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Aliases for C11orf31 Gene

Aliases for C11orf31 Gene

  • Chromosome 11 Open Reading Frame 31 2 3
  • Selenoprotein H 2 3
  • SELH 3 4
  • C17orf10 3

External Ids for C11orf31 Gene

Previous GeneCards Identifiers for C11orf31 Gene

  • GC11U990622
  • GC11P057285
  • GC11P057265
  • GC11P057508
  • GC11P053857

Summaries for C11orf31 Gene

Entrez Gene Summary for C11orf31 Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. The exact function of this gene is not known, however, selenoproteins are thought to be responsible for most biomedical effects of dietary selenium. [provided by RefSeq, Jul 2008]

GeneCards Summary for C11orf31 Gene

C11orf31 (Chromosome 11 Open Reading Frame 31) is a Protein Coding gene. Diseases associated with C11orf31 include staphyloenterotoxemia. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot for C11orf31 Gene

  • May be involved in a redox-related process.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf31 Gene

Genomics for C11orf31 Gene

Regulatory Elements for C11orf31 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C11orf31 Gene

57,741,250 bp from pter
57,743,554 bp from pter
2,305 bases
Plus strand

Genomic View for C11orf31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C11orf31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf31 Gene

Proteins for C11orf31 Gene

  • Protein details for C11orf31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Selenoprotein H
    Protein Accession:
    Secondary Accessions:
    • Q8N672

    Protein attributes for C11orf31 Gene

    122 amino acids
    Molecular mass:
    13453 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf31 Gene

Proteomics data for C11orf31 Gene at MOPED

Post-translational modifications for C11orf31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf31 Gene

No data available for DME Specific Peptides for C11orf31 Gene

Domains for C11orf31 Gene

Protein Domains for C11orf31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8IZQ5
  • Belongs to the SelWTH family.
genes like me logo Genes that share domains with C11orf31: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C11orf31 Gene

Function for C11orf31 Gene

Molecular function for C11orf31 Gene

UniProtKB/Swiss-Prot Function:
May be involved in a redox-related process.

Gene Ontology (GO) - Molecular Function for C11orf31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008430 selenium binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with C11orf31: view

Animal Model Products

CRISPR Products

miRNA for C11orf31 Gene

miRTarBase miRNAs that target C11orf31

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C11orf31

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C11orf31 Gene

Localization for C11orf31 Gene

Subcellular locations from

Jensen Localization Image for C11orf31 Gene COMPARTMENTS Subcellular localization image for C11orf31 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf31 Gene

Pathways for C11orf31 Gene

genes like me logo Genes that share pathways with C11orf31: view

Pathways by source for C11orf31 Gene

2 BioSystems pathways for C11orf31 Gene

Interacting Proteins for C11orf31 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000373509 Q8IZQ5-SELH_HUMAN for C11orf31 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C11orf31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with C11orf31: view

Transcripts for C11orf31 Gene

Unigene Clusters for C11orf31 Gene

Chromosome 11 open reading frame 31:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C11orf31

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf31 Gene

No ASD Table

Relevant External Links for C11orf31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf31 Gene

mRNA expression in normal human tissues for C11orf31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for C11orf31 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.3), Blymphocyte (8.7), and Uterus (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C11orf31 Gene

SOURCE GeneReport for Unigene cluster for C11orf31 Gene Hs.655373

genes like me logo Genes that share expressions with C11orf31: view

Expression partners for C11orf31 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C11orf31 Gene

Orthologs for C11orf31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C15H11orf31 35
  • 84.7 (n)
  • 83.61 (a)
(Canis familiaris)
Mammalia C18H11orf31 35
  • 88.25 (n)
  • 86.07 (a)
(Mus musculus)
Mammalia 2700094K13Rik 35
  • 81.32 (n)
  • 85.34 (a)
2700094K13Rik 16
2700094K13Rik 36
  • 84 (a)
(Pan troglodytes)
Mammalia C11H11orf31 35
  • 99.73 (n)
  • 99.18 (a)
C11H11orf31 36
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1563348 35
  • 80.46 (n)
  • 82.76 (a)
(Gallus gallus)
Aves LOC100858006 35
  • 65.57 (n)
  • 60.66 (a)
(Anolis carolinensis)
Reptilia C11orf31 36
  • 60 (a)
(Danio rerio)
Actinopterygii seph 35
  • 64.37 (n)
  • 62.07 (a)
Species with no ortholog for C11orf31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf31 Gene

Gene Tree for C11orf31 (if available)
Gene Tree for C11orf31 (if available)

Paralogs for C11orf31 Gene

Selected SIMAP similar genes for C11orf31 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C11orf31: view

No data available for Paralogs for C11orf31 Gene

Variants for C11orf31 Gene

Structural Variations from Database of Genomic Variants (DGV) for C11orf31 Gene

Variant ID Type Subtype PubMed ID
nsv832164 CNV Loss 17160897
nsv508633 CNV Loss 20534489
nsv326 CNV Insertion 18451855

Relevant External Links for C11orf31 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for C11orf31 Gene

Disorders for C11orf31 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for C11orf31 Gene in MalaCards »

(1) Diseases for C11orf31 Gene including...

(2) University of Copenhagen DISEASES for C11orf31 Gene

Relevant External Links for C11orf31

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with C11orf31: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for C11orf31 Gene

Publications for C11orf31 Gene

  1. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov G.V. … Gladyshev V.N. (Science 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. (PMID: 17337453) Novoselov S.V. … Gladyshev V.N. (J. Biol. Chem. 2007) 3 23
  4. Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation. (PMID: 17389926) Ben Jilani K.E. … Li P.A. (Int. J. Biol. Sci. 2007) 3 23
  5. Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. (PMID: 17526492) Panee J. … Berry M.J. (J. Biol. Chem. 2007) 3 23

Products for C11orf31 Gene

Sources for C11orf31 Gene

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