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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C11orf34 Gene

protein-coding   GIFtS: 34
GCID: GC11M112118

Chromosome 11 Open Reading Frame 34

  Search for C11orf34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 11 Open Reading Frame 341 2
PLET12 5
Placenta-Expressed Transcript 11
Placenta Expressed Transcript 12
Placenta-Expressed Transcript 1 Protein2

External Ids:    HGNC: 300531   Entrez Gene: 3496332   Ensembl: ENSG000001887717   OMIM: 6119045   UniProtKB: Q6UQ283   

Export aliases for C11orf34 gene to outside databases

Previous GC identifers: GC11M111657 GC11U900619 GC11M111625 GC11M108044


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C11orf34 Gene: 
C11orf34 (chromosome 11 open reading frame 34) is a protein-coding gene.

UniProtKB/Swiss-Prot: PLET1_HUMAN, Q6UQ28
Function: May participate in the wound response during the healing process, and promote wound repair (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C11orf34 gene promoter:
         TBP   Elk-1   Pbx1a   COUP   CUTL1   Evi-1   FAC1   Nkx6-1   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C11orf34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

C11orf34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf34 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M112118:  view genomic region     (about GC identifiers)

Start:
112,118,876 bp from pter      End:
112,131,583 bp from pter
Size:
12,708 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLET1_HUMAN, Q6UQ28 (See protein sequence)
Recommended Name: Placenta-expressed transcript 1 protein precursor  
Size: 207 amino acids; 23385 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: Q6UQ24 Q6UQ25 Q6UQ27

Explore the universe of human proteins at neXtProt for C11orf34: NX_Q6UQ28

Explore proteomics data for C11orf34 at MOPED 

C11orf34 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

C11orf34 Protein Expression

REFSEQ proteins: NP_001138496.1  
ENSEMBL proteins: 
 ENSP00000433411   ENSP00000433513   ENSP00000341412  

Human Recombinant Protein Products for C11orf34: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0009897external side of plasma membrane IEA--
GO:0016021integral to membrane IEA--

C11orf34 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR026184 PLET1

Graphical View of Domain Structure for InterPro Entry Q6UQ28

ProtoNet protein and cluster: Q6UQ28


C11orf34 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PLET1_HUMAN, Q6UQ28
Function: May participate in the wound response during the healing process, and promote wound repair (By
similarity)

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf34

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C11orf34 (PLET1)

Search CenterWatch for drugs/clinical trials and news about C11orf34 / PLET1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C11orf34 gene: 
NM_001145024.1  

Unigene Cluster for C11orf34:

Chromosome 11 open reading frame 34
Hs.632097
Unigene Representative Sequence: NM_001145024
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000533819(uc001pnk.1) ENST00000527122 ENST00000338832(uc009yyp.2)

miRNA
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Additional mRNA sequence: 

AY364431.1 AY364432.1 AY364433.1 AY364434.1 AY364435.1 AY373755.1 

2 DOTS entries:

DT.101979319  DT.91793069 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C11orf34 expression in normal human tissues (normalized intensities)      C11orf34 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGCTGCAGC
C11orf34 Expression
About this image


C11orf34 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Kidney (Urinary System)    fully expand to see all 5 entries
         Ureteric Bud Cells Ureteric Bud
         Renal Collecting Duct System
         visceral organ/mesonephros/nephric duct, mesonephric portion   
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Muscle Progenitor Cells Mandibular Arch Muscles
 
 Placenta (Extraembryonic Tissues)
         Chorion Frondosum
 
 Pancreas (Endocrine System)
         Duct Cells Pancreatic Ducts
 
 Inner Cell Mass (Early Embryonic Tissues)
         Inner Cell Mass Cells Inner Cell Mass

See C11orf34 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.632097
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C11orf34 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 1600029D21Rik5 RIKEN cDNA 1600029D21 gene   --   9 (27.71 cM) 50494525 


ENSEMBL Gene Tree for C11orf34 (if available)
TreeFam Gene Tree for C11orf34 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/380 SNPs in C11orf34 are shown (see all 380)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1828874351,2
--112118466(+) AGGTGG/TTGTTA 1 -- ds50010--------
rs1881420271,2
--112118582(+) TATAGA/GTGTGT 1 -- ds50010--------
rs1467276011,2
C--112118591(+) GTGTG-/TATATAT 1 -- ds50010--------
rs29048701,2
H--112118609(+) ATATAC/TACACA 1 -- ds50011Minor allele frequency- T:0.00NS 120
rs1469532531,2
C--112118610(+) TATAT-/ACAC  
  ACACAC
ACACA
1 -- ds50010--------
rs796992981,2
C--112118611(+) ATATAC/TACACA 1 -- ds50010--------
rs1927331821,2
--112118649(+) ACACAC/TACATA 1 -- ds50010--------
rs1850152451,2
--112118664(+) TTGCCA/CATTTC 1 -- ds50010--------
rs1154113091,2
C,F--112118708(+) AGTTTT/GCACTT 1 -- ds50011Minor allele frequency- G:0.01WA 118
rs758661661,2
C,F--112118779(+) CTCACC/AATTTG 1 -- ds50011Minor allele frequency- A:0.01NA 120

HapMap Linkage Disequilibrium report for C11orf34 (112118876 - 112131583 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for C11orf34:    About this table     
Variant IDTypeSubtypePubMed ID
dgv167e201CNV Deletion23290073
esv2745078CNV Deletion23290073
esv2661060CNV Deletion23128226
esv2677815CNV Deletion23128226

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C11orf34 for disorders           About MalaCards
OMIM gene information: 611904    OMIM disorders: --


C11orf34 for disorders           About GeneDecksing


Export disorders for C11orf34 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C11orf34 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C11orf34)
    Utopia: connect your pdf to the dynamic
world of online information

  1. PLET1 (C11orf34), a highly expressed and processed novel gene in pig and mouse placenta, is transcribed but poorly spliced in human. (PubMed id 15203209)1, 2 Zhao S.-H.... Tuggle C.K. (2004)
  2. Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells. (PubMed id 18195351)1 Depreter M.G....Blackburn C.C. (2008)
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 349633 HGNC: 30053 Ensembl:ENSG00000188771 euGenes: HUgn349633 ECgene: C11orf34
H-InvDB: C11orf34

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C11orf34 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C11orf34 gene:
Search GeneIP for patents involving C11orf34

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

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 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for C11orf34
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf34
 Browse SwitchGear 3'UTR luciferase reporter plasmids for C11orf34
 Browse SwitchGear Promoter luciferase reporter plasmids for C11orf34
 Search ThermoFisher Antibodies for C11orf34
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C11orf34
 inGenious Targeting Laboratory - Custom generated mouse model solutions for C11orf34
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C11orf34
Customized:
 lentivirus for stable overexpression of C11orf34
 lentivirus expression plasmids for stable overexpression of C11orf34
 adenovirus for overexpression of C11orf34
 LSBio Antibodies in human, mouse, rat for C11orf34
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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