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Aliases for C11orf54 Gene

Aliases for C11orf54 Gene

  • Chromosome 11 Open Reading Frame 54 2 3
  • Ester Hydrolase C11orf54 3
  • EC 3.1.-.- 4
  • PTOD012 3
  • PTD012 3

External Ids for C11orf54 Gene

Previous GeneCards Identifiers for C11orf54 Gene

  • GC11P093115
  • GC11P093474
  • GC11P089552

Summaries for C11orf54 Gene

GeneCards Summary for C11orf54 Gene

C11orf54 (Chromosome 11 Open Reading Frame 54) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot for C11orf54 Gene

  • Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.

Gene Wiki entry for C11orf54 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf54 Gene

Genomics for C11orf54 Gene

Regulatory Elements for C11orf54 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C11orf54 Gene

Start:
93,741,591 bp from pter
End:
93,764,749 bp from pter
Size:
23,159 bases
Orientation:
Plus strand

Genomic View for C11orf54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C11orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf54 Gene

Proteins for C11orf54 Gene

  • Protein details for C11orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0W9-CK054_HUMAN
    Recommended name:
    Ester hydrolase C11orf54
    Protein Accession:
    Q9H0W9
    Secondary Accessions:
    • A8K850
    • Q6FI88
    • Q6XYB0
    • Q96EI3
    • Q96IX1
    • Q9Y6B4

    Protein attributes for C11orf54 Gene

    Size:
    315 amino acids
    Molecular mass:
    35117 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAH07110.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP34483.1; Type=Frameshift; Positions=125; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for C11orf54 Gene

    Alternative splice isoforms for C11orf54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf54 Gene

Proteomics data for C11orf54 Gene at MOPED

Post-translational modifications for C11orf54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for C11orf54 Gene

Domains for C11orf54 Gene

Protein Domains for C11orf54 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C11orf54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf54: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C11orf54 Gene

Function for C11orf54 Gene

Molecular function for C11orf54 Gene

UniProtKB/Swiss-Prot Function:
Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.

Enzyme Numbers (IUBMB) for C11orf54 Gene

Gene Ontology (GO) - Molecular Function for C11orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IDA 16522806
GO:0016788 hydrolase activity, acting on ester bonds IDA 16522806
genes like me logo Genes that share ontologies with C11orf54: view

Animal Model Products

CRISPR Products

miRNA for C11orf54 Gene

miRTarBase miRNAs that target C11orf54

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C11orf54 Gene

Localization for C11orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C11orf54 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C11orf54 Gene COMPARTMENTS Subcellular localization image for C11orf54 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C11orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with C11orf54: view

Pathways for C11orf54 Gene

SuperPathways for C11orf54 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with C11orf54: view

No data available for Pathways by source for C11orf54 Gene

Transcripts for C11orf54 Gene

Unigene Clusters for C11orf54 Gene

Chromosome 11 open reading frame 54:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C11orf54

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf54 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: - - -
SP12: - - - - - - - -
SP13: - -
SP14: - - - - - -
SP15: -
SP16: - - -

ExUns: 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for C11orf54 Gene

GeneLoc Exon Structure for
C11orf54
ECgene alternative splicing isoforms for
C11orf54

Expression for C11orf54 Gene

mRNA expression in normal human tissues for C11orf54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C11orf54 Gene

This gene is overexpressed in Kidney - Cortex (7.9) and Liver (4.2).

Protein differential expression in normal tissues for C11orf54 Gene

This gene is overexpressed in Liver, secretome (16.1) and Kidney (12.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C11orf54 Gene

SOURCE GeneReport for Unigene cluster for C11orf54 Gene Hs.8360

genes like me logo Genes that share expressions with C11orf54: view

Expression partners for C11orf54 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for C11orf54 Gene

Orthologs for C11orf54 Gene

This gene was present in the common ancestor of animals.

Orthologs for C11orf54 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C29H11orf54 35
  • 91.11 (n)
  • 91.11 (a)
C11orf54 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C21H11orf54 35
  • 90.48 (n)
  • 89.84 (a)
C11orf54 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4931406C07Rik 35
  • 85.61 (n)
  • 87.94 (a)
4931406C07Rik 16
4931406C07Rik 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf54 35
  • 99.68 (n)
  • 99.68 (a)
C11orf54 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309534 35
  • 82.43 (n)
  • 86.67 (a)
oppossum
(Monodelphis domestica)
Mammalia C11orf54 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf54 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H11ORF54 35
  • 73.31 (n)
  • 73.63 (a)
C1H11ORF54 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf54 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf54 35
  • 67.53 (n)
  • 64.72 (a)
Str.17657 35
zebrafish
(Danio rerio)
Actinopterygii wufc54a08 35
zgc:85789 35
  • 64.09 (n)
  • 63.67 (a)
C24H11orf54 36
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9818 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006729 35
  • 49.89 (n)
  • 45.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9119 35
  • 48.97 (n)
  • 48.53 (a)
CG32335 36
  • 36 (a)
OneToMany
CG9119 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C24B5.4 35
  • 52.64 (n)
  • 44.14 (a)
C24B5.4 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for C11orf54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C11orf54 Gene

ENSEMBL:
Gene Tree for C11orf54 (if available)
TreeFam:
Gene Tree for C11orf54 (if available)

Paralogs for C11orf54 Gene

No data available for Paralogs for C11orf54 Gene

Variants for C11orf54 Gene

Sequence variations from dbSNP and Humsavar for C11orf54 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7310 -- 93,762,809(+) TGAAC(A/G)TGACC utr-variant-3-prime
rs7814 -- 93,763,017(-) ACTCA(C/T)AAGAC utr-variant-3-prime
rs15345 -- 93,762,200(+) AACAT(C/T)ATTAC utr-variant-3-prime
rs584474 -- 93,754,342(+) AGCTT(A/C)TCTAT intron-variant
rs595650 -- 93,747,024(+) TCACA(A/C)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf54 Gene

Variant ID Type Subtype PubMed ID
nsv898173 CNV Loss 21882294
nsv898181 CNV Gain 21882294
nsv898182 CNV Gain 21882294
nsv832232 CNV Gain 17160897

Relevant External Links for C11orf54 Gene

HapMap Linkage Disequilibrium report
C11orf54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf54 Gene

Disorders for C11orf54 Gene

No disorders were found for C11orf54 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for C11orf54 Gene

Publications for C11orf54 Gene

  1. Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold. (PMID: 16522806) Manjasetty B.A. … Heinemann U. (Protein Sci. 2006) 2 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for C11orf54 Gene

Sources for C11orf54 Gene

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