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C11orf30 Gene

protein-coding   GIFtS: 52
GCID: GC11P076156

Chromosome 11 Open Reading Frame 30

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 11 Open Reading Frame 301 2
EMSY2 5
Protein EMSY2

External Ids:    HGNC: 180711   Entrez Gene: 569462   Ensembl: ENSG000001586367   OMIM: 6085745   UniProtKB: Q7Z5893   

Export aliases for C11orf30 gene to outside databases

Previous GC identifers: GC11P075884 GC11P075882 GC11P075833 GC11P072452


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C11orf30 Gene:
C11orf30 (chromosome 11 open reading frame 30) is a protein-coding gene.

UniProtKB/Swiss-Prot: EMSY_HUMAN, Q7Z589
Function: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein
chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a
central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may
mediate ligand-dependent transcriptional activation by nuclear hormone receptors

Gene Wiki entry for C11orf30 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C11orf30 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   GATA-2   Evi-1   MEF-2A   E2F   E2F-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC11orf30 promoter sequence
   Search Chromatin IP Primers for C11orf30

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C11orf30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13.5

C11orf30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf30 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P076156:  view genomic region     (about GC identifiers)

Start:
76,155,967 bp from pter      End:
76,264,069 bp from pter
Size:
108,103 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EMSY_HUMAN, Q7Z589 (See protein sequence)
Recommended Name: Protein EMSY  
Size: 1322 amino acids; 141468 Da
Subunit: Homodimer. Interacts with the transactivation domain of BRCA2. Interacts with the chromoshadow domain of
CBX1 and with ZMYND11. Does not interact with CBX3 or CBX5. Part of a complex composed at least of ASCL2,
C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone
H3-specific methyltransferase activity
Miscellaneous: Defects in EMSY may be a cause of sporadic breast cancer and higher-grade ovarian cancers.
Overexpressed through amplification almost exclusively in sporadic breast cancer (13%) and higher-grade ovarian
cancer (17%). Amplification is associated with worse survival, particularly in node-negative breast cancer,
suggesting that it may be of prognostic value
Miscellaneous: Was named EMSY by PubMed:14651845 because the protein sequence contains the word 'SISTER', after
the first author's sister, who is a breast cancer nurse
Sequence caution: Sequence=AAF86947.1; Type=Erroneous initiation; Sequence=AAH29375.1; Type=Erroneous initiation;
Sequence=AAL65260.1; Type=Erroneous initiation; Sequence=BAB14627.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for C11orf30:
1UTU (3D)        1UZ3 (3D)        2FMM (3D)    
Secondary accessions: Q4G109 Q8NBU6 Q8TE50 Q9H8I9 Q9NRH0
Alternative splicing: 3 isoforms:  Q7Z589-1   Q7Z589-2   Q7Z589-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C11orf30: NX_Q7Z589

Explore proteomics data for C11orf30 at MOPED

Post-translational modifications: 

  • O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the
    phosphorylation status1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C11orf30 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064578.2  
    ENSEMBL proteins: 
     ENSP00000434665   ENSP00000431166   ENSP00000434566   ENSP00000433205   ENSP00000433634  
     ENSP00000432010   ENSP00000436968   ENSP00000432327   ENSP00000433670   ENSP00000432234  
     ENSP00000436528   ENSP00000436307   ENSP00000334130   ENSP00000344688  

    C11orf30 Human Recombinant Protein Products:

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    Novus Biologicals C11orf30 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for C11orf30

     
    Search eBioscience for Proteins for C11orf30 

     
    antibodies-online proteins for C11orf30 (2 products) 

     
    antibodies-online peptides for C11orf30

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005491 ENT_N

    Graphical View of Domain Structure for InterPro Entry Q7Z589

    ProtoNet protein and cluster: Q7Z589

    UniProtKB/Swiss-Prot: EMSY_HUMAN, Q7Z589
    Similarity: Contains 1 ENT (EMSY N-terminal) domain


    Find genes that share domains with C11orf30           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EMSY_HUMAN, Q7Z589
    Function: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein
    chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a
    central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may
    mediate ligand-dependent transcriptional activation by nuclear hormone receptors

