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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C11orf57 Gene

protein-coding   GIFtS: 40
GCID: GC11P111944

chromosome 11 open reading frame 57

 Explore 1 disease affiliated with
C11orf57 via our new
 Human Malady Compendium 
Biological research products
for C11orf57
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chromosome 11 Open Reading Frame 571 2
FLJ107261
Uncharacterized Protein C11orf572

External Ids:    HGNC: 255691   Entrez Gene: 552162   Ensembl: ENSG000001507767   UniProtKB: Q6ZUT13   

Export aliases for C11orf57 gene to outside databases

Previous GC identifers: GC11P111451 GC11P107868


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C11orf57 gene promoter:
         RFX1   FOXD3   POU3F2 (N-Oct-5a)   POU3F2   Tal-1beta   AREB6   RORalpha1   Pax-4a   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C11orf57

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf57


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

C11orf57 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf57 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P111944:  view genomic region     (about GC identifiers)

Start:
111,944,810 bp from pter      End:
111,955,874 bp from pter
Size:
11,065 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CK057_HUMAN, Q6ZUT1 (See protein sequence)
Recommended Name: Uncharacterized protein C11orf57  
Size: 292 amino acids; 34110 Da
Secondary accessions: Q5RL41 Q6IN53 Q7Z357 Q8N2T3
Alternative splicing: 3 isoforms:  Q6ZUT1-1   Q6ZUT1-2   Q6ZUT1-3   (Contains a phosphothreonine at position 94. Contains a phosphoserine at position 96. Contains a phosphoserine at position 97)

Explore the universe of human proteins at neXtProt for C11orf57: NX_Q6ZUT1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZUT1

  • C11orf57 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001076438.1  NP_001076439.1  NP_060665.3  

    ENSEMBL proteins: 
     ENSP00000402208   ENSP00000432188   ENSP00000339076   ENSP00000435169   ENSP00000436169  
     ENSP00000432677   ENSP00000376767   ENSP00000435408   ENSP00000434054  

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    Novus Biologicals C11orf57 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for C11orf57


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    Uscn ELISAs and CLIAs for C11orf57


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6ZUT1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 3): C11orf57
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C11orf57
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate C11orf57 (see all 44):
    hsa-miR-3194-5p hsa-miR-3938 hsa-let-7d hsa-miR-29a hsa-miR-218 hsa-let-7g hsa-let-7a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidC11orf57 3' UTR sequence
    Inhib. RNA
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    Search LifeMap BioReagents cell lines for C11orf57

    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf57


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf57

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for C11orf57 (Q6ZUT13 ENSP000003767674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MKRN3Q130643I2D: score=1 
    S100BP042713I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    MAPK8ENSP000003534834STRING: ENSP00000353483
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C11orf57
    Search CenterWatch for drugs/clinical trials and news about C11orf57 / CK057 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C11orf57 gene (3 alternative transcripts): 
    NM_001082969.1  NM_001082970.1  NM_018195.3  

    Unigene Cluster for C11orf57:

    Chromosome 11 open reading frame 57
    Hs.195060  [show with all ESTs]
    Unigene Representative Sequence: NM_018195
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420986 ENST00000532163(uc001pmw.4 uc001pmr.4 uc001pmt.4 uc001pmv.4 uc001pms.4)
    ENST00000280352 ENST00000530104(uc001pmu.2) ENST00000526879 ENST00000524989
    ENST00000393047 ENST00000525785 ENST00000531378

    miRNA
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    OriGene 3'-UTR Clone (see all 3): C11orf57
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C11orf57
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate C11orf57 (see all 44):
    hsa-miR-3194-5p hsa-miR-3938 hsa-let-7d hsa-miR-29a hsa-miR-218 hsa-let-7g hsa-let-7a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidC11orf57 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C11orf57 (see all 4)
    OriGene shRNA RFP: C11orf57
    OriGene siRNA: C11orf57
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C11orf57
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf57 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf57 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): C11orf57 (NM_001082970)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C11orf57
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf57

    Additional cDNA sequence: 

