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Aliases for C10orf90 Gene

Aliases for C10orf90 Gene

  • Chromosome 10 Open Reading Frame 90 2 3
  • Fragile-Site Associated Tumor Suppressor Homolog 3 4
  • FATS 3 4
  • Fragile-Site Associated Tumor Suppressor 2
  • Centrosomal Protein C10orf90 3
  • BA422P15.2 3

External Ids for C10orf90 Gene

Summaries for C10orf90 Gene

GeneCards Summary for C10orf90 Gene

C10orf90 (Chromosome 10 Open Reading Frame 90) is a Protein Coding gene. GO annotations related to this gene include histone deacetylase binding.

UniProtKB/Swiss-Prot for C10orf90 Gene

  • Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf90 Gene

Genomics for C10orf90 Gene

Genomic Location for C10orf90 Gene

Start:
126,424,997 bp from pter
End:
126,670,446 bp from pter
Size:
245,450 bases
Orientation:
Minus strand

Genomic View for C10orf90 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C10orf90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf90 Gene

Regulatory Elements for C10orf90 Gene

Proteins for C10orf90 Gene

  • Protein details for C10orf90 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M02-CJ090_HUMAN
    Recommended name:
    Centrosomal protein C10orf90
    Protein Accession:
    Q96M02
    Secondary Accessions:
    • B9EIQ9
    • Q5JRP6
    • Q5T023
    • Q8NCV5
    • Q8WU75

    Protein attributes for C10orf90 Gene

    Size:
    699 amino acids
    Molecular mass:
    77910 Da
    Quaternary structure:
    • Interacts with HDAC1; the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21.
    SequenceCaution:
    • Sequence=AAM20911.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40680.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C10orf90 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C10orf90 Gene

Proteomics data for C10orf90 Gene at MOPED

Post-translational modifications for C10orf90 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C10orf90 Gene

No data available for DME Specific Peptides for C10orf90 Gene

Domains for C10orf90 Gene

Protein Domains for C10orf90 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C10orf90: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C10orf90 Gene

Function for C10orf90 Gene

Molecular function for C10orf90 Gene

UniProtKB/Swiss-Prot Function: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia.

Gene Ontology (GO) - Molecular Function for C10orf90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042826 histone deacetylase binding IEA --
genes like me logo Genes that share ontologies with C10orf90: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C10orf90 Gene

Localization for C10orf90 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf90 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C10orf90 Gene COMPARTMENTS Subcellular localization image for C10orf90 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C10orf90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20844083
GO:0005813 centrosome IDA 20844083
GO:0015629 actin cytoskeleton IDA 20844083
genes like me logo Genes that share ontologies with C10orf90: view

Pathways for C10orf90 Gene

SuperPathways for C10orf90 Gene

No Data Available

Interacting Proteins for C10orf90 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000284694%0d%0a9606.ENSP00000269305%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000284694 Q96M02-CJ090_HUMAN for C10orf90 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C10orf90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus --
GO:0007095 mitotic G2 DNA damage checkpoint IEA --
GO:0009411 response to UV IEA --
GO:0010212 response to ionizing radiation IEA --
GO:0030308 negative regulation of cell growth IEA --
genes like me logo Genes that share ontologies with C10orf90: view

No data available for Pathways by source for C10orf90 Gene

Transcripts for C10orf90 Gene

Unigene Clusters for C10orf90 Gene

Chromosome 10 open reading frame 90:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf90 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6:
SP7:
SP8:

Relevant External Links for C10orf90 Gene

GeneLoc Exon Structure for
C10orf90
ECgene alternative splicing isoforms for
C10orf90

Expression for C10orf90 Gene

mRNA expression in normal human tissues for C10orf90 Gene

mRNA differential expression in normal tissues according to GTEx for C10orf90 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (9.6), Brain - Substantia nigra (6.6), Brain - Hippocampus (4.7), Brain - Putamen (basal ganglia) (4.2), and Testis (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C10orf90 Gene

SOURCE GeneReport for Unigene cluster for C10orf90 Gene Hs.587663

genes like me logo Genes that share expressions with C10orf90: view

Orthologs for C10orf90 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf90 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf90 36
  • 99.09 (n)
  • 98.57 (a)
C10orf90 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10orf90 37
  • 67 (a)
OneToOne
C26H10orf90 36
  • 78.6 (n)
  • 70.01 (a)
dog
(Canis familiaris)
Mammalia C10orf90 37
  • 65 (a)
OneToOne
C28H10orf90 36
  • 76.8 (n)
  • 67.29 (a)
mouse
(Mus musculus)
Mammalia D7Ertd443e 36
  • 76.38 (n)
  • 67.83 (a)
D7Ertd443e 16
D7Ertd443e 37
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C10orf90 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf90 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100302465 36
  • 75.85 (n)
  • 67.39 (a)
chicken
(Gallus gallus)
Aves C6H10ORF90 36
  • 53.69 (n)
  • 40.35 (a)
lizard
(Anolis carolinensis)
Reptilia C10orf90 37
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C12H10orf90 37
  • 15 (a)
OneToOne
Species with no ortholog for C10orf90:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf90 Gene

ENSEMBL:
Gene Tree for C10orf90 (if available)
TreeFam:
Gene Tree for C10orf90 (if available)

Paralogs for C10orf90 Gene

No data available for Paralogs for C10orf90 Gene

Variants for C10orf90 Gene

Sequence variations from dbSNP and Humsavar for C10orf90 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs884029 -- 126,525,550(+) TGAGG(C/T)TGGGG upstream-variant-2KB
rs920165 -- 126,520,228(+) AAGGT(A/C)ACAAT intron-variant
rs920166 -- 126,520,387(+) GCACA(C/G)ATGTA intron-variant
rs1036454 -- 126,523,005(+) GTGCT(A/G)TCATG upstream-variant-2KB, intron-variant
rs1036455 -- 126,523,106(+) ATTTT(A/T)AAAGC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf90 Gene

Variant ID Type Subtype PubMed ID
nsv525054 CNV Loss 19592680
esv2677894 CNV Deletion 23128226
nsv7602 CNV Loss 18451855
nsv521809 CNV Loss 19592680
esv2743062 CNV Deletion 23290073

Relevant External Links for C10orf90 Gene

HapMap Linkage Disequilibrium report
C10orf90

Disorders for C10orf90 Gene

Relevant External Links for C10orf90

Genetic Association Database (GAD)
C10orf90
genes like me logo Genes that share disorders with C10orf90: view

No data available for UniProtKB/Swiss-Prot for C10orf90 Gene

Publications for C10orf90 Gene

  1. An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. (PMID: 20154723) Li Z. … Cai W.W. (Oncogene 2010) 2 3
  2. FATS is a transcriptional target of p53 and associated with antitumor activity. (PMID: 20843368) Zhang X. … Li Z. (Mol. Cancer 2010) 2 3
  3. Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731. (PMID: 20844083) Knorz V.J. … Hearn T. (Mol. Biol. Cell 2010) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4

Products for C10orf90 Gene

Sources for C10orf90 Gene

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