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Aliases for C11orf65 Gene

Aliases for C11orf65 Gene

  • Chromosome 11 Open Reading Frame 65 2 3 5

External Ids for C11orf65 Gene

Previous GeneCards Identifiers for C11orf65 Gene

  • GC11M107708
  • GC11M108179
  • GC11M104179

Summaries for C11orf65 Gene

GeneCards Summary for C11orf65 Gene

C11orf65 (Chromosome 11 Open Reading Frame 65) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf65 Gene

Genomics for C11orf65 Gene

Regulatory Elements for C11orf65 Gene

Enhancers for C11orf65 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G108233 1.4 Ensembl ENCODE dbSUPER 7.9 +228.9 228942 11.1 FOXA2 ZNF48 ZBTB40 RARA YY1 EGR1 CBX5 SCRT2 FOS ETV6 ACAT1 ATM ENSG00000255467 DDX10 C11orf65 KDELC2 ENSG00000206967 GC11M108232 PIR35860
GH11G108219 1.4 ENCODE dbSUPER 4.9 +241.7 241686 12.2 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ACAT1 KDELC2 ENSG00000255467 DDX10 C11orf65 ENSG00000206967 GC11M108232 NPAT
GH11G108246 0.7 dbSUPER 4.9 +220.5 220454 1.5 PAF1 CTCF ZNF654 MAFG CEBPB CEBPG REST RAD21 MAFF ZNF316 ACAT1 NPAT ATM ENSG00000255467 DDX10 C11orf65 ENSG00000206967 GC11M108232 PIR35860
GH11G108215 0.6 dbSUPER 5.1 +251.1 251122 2.2 ZNF263 EGR1 POLR2A SCRT2 CEBPB CEBPG ACAT1 ENSG00000255467 C11orf65 ATM
GH11G108432 0.4 ENCODE 4.7 +34.5 34544 1.8 MTA2 KDELC2 ACAT1 C11orf65 PIR35860
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C11orf65 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf65 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044527 147 1601 PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5

Genomic Location for C11orf65 Gene

Chromosome:
11
Start:
108,308,519 bp from pter
End:
108,467,547 bp from pter
Size:
159,029 bases
Orientation:
Minus strand

Genomic View for C11orf65 Gene

Genes around C11orf65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf65 Gene

Proteins for C11orf65 Gene

  • Protein details for C11orf65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCR3-CK065_HUMAN
    Recommended name:
    Uncharacterized protein C11orf65
    Protein Accession:
    Q8NCR3
    Secondary Accessions:
    • B4DZU4
    • Q6PCA8

    Protein attributes for C11orf65 Gene

    Size:
    313 amino acids
    Molecular mass:
    36720 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf65 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf65 Gene

Post-translational modifications for C11orf65 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C11orf65 Gene

Domains & Families for C11orf65 Gene

Protein Domains for C11orf65 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C11orf65 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf65: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C11orf65 Gene

Function for C11orf65 Gene

Gene Ontology (GO) - Molecular Function for C11orf65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C11orf65: view
genes like me logo Genes that share phenotypes with C11orf65: view

Animal Model Products

CRISPR Products

miRNA for C11orf65 Gene

miRTarBase miRNAs that target C11orf65

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf65 Gene

Localization for C11orf65 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf65 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf65 Gene

Pathways & Interactions for C11orf65 Gene

SuperPathways for C11orf65 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf65 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf65 Gene

Drugs & Compounds for C11orf65 Gene

(1) Drugs for C11orf65 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 1803
genes like me logo Genes that share compounds with C11orf65: view

Transcripts for C11orf65 Gene

mRNA/cDNA for C11orf65 Gene

Unigene Clusters for C11orf65 Gene

Chromosome 11 open reading frame 65:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf65 Gene

No ASD Table

Relevant External Links for C11orf65 Gene

GeneLoc Exon Structure for
C11orf65
ECgene alternative splicing isoforms for
C11orf65

Expression for C11orf65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf65 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C11orf65 Gene

This gene is overexpressed in Testis (x22.8).

NURSA nuclear receptor signaling pathways regulating expression of C11orf65 Gene:

C11orf65

SOURCE GeneReport for Unigene cluster for C11orf65 Gene:

Hs.653180
genes like me logo Genes that share expression patterns with C11orf65: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf65 Gene

Orthologs for C11orf65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11orf65 35
  • 100 (a)
OneToOne
C11H11orf65 34
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia C5H11orf65 34
  • 86.11 (n)
C11orf65 35
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15H11orf65 34
  • 85.04 (n)
mouse
(Mus musculus)
Mammalia 4930550C14Rik 34 16 35
  • 78.22 (n)
rat
(Rattus norvegicus)
Mammalia RGD1311251 34
  • 77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf65 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C11orf65 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf65 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490935 34
  • 59.25 (n)
zebrafish
(Danio rerio)
Actinopterygii gb:co360592 34
  • 57.12 (n)
C24H11orf65 35
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3681 35
  • 51 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13913 34
Species where no ortholog for C11orf65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf65 Gene

ENSEMBL:
Gene Tree for C11orf65 (if available)
TreeFam:
Gene Tree for C11orf65 (if available)

Paralogs for C11orf65 Gene

Pseudogenes.org Pseudogenes for C11orf65 Gene

genes like me logo Genes that share paralogs with C11orf65: view

No data available for Paralogs for C11orf65 Gene

Variants for C11orf65 Gene

Sequence variations from dbSNP and Humsavar for C11orf65 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11212617 drug-response 108,412,434(+) agaga(A/C)tgtca intron-variant
rs1057519029 Pathogenic 108,335,894(+) CCAGA(NNNNNN/TGTGTAATACA)TTACT intron-variant
rs121434216 Pathogenic 108,345,804(+) AAATT(G/T)TCAAC intron-variant, reference, missense
rs121434218 Pathogenic 108,333,925(+) TAAAC(C/T)TAAGA intron-variant, reference, missense
rs121434219 Pathogenic 108,365,476(+) TCAGC(C/T)GACTT intron-variant, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for C11orf65 Gene

Variant ID Type Subtype PubMed ID
dgv2182n54 CNV gain 21841781
esv1612880 CNV insertion 17803354
esv21753 CNV gain 19812545
esv3627675 CNV gain 21293372
esv3627676 CNV loss 21293372
esv3627677 CNV loss 21293372
esv3892100 CNV loss 25118596
nsv832262 CNV loss 17160897
nsv832263 CNV gain 17160897

Variation tolerance for C11orf65 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf65 Gene

Human Gene Mutation Database (HGMD)
C11orf65
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf65 Gene

Disorders for C11orf65 Gene

Relevant External Links for C11orf65

Genetic Association Database (GAD)
C11orf65
Human Genome Epidemiology (HuGE) Navigator
C11orf65
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf65

No disorders were found for C11orf65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf65 Gene

Publications for C11orf65 Gene

  1. Does metformin work for everyone? A genome-wide association study for metformin response. (PMID: 21845381) Florez J.C. (Curr. Diab. Rep. 2011) 3 46 64
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for C11orf65 Gene

Sources for C11orf65 Gene

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