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Aliases for C11orf57 Gene

Aliases for C11orf57 Gene

  • Chromosome 11 Open Reading Frame 57 2 3 5

External Ids for C11orf57 Gene

Previous GeneCards Identifiers for C11orf57 Gene

  • GC11P111451
  • GC11P111944
  • GC11P107868

Summaries for C11orf57 Gene

GeneCards Summary for C11orf57 Gene

C11orf57 (Chromosome 11 Open Reading Frame 57) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf57 Gene

Genomics for C11orf57 Gene

Regulatory Elements for C11orf57 Gene

Enhancers for C11orf57 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G111934 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -134.0 -134022 11.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 PPP2R1B SDHD C11orf52 HSPB2-C11orf52 HSPB2 TIMM8B FDXACB1 C11orf1 ALG9 PIH1D2
GH11G112289 1.5 Ensembl ENCODE dbSUPER 9.3 +218.0 217957 4.8 ATF1 ARNT CREB3L1 SIN3A FEZF1 GLIS2 GATA2 ZNF143 ZNF207 KLF7 LOC283140 RNU6-44P TEX12 PIH1D2 C11orf57 BCO2 GC11M112270 GC11P112339
GH11G112023 1.1 ENCODE 11.3 -49.0 -48960 2.5 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 PPP2R1B PIH1D2 C11orf57 DIXDC1 CRYAB C11orf52 DLAT GC11M112030
GH11G112016 1.1 Ensembl ENCODE 11.1 -57.0 -56974 2.0 PKNOX1 FOXA2 ATF1 RAD21 RARA KAT2B GATA4 GATA2 CBX5 FOS C11orf57 PIH1D2 SDHD TIMM8B FDXACB1 C11orf1 ALG9 ENSG00000255334 GC11M112018
GH11G112041 0.9 ENCODE 12.4 -31.4 -31402 1.4 HDAC1 HDGF ATF1 TBL1XR1 NFXL1 ZNF48 GATA2 FOS PAF1 ZNF263 C11orf57 PIH1D2 SDHD TIMM8B DLAT TEX12 ENSG00000271025
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C11orf57 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044954 314 1601 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for C11orf57 Gene

Chromosome:
11
Start:
112,074,086 bp from pter
End:
112,085,150 bp from pter
Size:
11,065 bases
Orientation:
Plus strand

Genomic View for C11orf57 Gene

Genes around C11orf57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf57 Gene

Proteins for C11orf57 Gene

  • Protein details for C11orf57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUT1-CK057_HUMAN
    Recommended name:
    Uncharacterized protein C11orf57
    Protein Accession:
    Q6ZUT1
    Secondary Accessions:
    • Q5RL41
    • Q6IN53
    • Q7Z357
    • Q8N2T3

    Protein attributes for C11orf57 Gene

    Size:
    292 amino acids
    Molecular mass:
    34110 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf57 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf57 Gene

Post-translational modifications for C11orf57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C11orf57 Gene

Domains & Families for C11orf57 Gene

Protein Domains for C11orf57 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf57: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf57 Gene

Function for C11orf57 Gene

Gene Ontology (GO) - Molecular Function for C11orf57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C11orf57: view

Phenotypes for C11orf57 Gene

genes like me logo Genes that share phenotypes with C11orf57: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf57 Gene

Localization for C11orf57 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf57 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf57 Gene

Pathways & Interactions for C11orf57 Gene

SuperPathways for C11orf57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf57 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf57 Gene

Transcripts for C11orf57 Gene

Unigene Clusters for C11orf57 Gene

Chromosome 11 open reading frame 57:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf57 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for C11orf57 Gene

GeneLoc Exon Structure for
C11orf57
ECgene alternative splicing isoforms for
C11orf57

Expression for C11orf57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf57 Gene

Protein differential expression in normal tissues from HIPED for C11orf57 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C11orf57 Gene



Protein tissue co-expression partners for C11orf57 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf57 Gene:

C11orf57

SOURCE GeneReport for Unigene cluster for C11orf57 Gene:

Hs.195060

Evidence on tissue expression from TISSUES for C11orf57 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with C11orf57: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf57 Gene

Orthologs for C11orf57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf57 34
  • 99.54 (n)
C11orf57 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15H11orf57 34
  • 93.41 (n)
MGC143285 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H11orf57 34
  • 92.61 (n)
C11orf57 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100151767 34
  • 86.03 (n)
mouse
(Mus musculus)
Mammalia AU019823 34 16 35
  • 85.16 (n)
oppossum
(Monodelphis domestica)
Mammalia C11orf57 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf57 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves C24H11ORF57 34
  • 67.13 (n)
C11orf57 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf57 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf57 34
  • 54.69 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1381 34
zebrafish
(Danio rerio)
Actinopterygii C15H11orf57 35
  • 42 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5815 34
Species where no ortholog for C11orf57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf57 Gene

ENSEMBL:
Gene Tree for C11orf57 (if available)
TreeFam:
Gene Tree for C11orf57 (if available)

Paralogs for C11orf57 Gene

No data available for Paralogs for C11orf57 Gene

Variants for C11orf57 Gene

Sequence variations from dbSNP and Humsavar for C11orf57 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000001540 -- 112,080,290(+) TTTAA(A/G)CAGTA intron-variant
rs1000003560 -- 112,084,206(+) CTGGC(C/G)TTACT nc-transcript-variant, utr-variant-3-prime
rs1000436736 -- 112,083,974(+) CTATA(C/T)TGTGA nc-transcript-variant, utr-variant-3-prime
rs1000856537 -- 112,075,312(+) TGGTG(C/T)TCATG intron-variant, upstream-variant-2KB
rs1001036450 -- 112,079,058(+) CTCTT(A/T)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf57 Gene

Variant ID Type Subtype PubMed ID
esv2745077 CNV deletion 23290073

Variation tolerance for C11orf57 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf57

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf57 Gene

Disorders for C11orf57 Gene

Relevant External Links for C11orf57

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf57

No disorders were found for C11orf57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf57 Gene

Publications for C11orf57 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for C11orf57 Gene

Sources for C11orf57 Gene

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