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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C11orf58 Gene

protein-coding   GIFtS: 48
GCID: GC11P016717

Chromosome 11 Open Reading Frame 58

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 11 Open Reading Frame 581 2
Small Acidic Protein1 2
IMAGE1450522
SMAP2

External Ids:    HGNC: 169901   Entrez Gene: 109442   Ensembl: ENSG000001106967   UniProtKB: O001933   

Export aliases for C11orf58 gene to outside databases

Previous GC identifer: GC11P016444


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C11orf58 Gene: 
C11orf58 (chromosome 11 open reading frame 58) is a protein-coding gene. Diseases associated with C11orf58 include gaucher's disease, and velocardiofacial syndrome. GO annotations related to this gene include molecular_function.

Gene Wiki entry for C11orf58 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C11orf58 gene promoter:
         Sox5   Lmo2   Nkx2-5   Roaz   MEF-2A   SRY   E2F-1   E2F   aMEF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC11orf58 promoter sequence
   Search SABiosciences Chromatin IP Primers for C11orf58

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf58


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

C11orf58 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf58 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P016717:  view genomic region     (about GC identifiers)

Start:
16,634,679 bp from pter      End:
16,779,901 bp from pter
Size:
145,223 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SMAP_HUMAN, O00193 (See protein sequence)
Recommended Name: Small acidic protein  
Size: 183 amino acids; 20333 Da
Secondary accessions: B2RD28

Explore the universe of human proteins at neXtProt for C11orf58: NX_O00193

Explore proteomics data for C11orf58 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00193

  • C11orf58 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C11orf58 Protein Expression
    REFSEQ proteins: NP_055082.1  
    ENSEMBL proteins: 
     ENSP00000228136   ENSP00000432207   ENSP00000431237   ENSP00000432534   ENSP00000406221  

    Human Recombinant Protein Products for C11orf58: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    C11orf58 for ontologies           About GeneDecksing



    C11orf58 Antibody Products: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026714 SMAP

    Graphical View of Domain Structure for InterPro Entry O00193

    ProtoNet protein and cluster: O00193

    UniProtKB/Swiss-Prot: SMAP_HUMAN, O00193
    Similarity: Belongs to the SMAP family


    C11orf58 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    C11orf58 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for C11orf58:
     Cells with protrusions  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C11orf58 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C11orf58

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C11orf58 
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    miRNA
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    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate C11orf58 (see all 79):
    hsa-miR-3607-3p hsa-miR-300 hsa-miR-128 hsa-miR-374a hsa-miR-371-5p hsa-miR-1273d hsa-miR-3122 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidC11orf58 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf58


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf58

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/23 Interacting proteins for C11orf58 (O001932, 3 ENSP000002281364) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2CP193872, 3, ENSP000002192524MINT-8249828 I2D: score=2 STRING: ENSP00000219252
    SF3B1O755332, 3, ENSP000003353214MINT-8249887 I2D: score=2 STRING: ENSP00000335321
    SNCAIPQ9Y6H52, 3, ENSP000002613684MINT-8249920 I2D: score=2 STRING: ENSP00000261368
    EEF1GP266412, 3MINT-8249784 I2D: score=2 
    FBN3Q75N902, 3MINT-8249795 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    C11orf58 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    C11orf58 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C11orf58 (SMAP)

    1 Novoseek inferred chemical compound relationship for C11orf58 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 3.57 1 16698547 (1)

    Search CenterWatch for drugs/clinical trials and news about C11orf58 / SMAP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C11orf58 gene (2 alternative transcripts): 
    NM_001142705.1  NM_014267.5  

    Unigene Cluster for C11orf58:

    Chromosome 11 open reading frame 58
    Hs.645792  [show with all ESTs]
    Unigene Representative Sequence: BX648095
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527893 ENST00000228136(uc001mmk.2) ENST00000524439 ENST00000528634
    ENST00000525684 ENST00000525256 ENST00000525106 ENST00000524461 ENST00000531658
    ENST00000524508 ENST00000422258
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C11orf58
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate C11orf58 (see all 79):
    hsa-miR-3607-3p hsa-miR-300 hsa-miR-128 hsa-miR-374a hsa-miR-371-5p hsa-miR-1273d hsa-miR-3122 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidC11orf58 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C11orf58
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C11orf58
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf58

    Additional mRNA sequence: 

    AK057169.1 AK093998.1 AK094549.1 AK315382.1 BC007103.1 BC016352.1 BC020937.1 BC103747.1 
    BX648095.1 CR456882.1 U51678.1 

    24/43 DOTS entries (see all 43):

