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Aliases for C11orf21 Gene

Aliases for C11orf21 Gene

  • Chromosome 11 Open Reading Frame 21 2 3

External Ids for C11orf21 Gene

Previous GeneCards Identifiers for C11orf21 Gene

  • GC11M002378
  • GC11M002517
  • GC11M002277
  • GC11M002281
  • GC11U900669
  • GC11M002121

Summaries for C11orf21 Gene

GeneCards Summary for C11orf21 Gene

C11orf21 (Chromosome 11 Open Reading Frame 21) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf21 Gene

Genomics for C11orf21 Gene

Regulatory Elements for C11orf21 Gene

Genomic Location for C11orf21 Gene

2,295,645 bp from pter
2,303,049 bp from pter
7,405 bases
Minus strand

Genomic View for C11orf21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C11orf21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf21 Gene

Proteins for C11orf21 Gene

  • Protein details for C11orf21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf21
    Protein Accession:
    Secondary Accessions:

    Protein attributes for C11orf21 Gene

    132 amino acids
    Molecular mass:
    14447 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf21 Gene

Proteomics data for C11orf21 Gene at MOPED

Post-translational modifications for C11orf21 Gene

No Post-translational modifications

Other Protein References for C11orf21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C11orf21 Gene

Domains for C11orf21 Gene

Protein Domains for C11orf21 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf21: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf21 Gene

Function for C11orf21 Gene

Phenotypes for C11orf21 Gene

genes like me logo Genes that share phenotypes with C11orf21: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C11orf21

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C11orf21 Gene

Localization for C11orf21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C11orf21 Gene


Subcellular locations from

Jensen Localization Image for C11orf21 Gene COMPARTMENTS Subcellular localization image for C11orf21 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C11orf21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with C11orf21: view

Pathways for C11orf21 Gene

SuperPathways for C11orf21 Gene

No Data Available

Interacting Proteins for C11orf21 Gene

Gene Ontology (GO) - Biological Process for C11orf21 Gene


No data available for Pathways by source for C11orf21 Gene

Transcripts for C11orf21 Gene

mRNA/cDNA for C11orf21 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C11orf21 Gene

Chromosome 11 open reading frame 21:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C11orf21

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP2: -

Relevant External Links for C11orf21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf21 Gene

mRNA expression in normal human tissues for C11orf21 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf21 Gene

This gene is overexpressed in Whole Blood (22.3), Heart - Left Ventricle (9.2), and Spleen (5.1).

SOURCE GeneReport for Unigene cluster for C11orf21 Gene Hs.559181

mRNA Expression by UniProt/SwissProt for C11orf21 Gene

Tissue specificity: Expressed exclusively in heart
genes like me logo Genes that share expressions with C11orf21: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for C11orf21 Gene

Orthologs for C11orf21 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C11orf21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11H11orf21 35
  • 90.89 (n)
  • 90.12 (a)
C11orf21 36
  • 96 (a)
Species with no ortholog for C11orf21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C11orf21 Gene

Gene Tree for C11orf21 (if available)
Gene Tree for C11orf21 (if available)

Paralogs for C11orf21 Gene

No data available for Paralogs for C11orf21 Gene

Variants for C11orf21 Gene

Sequence variations from dbSNP and Humsavar for C11orf21 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1501466 -- 2,299,654(+) AGGGC(A/G)CCATG synonymous-codon, reference, nc-transcript-variant
rs2074019 -- 2,297,637(+) GGGGC(A/G)GTGTG utr-variant-3-prime, nc-transcript-variant
rs2074020 -- 2,297,638(+) GGGCA(A/G)TGTGT utr-variant-3-prime, nc-transcript-variant
rs2244891 -- 2,298,125(+) CATAG(C/T)GAACA intron-variant
rs2521266 -- 2,295,893(+) gctct(A/G)aaaaa downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C11orf21 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV Gain 19166990
nsv896776 CNV Loss 21882294
nsv896801 CNV Loss 21882294
nsv467651 CNV Loss 19166990
dgv999n71 CNV Loss 21882294
nsv896804 CNV Loss 21882294
nsv896805 CNV Gain+Loss 21882294
nsv896806 CNV Loss 21882294
nsv469928 CNV Loss 18288195
esv29043 CNV Gain 19812545
esv2744000 CNV Deletion 23290073
esv2744001 CNV Deletion 23290073
esv2744002 CNV Deletion 23290073

Relevant External Links for C11orf21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf21 Gene

Disorders for C11orf21 Gene

(1) University of Copenhagen DISEASES for C11orf21 Gene

genes like me logo Genes that share disorders with C11orf21: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for C11orf21 Gene

Publications for C11orf21 Gene

  1. C11orf21, a novel gene within the Beckwith-Wiedemann syndrome region in human chromosome 11p15.5. (PMID: 11054561) Zhu X. … Joh K. (Gene 2000) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. (PMID: 24292274) Speedy H.E. … Houlston R.S. (Nat. Genet. 2014) 3
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for C11orf21 Gene

Sources for C11orf21 Gene

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