Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C11orf31 Gene

Aliases for C11orf31 Gene

  • Chromosome 11 Open Reading Frame 31 2 3 5
  • Selenoprotein H 2 3
  • SELH 3 4
  • C17orf10 3

External Ids for C11orf31 Gene

Previous GeneCards Identifiers for C11orf31 Gene

  • GC11U990622
  • GC11P057285
  • GC11P057265
  • GC11P057508
  • GC11P053857

Summaries for C11orf31 Gene

Entrez Gene Summary for C11orf31 Gene

  • This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]

GeneCards Summary for C11orf31 Gene

C11orf31 (Chromosome 11 Open Reading Frame 31) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway. GO annotations related to this gene include poly(A) RNA binding and selenium binding.

UniProtKB/Swiss-Prot for C11orf31 Gene

  • May be involved in a redox-related process.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf31 Gene

Genomics for C11orf31 Gene

Regulatory Elements for C11orf31 Gene

Enhancers for C11orf31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C11orf31 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C11orf31 Gene

57,741,250 bp from pter
57,743,554 bp from pter
2,305 bases
Plus strand

Genomic View for C11orf31 Gene

Genes around C11orf31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf31 Gene

Proteins for C11orf31 Gene

  • Protein details for C11orf31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Selenoprotein H
    Protein Accession:
    Secondary Accessions:
    • Q8N672

    Protein attributes for C11orf31 Gene

    122 amino acids
    Molecular mass:
    13453 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf31 Gene

Post-translational modifications for C11orf31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf31 Gene

No data available for DME Specific Peptides for C11orf31 Gene

Domains & Families for C11orf31 Gene

Protein Domains for C11orf31 Gene

Suggested Antigen Peptide Sequences for C11orf31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SelWTH family.
  • Belongs to the SelWTH family.
genes like me logo Genes that share domains with C11orf31: view

No data available for Gene Families for C11orf31 Gene

Function for C11orf31 Gene

Molecular function for C11orf31 Gene

UniProtKB/Swiss-Prot Function:
May be involved in a redox-related process.

Gene Ontology (GO) - Molecular Function for C11orf31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with C11orf31: view
genes like me logo Genes that share phenotypes with C11orf31: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf31 Gene

Localization for C11orf31 Gene

Subcellular locations from

Jensen Localization Image for C11orf31 Gene COMPARTMENTS Subcellular localization image for C11orf31 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf31 Gene

Pathways & Interactions for C11orf31 Gene

genes like me logo Genes that share pathways with C11orf31: view

Pathways by source for C11orf31 Gene

2 BioSystems pathways for C11orf31 Gene

Interacting Proteins for C11orf31 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000373509 Q8IZQ5-SELH_HUMAN for C11orf31 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C11orf31 Gene


No data available for SIGNOR curated interactions for C11orf31 Gene

Drugs & Compounds for C11orf31 Gene

No Compound Related Data Available

Transcripts for C11orf31 Gene

Unigene Clusters for C11orf31 Gene

Chromosome 11 open reading frame 31:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf31 Gene

No ASD Table

Relevant External Links for C11orf31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf31 Gene

mRNA expression in normal human tissues for C11orf31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C11orf31 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.3), Blymphocyte (8.7), and Uterus (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C11orf31 Gene

Protein tissue co-expression partners for C11orf31 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf31 Gene:


SOURCE GeneReport for Unigene cluster for C11orf31 Gene:

genes like me logo Genes that share expression patterns with C11orf31: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C11orf31 Gene

Orthologs for C11orf31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C15H11orf31 34
  • 84.7 (n)
  • 83.61 (a)
(Canis familiaris)
Mammalia C18H11orf31 34
  • 88.25 (n)
  • 86.07 (a)
(Mus musculus)
Mammalia 2700094K13Rik 34
  • 81.32 (n)
  • 85.34 (a)
2700094K13Rik 16
2700094K13Rik 35
  • 84 (a)
(Pan troglodytes)
Mammalia C11H11orf31 34
  • 99.73 (n)
  • 99.18 (a)
C11H11orf31 35
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1563348 34
  • 80.46 (n)
  • 82.76 (a)
(Gallus gallus)
Aves LOC100858006 34
  • 65.57 (n)
  • 60.66 (a)
(Anolis carolinensis)
Reptilia C11orf31 35
  • 60 (a)
(Danio rerio)
Actinopterygii seph 34
  • 64.37 (n)
  • 62.07 (a)
Species where no ortholog for C11orf31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf31 Gene

Gene Tree for C11orf31 (if available)
Gene Tree for C11orf31 (if available)

Paralogs for C11orf31 Gene

(1) SIMAP similar genes for C11orf31 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C11orf31: view

No data available for Paralogs for C11orf31 Gene

Variants for C11orf31 Gene

Structural Variations from Database of Genomic Variants (DGV) for C11orf31 Gene

Variant ID Type Subtype PubMed ID
nsv326 CNV insertion 18451855
nsv508633 CNV deletion 20534489
nsv832164 CNV loss 17160897

Variation tolerance for C11orf31 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for C11orf31 Gene

Disorders for C11orf31 Gene

Relevant External Links for C11orf31

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C11orf31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf31 Gene

Publications for C11orf31 Gene

  1. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov G.V. … Gladyshev V.N. (Science 2003) 2 3 4 65
  2. Overexpression of human selenoprotein H in neuronal cells ameliorates ultraviolet irradiation-induced damage by modulating cell signaling pathways. (PMID: 19766117) Mendelev N. … Li P.A. (Exp. Neurol. 2009) 3 22 65
  3. Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. (PMID: 17337453) Novoselov S.V. … Gladyshev V.N. (J. Biol. Chem. 2007) 3 22 65
  4. Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. (PMID: 17526492) Panee J. … Berry M.J. (J. Biol. Chem. 2007) 3 22 65
  5. Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation. (PMID: 17389926) Ben Jilani K.E. … Li P.A. (Int. J. Biol. Sci. 2007) 3 22 65

Products for C11orf31 Gene

Sources for C11orf31 Gene

Loading form....