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Aliases for C10orf99 Gene

Aliases for C10orf99 Gene

  • Chromosome 10 Open Reading Frame 99 2 3 5
  • Colon-Derived SUSD2 Binding Factor 2 3 4
  • Anti-Microbial Peptide With 57 Amino Acid Residues 2 3
  • Antimicrobial Peptide-57 3 4
  • AP-57 3 4
  • CSBF 3 4
  • RLLV1833 3
  • UNQ1833 3

External Ids for C10orf99 Gene

Previous GeneCards Identifiers for C10orf99 Gene

  • GC10P085590
  • GC10P085923
  • GC10P079779

Summaries for C10orf99 Gene

GeneCards Summary for C10orf99 Gene

C10orf99 (Chromosome 10 Open Reading Frame 99) is a Protein Coding gene. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for C10orf99 Gene

  • Potential cytokine proposed to be a ligand of SUSD2; can induce SUSD2 internalization upon binding. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). Specifically inhibits cell growth of lymphoblastoid Raji cell line (PubMed:25585381).

  • Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed:25585381).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf99 Gene

Genomics for C10orf99 Gene

Regulatory Elements for C10orf99 Gene

Genomic Location for C10orf99 Gene

Chromosome:
10
Start:
84,173,738 bp from pter
End:
84,185,294 bp from pter
Size:
11,557 bases
Orientation:
Plus strand

Genomic View for C10orf99 Gene

Genes around C10orf99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf99 Gene

Proteins for C10orf99 Gene

  • Protein details for C10orf99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWK7-CJ099_HUMAN
    Recommended name:
    Secreted protein C10orf99
    Protein Accession:
    Q6UWK7

    Protein attributes for C10orf99 Gene

    Size:
    81 amino acids
    Molecular mass:
    9173 Da
    Quaternary structure:
    • Interacts with SUSD2; the interaction is direct.

neXtProt entry for C10orf99 Gene

Proteomics data for C10orf99 Gene at MOPED

Post-translational modifications for C10orf99 Gene

Other Protein References for C10orf99 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C10orf99 Gene

Domains & Families for C10orf99 Gene

Protein Domains for C10orf99 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf99: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C10orf99 Gene

Function for C10orf99 Gene

Molecular function for C10orf99 Gene

UniProtKB/Swiss-Prot Function:
Potential cytokine proposed to be a ligand of SUSD2; can induce SUSD2 internalization upon binding. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). Specifically inhibits cell growth of lymphoblastoid Raji cell line (PubMed:25585381).
UniProtKB/Swiss-Prot Function:
Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed:25585381).

Phenotypes for C10orf99 Gene

genes like me logo Genes that share phenotypes with C10orf99: view

Animal Model Products

CRISPR Products

miRNA for C10orf99 Gene

miRTarBase miRNAs that target C10orf99

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C10orf99 Gene

Localization for C10orf99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf99 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C10orf99 Gene COMPARTMENTS Subcellular localization image for C10orf99 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for C10orf99 Gene

Pathways & Interactions for C10orf99 Gene

SuperPathways for C10orf99 Gene

No Data Available

Interacting Proteins for C10orf99 Gene

Gene Ontology (GO) - Biological Process for C10orf99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902807 negative regulation of cell cycle G1/S phase transition IDA 25351403
genes like me logo Genes that share ontologies with C10orf99: view

No data available for Pathways by source and SIGNOR curated interactions for C10orf99 Gene

Drugs & Compounds for C10orf99 Gene

No Compound Related Data Available

Transcripts for C10orf99 Gene

mRNA/cDNA for C10orf99 Gene

Unigene Clusters for C10orf99 Gene

Chromosome 10 open reading frame 99:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf99 Gene

No ASD Table

Relevant External Links for C10orf99 Gene

GeneLoc Exon Structure for
C10orf99
ECgene alternative splicing isoforms for
C10orf99

Expression for C10orf99 Gene

mRNA expression in normal human tissues for C10orf99 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C10orf99 Gene

This gene is overexpressed in Colon - Transverse (x18.9), Esophagus - Mucosa (x12.9), and Vagina (x6.8).

SOURCE GeneReport for Unigene cluster for C10orf99 Gene Hs.298713

mRNA Expression by UniProt/SwissProt for C10orf99 Gene

Q6UWK7-CJ099_HUMAN
Tissue specificity: Expressed at high levels in colon and at moderate level in tonsil. Highly reduced expression in primary colon cancer tissues compared with that in adjacent tissues (PubMed:25351403). Highest levels of expression detected in stomach and colon; expressed in epithelium of skin and esophagus, and in some tumor and/or tumor adjacent tissues (TAT), including TAT of esophagus cancer, hepatocellular carcinoma (HCC), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and invasive ductal carcinoma (IDC) tissues (at protein level) (PubMed:25585381).
genes like me logo Genes that share expression patterns with C10orf99: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for C10orf99 Gene

Orthologs for C10orf99 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for C10orf99 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf99 35
  • 100 (n)
  • 100 (a)
C10orf99 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2610528A11Rik 36
  • 56 (a)
OneToOne
Species with no ortholog for C10orf99:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C10orf99 Gene

ENSEMBL:
Gene Tree for C10orf99 (if available)
TreeFam:
Gene Tree for C10orf99 (if available)

Paralogs for C10orf99 Gene

No data available for Paralogs for C10orf99 Gene

Variants for C10orf99 Gene

Sequence variations from dbSNP and Humsavar for C10orf99 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs13697 -- 84,185,099(-) TTGCC(A/T)CCCTG utr-variant-3-prime
rs3887087 -- 84,174,494(-) AAAAA(A/G)AAAAA intron-variant
rs4390287 -- 84,185,428(+) AGAGG(C/G)CCTGG downstream-variant-500B
rs4315004 -- 84,179,795(+) CAATG(C/G/T)GACAA intron-variant
rs4348833 -- 84,176,404(+) AGCCC(C/T)GTGCC intron-variant

Variation tolerance for C10orf99 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf99 Gene

HapMap Linkage Disequilibrium report
C10orf99

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C10orf99 Gene

Disorders for C10orf99 Gene

Relevant External Links for C10orf99

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C10orf99

No disorders were found for C10orf99 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf99 Gene

Publications for C10orf99 Gene

  1. AP-57/C10orf99 is a new type of mutifunctional antimicrobial peptide. (PMID: 25585381) Yang M. … Tong A. (Biochem. Biophys. Res. Commun. 2015) 2 3 4 67
  2. CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest. (PMID: 25351403) Pan W. … Han W. (Sci. Rep. 2014) 2 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C10orf99 Gene

Sources for C10orf99 Gene

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