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Aliases for C11orf53 Gene

Aliases for C11orf53 Gene

  • Chromosome 11 Open Reading Frame 53 2 3

External Ids for C11orf53 Gene

Previous GeneCards Identifiers for C11orf53 Gene

  • GC11P110632
  • GC11P111126
  • GC11P107051

Summaries for C11orf53 Gene

GeneCards Summary for C11orf53 Gene

C11orf53 (Chromosome 11 Open Reading Frame 53) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf53 Gene

Genomics for C11orf53 Gene

Regulatory Elements for C11orf53 Gene

Genomic Location for C11orf53 Gene

111,245,704 bp from pter
111,286,406 bp from pter
40,703 bases
Plus strand

Genomic View for C11orf53 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C11orf53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf53 Gene

Proteins for C11orf53 Gene

  • Protein details for C11orf53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf53
    Protein Accession:

    Protein attributes for C11orf53 Gene

    236 amino acids
    Molecular mass:
    25393 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf53 Gene

Proteomics data for C11orf53 Gene at MOPED

Post-translational modifications for C11orf53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf53 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C11orf53 Gene

Domains & Families for C11orf53 Gene

Protein Domains for C11orf53 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf53: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf53 Gene

Function for C11orf53 Gene

Phenotypes for C11orf53 Gene

genes like me logo Genes that share phenotypes with C11orf53: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C11orf53

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf53 Gene

Localization for C11orf53 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C11orf53 Gene

Pathways & Interactions for C11orf53 Gene

SuperPathways for C11orf53 Gene

No Data Available

Interacting Proteins for C11orf53 Gene

Selected Interacting proteins: Q8IXP5-CK053_HUMAN for C11orf53 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C11orf53 Gene


No data available for Pathways by source and SIGNOR curated interactions for C11orf53 Gene

Drugs & Compounds for C11orf53 Gene

No Compound Related Data Available

Transcripts for C11orf53 Gene

mRNA/cDNA for C11orf53 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C11orf53 Gene

Chromosome 11 open reading frame 53:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C11orf53

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf53 Gene

No ASD Table

Relevant External Links for C11orf53 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf53 Gene

mRNA expression in normal human tissues for C11orf53 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf53 Gene

This gene is overexpressed in Testis (x12.4), Breast - Mammary Tissue (x7.6), Stomach (x6.0), and Colon - Transverse (x4.2).

Protein differential expression in normal tissues from HIPED for C11orf53 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf53 Gene

SOURCE GeneReport for Unigene cluster for C11orf53 Gene Hs.298685

genes like me logo Genes that share expression patterns with C11orf53: view

Protein tissue co-expression partners for C11orf53 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C11orf53 Gene

Orthologs for C11orf53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf53 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C15H11orf53 35
  • 79.29 (n)
  • 76.6 (a)
C11orf53 36
  • 74 (a)
(Canis familiaris)
Mammalia C5H11orf53 35
  • 79.57 (n)
  • 75.74 (a)
C11orf53 36
  • 76 (a)
(Mus musculus)
Mammalia 1810046K07Rik 35
  • 80.71 (n)
  • 82.55 (a)
1810046K07Rik 16
1810046K07Rik 36
  • 83 (a)
(Pan troglodytes)
Mammalia C11H11orf53 35
  • 99.01 (n)
  • 100 (a)
C11orf53 36
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1562914 35
  • 81.7 (n)
  • 83.4 (a)
(Monodelphis domestica)
Mammalia C11orf53 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf53 36
  • 59 (a)
(Anolis carolinensis)
Reptilia C11orf53 36
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496834 35
  • 57.18 (n)
  • 47.41 (a)
(Danio rerio)
Actinopterygii LOC101884656 35
  • 51.02 (n)
  • 42.11 (a)
C15H11orf53 (2 of 2) 36
  • 32 (a)
C5H11orf53 (1 of 2) 36
  • 30 (a)
Species with no ortholog for C11orf53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf53 Gene

Gene Tree for C11orf53 (if available)
Gene Tree for C11orf53 (if available)

Paralogs for C11orf53 Gene

No data available for Paralogs for C11orf53 Gene

Variants for C11orf53 Gene

Sequence variations from dbSNP and Humsavar for C11orf53 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs950341 -- 111,245,384(+) ATAAC(C/T)TAAGT upstream-variant-2KB
rs950342 -- 111,245,561(+) TGTTC(C/T)TAATG upstream-variant-2KB
rs1568202 -- 111,245,754(+) AGGCT(A/G)AGCTT utr-variant-5-prime
rs1893987 -- 111,277,641(+) ATTGG(A/C/G)CATGT intron-variant
rs1893992 -- 111,281,927(-) GAGAT(G/T)GTCTT intron-variant

Variation tolerance for C11orf53 Gene

Residual Variation Intolerance Score: 64.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf53 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C11orf53 Gene

Disorders for C11orf53 Gene

Relevant External Links for C11orf53

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C11orf53: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf53 Gene

Publications for C11orf53 Gene

  1. Open reading frames associated with cancer in the dark matter of the human genome. (PMID: 25048349) Delgado A.P. … Narayanan R. (Cancer Genomics Proteomics 2014) 2 67
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 67
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for C11orf53 Gene

Sources for C11orf53 Gene

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