Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C11orf63 Gene

Aliases for C11orf63 Gene

  • Chromosome 11 Open Reading Frame 63 2 3 5

External Ids for C11orf63 Gene

Previous GeneCards Identifiers for C11orf63 Gene

  • GC11P122260
  • GC11P122753
  • GC11P118697

Summaries for C11orf63 Gene

GeneCards Summary for C11orf63 Gene

C11orf63 (Chromosome 11 Open Reading Frame 63) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf63 Gene

Genomics for C11orf63 Gene

Regulatory Elements for C11orf63 Gene

Enhancers for C11orf63 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C11orf63 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf63 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C11orf63 on UCSC Golden Path with GeneCards custom track

Genomic Location for C11orf63 Gene

122,881,639 bp from pter
122,959,798 bp from pter
78,160 bases
Plus strand

Genomic View for C11orf63 Gene

Genes around C11orf63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf63 Gene

Proteins for C11orf63 Gene

  • Protein details for C11orf63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf63
    Protein Accession:
    Secondary Accessions:
    • A8K6G0
    • Q96GB5
    • Q9H5D6

    Protein attributes for C11orf63 Gene

    778 amino acids
    Molecular mass:
    88569 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH09820.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15691.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C11orf63 Gene


neXtProt entry for C11orf63 Gene

Post-translational modifications for C11orf63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf63 Gene

No data available for DME Specific Peptides for C11orf63 Gene

Domains & Families for C11orf63 Gene

Protein Domains for C11orf63 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf63: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf63 Gene

Function for C11orf63 Gene

genes like me logo Genes that share phenotypes with C11orf63: view

Animal Model Products

CRISPR Products

miRNA for C11orf63 Gene

miRTarBase miRNAs that target C11orf63

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf63 Gene

Localization for C11orf63 Gene

Subcellular locations from

Jensen Localization Image for C11orf63 Gene COMPARTMENTS Subcellular localization image for C11orf63 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf63 Gene

Pathways & Interactions for C11orf63 Gene

SuperPathways for C11orf63 Gene

No Data Available

Interacting Proteins for C11orf63 Gene

Gene Ontology (GO) - Biological Process for C11orf63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007420 brain development IEA --
GO:0032053 ciliary basal body organization IEA --
GO:0033326 cerebrospinal fluid secretion IEA --
GO:0035082 axoneme assembly IEA --
genes like me logo Genes that share ontologies with C11orf63: view

No data available for Pathways by source and SIGNOR curated interactions for C11orf63 Gene

Drugs & Compounds for C11orf63 Gene

No Compound Related Data Available

Transcripts for C11orf63 Gene

Unigene Clusters for C11orf63 Gene

Chromosome 11 open reading frame 63:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf63 Gene

No ASD Table

Relevant External Links for C11orf63 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf63 Gene

mRNA expression in normal human tissues for C11orf63 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C11orf63 Gene

This gene is overexpressed in Testis (x8.0).

NURSA nuclear receptor signaling pathways regulating expression of C11orf63 Gene:


SOURCE GeneReport for Unigene cluster for C11orf63 Gene:

genes like me logo Genes that share expression patterns with C11orf63: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C11orf63 Gene

Orthologs for C11orf63 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf63 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C15H11orf63 34
  • 82.4 (n)
  • 73.8 (a)
C11orf63 35
  • 65 (a)
(Canis familiaris)
Mammalia C5H11orf63 34
  • 84.02 (n)
  • 74.55 (a)
C11orf63 35
  • 74 (a)
(Mus musculus)
Mammalia 4931429I11Rik 34
  • 75.71 (n)
  • 68.06 (a)
Jhy 16
4931429I11Rik 35
  • 67 (a)
(Pan troglodytes)
Mammalia LOC451628 34
  • 99.08 (n)
  • 97.58 (a)
C11orf63 35
  • 98 (a)
(Rattus norvegicus)
Mammalia RGD1309108 34
  • 74.15 (n)
  • 66.53 (a)
(Monodelphis domestica)
Mammalia C11orf63 35
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf63 35
  • 47 (a)
(Gallus gallus)
Aves C24H11orf63 34
  • 55.27 (n)
  • 43.29 (a)
C11orf63 35
  • 33 (a)
(Anolis carolinensis)
Reptilia C11orf63 35
  • 31 (a)
(Danio rerio)
Actinopterygii C10H11orf63 35
  • 26 (a)
Species where no ortholog for C11orf63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf63 Gene

Gene Tree for C11orf63 (if available)
Gene Tree for C11orf63 (if available)

Paralogs for C11orf63 Gene

No data available for Paralogs for C11orf63 Gene

Variants for C11orf63 Gene

Sequence variations from dbSNP and Humsavar for C11orf63 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs33999612 - 122,934,898(+) GCTAC(A/G)CACCC nc-transcript-variant, reference, missense
rs1057703 -- 122,959,543(+) CCTAT(G/T)ATTAT downstream-variant-500B, utr-variant-3-prime
rs1057704 -- 122,959,566(+) GTCCA(C/T)GTTTG downstream-variant-500B, utr-variant-3-prime
rs1343784 -- 122,923,172(-) CTAAC(G/T)CCTTC intron-variant
rs1461505 -- 122,951,300(+) CAAAC(A/G)GTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf63 Gene

Variant ID Type Subtype PubMed ID
esv2661962 CNV deletion 23128226
esv3627950 CNV loss 21293372
nsv1040084 CNV loss 25217958
nsv1138082 CNV deletion 24896259
nsv510278 OTHER sequence alteration 20534489
nsv520988 CNV gain 19592680
nsv522969 CNV loss 19592680
nsv556482 CNV loss 21841781

Variation tolerance for C11orf63 Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf63 Gene

Disorders for C11orf63 Gene

Relevant External Links for C11orf63

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C11orf63 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf63 Gene

Publications for C11orf63 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3 65
  5. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira F.R. … Gomes M.D. (J. Biol. Chem. 2013) 3 65

Products for C11orf63 Gene

Sources for C11orf63 Gene