Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C11orf21 Gene

Aliases for C11orf21 Gene

  • Chromosome 11 Open Reading Frame 21 2 3 5

External Ids for C11orf21 Gene

Previous GeneCards Identifiers for C11orf21 Gene

  • GC11M002378
  • GC11M002517
  • GC11M002277
  • GC11M002281
  • GC11U900669
  • GC11M002121
  • GC11M002316

Summaries for C11orf21 Gene

GeneCards Summary for C11orf21 Gene

C11orf21 (Chromosome 11 Open Reading Frame 21) is a Protein Coding gene. Diseases associated with C11orf21 include Beckwith-Wiedemann Syndrome.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf21 Gene

Genomics for C11orf21 Gene

Regulatory Elements for C11orf21 Gene

Enhancers for C11orf21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G002300 1.3 ENCODE dbSUPER 24.4 -1.3 -1303 7.9 HDGF PKNOX1 CREB3L1 ARNT YY1 ZNF766 ZNF143 FOS ZNF263 REST C11orf21 TSPAN32 RNU6-878P
GH11G002209 1.2 ENCODE dbSUPER 12 +92.5 92503 2.9 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 SP5 ZHX2 MXD4 NFYC TSPAN32 C11orf21 TH ENSG00000236710 GC11M002206 MIR4686
GH11G002311 1 Ensembl ENCODE dbSUPER 10.8 -9.4 -9396 1.4 CTCF JUND AGO1 C11orf21 RNU6-878P
GH11G002445 1.2 FANTOM5 ENCODE dbSUPER 7.7 -143.5 -143452 3.3 CTCF RNF2 L3MBTL2 SUZ12 ZNF407 CBX2 RBBP5 GABPA ZNF7 SCRT2 KCNQ1 C11orf21 TSPAN32 TSSC4 GC11P002446 GC11M002505
GH11G002265 1.4 FANTOM5 Ensembl ENCODE 6.5 +37.2 37153 1.5 HDAC1 FOSL1 IKZF2 MAFK STAT1 JUNB USF2 MNT REST ZEB2 C11orf21 LSP1 ASCL2 GC11M002224
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C11orf21 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035923 1049 401 HDGF PKNOX1 TCF12 ZNF766 GATA2 EGR1 CREM ZBTB11 ELF1 ZNF589

Genomic Location for C11orf21 Gene

Chromosome:
11
Start:
2,295,645 bp from pter
End:
2,303,049 bp from pter
Size:
7,405 bases
Orientation:
Minus strand

Genomic View for C11orf21 Gene

Genes around C11orf21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf21 Gene

Proteins for C11orf21 Gene

  • Protein details for C11orf21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2W6-CK021_HUMAN
    Recommended name:
    Uncharacterized protein C11orf21
    Protein Accession:
    Q9P2W6

    Protein attributes for C11orf21 Gene

    Size:
    132 amino acids
    Molecular mass:
    14447 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf21 Gene

Post-translational modifications for C11orf21 Gene

No Post-translational modifications

Other Protein References for C11orf21 Gene

No data available for DME Specific Peptides for C11orf21 Gene

Domains & Families for C11orf21 Gene

Protein Domains for C11orf21 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf21: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf21 Gene

Function for C11orf21 Gene

Phenotypes for C11orf21 Gene

GenomeRNAi human phenotypes for C11orf21:
genes like me logo Genes that share phenotypes with C11orf21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf21 Gene

Localization for C11orf21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C11orf21 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf21 gene
Compartment Confidence
extracellular 2
nucleus 2
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C11orf21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with C11orf21: view

Pathways & Interactions for C11orf21 Gene

SuperPathways for C11orf21 Gene

No Data Available

Interacting Proteins for C11orf21 Gene

Gene Ontology (GO) - Biological Process for C11orf21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf21 Gene

Transcripts for C11orf21 Gene

mRNA/cDNA for C11orf21 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C11orf21 Gene

Chromosome 11 open reading frame 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: -

Relevant External Links for C11orf21 Gene

GeneLoc Exon Structure for
C11orf21
ECgene alternative splicing isoforms for
C11orf21

Expression for C11orf21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C11orf21 Gene

This gene is overexpressed in Whole Blood (x22.3), Heart - Left Ventricle (x9.2), and Spleen (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of C11orf21 Gene:

C11orf21

SOURCE GeneReport for Unigene cluster for C11orf21 Gene:

Hs.559181

mRNA Expression by UniProt/SwissProt for C11orf21 Gene:

Q9P2W6-CK021_HUMAN
Tissue specificity: Expressed exclusively in heart.
genes like me logo Genes that share expression patterns with C11orf21: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf21 Gene

Orthologs for C11orf21 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C11orf21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11orf21 35
  • 96 (a)
OneToOne
C11H11orf21 34
  • 90.89 (n)
Species where no ortholog for C11orf21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C11orf21 Gene

ENSEMBL:
Gene Tree for C11orf21 (if available)
TreeFam:
Gene Tree for C11orf21 (if available)

Paralogs for C11orf21 Gene

No data available for Paralogs for C11orf21 Gene

Variants for C11orf21 Gene

Sequence variations from dbSNP and Humsavar for C11orf21 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000135988 -- 2,299,008(+) GTTGG(A/G)AGCAG intron-variant, upstream-variant-2KB
rs1000271975 -- 2,298,835(+) ATGAA(A/G)GGGCA intron-variant, upstream-variant-2KB
rs1000318598 -- 2,304,502(+) AGCTC(G/T)GAAAG intron-variant, upstream-variant-2KB
rs1000503694 -- 2,300,431(+) GGGGT(-/G)GGAGG intron-variant, upstream-variant-2KB
rs1000598029 -- 2,299,882(+) TCCAC(A/G)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf21 Gene

Variant ID Type Subtype PubMed ID
esv2744000 CNV deletion 23290073
esv2744001 CNV deletion 23290073
esv2744002 CNV deletion 23290073
esv29043 CNV gain 19812545
nsv1070427 CNV deletion 25765185
nsv467645 CNV gain 19166990
nsv467651 CNV loss 19166990
nsv469928 CNV loss 18288195
nsv553047 CNV gain 21841781
nsv553080 CNV loss 21841781
nsv553081 CNV loss 21841781
nsv553082 CNV loss 21841781
nsv553083 CNV gain+loss 21841781
nsv553084 CNV gain+loss 21841781
nsv553085 CNV gain 21841781
nsv553086 CNV loss 21841781
nsv951285 CNV deletion 24416366

Variation tolerance for C11orf21 Gene

Gene Damage Index Score: 4.53; 64.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf21 Gene

Disorders for C11orf21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C11orf21 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C11orf21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf21
genes like me logo Genes that share disorders with C11orf21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C11orf21 Gene

Publications for C11orf21 Gene

  1. C11orf21, a novel gene within the Beckwith-Wiedemann syndrome region in human chromosome 11p15.5. (PMID: 11054561) Zhu X. … Joh K. (Gene 2000) 2 3 4 64
  2. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. (PMID: 24292274) Speedy H.E. … Houlston R.S. (Nat. Genet. 2014) 3 64
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for C11orf21 Gene

Sources for C11orf21 Gene

Content
Loading form....