Aliases for C11orf31 Gene
External Ids for C11orf31 Gene
Previous GeneCards Identifiers for C11orf31 Gene
This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
GeneCards Summary for C11orf31 Gene
C11orf31 (Chromosome 11 Open Reading Frame 31) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway. GO annotations related to this gene include poly(A) RNA binding and selenium binding.
UniProtKB/Swiss-Prot for C11orf31 Gene
May be involved in a redox-related process.