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Aliases for C11orf49 Gene

Aliases for C11orf49 Gene

  • Chromosome 11 Open Reading Frame 49 2 3 5

External Ids for C11orf49 Gene

Previous GeneCards Identifiers for C11orf49 Gene

  • GC11P046663

Summaries for C11orf49 Gene

GeneCards Summary for C11orf49 Gene

C11orf49 (Chromosome 11 Open Reading Frame 49) is a Protein Coding gene.

Gene Wiki entry for C11orf49 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf49 Gene

Genomics for C11orf49 Gene

Regulatory Elements for C11orf49 Gene

Promoters for C11orf49 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C11orf49 on UCSC Golden Path with GeneCards custom track

Genomic Location for C11orf49 Gene

Chromosome:
11
Start:
46,936,528 bp from pter
End:
47,164,385 bp from pter
Size:
227,858 bases
Orientation:
Plus strand

Genomic View for C11orf49 Gene

Genes around C11orf49 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf49 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf49 Gene

Proteins for C11orf49 Gene

  • Protein details for C11orf49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6J7-CK049_HUMAN
    Recommended name:
    UPF0705 protein C11orf49
    Protein Accession:
    Q9H6J7
    Secondary Accessions:
    • D3DQQ8
    • E9PAX7
    • Q7L077
    • Q96CS8
    • Q9BQH4
    • Q9BUW5

    Protein attributes for C11orf49 Gene

    Size:
    331 amino acids
    Molecular mass:
    37353 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf49 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf49 Gene

Proteomics data for C11orf49 Gene at MOPED

Post-translational modifications for C11orf49 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C11orf49 Gene

Domains & Families for C11orf49 Gene

Protein Domains for C11orf49 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C11orf49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6J7

UniProtKB/Swiss-Prot:

CK049_HUMAN :
  • Belongs to the UPF0705 family.
Family:
  • Belongs to the UPF0705 family.
genes like me logo Genes that share domains with C11orf49: view

No data available for Gene Families for C11orf49 Gene

Function for C11orf49 Gene

genes like me logo Genes that share phenotypes with C11orf49: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf49 Gene

Localization for C11orf49 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C11orf49 Gene COMPARTMENTS Subcellular localization image for C11orf49 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf49 Gene

Pathways & Interactions for C11orf49 Gene

SuperPathways for C11orf49 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf49 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf49 Gene

Drugs & Compounds for C11orf49 Gene

No Compound Related Data Available

Transcripts for C11orf49 Gene

Unigene Clusters for C11orf49 Gene

Chromosome 11 open reading frame 49:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf49 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for C11orf49 Gene

GeneLoc Exon Structure for
C11orf49
ECgene alternative splicing isoforms for
C11orf49

Expression for C11orf49 Gene

mRNA expression in normal human tissues for C11orf49 Gene

Protein differential expression in normal tissues from HIPED for C11orf49 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C11orf49 Gene



SOURCE GeneReport for Unigene cluster for C11orf49 Gene Hs.368296

genes like me logo Genes that share expression patterns with C11orf49: view

Protein tissue co-expression partners for C11orf49 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C11orf49 Gene

Orthologs for C11orf49 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf49 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C15H11orf49 35
  • 89.73 (n)
  • 94.2 (a)
C11orf49 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110051M20Rik 35
  • 87.81 (n)
  • 93.66 (a)
1110051M20Rik 16
1110051M20Rik 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf49 35
  • 99.51 (n)
  • 98.81 (a)
C11ORF49 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309540 35
  • 88.12 (n)
  • 93.35 (a)
dog
(Canis familiaris)
Mammalia C11ORF49 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C11orf49 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf49 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves C11ORF49 35
  • 74.47 (n)
  • 79.03 (a)
C11orf49 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf49 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf49 35
  • 64.43 (n)
  • 64.02 (a)
Str.11880 35
zebrafish
(Danio rerio)
Actinopterygii zgc:92873 35
  • 60.18 (n)
  • 56.23 (a)
C25H11orf49 36
  • 56 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6650 36
  • 44 (a)
OneToOne
Species with no ortholog for C11orf49:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf49 Gene

ENSEMBL:
Gene Tree for C11orf49 (if available)
TreeFam:
Gene Tree for C11orf49 (if available)

Paralogs for C11orf49 Gene

No data available for Paralogs for C11orf49 Gene

Variants for C11orf49 Gene

Sequence variations from dbSNP and Humsavar for C11orf49 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs14051 -- 47,052,425(+) TCTTT(C/T)GAGAA intron-variant, nc-transcript-variant, reference, stop-gained
rs14717 -- 47,162,022(-) CTATT(C/T)GGGTT intron-variant, nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime
rs14718 -- 47,162,106(-) TGTTC(C/T)CCAAC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs923324 -- 47,142,657(-) TGAAG(C/G)CTCAC intron-variant
rs1060573 -- 47,158,278(-) TCTCT(C/T)TGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf49 Gene

Variant ID Type Subtype PubMed ID
esv2675104 CNV Deletion 23128226
esv2661994 CNV Deletion 23128226
nsv510253 CNV Loss 20534489
nsv312 CNV Loss 18451855
nsv508627 CNV Loss 20534489
esv33095 CNV Loss 17666407
esv998583 CNV Deletion 20482838
nsv512222 CNV Loss 21212237
esv4508 CNV Deletion 18987735
esv2744435 CNV Deletion 23290073
nsv498753 CNV Loss 21111241
esv23070 CNV Gain 19812545
nsv821175 CNV Deletion 20802225
nsv825868 CNV Loss 20364138
nsv820057 CNV Gain 19587683
esv990426 CNV Loss 20482838
nsv825869 CNV Loss 20364138
nsv514618 CNV Loss 21397061
esv2542584 CNV Deletion 19546169
nsv313 CNV Insertion 18451855
nsv526628 CNV Loss 19592680
nsv897323 CNV Loss 21882294

Variation tolerance for C11orf49 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf49 Gene

HapMap Linkage Disequilibrium report
C11orf49

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf49 Gene

Disorders for C11orf49 Gene

Relevant External Links for C11orf49

Genetic Association Database (GAD)
C11orf49
Human Genome Epidemiology (HuGE) Navigator
C11orf49
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf49

No disorders were found for C11orf49 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf49 Gene

Publications for C11orf49 Gene

  1. Genetic predictors of fibrin D-dimer levels in healthy adults. (PMID: 21502573) Smith N.L. … Hayward C. (Circulation 2011) 3 48 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne. (PMID: 24399259) He L. … Zhang Y.P. (Nat Commun 2014) 3

Products for C11orf49 Gene

Sources for C11orf49 Gene

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