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C11orf65 Gene

protein-coding   GIFtS: 42
GCID: GC11M108179

Chromosome 11 Open Reading Frame 65

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 11 Open Reading Frame 651 2
Uncharacterized Protein C11orf652

External Ids:    HGNC: 285191   Entrez Gene: 1601402   Ensembl: ENSG000001663237   UniProtKB: Q8NCR33   

Export aliases for C11orf65 gene to outside databases

Previous GC identifers: GC11M107708 GC11M104179


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C11orf65 Gene:
C11orf65 (chromosome 11 open reading frame 65) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C11orf65 gene promoter:
         HOXA9B   HOXA9   C/EBPbeta   Pbx1a   AML1a   E4BP4   Sox9   SEF-1 (1)   Pax-4a   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C11orf65

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C11orf65


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.3

C11orf65 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf65 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M108179:  view genomic region     (about GC identifiers)

Start:
108,179,246 bp from pter      End:
108,338,258 bp from pter
Size:
159,013 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CK065_HUMAN, Q8NCR3 (See protein sequence)
Recommended Name: Uncharacterized protein C11orf65  
Size: 313 amino acids; 36720 Da
Secondary accessions: Q6PCA8

Explore the universe of human proteins at neXtProt for C11orf65: NX_Q8NCR3

Explore proteomics data for C11orf65 at MOPED


See C11orf65 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689800.3  
ENSEMBL proteins: 
 ENSP00000433395   ENSP00000431706   ENSP00000432827   ENSP00000436400   ENSP00000434500  
 ENSP00000376799  

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antibodies-online peptides for C11orf65

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antibodies-online antibodies for C11orf65 (17 products) 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8NCR3


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for C11orf65

miRNA
Products:
    
miRTarBase miRNAs that target C11orf65:
hsa-mir-145-5p (MIRT021504), hsa-mir-335-5p (MIRT018726)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C11orf65
Interactions:

    Search GeneGlobe Interaction Network for C11orf65

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for C11orf65 (Q8NCR32, 3 ENSP000003767994) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SUMO1P631652, 3, ENSP000003760764MINT-66561 I2D: score=4 STRING: ENSP00000376076
SENP2ENSP000002962574STRING: ENSP00000296257
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C11orf65 (CK065)

1 PharmGKB related drug/compound annotation for C11orf65 gene    About this table
Drug/compound PharmGKB Annotation
metforminCA  



Find genes that share compounds with C11orf65           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C11orf65 gene: 
NM_152587.3  

Unigene Cluster for C11orf65:

Chromosome 11 open reading frame 65
Hs.653180  [show with all ESTs]
Unigene Representative Sequence: AK303096
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000525729(uc010rvx.1) ENST00000527531(uc009yxu.2) ENST00000524755
ENST00000526725 ENST00000529391 ENST00000533583 ENST00000393084(uc001pkh.3)

miRNA
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Additional mRNA sequence: 

AK303096.1 BC029536.1 

5 DOTS entries:

DT.100015668  DT.95307173  DT.95222981  DT.120760464  DT.75179609 

11 AceView cDNA sequences:

AA382993 BC029536 BX101217 AA412245 AA960806 BC059411 NM_152587 AA469976 
BP370017 BI562544 AA912542 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C11orf65 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAACTCTAGG
C11orf65 Expression
About this image


C11orf65 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Blood (Hematopoietic System)
         Proerythroblasts Hematopoietic Bone Marrow
 
 Testis (Reproductive System)
C11orf65 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C11orf65 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.653180
    Custom PCR Arrays for C11orf65
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf65

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for C11orf65 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 4930550C14Rik1 , 5 RIKEN cDNA 4930550C14 gene1, 5 78.22(n)1
71.95(a)1
  9 (29.12 cM)5
753111  NM_029247.31  NP_083523.11 
 534052865 
lizard
(Anolis carolinensis)
Reptilia C11orf656
chromosome 11 open reading frame 65
42(a)
1 ↔ 1
5(124976226-124987065)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004909351 chromosome unknown open reading frame, human C11orf65 59.25(n)
51.7(a)
  100490935  XM_002934929.2  XP_002934975.1 
zebrafish
(Danio rerio)
Actinopterygii gb:co3605921 expressed sequence CO360592 57.12(n)
45.64(a)
  558891  XM_005162753.1  XP_005162810.1 


ENSEMBL Gene Tree for C11orf65 (if available)
TreeFam Gene Tree for C11orf65 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for C11orf65 gene

Find genes that share paralogs with C11orf65           About GenesLikeMe


1 Pseudogenes.org Pseudogene for C11orf65
PGOHUM00000238677


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C11orf65 (see all 1851)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2270771,2
C,F,A,H--108253252(-) TTCTCG/AGTTTC 1 -- ds500127Minor allele frequency- A:0.46NS EA NA WA CSA 2776
rs1383975281,2
--108253268(+) AAGACA/CAACTA 1 -- ds50010--------
rs1429892361,2
C--108253308(+) GAAGAA/GAGAAA 1 -- ds50010--------
rs1868476571,2
--108253356(+) ATAAAC/TGTGGG 1 -- ds50010--------
rs1451159171,2
--108253357(+) TAAACA/GTGGGA 1 -- ds50010--------
rs1152483901,2
C,F--108253482(+) GCTTCT/CTGCAC 1 -- ds50011Minor allele frequency- C:0.08WA 118
rs1921068111,2
--108253529(+) AATACC/TACAGT 1 -- ds50010--------
rs1821691131,2
--108253546(+) GAATAC/TTAGGA 1 -- ds50010--------
rs781727431,2
C,F--108253645(+) GCCCAG/TAATAT 1 -- ds50011Minor allele frequency- T:0.02NA 120
rs729921031,2
C,F--108253700(+) ACTGAT/CGGATG 1 -- ds50011Minor allele frequency- C:0.04NA 120

HapMap Linkage Disequilibrium report for C11orf65 (108179246 - 108338258 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for C11orf65:    About this table    
Variant IDTypeSubtypePubMed ID
esv1612880CNV Insertion17803354
nsv832262CNV Loss17160897
esv21753CNV Gain19812545
nsv832263CNV Gain17160897

Human Gene Mutation Database (HGMD): C11orf65
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing C11orf65
DNA2.0 Custom Variant and Variant Library Synthesis for C11orf65

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with C11orf65           About GenesLikeMe

Genetic Association Database (GAD): C11orf65
Human Genome Epidemiology (HuGE) Navigator: C11orf65 (1 document)

Export disorders for C11orf65 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C11orf65 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C11orf65)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Does metformin work for everyone? A genome-wide association study for metformin response. (PubMed id 21845381)1, 4 Florez J.C. (Curr. Diab. Rep. 2011)
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. (PubMed id 21186350)1  ....Pearson E.R. (Nat. Genet. 2011)
  6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 160140 HGNC: 28519 AceView: MGC33948 Ensembl:ENSG00000166323 euGenes: HUgn160140
ECgene: C11orf65 H-InvDB: C11orf65

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C11orf65 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C11orf65 gene:
Search GeneIP for patents involving C11orf65

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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