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Aliases for C10orf90 Gene

Aliases for C10orf90 Gene

  • Chromosome 10 Open Reading Frame 90 2 3 5
  • Fragile-Site Associated Tumor Suppressor Homolog 3 4
  • FATS 3 4
  • Fragile-Site Associated Tumor Suppressor 2
  • Centrosomal Protein C10orf90 3
  • BA422P15.2 3

External Ids for C10orf90 Gene

Previous GeneCards Identifiers for C10orf90 Gene

  • GC10M127687
  • GC10M128103
  • GC10M121800
  • GC10M128113

Summaries for C10orf90 Gene

GeneCards Summary for C10orf90 Gene

C10orf90 (Chromosome 10 Open Reading Frame 90) is a Protein Coding gene. GO annotations related to this gene include histone deacetylase binding. An important paralog of this gene is ALMS1.

UniProtKB/Swiss-Prot for C10orf90 Gene

  • Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia.

Additional gene information for C10orf90 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf90 Gene

Genomics for C10orf90 Gene

Regulatory Elements for C10orf90 Gene

Enhancers for C10orf90 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H126456 1.2 ENCODE dbSUPER 16.9 +211.7 211723 5 ELF3 TBP FOXA2 INSM2 KLF17 RAD21 ZNF2 RFX5 ELK1 SCRT2 C10orf90 LOC728158 LOC105378549
GH10H126496 0.3 FANTOM5 34.3 +174.2 174249 0 C10orf90 LOC105378549 LOC728158
GH10H126583 0.6 dbSUPER 16 +85.7 85713 2 ZNF776 POLR2A ZNF473 ZNF366 GLIS1 ZNF512 ZIC2 PRDM1 EDRF1 C10orf90 EDRF1-AS1 GC10P126579 LOC105378548
GH10H126623 0.8 dbSUPER 11.9 +38.4 38384 17 TBL1XR1 FEZF1 TCF12 GATA2 EGR1 SCRT2 ATF7 USF2 CEBPB ZNF843 C10orf90 LOC105378548
GH10H126521 0.7 ENCODE 11.5 +149.5 149452 0 FOXA2 CEBPB RAD21 EP300 BRCA1 JUND POLR2A STAT3 TCF7 CREM C10orf90 LOC105378549 GC10M126510
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C10orf90 on UCSC Golden Path with GeneCards custom track

Genomic Location for C10orf90 Gene

Chromosome:
10
Start:
126,424,997 bp from pter
End:
126,671,038 bp from pter
Size:
246,042 bases
Orientation:
Minus strand

Genomic View for C10orf90 Gene

Genes around C10orf90 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf90 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf90 Gene

Proteins for C10orf90 Gene

  • Protein details for C10orf90 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M02-CJ090_HUMAN
    Recommended name:
    Centrosomal protein C10orf90
    Protein Accession:
    Q96M02
    Secondary Accessions:
    • B9EIQ9
    • Q5JRP6
    • Q5T023
    • Q8NCV5
    • Q8WU75

    Protein attributes for C10orf90 Gene

    Size:
    699 amino acids
    Molecular mass:
    77910 Da
    Quaternary structure:
    • Interacts with HDAC1; the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21.
    SequenceCaution:
    • Sequence=AAM20911.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40680.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C10orf90 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C10orf90 Gene

Post-translational modifications for C10orf90 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C10orf90 Gene

Domains & Families for C10orf90 Gene

Gene Families for C10orf90 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C10orf90 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf90: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C10orf90 Gene

Function for C10orf90 Gene

Molecular function for C10orf90 Gene

UniProtKB/Swiss-Prot Function:
Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia.

Phenotypes From GWAS Catalog for C10orf90 Gene

Gene Ontology (GO) - Molecular Function for C10orf90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042826 histone deacetylase binding IBA --
GO:0051393 alpha-actinin binding IBA --
genes like me logo Genes that share ontologies with C10orf90: view

Phenotypes for C10orf90 Gene

MGI mutant phenotypes for C10orf90:
inferred from 1 alleles
GenomeRNAi human phenotypes for C10orf90:
genes like me logo Genes that share phenotypes with C10orf90: view

Animal Models for C10orf90 Gene

MGI Knock Outs for C10orf90:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C10orf90 Gene

Localization for C10orf90 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf90 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf90 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C10orf90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 20844083
GO:0005813 centrosome IDA,IEA 20844083
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with C10orf90: view

