Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C11orf57 Gene

Aliases for C11orf57 Gene

  • Chromosome 11 Open Reading Frame 57 2 3 5

External Ids for C11orf57 Gene

Previous GeneCards Identifiers for C11orf57 Gene

  • GC11P111451
  • GC11P111944
  • GC11P107868

Summaries for C11orf57 Gene

GeneCards Summary for C11orf57 Gene

C11orf57 (Chromosome 11 Open Reading Frame 57) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf57 Gene

Genomics for C11orf57 Gene

Regulatory Elements for C11orf57 Gene

Enhancers for C11orf57 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F112041 0.5 ENCODE 12.4 -31.4 -31402 1.4 HDGF ATF1 TBL1XR1 JUN NFXL1 ZNF48 ZNF316 GATA2 ZSCAN29 NFE2 C11orf57 PIH1D2 TIMM8B ENSG00000255292 SDHD DLAT TEX12 ENSG00000271025
GH11F112099 0.5 ENCODE 11.6 +26.6 26571 1.4 ZNF316 BHLHE40 ZNF384 MAFK C11orf57 PIH1D2 TEX12 DIXDC1 CRYAB C11orf52 HSPB2 HSPB2-C11orf52 SDHD PPP2R1B
GH11F112023 1.1 ENCODE 11.3 -49.0 -48960 2.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PPP2R1B C11orf57 PIH1D2 DIXDC1 RPS6P16 CRYAB C11orf52 DLAT GC11M112030
GH11F112016 1.1 Ensembl ENCODE 11 -57.0 -56974 2.0 PKNOX1 ATF1 RAD21 RARA KAT2B CBX5 FOS CREM MIXL1 CBFB PIH1D2 C11orf57 SDHD TIMM8B ENSG00000255292 C11orf1 FDXACB1 ALG9 ENSG00000255334 GC11M112018
GH11F112103 0.5 Ensembl 10.5 +29.5 29515 0.8 PPP2R1B C11orf57 PIH1D2 TEX12 CRYAB HSPB2 HSPB2-C11orf52 C11orf52 ENSG00000255292 IL18
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C11orf57 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C11orf57 Gene

112,074,086 bp from pter
112,085,150 bp from pter
11,065 bases
Plus strand

Genomic View for C11orf57 Gene

Genes around C11orf57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf57 Gene

Proteins for C11orf57 Gene

  • Protein details for C11orf57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf57
    Protein Accession:
    Secondary Accessions:
    • Q5RL41
    • Q6IN53
    • Q7Z357
    • Q8N2T3

    Protein attributes for C11orf57 Gene

    292 amino acids
    Molecular mass:
    34110 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf57 Gene


neXtProt entry for C11orf57 Gene

Post-translational modifications for C11orf57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C11orf57 Gene

Domains & Families for C11orf57 Gene

Protein Domains for C11orf57 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf57: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf57 Gene

Function for C11orf57 Gene

Gene Ontology (GO) - Molecular Function for C11orf57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C11orf57: view

Phenotypes for C11orf57 Gene

genes like me logo Genes that share phenotypes with C11orf57: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf57 Gene

Localization for C11orf57 Gene

Subcellular locations from

Jensen Localization Image for C11orf57 Gene COMPARTMENTS Subcellular localization image for C11orf57 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf57 Gene

Pathways & Interactions for C11orf57 Gene

SuperPathways for C11orf57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf57 Gene


No data available for Pathways by source and SIGNOR curated interactions for C11orf57 Gene

Transcripts for C11orf57 Gene

Unigene Clusters for C11orf57 Gene

Chromosome 11 open reading frame 57:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf57 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for C11orf57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C11orf57 Gene

Protein differential expression in normal tissues from HIPED for C11orf57 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C11orf57 Gene

Protein tissue co-expression partners for C11orf57 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf57 Gene:


SOURCE GeneReport for Unigene cluster for C11orf57 Gene:

genes like me logo Genes that share expression patterns with C11orf57: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C11orf57 Gene

Orthologs for C11orf57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf57 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11H11orf57 34
  • 99.54 (n)
C11orf57 35
  • 99 (a)
(Bos Taurus)
Mammalia C15H11orf57 34
  • 93.41 (n)
MGC143285 35
  • 93 (a)
(Canis familiaris)
Mammalia C5H11orf57 34
  • 92.61 (n)
C11orf57 35
  • 92 (a)
(Rattus norvegicus)
Mammalia LOC100151767 34
  • 86.03 (n)
(Mus musculus)
Mammalia AU019823 34 16 35
  • 85.16 (n)
(Monodelphis domestica)
Mammalia C11orf57 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf57 35
  • 57 (a)
(Gallus gallus)
Aves C24H11ORF57 34
  • 67.13 (n)
C11orf57 35
  • 50 (a)
(Anolis carolinensis)
Reptilia C11orf57 35
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf57 34
  • 54.69 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1381 34
(Danio rerio)
Actinopterygii C15H11orf57 35
  • 42 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5815 34
Species where no ortholog for C11orf57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf57 Gene

Gene Tree for C11orf57 (if available)
Gene Tree for C11orf57 (if available)

Paralogs for C11orf57 Gene

No data available for Paralogs for C11orf57 Gene

Variants for C11orf57 Gene

Sequence variations from dbSNP and Humsavar for C11orf57 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10255 -- 112,083,292(-) GATTG(G/T)TGTAC nc-transcript-variant, utr-variant-3-prime
rs10749987 -- 112,072,710(+) AATAC(A/C)AAAAT intron-variant, upstream-variant-2KB
rs10812 -- 112,084,778(-) CTTGC(A/G)AAAGA intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111491176 -- 112,072,320(+) TAGGA(-/G)GGTTG intron-variant, upstream-variant-2KB
rs111798527 -- 112,077,305(+) ATTAT(G/T)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf57 Gene

Variant ID Type Subtype PubMed ID
esv2745077 CNV deletion 23290073

Variation tolerance for C11orf57 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf57 Gene

Disorders for C11orf57 Gene

Relevant External Links for C11orf57

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C11orf57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf57 Gene

Publications for C11orf57 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for C11orf57 Gene

Sources for C11orf57 Gene

Loading form....