    Phenotypes:
         3 GenomeRNAi human phenotypes for C11orf30:

     Decreased viability with pacli  G0/1 arrest  Increased S DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for C11orf30

    miRNA
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    miRTarBase miRNAs that target C11orf30:
    hsa-mir-26b-5p (MIRT030078)

    Block miRNA regulation of human, mouse, rat C11orf30 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate C11orf30 (see all 84):
    hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p hsa-miR-29a* hsa-miR-1537
    SwitchGear 3'UTR luciferase reporter plasmidC11orf30 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat C11orf30

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EMSY_HUMAN, Q7Z589: Nucleus. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it
    participates in DNA repair process
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with C11orf30           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C11orf30
    Interactions:

        GeneGlobe Interaction Network for C11orf30

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for C11orf30 (Q7Z5893 ENSP000003341304) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    ENSG00000233911Q018603I2D: score=1 
    ENSG00000235068Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0016568chromatin modification IEA--

    Find genes that share ontologies with C11orf30           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C11orf30 (EMSY)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C11orf30 gene: 
    NM_020193.3  

    Unigene Cluster for C11orf30:

    Chromosome 11 open reading frame 30
    Hs.352588  [show with all ESTs]
    Unigene Representative Sequence: NM_020193
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000427574(uc009yuj.1) ENST00000533988(uc001oxj.3) ENST00000524490
    ENST00000525959 ENST00000533972 ENST00000528826(uc001oxk.3) ENST00000524767
    ENST00000533248 ENST00000525919 ENST00000525038 ENST00000529032(uc010rse.2 uc001oxp.3)
    ENST00000531998 ENST00000524451 ENST00000531641(uc001oxo.1) ENST00000534573
    ENST00000532719 ENST00000531793 ENST00000334736(uc001oxl.3 uc001oxm.3 uc010rsb.2 uc010rsc.2 uc001oxn.3 uc010rsd.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate C11orf30 (see all 84):
    hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p hsa-miR-29a* hsa-miR-1537
    SwitchGear 3'UTR luciferase reporter plasmidC11orf30 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat C11orf30
      QuantiFast Probe-based Assays in human, mouse, rat C11orf30

    Additional mRNA sequence: 

    AF226047.1 AJ430203.1 AK023651.1 AK125114.1 AK126030.1 AK300400.1 AK304043.1 AK304106.1 
    AK309621.1 AY070433.1 BC021688.1 BC029375.1 BC033404.1 BC117265.1 BC143370.1 BC143374.1 
    BC143376.1 BX647398.1 

    12 DOTS entries:

    DT.211641  DT.102828044  DT.95197020  DT.95366490  DT.105638  DT.430271  DT.101966512  DT.101971716 
    DT.40113811  DT.95228372  DT.97858752  DT.92421799 

    Selected AceView cDNA sequences (see all 188):

    W47416 BQ025319 AA399571 AA970698 BQ025646 AI742062 BX109175 AA770420 
    BQ022860 BC033404 AI147074 BC029375 AI804801 R23009 BM470624 CD629925 
    AI570290 BM714176 AA279671 AI379464 AJ430203 BF507386 AA456413 CK821861 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for C11orf30 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
    SP1:                                      -                                                     -                                                               
    SP2:                                      -                             -                       -                                         -                     
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c
    SP1:  -                 -                     
    SP2:  -                 -                     
    SP3:                                          
    SP4:                                          
    SP5:  -     -     -     -                     


    ECgene alternative splicing isoforms for C11orf30

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C11orf30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCCAAAG
    C11orf30 Expression
    About this image

    C11orf30 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C11orf30 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.352588
        Custom PCR Arrays for C11orf30
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for C11orf30 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2210018M11Rik1 , 5 RIKEN cDNA 2210018M11 gene1, 5 92.53(n)1
    95.2(a)1
      7 (53.86 cM)5
    2335451  NM_172280.21  NP_758484.21 
     985906155 
    chicken
    (Gallus gallus)
    Aves C11ORF301 chromosome 1 open reading frame, human C11orf30 80.92(n)
    85.71(a)
      419090  XM_417282.4  XP_417282.4 
    lizard
    (Anolis carolinensis)
    Reptilia C11orf306
    chromosome 11 open reading frame 30
    82(a)
    1 ↔ 1
    GL343493.1(503751-551762)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF548821.12   -- 76.53(n)    CF548821.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj36b042 wufj36b04 74.03(n)   335889  BC047813.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG153566
    --
    21(a)
    1 ↔ 1
    2L(1976236-1980755)


