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Aliases for C11orf24 Gene

Aliases for C11orf24 Gene

  • Chromosome 11 Open Reading Frame 24 2 3 5
  • Uncharacterized Protein C11orf24 3
  • Protein DM4E3 4
  • DM4E3 3

External Ids for C11orf24 Gene

Previous GeneCards Identifiers for C11orf24 Gene

  • GC11M070551
  • GC11M069725
  • GC11M067804
  • GC11M067787
  • GC11M068028
  • GC11M064363

Summaries for C11orf24 Gene

GeneCards Summary for C11orf24 Gene

C11orf24 (Chromosome 11 Open Reading Frame 24) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf24 Gene

Genomics for C11orf24 Gene

Regulatory Elements for C11orf24 Gene

Enhancers for C11orf24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F068268 0.4 ENCODE 80.8 +0.2 182 5.6 HDGF PKNOX1 MLX ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 C11orf24 PIR35627
GH11F068265 1.1 Ensembl ENCODE 79.9 +5.0 4985 2.8 ATF1 GATA2 ELK1 ZNF207 FOS JUNB TBX21 MBD2 MEF2D MAFF C11orf24 NDUFS8 UNC93B1 PIR35627
GH11F068255 1.1 Ensembl ENCODE 79.5 +15.0 14985 2.3 HDGF ARID4B DMAP1 ZNF48 KLF7 KLF13 DEK SP5 MXD4 REST C11orf24 OR7E145P CABP2 NDUFS8 UNC93B1 PIR35627
GH11F068296 1.5 FANTOM5 Ensembl ENCODE 37.3 -26.3 -26309 3.3 PKNOX1 MLX ARID4B DMAP1 ZNF48 BRCA1 YY1 SLC30A9 ZNF143 ZNF263 C11orf24 CHKA LRP5 LOC105369363
GH11F068310 0.2 ENCODE 31.2 -42.4 -42364 7.2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 PAF1 SP5 NFYC C11orf24 LRP5 GC11P068379
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C11orf24 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C11orf24 Gene

68,261,335 bp from pter
68,272,001 bp from pter
10,667 bases
Minus strand

Genomic View for C11orf24 Gene

Genes around C11orf24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf24 Gene

Proteins for C11orf24 Gene

  • Protein details for C11orf24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf24
    Protein Accession:
    Secondary Accessions:
    • Q9H2K4

    Protein attributes for C11orf24 Gene

    449 amino acids
    Molecular mass:
    46101 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf24 Gene

Post-translational modifications for C11orf24 Gene

  • Glycosylation at Asn 49 and Thr 212
  • Modification sites at PhosphoSitePlus

Other Protein References for C11orf24 Gene

No data available for DME Specific Peptides for C11orf24 Gene

Domains & Families for C11orf24 Gene

Protein Domains for C11orf24 Gene


Suggested Antigen Peptide Sequences for C11orf24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf24: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C11orf24 Gene

Function for C11orf24 Gene

genes like me logo Genes that share phenotypes with C11orf24: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf24 Gene

Localization for C11orf24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C11orf24 Gene

Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Cycles to the plasma membrane via endosomes in a pH sensitive manner. Associated with Rab6-positive vesicles.

Subcellular locations from

Jensen Localization Image for C11orf24 Gene COMPARTMENTS Subcellular localization image for C11orf24 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 4
extracellular 3
nucleus 2
endoplasmic reticulum 1
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for C11orf24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C11orf24: view

Pathways & Interactions for C11orf24 Gene

SuperPathways for C11orf24 Gene

No Data Available

Interacting Proteins for C11orf24 Gene

Gene Ontology (GO) - Biological Process for C11orf24 Gene


No data available for Pathways by source and SIGNOR curated interactions for C11orf24 Gene

Transcripts for C11orf24 Gene

Unigene Clusters for C11orf24 Gene

Chromosome 11 open reading frame 24:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf24 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: -

Relevant External Links for C11orf24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf24 Gene

mRNA expression in normal human tissues for C11orf24 Gene

Protein differential expression in normal tissues from HIPED for C11orf24 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf24 Gene

Protein tissue co-expression partners for C11orf24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf24 Gene:


SOURCE GeneReport for Unigene cluster for C11orf24 Gene:


mRNA Expression by UniProt/SwissProt for C11orf24 Gene:

Tissue specificity: Highest expression in heart, placenta, liver, pancreas and colon. Also detected in brain, lung, skeletal muscle, kidney, spleen, prostate, testis, ovary and small intestine. Lowest expression in thymus and leukocytes.
genes like me logo Genes that share expression patterns with C11orf24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for C11orf24 Gene

Orthologs for C11orf24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11orf24 35
  • 99 (a)
C11H11orf24 34
  • 98.95 (n)
(Rattus norvegicus)
Mammalia RGD1311946 34
  • 73.13 (n)
(Mus musculus)
Mammalia 1810055G02Rik 34 16 35
  • 67.18 (n)
(Bos Taurus)
Mammalia MGC139603 34
  • 67.03 (n)
C11orf24 35
  • 50 (a)
(Canis familiaris)
Mammalia C18H11orf24 34
  • 63.59 (n)
C11orf24 35
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf24 35
  • 29 (a)
(Monodelphis domestica)
Mammalia C11orf24 35
  • 25 (a)
(Gallus gallus)
Aves C11orf24 35
  • 23 (a)
(Anolis carolinensis)
Reptilia C11orf24 35
  • 44 (a)
(Danio rerio)
Actinopterygii C25H11orf24 35
  • 23 (a)
Species where no ortholog for C11orf24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf24 Gene

Gene Tree for C11orf24 (if available)
Gene Tree for C11orf24 (if available)

Paralogs for C11orf24 Gene

No data available for Paralogs for C11orf24 Gene

Variants for C11orf24 Gene

Sequence variations from dbSNP and Humsavar for C11orf24 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10082643 -- 68,261,017(+) TCTGC(A/G)CAGGT downstream-variant-500B
rs10631184 -- 68,270,587(+) CTCTT(-/A)AAAAA intron-variant, upstream-variant-2KB
rs10791970 -- 68,266,788(+) CTACC(A/G)AATGT intron-variant
rs10791971 -- 68,267,304(+) CAGAC(A/G)AGGAC intron-variant
rs111242284 -- 68,272,088(+) GAAGT(-/G/GG/GGG)GGGGG nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C11orf24 Gene

Variant ID Type Subtype PubMed ID
esv1166069 CNV insertion 17803354
esv1589088 CNV insertion 17803354
esv2584634 CNV insertion 19546169
nsv825963 CNV gain 20364138

Variation tolerance for C11orf24 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.78; 91.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf24 Gene

Disorders for C11orf24 Gene

Relevant External Links for C11orf24

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C11orf24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf24 Gene

Publications for C11orf24 Gene

  1. C11ORF24 is a novel type I membrane protein that cycles between the Golgi apparatus and the plasma membrane in Rab6-positive vesicles. (PMID: 24312644) Fraisier V. … Dimitrov A. (PLoS ONE 2013) 2 3 4 64
  2. The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13. (PMID: 11401438) Twells R.C.J. … Hess J.F. (Genomics 2001) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for C11orf24 Gene

Sources for C11orf24 Gene

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