    AB096251.1 AK001588.1 AK125340.1 BC005403.1 BC030546.1 BC048133.1 BC072455.1 

    16 DOTS entries:

    DT.100651701  DT.101982480  DT.86854195  DT.453563  DT.101982479  DT.75123191  DT.120733715  DT.101983723 
    DT.100651700  DT.120733801  DT.100724649  DT.120733870  DT.91973611  DT.95178995  DT.100694767  DT.95138569 

    24/177 AceView cDNA sequences (see all 177):

    AB096251 BX473057 BX280182 BU187413 AL544946 AW243438 AA355459 AI318070 
    C20585 N67983 AI278841 AA862760 AI474050 BC005403 AW629340 AA991664 
    AU117931 CB132081 AK094203 AA195401 BC030546 BI855601 AA384827 CB125824 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C11orf57 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                          -           -     -                 -                     
    SP2:                          -                                   -                     
    SP3:                          -           -     -                 -                     
    SP4:                                      -     -                 -                     
    SP5:                                                              -                     


    ECgene alternative splicing isoforms for C11orf57

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C11orf57 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTTGGTATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See C11orf57 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C11orf57

    SOURCE GeneReport for Unigene cluster: Hs.195060
        SABiosciences Custom PCR Arrays for C11orf57
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf57

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C11orf57 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia AU0198231 , 5 expressed sequence AU0198231, 5 84.88(n)1
    83.85(a)1
      9 (27.75 cM)5
    2701561  NM_001134902.11  NP_001128374.11 
     506052405 
    chicken
    (Gallus gallus)
    Aves C24H11orf571 chromosome 24 open reading frame, human C11orf57 67.01(n)
    60.69(a)
      419794  XM_417931.3  XP_417931.3 
    lizard
    (Anolis carolinensis)
    Reptilia C11orf576
    --
    49(a)
    1 ↔ 1
    GL343973.1(75749-78910)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.13812 Xenopus laevis transcribed sequences 78.86(n)    BJ624188.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1623391 zgc:162339 52.52(n)
    45.71(a)
      556473  NM_001160409.1  NP_001153881.1 


    ENSEMBL Gene Tree for C11orf57 (if available)
    TreeFam Gene Tree for C11orf57 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/199 NCBI SNPs in C11orf57 are shown (see all 199    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114911761,2
    C,--111943044(+) TAGGAG/-GGTTG 5 -- us2k1 int11Minor allele frequency- -:0.50CSA 2
    rs1412976791,2
    --111943229(+) TGTGCC/TACTGC 5 -- us2k1 int10--------
    rs107499871,2
    C,H,--111943434(+) AATACA/CAAAAT 5 -- int1 us2k17Minor allele frequency- C:0.00NA WA CSA 13
    rs1925573311,2
    --111943467(+) CCTGTA/GATCCC 5 -- us2k1 int10--------
    rs1379571641,2
    --111943503(+) GAATCA/GCTTAA 5 -- us2k1 int10--------
    rs1494826891,2
    --111943514(+) ACCCGA/GGAGGC 5 -- us2k1 int10--------
    rs1841376821,2
    --111943521(+) AGGCAC/GAGGTT 5 -- us2k1 int10--------
    rs2022376071,2
    --111943608(+) AAAAC-/AAAAAC 5 -- us2k1 int10--------
    rs5006381,2
    C,H--111943613(+) CAAAAA/CAAAAA 5 -- us2k1 int12Minor allele frequency- C:0.25NA 4
    rs2004355151,2
    --111943617(+) CAAAA-/CAAAAA 5 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for C11orf57 (111944810 - 111955874 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for C11orf57: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C11orf57
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C11orf57 for disorders           About GeneDecksing

    1 disease for C11orf57:    About MalaCards
    parkinson's disease

    1 disease from the University of Copenhagen DISEASES database for C11orf57:
    Paraganglioma

    Export disorders for C11orf57 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C11orf57 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C11orf57)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    5. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Identification of genes related to Parkinson's disease using expressed sequence tags. (PubMed id 17213182)1 Kim J.M....Kim N.S. (2006)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55216 HGNC: 25569 AceView: FLJ10726 Ensembl:ENSG00000150776 euGenes: HUgn55216
    ECgene: C11orf57 H-InvDB: C11orf57

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C11orf57 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C11orf57 gene:
    Search GeneIP for patents involving C11orf57

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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