    ENSEMBL Gene Tree for C11orf30 (if available)
    TreeFam Gene Tree for C11orf30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C11orf30 gene
    1 SIMAP similar gene for C11orf30 using alignment to 11 protein entries:     B7ZKT8_HUMAN (see all proteins):
    EMSY

    Find genes that share paralogs with C11orf30           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C11orf30 (see all 1842)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156329641,2
    F--76157830(+) GTAAAA/GTAGTA 1 -- int11Minor allele frequency- G:0.04WA 118
    rs1402666271,2
    --76158435(+) TAATGG/TTGATA 1 -- int10--------
    rs107931681,2
    C,F,H--76158636(+) TAGTGC/TTTCTT 1 -- int1 trp317Minor allele frequency- T:0.04EA NS NA WA CSA 972
    rs1125063951,2
    C,F--76158737(+) GCCCTG/CTGCAT 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs778046771,2
    F--76158786(+) GAGAAA/GAAGAG 1 -- int12Minor allele frequency- G:0.03CSA WA 120
    rs1402009881,2
    --76159084(+) ATTTAC/TTCTTC 1 -- int10--------
    rs2020896831,2
    --76159117(+) AAAAC-/AAAAAA 1 -- int10--------
    rs1499302081,2
    --76159188(+) GGGCCC/TGTCAT 1 -- int10--------
    rs1464993221,2
    --76159326(+) TTAAAA/GCAAGT 1 -- int10--------
    rs1907956351,2
    --76159363(+) GTGGGA/GGATGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for C11orf30 (76155967 - 76264069 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for C11orf30:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744790CNV Deletion23290073
    nsv528623CNV Loss19592680

    Human Gene Mutation Database (HGMD): C11orf30
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing C11orf30:
    Breast Cancer
    SeqTarget long-range PCR primers for resequencing C11orf30
    DNA2.0 Custom Variant and Variant Library Synthesis for C11orf30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608574    OMIM disorders: --


    Find genes that share disorders with C11orf30           About GenesLikeMe

    Genetic Association Database (GAD): C11orf30
    Human Genome Epidemiology (HuGE) Navigator: C11orf30 (9 documents)

    Export disorders for C11orf30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C11orf30 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with C11orf30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69. (PubMed id 15947784)1, 2, 9 Ekblad C.M.S.... Itzhaki L.S. (EMBO Rep. 2005)
    2. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. (PubMed id 14651845)1, 2, 9 Hughes-Davies L.... Kouzarides T. (Cell 2003)
    3. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. (PubMed id 22036096)1, 4 Ramasamy A....Jarvis D.L. (J. Allergy Clin. Immunol. 2011)
    4. A common variant on chromosome 11q13 is associated with atopic dermatitis. (PubMed id 19349984)1, 4 Esparza-Gordillo J....Ruether A. (Nat. Genet. 2009)
    5. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. (PubMed id 19131338)1, 2 Garapaty S....Samuels H.H. (J. Biol. Chem. 2009)
    6. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. (PubMed id 18587394)1, 4 Barrett J.C....Daly M.J. (Nat. Genet. 2008)
    7. Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding. (PubMed id 16615912)1, 2 Huang Y.... Xu R.-M. (Structure 2006)
    8. Crystal structure of the ENT domain of human EMSY. (PubMed id 15978617)1, 2 Chavali G.B.... Doherty A.J. (J. Mol. Biol. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56946 HGNC: 18071 AceView: C11orf30 Ensembl:ENSG00000158636 euGenes: HUgn56946
    ECgene: C11orf30 H-InvDB: C11orf30

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for C11orf30 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for C11orf30 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for C11orf30 gene:
    Search GeneIP for patents involving C11orf30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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