Pathways & Interactions for C10orf90 Gene

SuperPathways for C10orf90 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C10orf90 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf90 Gene

Drugs & Compounds for C10orf90 Gene

No Compound Related Data Available

Transcripts for C10orf90 Gene

mRNA/cDNA for C10orf90 Gene

(20) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C10orf90 Gene

Chromosome 10 open reading frame 90:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf90 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6:
SP7:
SP8:

Relevant External Links for C10orf90 Gene

GeneLoc Exon Structure for
C10orf90
ECgene alternative splicing isoforms for
C10orf90

Expression for C10orf90 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C10orf90 Gene

mRNA differential expression in normal tissues according to GTEx for C10orf90 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.6), Brain - Substantia nigra (x6.6), Brain - Hippocampus (x4.7), Brain - Putamen (basal ganglia) (x4.2), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for C10orf90 Gene

This gene is overexpressed in Plasma (52.8) and Platelet (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C10orf90 Gene



Protein tissue co-expression partners for C10orf90 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C10orf90 Gene:

C10orf90

SOURCE GeneReport for Unigene cluster for C10orf90 Gene:

Hs.587663

Evidence on tissue expression from TISSUES for C10orf90 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with C10orf90: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf90 Gene

Orthologs for C10orf90 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf90 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf90 33
  • 99.09 (n)
C10orf90 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf90 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C26H10orf90 33
  • 78.6 (n)
C10orf90 34
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C28H10orf90 33
  • 76.8 (n)
C10orf90 34
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D7Ertd443e 33 16 34
  • 76.38 (n)
rat
(Rattus norvegicus)
Mammalia LOC100302465 33
  • 75.85 (n)
oppossum
(Monodelphis domestica)
Mammalia C10orf90 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves C6H10ORF90 33
  • 53.69 (n)
lizard
(Anolis carolinensis)
Reptilia C10orf90 34
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C12H10orf90 34
  • 15 (a)
OneToOne
Species where no ortholog for C10orf90 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf90 Gene

ENSEMBL:
Gene Tree for C10orf90 (if available)
TreeFam:
Gene Tree for C10orf90 (if available)

Paralogs for C10orf90 Gene

Paralogs for C10orf90 Gene

genes like me logo Genes that share paralogs with C10orf90: view

Variants for C10orf90 Gene

Sequence variations from dbSNP and Humsavar for C10orf90 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000007496 -- 126,599,518(+) TTCAA(C/T)TGATG intron-variant
rs1000011280 -- 126,635,048(+) TGCCT(A/G)TCTCA intron-variant
rs1000026826 -- 126,482,220(+) TTGTT(A/T)TAGGG intron-variant
rs1000031490 -- 126,434,823(+) TTTAA(A/C)CTTGA intron-variant, nc-transcript-variant
rs1000037192 -- 126,489,532(+) ACTTC(C/T)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf90 Gene

Variant ID Type Subtype PubMed ID
esv2677894 CNV deletion 23128226
esv3323965 CNV insertion 20981092
esv3579218 CNV loss 25503493
esv3624852 CNV gain 21293372
esv3624860 CNV loss 21293372
esv3891896 CNV gain 25118596
nsv1035647 CNV gain 25217958
nsv1045509 CNV gain 25217958
nsv477618 CNV novel sequence insertion 20440878
nsv521809 CNV loss 19592680
nsv525054 CNV loss 19592680
nsv7602 CNV deletion 18451855

Variation tolerance for C10orf90 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf90 Gene

Human Gene Mutation Database (HGMD)
C10orf90
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf90

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf90 Gene

Disorders for C10orf90 Gene

Relevant External Links for C10orf90

Genetic Association Database (GAD)
C10orf90
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C10orf90

No disorders were found for C10orf90 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf90 Gene

Publications for C10orf90 Gene

  1. FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage. (PMID: 24240685) Yan S … Li Z (Oncogene 2014) 2 3 60
  2. An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. (PMID: 20154723) Li Z … Cai WW (Oncogene 2010) 2 3 60
  3. FATS is a transcriptional target of p53 and associated with antitumor activity. (PMID: 20843368) Zhang X … Li Z (Molecular cancer 2010) 2 3 60
  4. Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731. (PMID: 20844083) Knorz VJ … Hearn T (Molecular biology of the cell 2010) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for C10orf90 Gene

Sources for C10orf90 Gene

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