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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C11orf34 Gene

protein-coding GIFtS: 34
GCID: GC11M112118

chromosome 11 open reading frame 34

Search for C11orf34
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 11 Open Reading Frame 34¹ ²
PLET1¹ ² ⁵
Placenta Expressed Transcript 1²
Placenta-Expressed Transcript 1 Protein²

External Ids:	HGNC: 30053¹	Entrez Gene: 349633²	Ensembl: ENSG00000188771⁷	OMIM: 611904⁵	UniProtKB: Q6UQ28³

Export aliases for C11orf34 gene to outside databases

Previous GC identifers: GC11M111657 GC11U900619 GC11M111625 GC11M108044

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PLET1_HUMAN, Q6UQ28

Function: May participate in the wound response during the healing process, and promote wound repair (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C11orf34 gene promoter:
TBP Elk-1 Pbx1a COUP CUTL1 Evi-1 FAC1 Nkx6-1 POU2F1 POU2F1a
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf34

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1 Ensembl cytogenetic band: 11q23.1 HGNC cytogenetic band: 11q23.1

C11orf34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf34 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M112118: view genomic region (about GC identifiers)

Start:	112,118,876 bp from pter	End:	112,131,583 bp from pter
Size:	12,708 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: PLET1_HUMAN, Q6UQ28 (See protein sequence)

Recommended Name: Placenta-expressed transcript 1 protein precursor

Size: 207 amino acids; 23385 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: Q6UQ24 Q6UQ25 Q6UQ27

Explore the universe of human proteins at neXtProt for C11orf34: NX_Q6UQ28

C11orf34 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001138496.1

ENSEMBL proteins:

ENSP00000433411 ENSP00000433513 ENSP00000341412

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009897	external side of plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

C11orf34 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C11orf34 for domains About GeneDecksing

1 InterPro domain/family:

IPR026184 PLET1

Graphical View of Domain Structure for InterPro Entry Q6UQ28

ProtoNet protein and cluster: Q6UQ28

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PLET1_HUMAN, Q6UQ28

Function: May participate in the wound response during the healing process, and promote wound repair (By similarity)

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C11orf34

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about C11orf34 / PLET1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for C11orf34 gene:

NM_001145024.1

Unigene Cluster for C11orf34:

Chromosome 11 open reading frame 34

Hs.632097

Unigene Representative Sequence: NM_001145024

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000533819(uc001pnk.1) ENST00000527122 ENST00000338832(uc009yyp.2)

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Additional cDNA sequence:

AY364431.1 AY364432.1 AY364433.1 AY364434.1 AY364435.1 AY373755.1

2 DOTS entries:

DT.101979319 DT.91793069

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C11orf34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCTGCAGC

About this image

C11orf34 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Chorioallantoic Placenta

Extraembryonic Angioblasts

Endothelium

Testis

Renal Collecting Duct System

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C11orf34 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.632097

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C11orf34 gene from 1/3 species (see all 3) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	1600029D21Rik⁵	RIKEN cDNA 1600029D21 gene	--		9 (27.71 cM) 50494525

ENSEMBL Gene Tree for C11orf34 (if available)
TreeFam Gene Tree for C11orf34 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182887435^1,2		--	112118466(+)	`AGGTGG/TTGTTA`	1	--	ds500¹		0	--	--	--	--
rs188142027^1,2		--	112118582(+)	`TATAGA/GTGTGT`	1	--	ds500¹		0	--	--	--	--
rs146727601^1,2	C,	--	112118591(+)	`GTGTG-/TATATAT`	1	--	ds500¹		0	--	--	--	--
rs2904870^1,2	H	--	112118609(+)	`ATATAC/TACACA`	1	--	ds500¹		1		NS	120
rs146953253^1,2	C,	--	112118610(+)	`TATAT-/ACAC ACACACACACA`	1	--	ds500¹		0	--	--	--	--
rs79699298^1,2	C	--	112118611(+)	`ATATAC/TACACA`	1	--	ds500¹		0	--	--	--	--
rs192733182^1,2		--	112118649(+)	`ACACAC/TACATA`	1	--	ds500¹		0	--	--	--	--
rs185015245^1,2		--	112118664(+)	`TTGCCA/CATTTC`	1	--	ds500¹		0	--	--	--	--
rs115411309^1,2	C,	--	112118708(+)	`AGTTTT/GCACTT`	1	--	ds500¹		1		WA	118
rs75866166^1,2		--	112118779(+)	`CTCACC/AATTTG`	1	--	ds500¹		1		NA	120

HapMap Linkage Disequilibrium report for C11orf34 (112118876 - 112131583 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C11orf34: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C11orf34 for disorders About MalaCards

C11orf34 for disorders About GeneDecksing

OMIM gene information: 611904 OMIM disorders: --

Export disorders for C11orf34 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C11orf34 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C11orf34)

Utopia: connect your pdf to the dynamic
world of online information

PLET1 (C11orf34), a highly expressed and processed novel gene in pig and mouse placenta, is transcribed but poorly spliced in human. (PubMed id 15203209)^{1, 2} Zhao S.-H.... Tuggle C.K. (2004)
Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells. (PubMed id 18195351)¹ Depreter M.G....Blackburn C.C. (2008)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 349633	HGNC: 30053	Ensembl:ENSG00000188771	euGenes: HUgn349633	ECgene: C11orf34
H-InvDB: C11orf34

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C11orf34	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C11orf34 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C11orf34 gene:
Search GeneIP for patents involving C11orf34

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C11orf34 gene at Home site.

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C11orf34 Gene

chromosome 11 open reading frame 34

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C11orf34 Gene

chromosome 11 open reading frame 34

Aliasesfor C11orf34 gene

Summariesfor C11orf34 gene

Genomic Viewsfor C11orf34 gene

Proteinsfor C11orf34 gene

Protein Domains /Familiesfor C11orf34 gene

Functionfor C11orf34 gene

Pathways & Interactionsfor C11orf34 gene

Drugs & Compoundsfor C11orf34 gene

Transcriptsfor C11orf34 gene

Expression for C11orf34 gene

Orthologsfor C11orf34 gene

Paralogsfor C11orf34 gene

Genomic Variantsfor C11orf34 gene

Disorders / Diseasesfor C11orf34 gene

Publicationsfor C11orf34 gene

External Searches for C11orf34 gene

Genome Databases showing C11orf34 gene

Other Databases showing C11orf34 gene

Specialized Databases showing C11orf34 gene

Intellectual Propertyfor C11orf34 gene

Productsfor C11orf34 gene

View Random Gene

Aliases
for C11orf34 gene

Summaries
for C11orf34 gene

Genomic Views
for C11orf34 gene

Proteins
for C11orf34 gene

Protein Domains /
Families
for C11orf34 gene

Function
for C11orf34 gene

Pathways & Interactions
for C11orf34 gene

Drugs & Compounds
for C11orf34 gene

Transcripts
for C11orf34 gene

Expression
for C11orf34 gene

Orthologs
for C11orf34 gene

Paralogs
for C11orf34 gene

Genomic Variants
for C11orf34 gene

Disorders / Diseases
for C11orf34 gene

Publications
for C11orf34 gene

Intellectual Property
for C11orf34 gene

Products
for C11orf34 gene