11orf65 gene from 2/14 species (see all 14) About this table
ENSEMBL Gene Tree for C11orf65 (if available)
TreeFam Gene Tree for C11orf65 (if available) |
Paralogs
for C11orf65 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C11orf65 gene
C11orf65 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for C11orf65
PGOHUM00000238677
|
Genomic Variants
for C11orf65 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C11orf65 (108179246 - 108338258 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C11orf65
1 CNV: 66065
Human Gene Mutation Database (HGMD): C11orf65
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C11orf65 |
|
Disorders
/ Diseases
for C11orf65 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C11orf65 for disorders About MalaCards
C11orf65 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: C11orf65 (1 document)
Export disorders for C11orf65 gene to outside databases
|
Publications
for C11orf65 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C11orf65 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C11orf65) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Does metformin work for everyone? A genome-wide associ ation study for metformin response. (PubMed id 21845381)1 Florez J.C. (2011)
- Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. (PubMed id 21186350)1 ....Pearson E.R. (2011)
- Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for C11orf65 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C11orf65 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C11orf65 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C11orf65 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C11orf65 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C11orf65 gene:
Search GeneIP for patents involving C11orf65
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C11orf65 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C11orf65 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C11orf65 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C11orf65 | | | OriGene Protein Over-expression Lysate for C11orf65 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C11orf65 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf65 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf65 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C11orf65 | | OriGene Custom Protein Services for C11orf65 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C11orf65 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C11orf65 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf65 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C11orf65 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf65 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C11orf65 |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | C11orf65 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf65 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf65 |
|
|
|
|
