C11orf57 Gene
protein-coding GIFtS : 40
GCID: GC11 P111944
chromosome 11 open reading frame 57
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Aliasesfor C11orf57 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome 11 Open Reading Frame 57 1 2 FLJ107261 Uncharacterized Protein C11orf572
Export aliases for C11orf57 gene to outside databases Previous GC identifers: GC11P111451 GC11P107868
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Summariesfor C11orf57 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor C11orf57 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_033899.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the C11orf57 gene promoter: RFX1 FOXD3 POU3F2 (N-Oct-5a) POU3F2 Tal-1beta AREB6 RORalpha1 Pax-4a ITF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for C11orf57 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf57
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q23.1 Ensembl cytogenetic band: 11q23.1 HGNC cytogenetic band: 11q23.1 C11orf57 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P111944: view genomic region
(about GC identifiers )
Start:
111,944,810 bp from pter
End:
111,955,874 bp from pter
Size:
11,065 bases
Orientation:
plus strand
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Proteinsfor C11orf57 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CK057_HUMAN, Q6ZUT1 (See
protein sequence )Recommended Name: Uncharacterized protein C11orf57 Size : 292 amino acids; 34110 Da
Secondary accessions : Q5RL41 Q6IN53 Q7Z357 Q8N2T3Alternative splicing : 3 isoforms : Q6ZUT1-1 Q6ZUT1-2 Q6ZUT1-3 (Contains a phosphothreonine at position 94. Contains a phosphoserine at position 96. Contains a phosphoserine at position 97)Explore the universe of human proteins at neXtProt for C11orf57: NX_Q6ZUT1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6ZUT1 C11orf57 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001076438.1 NP_001076439.1 NP_060665.3 ENSEMBL proteins: ENSP00000402208 ENSP00000432188 ENSP00000339076 ENSP00000435169 ENSP00000436169 ENSP00000432677 ENSP00000376767 ENSP00000435408 ENSP00000434054 Human Recombinant Protein Products: C11orf57 Antibody Products: Assay Products for C11orf57:
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Protein
Domains / Familiesfor C11orf57 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q6ZUT1
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Functionfor C11orf57 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C11orf57 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C11orf57 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): C11orf57 (NM_001082970 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C11orf57 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C11orf57
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf57
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Pathways & Interactionsfor C11orf57 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf57 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)4 Interacting proteins for C11orf57 (Q6ZUT1 3 ENSP00000376767 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor C11orf57 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for C11orf57 Search CenterWatch for drugs/clinical trials and news about C11orf57 / CK057
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Transcriptsfor C11orf57 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for C11orf57 gene (3 alternative transcripts): NM_001082969.1 NM_001082970.1 NM_018195.3 Unigene Cluster for C11orf57:
Chromosome 11 open reading frame 57 Hs.195060 [show with all ESTs ] Unigene Representative Sequence: NM_018195 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000420986 ENST00000532163 (uc001pmw.4 uc001pmr.4 uc001pmt.4 uc001pmv.4 uc001pms.4 )ENST00000280352 ENST00000530104 (uc001pmu.2 ) ENST00000526879 ENST00000524989 ENST00000393047 ENST00000525785 ENST00000531378 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C11orf57 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C11orf57 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): C11orf57 (NM_001082970 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C11orf57 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C11orf57
Additional cDNA sequence: AB096251.1 AK001588.1 AK125340.1 BC005403.1 BC030546.1 BC048133.1 BC072455.1
16 DOTS entries : DT.100651701 DT.101982480
DT.86854195 DT.453563 DT.101982479 DT.75123191 DT.120733715 DT.101983723 DT.100651700 DT.120733801 DT.100724649 DT.120733870 DT.91973611 DT.95178995 DT.100694767 DT.95138569 24/177 AceView cDNA sequences (see all 177 ):
AB096251 BX473057 BX280182 BU187413 AL544946 AW243438 AA355459 AI318070 C20585 N67983 AI278841 AA862760 AI474050 BC005403 AW629340 AA991664 AU117931 CB132081 AK094203 AA195401 BC030546 BI855601 AA384827 CB125824 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C11orf57 (see all 7 ) About this scheme ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b SP1 :         -     -   -       -         SP2 :         -             -         SP3 :         -     -   -       -         SP4 :             -   -       -         SP5 :                     -        
ECgene alternative splicing isoforms for C11orf57
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Expression for C11orf57 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section C11orf57 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGTTGGTATT
About this image See C11orf57 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for C11orf57 SOURCE GeneReport for Unigene cluster: Hs.195060 SABiosciences Custom PCR Arrays for C11orf57 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C11orf57Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat C11orf57 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C11orf57 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C11orf57 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf57
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Orthologsfor C11orf57 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for C11orf57 gene from 5/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for C11orf57 (if available)TreeFam Gene Tree for C11orf57 (if available)
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Paralogsfor C11orf57 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor C11orf57 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for C11orf57 (111944810 - 111955874 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for C11orf57: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C11orf57
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Disorders
/ Diseasesfor C11orf57 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
C11orf57 for disorders About GeneDecksing 1 disease for C11orf57 : About MalaCards parkinson's disease 1 disease from the University of Copenhagen DISEASES database for C11orf57 :Paraganglioma Export disorders for C11orf57 gene to outside databases
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Publicationsfor C11orf57 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for C11orf57 gene integrated from 9 sources : (articles sorted by number of sources associating them with C11orf57) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Identification of genes related to Parkinson's disease using expressed sequence tags. (PubMed id 17213182) 1 Kim J.M....Kim N.S. (2006) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for C11orf57 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing C11orf57 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing C11orf57 gene
(According to HUGE )
About This Section --
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Specialized Databases showing C11orf57 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for C11orf57 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for C11orf57 gene: Search GeneIP for patents involving C11orf57 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor C11orf57 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for C11orf57 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for C11orf57 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C11orf57 OriGene Protein Over-expression Lysate for C11orf57 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for C11orf57 OriGene 3'-UTR Clone for C11orf57 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C11orf57 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C11orf57 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for C11orf57 OriGene Custom Protein Services for C11orf57 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C11orf57 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C11orf57 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf57 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat C11orf57 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C11orf57 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C11orf57
C11orf57 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf57
Search ThermoFisher Antibodies for C11orf57
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C11orf57
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Aliases for C11orf57
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Disorders / Diseases for C11orf57
Domains / Families for C11orf57
Drugs / Compounds for C11orf57
Expression for C11orf57
Function for C11orf57
Genomic Views for C11orf57
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Paralogs for C11orf57
Pathways / Interactions for C11orf57
Products for C11orf57
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