Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C11orf58 Gene

Aliases for C11orf58 Gene

  • Chromosome 11 Open Reading Frame 58 2 3 5
  • Small Acidic Protein 2 3
  • SMAP 3 4
  • IMAGE145052 3

External Ids for C11orf58 Gene

Previous GeneCards Identifiers for C11orf58 Gene

  • GC11P016717
  • GC11P016444

Summaries for C11orf58 Gene

GeneCards Summary for C11orf58 Gene

C11orf58 (Chromosome 11 Open Reading Frame 58) is a Protein Coding gene.

Gene Wiki entry for C11orf58 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf58 Gene

Genomics for C11orf58 Gene

Regulatory Elements for C11orf58 Gene

Enhancers for C11orf58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F015965 2.3 FANTOM5 ENCODE 9.6 -644.8 -644819 6.4 CREB3L1 GATA2 FOS JUNB TBX21 CREB3 RFX3 SMARCA4 PBX2 MYNN LOC105376572 C11orf58 MIR6073 SOX6 GC11M015966 GC11P015996
GH11F017273 1.4 Ensembl ENCODE 15.7 +663.8 663755 6.3 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 OR7E14P C11orf58 RPL36AP37 PIK3C2A NUCB2 SNORD14A GC11M017256 LOC105376575
GH11F016737 1.1 ENCODE 15.8 +125.9 125909 3.0 HDGF CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PIK3C2A RPL36AP37 C11orf58 SNORD14A SNORD14B RPS13 SOX6 MIR6073 PIR48413
GH11F017075 1.1 ENCODE 15.7 +464.3 464299 3.6 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 RPL36AP37 RPS13 C11orf58 OR7E14P SNORD14A PIK3C2A SNORD14B GC11M017076 GC11M017077 GC11M017078
GH11F016193 1.1 Ensembl ENCODE 11.2 -418.2 -418243 2.3 HDAC1 FEZF1 CHAMP1 GATA2 ZNF843 MBD2 KLF16 SMARCA4 HMBOX1 FOXJ2 SOX6 C11orf58 MIR6073 GC11M016200 GC11P016141
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C11orf58 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000559213 669 1599 PKNOX1 ZNF76 ARID4B ZNF48 ZNF2 RAD21 ZEB1 CBX5 ZNF143 ZNF391

Genomic Location for C11orf58 Gene

Chromosome:
11
Start:
16,613,132 bp from pter
End:
16,758,354 bp from pter
Size:
145,223 bases
Orientation:
Plus strand

Genomic View for C11orf58 Gene

Genes around C11orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf58 Gene

Proteins for C11orf58 Gene

  • Protein details for C11orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00193-SMAP_HUMAN
    Recommended name:
    Small acidic protein
    Protein Accession:
    O00193
    Secondary Accessions:
    • B2RD28

    Protein attributes for C11orf58 Gene

    Size:
    183 amino acids
    Molecular mass:
    20333 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf58 Gene

Post-translational modifications for C11orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf58 Gene

No data available for DME Specific Peptides for C11orf58 Gene

Domains & Families for C11orf58 Gene

Protein Domains for C11orf58 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O00193

UniProtKB/Swiss-Prot:

SMAP_HUMAN :
  • Belongs to the SMAP family.
Family:
  • Belongs to the SMAP family.
genes like me logo Genes that share domains with C11orf58: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C11orf58 Gene

Function for C11orf58 Gene

Gene Ontology (GO) - Molecular Function for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C11orf58: view

Phenotypes for C11orf58 Gene

genes like me logo Genes that share phenotypes with C11orf58: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf58 Gene

Localization for C11orf58 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf58 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C11orf58: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C11orf58 Gene

Pathways & Interactions for C11orf58 Gene

SuperPathways for C11orf58 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C11orf58: view

No data available for Pathways by source and SIGNOR curated interactions for C11orf58 Gene

Drugs & Compounds for C11orf58 Gene

(1) Drugs for C11orf58 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with C11orf58: view

Transcripts for C11orf58 Gene

Unigene Clusters for C11orf58 Gene

Chromosome 11 open reading frame 58:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf58 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - -
SP8: - -
SP9: - - -

Relevant External Links for C11orf58 Gene

GeneLoc Exon Structure for
C11orf58
ECgene alternative splicing isoforms for
C11orf58

Expression for C11orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C11orf58 Gene

Protein differential expression in normal tissues from HIPED for C11orf58 Gene

This gene is overexpressed in Adrenal (47.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C11orf58 Gene



Protein tissue co-expression partners for C11orf58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf58 Gene:

C11orf58

SOURCE GeneReport for Unigene cluster for C11orf58 Gene:

Hs.645792
genes like me logo Genes that share expression patterns with C11orf58: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C11orf58 Gene

Orthologs for C11orf58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf58 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 99 (a)
OneToMany
C21H11orf58 34
  • 93.77 (n)
-- 35
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SMAP 35
  • 98 (a)
OneToOne
C15H11orf58 34
  • 93 (n)
oppossum
(Monodelphis domestica)
Mammalia C11orf58 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf58 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1311703 34
  • 85.27 (n)
mouse
(Mus musculus)
Mammalia 1110004F10Rik 16 35 34
  • 85.27 (n)
chicken
(Gallus gallus)
Aves C5H11ORF58 34 35
  • 77 (n)
lizard
(Anolis carolinensis)
Reptilia C11orf58 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf58 34
  • 58.38 (n)
Str.5966 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.18476 34
zebrafish
(Danio rerio)
Actinopterygii zgc:56106 34
  • 71.09 (n)
C18H11orf58 35
  • 55 (a)
OneToOne
zgc56106 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5834 34
Species where no ortholog for C11orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf58 Gene

ENSEMBL:
Gene Tree for C11orf58 (if available)
TreeFam:
Gene Tree for C11orf58 (if available)

Paralogs for C11orf58 Gene

(2) SIMAP similar genes for C11orf58 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for C11orf58 Gene

genes like me logo Genes that share paralogs with C11orf58: view

No data available for Paralogs for C11orf58 Gene

Variants for C11orf58 Gene

Sequence variations from dbSNP and Humsavar for C11orf58 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1044315 -- 16,757,719(+) AAATG(C/T)ACTTT utr-variant-3-prime
rs10634210 -- 16,741,095(+) GTTTA(-/A)AAAAA intron-variant, upstream-variant-2KB
rs10690437 -- 16,748,595(+) AAAAA(-/A)TTAGC intron-variant
rs10734249 -- 16,753,707(+) TGAAA(A/G)TGAAA intron-variant
rs10741708 -- 16,742,680(+) TTTTT(A/T)AATAT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C11orf58 Gene

Variant ID Type Subtype PubMed ID
nsv553566 CNV gain 21841781
esv2571561 CNV deletion 19546169
esv23566 CNV loss 19812545

Variation tolerance for C11orf58 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf58 Gene

Disorders for C11orf58 Gene

Relevant External Links for C11orf58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf58

No disorders were found for C11orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf58 Gene

Publications for C11orf58 Gene

  1. Novel genes expressed in the chick otocyst during development: identification using differential display of RNA. (PMID: 9263035) Gong T.-W. … Lomax M.I. (Int. J. Dev. Neurosci. 1997) 2 3 4 22 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for C11orf58 Gene

Sources for C11orf58 Gene

Content
Loading form....