    DT.97760043  DT.85104842  DT.100677727  DT.95271486  DT.97815068  DT.100677728  DT.120686628  DT.114192 
    DT.120731753  DT.87006737  DT.100715770  DT.429593  DT.100716000  DT.75190941  DT.92468241  DT.100677724 
    DT.100751624  DT.120686673  DT.100677735  DT.100751264  DT.92468258  DT.95135924  DT.95271468  DT.120686571 

    24/1090 AceView cDNA sequences (see all 1090):

    BM460145 BQ189349 AW161321 AW272755 CA771437 AI085536 AA614275 BM761692 
    BF002807 AA375382 BU623950 CF130361 CR616149 BE858671 AA886178 CF242974 
    CK299490 AA707447 AA422093 AW272734 BG771383 BQ019026 BE463541 BM458953 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for C11orf58 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
    SP1:                          -                 -           -           -                                 
    SP2:                          -     -           -           -           -                                 
    SP3:                          -     -           -           -                                             
    SP4:                          -     -           -           -     -     -                                 
    SP5:                          -     -     -     -           -           -                                 


    ECgene alternative splicing isoforms for C11orf58

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C11orf58 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGCAAGTA
    C11orf58 Expression
    About this image


    See C11orf58 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C11orf58

    SOURCE GeneReport for Unigene cluster: Hs.645792
        SABiosciences Custom PCR Arrays for C11orf58
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf58

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C11orf58 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1110004F10Rik1 , 5 RIKEN cDNA 1110004F10 gene1, 5 87.29(n)1
    96.13(a)1
      7 (61.42 cM)5
    563721  NM_019772.21  NP_062746.11 
     1160933015 
    chicken
    (Gallus gallus)
    Aves C5H11orf581 chromosome 5 open reading frame, human C11orf58 77.39(n)
    77.78(a)
      395520  NM_204758.1  NP_990089.1 
    lizard
    (Anolis carolinensis)
    Reptilia C11ORF586
    Uncharacterized protein
    72(a)
    1 ↔ 1
    1(66306676-66314838)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.184762 Xenopus laevis transcribed sequences 82.36(n)    BG347061.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc561062 similar to small acidic protein 74.02(n)   393163  BC045914.1 


    ENSEMBL Gene Tree for C11orf58 (if available)
    TreeFam Gene Tree for C11orf58 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C11orf58 gene
    2 SIMAP similar genes for C11orf58 using alignment to 5 protein entries:     E3W975_HUMAN (see all proteins):
    SMAP    PPP2R1A

    C11orf58 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for C11orf58
    PGOHUM00000247786 PGOHUM00000258259


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/414 SNPs in C11orf58 are shown (see all 414)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854286561,2
    --16758214(+) AAATCA/GCCATT 1 -- us2k10--------
    rs38090951,2
    C,F,H--16758246(+) ACTGTA/GGTCGA 1 -- us2k120Minor allele frequency- G:0.13NS EA NA 2082
    rs122792821,2
    H--16758250(+) TAGTCG/AAAACT 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs1478739261,2
    --16758297(+) CTAATA/GGAACC 1 -- us2k10--------
    rs1910614591,2
    --16758340(+) AATTCC/TAGCAA 1 -- us2k10--------
    rs1823550441,2
    C--16758405(+) TCTCCA/TCCTCC 1 -- us2k10--------
    rs759338501,2
    C,F--16758485(+) CTGACA/GTCTCT 1 -- us2k11Minor allele frequency- G:0.08NA 120
    rs1891425711,2
    --16758501(+) TATTAC/TAGTAC 1 -- us2k10--------
    rs604892701,2
    C,F--16758520(+) ATGCTA/TTTTTT 1 -- us2k14Minor allele frequency- T:0.09WA NA 242
    rs1918328281,2
    --16758529(+) TTCTGC/TTTCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C11orf58 (16634679 - 16779901 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for C11orf58:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2571561CNV Deletion19546169
    esv23566CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing C11orf58
    DNA2.0 Custom Variant and Variant Library Synthesis for C11orf58

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for C11orf58:    About MalaCards
    gaucher's disease    velocardiofacial syndrome    adrenoleukodystrophy    thyroiditis


    C11orf58 for disorders           About GeneDecksing


    Export disorders for C11orf58 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C11orf58 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with C11orf58)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel genes expressed in the chick otocyst during development: identification using differential display of RNA. (PubMed id 9263035)1, 2, 3, 9 Gong T.-W....Lomax M.I. (1997)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10944 HGNC: 16990 AceView: SMAP Ensembl:ENSG00000110696 euGenes: HUgn10944
    ECgene: C11orf58 H-InvDB: C11orf58

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C11orf58 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C11orf58 gene:
    Search GeneIP for patents involving C11orf58

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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