C11orf31 Gene
protein-coding GIFtS: 46
GCID: GC11P057508
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|
chromosome 11 open reading frame 31
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Aliases
for C11orf31 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 11 Open Reading Frame 311 2 | | SELH1 2 | | C17orf102 | | Selenoprotein H2 | | SelH3 |
Export aliases for C11orf31 gene to outside databasesPrevious GC identifers: GC11U990622 GC11P057285 GC11P057265 GC11P053857 |
Summaries
for C11orf31 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for C11orf31:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteineis encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have acommon stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Seccodon rather than as a stop signal. The exact function of this gene is not known, however, selenoproteins are thoughtto be responsible for most biomedical effects of dietary selenium. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SELH_HUMAN, Q8IZQ5Function: May be involved in a redox-related process (Potential)
|
Genomic Views
for C11orf31 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C11orf31 gene promoter:
AREB6 CREB AML1a Pax-5 deltaCREB Pax-2 Pax-2a NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for C11orf31
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf31 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.1 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12.1C11orf31 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P057508: view genomic region
(about GC identifiers)
Start:
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57,508,722 bp from pter |
End:
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57,510,883 bp from pter |
Size:
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2,162 bases |
Orientation:
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plus strand |
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Proteins
for C11orf31 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SELH_HUMAN, Q8IZQ5 (See
protein sequence)Recommended Name: Selenoprotein H Size: 122 amino acids; 13453 Da
Secondary accessions: Q8N672Explore the universe of human proteins at neXtProt for C11orf31: NX_Q8IZQ5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZQ5
C11orf31 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_734467.1
ENSEMBL proteins: ENSP00000434511 ENSP00000373509 ENSP00000434875 ENSP00000432484
Human Recombinant Protein Products:
C11orf31 Antibody Products:
Assay Products for C11orf31: |
Protein
Domains /
Families
for C11orf31 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C11orf31 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZQ5ProtoNet protein and cluster: Q8IZQ5 UniProtKB/Swiss-Prot: SELH_HUMAN, Q8IZQ5Similarity: Belongs to the SelWTH family |
Function
for C11orf31 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SELH_HUMAN, Q8IZQ5Function: May be involved in a redox-related process (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf31 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf31
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008430 | selenium binding |
IEA | -- |
C11orf31 for ontologies About GeneDecksing
|
Pathways & Interactions
for C11orf31 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Selenium Metabolism and Selenoproteins | | | 2 | Selenium Pathway | |
2  BioSystems Pathways for C11orf31
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf31
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for C11orf31 (Q8IZQ53 ENSP000003735094) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045454 | cell redox homeostasis |
IEA | -- |
C11orf31 for ontologies About GeneDecksing
|
Drugs & Compounds
for C11orf31 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C11orf31
Search CenterWatch for drugs/clinical trials and news about C11orf31 / SELH
|
Transcripts
for C11orf31 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C11orf31 gene: NM_170746.2 Unigene Clusters for C11orf31: Chromosome 11 open reading frame 31 Hs.655373 [show with all ESTs], Hs.744024 [show with all ESTs]Unigene Representative Sequences: BU526928, BM8077765 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000534355(uc021qjj.1) ENST00000533321 ENST00000388857 ENST00000528798
ENST00000534386
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf31 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf31
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C11orf31 (NM_170746) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C11orf31 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf31 |
Additional cDNA sequence: AF085883.1 AF536829.1 BC021122.1 14 DOTS entries: DT.448773 DT.101955276 DT.92436660 DT.100819902 DT.100718376 DT.102843843 DT.100819898 DT.97767346 DT.75103731 DT.120747331 DT.120747256 DT.120747324 DT.95157523 DT.100700188 24/274 AceView cDNA sequences (see all 274): CK430637 AI862987 BX501542 BM742406 BU543593 BM826996 BU151096 BQ921000 AW388118 CR599464 BM551541 T58545 AA125736 BG764431 BM552065 AJ276250 CB105393 AI693331 BX459215 BM710534 BM755870 BM771494 BU935080 BI518324
GeneLoc Exon Structure
|
Expression
for C11orf31 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C11orf31 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTCTTCCC
About this image
See C11orf31 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C11orf31
SOURCE GeneReport for Unigene clusters: Hs.655373 Hs.744024
SABiosciences Custom PCR Arrays for C11orf31
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C11orf31 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C11orf31 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf31 |
Orthologs
for C11orf31 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C11orf31 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for C11orf31 (if available)
TreeFam Gene Tree for C11orf31 (if available) |
Paralogs
for C11orf31 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C11orf31 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C11orf31 (57508722 - 57510883 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C11orf31: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C11orf31 |
|
Disorders
/ Diseases
for C11orf31 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C11orf31 for disorders About GeneDecksing
OMIM gene information: 607914
OMIM disorders: --
6  diseases for C11orf31: About MalaCardsspina bifida staphyloenterotoxemia chronic lymphocytic leukemia lymphocytic leukemia
leukemia neuronitis
2 diseases from the University of Copenhagen DISEASES database for C11orf31:Spina bifida Staphyloenterotoxemia Human Genome Epidemiology (HuGE) Navigator: C11orf31 (1 document)
Export disorders for C11orf31 gene to outside databases
|
Publications
for C11orf31 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C11orf31 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with C11orf31) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of mammalian selenoproteomes. (PubMed id 12775843)1, 2, 3 Kryukov G.V.... Gladyshev V.N. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. (PubMed id 17337453)1, 9 Novoselov S.V....Gladyshev V.N. (2007)
- Overexpression of human selenoprotein H in neuronal c ells ameliorates ultraviolet irradiation-induced damage by modulating cell sign aling pathways. (PubMed id 19766117)1, 9 Mendelev N....Li P.A. (2009)
- Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. (PubMed id 17526492)1, 9 Panee J....Berry M.J. (2007)
- Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation. (PubMed id 17389926)1, 9 Ben Jilani K.E....Li P.A. (2007)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Upregulation of human selenoprotein H in murine hippo campal neuronal cells promotes mitochondrial biogenesis and functional performa nce. (PubMed id 20656065)1 Mendelev N....Li P.A. (2011)
- Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
|
External Searches for C11orf31 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C11orf31 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C11orf31 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C11orf31 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C11orf31 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C11orf31 gene:
Search GeneIP for patents involving C11orf31
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C11orf31 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C11orf31 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C11orf31 | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C11orf31 | | OriGene 3'-UTR Clone for C11orf31 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf31 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C11orf31 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C11orf31 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C11orf31 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf31 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C11orf31 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf31 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C11orf31 |
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 | | | C11orf31 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for C11orf31 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf31 |
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