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Aliases for C11orf16 Gene

Aliases for C11orf16 Gene

  • Chromosome 11 Open Reading Frame 16 2 3 5

External Ids for C11orf16 Gene

Previous GeneCards Identifiers for C11orf16 Gene

  • GC11P009967
  • GC11M009632
  • GC11M008980
  • GC11M008905
  • GC11M008898
  • GC11M008611

Summaries for C11orf16 Gene

GeneCards Summary for C11orf16 Gene

C11orf16 (Chromosome 11 Open Reading Frame 16) is a Protein Coding gene.

Gene Wiki entry for C11orf16 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf16 Gene

Genomics for C11orf16 Gene

Regulatory Elements for C11orf16 Gene

Enhancers for C11orf16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G008905 0.9 ENCODE 6.5 +26.3 26334 3.3 TBP PKNOX1 FOXA2 INSM2 SIN3A BRCA1 RFX5 ZNF121 GATA2 ZNF366 TMEM9B-AS1 AKIP1 ASCL3 ENSG00000223080 TMEM9B SCUBE2 C11orf16 ST5 ENSG00000202276 GC11M008877
GH11G008865 1.3 FANTOM5 Ensembl ENCODE 4.4 +65.6 65603 4.0 GTF2F1 TBP CEBPG ZNF384 RAD21 ZFHX2 SCRT2 RCOR1 EGR2 TCF7L2 TMEM9B-AS1 AKIP1 SCUBE2 C11orf16 ST5 GC11M008877 ENSG00000202276 RNA5SP330
GH11G008934 1 Ensembl ENCODE 0.7 -2.2 -2161 1.5 PKNOX1 JUN RFX5 FOSL1 ZNF121 ZFHX2 GATA3 GATA2 FOS EGR2 AKIP1 ST5 TMEM9B-AS1 C11orf16 ASCL3
GH11G008913 1.5 FANTOM5 Ensembl ENCODE 0.4 +18.7 18741 1.7 PKNOX1 ATF1 ZNF121 GATA2 ELK1 FOS ZNF263 SP3 REST ZNF592 AKIP1 RPL27A C11orf16
GH11G008929 0.6 ENCODE 0.7 +3.8 3818 0.2 FOXA2 TEAD1 FOXA3 CEBPA HLF TEAD3 C11orf16 AKIP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C11orf16 on UCSC Golden Path with GeneCards custom track

Genomic Location for C11orf16 Gene

Chromosome:
11
Start:
8,920,076 bp from pter
End:
8,933,006 bp from pter
Size:
12,931 bases
Orientation:
Minus strand

Genomic View for C11orf16 Gene

Genes around C11orf16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf16 Gene

Proteins for C11orf16 Gene

  • Protein details for C11orf16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ32-CK016_HUMAN
    Recommended name:
    Uncharacterized protein C11orf16
    Protein Accession:
    Q9NQ32
    Secondary Accessions:
    • Q53FB2
    • Q8N6Y9

    Protein attributes for C11orf16 Gene

    Size:
    467 amino acids
    Molecular mass:
    51609 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf16 Gene

Post-translational modifications for C11orf16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf16 Gene

No data available for DME Specific Peptides for C11orf16 Gene

Domains & Families for C11orf16 Gene

Protein Domains for C11orf16 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf16: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf16 Gene

Function for C11orf16 Gene

genes like me logo Genes that share phenotypes with C11orf16: view

Animal Model Products

CRISPR Products

miRNA for C11orf16 Gene

miRTarBase miRNAs that target C11orf16

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf16 Gene

Localization for C11orf16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf16 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf16 Gene

Pathways & Interactions for C11orf16 Gene

SuperPathways for C11orf16 Gene

No Data Available

Interacting Proteins for C11orf16 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000318999%0d%0a9606.ENSP00000430505%0d%0a9606.ENSP00000443432%0d%0a
Selected Interacting proteins: Q9NQ32-CK016_HUMAN ENSP00000318999 for C11orf16 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for C11orf16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf16 Gene

Drugs & Compounds for C11orf16 Gene

No Compound Related Data Available

Transcripts for C11orf16 Gene

mRNA/cDNA for C11orf16 Gene

Unigene Clusters for C11orf16 Gene

Chromosome 11 open reading frame 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf16 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for C11orf16 Gene

GeneLoc Exon Structure for
C11orf16
ECgene alternative splicing isoforms for
C11orf16

Expression for C11orf16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf16 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf16 Gene

This gene is overexpressed in Fallopian Tube (x11.0), Cervix - Endocervix (x8.5), Testis (x8.0), and Lung (x6.7).

Protein differential expression in normal tissues from HIPED for C11orf16 Gene

This gene is overexpressed in Pancreatic juice (54.3) and Adipocyte (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf16 Gene



Protein tissue co-expression partners for C11orf16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf16 Gene:

C11orf16

SOURCE GeneReport for Unigene cluster for C11orf16 Gene:

Hs.277349
genes like me logo Genes that share expression patterns with C11orf16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf16 Gene

Orthologs for C11orf16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf16 34
  • 98.5 (n)
C11orf16 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15H11orf16 34
  • 79.18 (n)
C11ORF16 35
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C21H11orf16 34
  • 77.9 (n)
C11orf16 35
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC499240 34
  • 74.49 (n)
mouse
(Mus musculus)
Mammalia BC051019 34 16 35
  • 73.37 (n)
oppossum
(Monodelphis domestica)
Mammalia C11orf16 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves C11ORF16 34
  • 51.51 (n)
C11orf16 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf16 35
  • 56 (a)
OneToOne
Species where no ortholog for C11orf16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C11orf16 Gene

ENSEMBL:
Gene Tree for C11orf16 (if available)
TreeFam:
Gene Tree for C11orf16 (if available)

Paralogs for C11orf16 Gene

No data available for Paralogs for C11orf16 Gene

Variants for C11orf16 Gene

Sequence variations from dbSNP and Humsavar for C11orf16 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000052672 -- 8,934,906(+) TCATC(A/G)CTAAT upstream-variant-2KB
rs1000063773 -- 8,926,385(+) CCGCT(A/G)CTCTG intron-variant
rs1000079087 -- 8,920,464(+) GGGGG(A/G)AAAAT intron-variant, downstream-variant-500B
rs1000100418 -- 8,928,844(+) ATGTG(A/G)CCTTA intron-variant
rs1000168262 -- 8,929,283(+) AAGAA(A/T)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf16 Gene

Variant ID Type Subtype PubMed ID
esv2759803 CNV gain 17122850
nsv435923 CNV deletion 17901297
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855
nsv832062 CNV loss 17160897

Variation tolerance for C11orf16 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.11; 87.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf16 Gene

Disorders for C11orf16 Gene

Relevant External Links for C11orf16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf16

No disorders were found for C11orf16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf16 Gene

Publications for C11orf16 Gene

  1. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PMID: 11528127) Amid C. … Schmidt E.R. (Cytogenet. Cell Genet. 2001) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for C11orf16 Gene

Sources for C11orf16 Gene

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