C11orf58 Gene
protein-coding GIFtS: 49
GCID: GC11P016717
|
|
chromosome 11 open reading frame 58
| |
Aliases
for C11orf58 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 11 Open Reading Frame 581 2 | | SMAP1 2 | | IMAGE1450522 | | Small Acidic Protein2 |
Export aliases for C11orf58 gene to outside databasesPrevious GC identifer: GC11P016444 |
Summaries
for C11orf58 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for C11orf58
|
Genomic Views
for C11orf58 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C11orf58 gene promoter:
Sox5 Lmo2 Nkx2-5 Roaz MEF-2A SRY E2F-1 E2F aMEF-2 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C11orf58
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf58 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1C11orf58 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P016717: view genomic region
(about GC identifiers)
Start:
|
16,634,679 bp from pter |
End:
|
16,779,901 bp from pter |
Size:
|
145,223 bases |
Orientation:
|
plus strand |
|
Proteins
for C11orf58 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SMAP_HUMAN, O00193 (See
protein sequence)Recommended Name: Small acidic protein Size: 183 amino acids; 20333 Da
Secondary accessions: B2RD28Explore the universe of human proteins at neXtProt for C11orf58: NX_O00193
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00193
C11orf58 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055082.1
ENSEMBL proteins: ENSP00000228136 ENSP00000432207 ENSP00000431237 ENSP00000432534 ENSP00000406221
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
C11orf58 for ontologies About GeneDecksing
C11orf58 Antibody Products:
Assay Products for C11orf58: |
Protein
Domains /
Families
for C11orf58 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C11orf58 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O00193ProtoNet protein and cluster: O00193 UniProtKB/Swiss-Prot: SMAP_HUMAN, O00193Similarity: Belongs to the SMAP family |
Function
for C11orf58 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf58 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf58 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: C11orf58 (NM_014267) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C11orf58 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf58 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf58 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
C11orf58 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for C11orf58:
|
Pathways & Interactions
for C11orf58 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf58
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/23 Interacting proteins for C11orf58 (O001932, 3 ENSP000002281364) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
C11orf58 for ontologies About GeneDecksing
|
Drugs & Compounds
for C11orf58 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
C11orf58 for compounds About GeneDecksing
 Browse Tocris compounds for C11orf58
1 Novoseek chemical compound relationship for C11orf58 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| iron |
3.57 |
1 |
16698547 (1) |
Search CenterWatch for drugs/clinical trials and news about C11orf58 / SMAP
|
Transcripts
for C11orf58 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C11orf58 gene (2 alternative transcripts): NM_001142705.1 NM_014267.5 Unigene Cluster for C11orf58: Chromosome 11 open reading frame 58 Hs.645792 [show with all ESTs]Unigene Representative Sequence: BX64809512 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000527893 ENST00000228136(uc001mmk.2) ENST00000524439 ENST00000528634
ENST00000525684 ENST00000525256 ENST00000525106 ENST00000524461 ENST00000531658
ENST00000524508 ENST00000426046 ENST00000422258
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf58 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf58 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C11orf58 (NM_014267) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C11orf58 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf58 |
Additional cDNA sequence: AK057169.1 AK093998.1 AK094549.1 AK315382.1 BC007103.1 BC016352.1 BC020937.1 BC103747.1 BX648095.1 CR456882.1 U51678.1 24/43 DOTS entries (see all 43): DT.97760043 DT.85104842 DT.100677727 DT.95271486 DT.97815068 DT.100677728 DT.120686628 DT.114192 DT.120731753 DT.87006737 DT.100715770 DT.429593 DT.100716000 DT.75190941 DT.92468241 DT.100677724 DT.100751624 DT.120686673 DT.100677735 DT.100751264 DT.92468258 DT.95135924 DT.95271468 DT.120686571 24/1090 AceView cDNA sequences (see all 1090): AA614275 T35310 BM788411 AA915874 BQ938229 BQ574739 BQ189349 CR614900 AI523592 CK299490 BM460145 AA359547 BG492468 AI085536 BX093754 BX091912 BQ048865 BI793222 BG771383 BI792940 BM678597 BM819190 CN478683 CA771437
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for C11orf58 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | - | | | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for C11orf58
|
Expression
for C11orf58 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C11orf58 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGCAAGTA
About this image
See C11orf58 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C11orf58
SOURCE GeneReport for Unigene cluster: Hs.645792
SABiosciences Custom PCR Arrays for C11orf58
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C11orf58
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C11orf58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C11orf58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf58 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf58 |
Orthologs
for C11orf58 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C11orf58 gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
1110004F10Rik1 , 5 |
RIKEN cDNA 1110004F10 gene1, 5 |
87.29(n)1
96.13(a)1 |
|
7 (61.42 cM)5
563721 NM_019772.21 NP_062746.11
1160933015 |
chicken
(Gallus gallus) |
Aves |
C5H11orf581 |
chromosome 5 open reading frame, human C11orf58 |
77.39(n)
77.78(a) |
|
395520 NM_204758.1 NP_990089.1 |
lizard
(Anolis carolinensis) |
Reptilia |
C11orf586 |
-- |
75(a) |
1 ↔ 1 |
1(66306676-66314838) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.184762 |
Xenopus laevis transcribed sequences |
82.36(n) |
|
BG347061.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc561062 |
similar to small acidic protein |
74.02(n) |
|
393163 BC045914.1 |
ENSEMBL Gene Tree for C11orf58 (if available)
TreeFam Gene Tree for C11orf58 (if available) |
Paralogs
for C11orf58 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C11orf58 gene
1 SIMAP similar gene for C11orf58 using alignment to 5 protein entries: E3W975_HUMAN (see all proteins):SMAP
C11orf58 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for C11orf58
PGOHUM00000247786 PGOHUM00000258259
|
Genomic Variants
for C11orf58 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C11orf58 (16634679 - 16779901 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for C11orf58
1 CNV: 101147
1 Indel: 71286 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C11orf58 |
|
Disorders
/ Diseases
for C11orf58 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C11orf58 for disorders About GeneDecksing
4  diseases for C11orf58: About MalaCardsvelocardiofacial syndrome gaucher's disease adrenoleukodystrophy thyroiditis
Export disorders for C11orf58 gene to outside databases
|
Publications
for C11orf58 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C11orf58 gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with C11orf58) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel genes expressed in the chick otocyst during development: identification using differential display of RNA. (PubMed id 9263035)1, 2, 3, 9 Gong T.-W....Lomax M.I. (1997)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for C11orf58 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C11orf58 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C11orf58 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C11orf58 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C11orf58 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C11orf58 gene:
Search GeneIP for patents involving C11orf58
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C11orf58 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C11orf58 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C11orf58 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C11orf58 | | | OriGene Protein Over-expression Lysate for C11orf58 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C11orf58 | | OriGene 3'-UTR Clone for C11orf58 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf58 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf58 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C11orf58 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |
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 | | | C11orf58 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf58 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf58 |
|
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