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Aliases for C10orf90 Gene

Aliases for C10orf90 Gene

  • Chromosome 10 Open Reading Frame 90 2 3 5
  • Fragile-Site Associated Tumor Suppressor Homolog 3 4
  • FATS 3 4
  • Fragile-Site Associated Tumor Suppressor 2
  • BA422P15.2 3

External Ids for C10orf90 Gene

Previous GeneCards Identifiers for C10orf90 Gene

  • GC10M127687
  • GC10M128103
  • GC10M121800
  • GC10M128113

Summaries for C10orf90 Gene

GeneCards Summary for C10orf90 Gene

C10orf90 (Chromosome 10 Open Reading Frame 90) is a Protein Coding gene. Diseases associated with C10orf90 include Actinomycosis. GO annotations related to this gene include histone deacetylase binding. An important paralog of this gene is ALMS1.

UniProtKB/Swiss-Prot for C10orf90 Gene

  • Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf90 Gene

Genomics for C10orf90 Gene

Regulatory Elements for C10orf90 Gene

Enhancers for C10orf90 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C10orf90 on UCSC Golden Path with GeneCards custom track

Genomic Location for C10orf90 Gene

126,424,997 bp from pter
126,671,038 bp from pter
246,042 bases
Minus strand

Genomic View for C10orf90 Gene

Genes around C10orf90 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf90 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf90 Gene

Proteins for C10orf90 Gene

  • Protein details for C10orf90 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centrosomal protein C10orf90
    Protein Accession:
    Secondary Accessions:
    • B9EIQ9
    • Q5JRP6
    • Q5T023
    • Q8NCV5
    • Q8WU75

    Protein attributes for C10orf90 Gene

    699 amino acids
    Molecular mass:
    77910 Da
    Quaternary structure:
    • Interacts with HDAC1; the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21.
    • Sequence=AAM20911.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40680.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C10orf90 Gene


neXtProt entry for C10orf90 Gene

Proteomics data for C10orf90 Gene at MOPED

Post-translational modifications for C10orf90 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C10orf90 Gene

No data available for DME Specific Peptides for C10orf90 Gene

Domains & Families for C10orf90 Gene

Protein Domains for C10orf90 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf90: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C10orf90 Gene

Function for C10orf90 Gene

Molecular function for C10orf90 Gene

UniProtKB/Swiss-Prot Function:
Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia.

Phenotypes for C10orf90 Gene

MGI mutant phenotypes for C10orf90:
inferred from 1 alleles
GenomeRNAi human phenotypes for C10orf90:
genes like me logo Genes that share phenotypes with C10orf90: view

Animal Models for C10orf90 Gene

MGI Knock Outs for C10orf90:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C10orf90 Gene

Localization for C10orf90 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf90 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin.

Subcellular locations from

Jensen Localization Image for C10orf90 Gene COMPARTMENTS Subcellular localization image for C10orf90 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3
plasma membrane 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C10orf90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20844083
GO:0015629 actin cytoskeleton IDA 20844083
genes like me logo Genes that share ontologies with C10orf90: view

Pathways & Interactions for C10orf90 Gene

SuperPathways for C10orf90 Gene

No Data Available

Interacting Proteins for C10orf90 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000284694 Q96M02-CJ090_HUMAN for C10orf90 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C10orf90 Gene


No data available for Pathways by source and SIGNOR curated interactions for C10orf90 Gene

Drugs & Compounds for C10orf90 Gene

No Compound Related Data Available

Transcripts for C10orf90 Gene

Unigene Clusters for C10orf90 Gene

Chromosome 10 open reading frame 90:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf90 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -

Relevant External Links for C10orf90 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C10orf90 Gene

mRNA expression in normal human tissues for C10orf90 Gene

mRNA differential expression in normal tissues according to GTEx for C10orf90 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.6), Brain - Substantia nigra (x6.6), Brain - Hippocampus (x4.7), Brain - Putamen (basal ganglia) (x4.2), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for C10orf90 Gene

This gene is overexpressed in Plasma (52.8) and Platelet (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C10orf90 Gene

SOURCE GeneReport for Unigene cluster for C10orf90 Gene Hs.587663

genes like me logo Genes that share expression patterns with C10orf90: view

Protein tissue co-expression partners for C10orf90 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C10orf90 Gene

Orthologs for C10orf90 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf90 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C26H10orf90 35
  • 78.6 (n)
  • 70.01 (a)
C10orf90 36
  • 67 (a)
(Canis familiaris)
Mammalia C28H10orf90 35
  • 76.8 (n)
  • 67.29 (a)
C10orf90 36
  • 65 (a)
(Mus musculus)
Mammalia D7Ertd443e 35
  • 76.38 (n)
  • 67.83 (a)
D7Ertd443e 16
D7Ertd443e 36
  • 63 (a)
(Pan troglodytes)
Mammalia C10H10orf90 35
  • 99.09 (n)
  • 98.57 (a)
C10orf90 36
  • 97 (a)
(Rattus norvegicus)
Mammalia LOC100302465 35
  • 75.85 (n)
  • 67.39 (a)
(Monodelphis domestica)
Mammalia C10orf90 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia C10orf90 36
  • 87 (a)
(Gallus gallus)
Aves C6H10ORF90 35
  • 53.69 (n)
  • 40.35 (a)
(Anolis carolinensis)
Reptilia C10orf90 36
  • 42 (a)
(Danio rerio)
Actinopterygii C12H10orf90 36
  • 15 (a)
Species with no ortholog for C10orf90:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf90 Gene

Gene Tree for C10orf90 (if available)
Gene Tree for C10orf90 (if available)

Paralogs for C10orf90 Gene

Paralogs for C10orf90 Gene

genes like me logo Genes that share paralogs with C10orf90: view

Variants for C10orf90 Gene

Sequence variations from dbSNP and Humsavar for C10orf90 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11245008 - 126,504,799(+) CTCTG(C/T)GGGGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs11245007 - 126,504,416(+) TGAAT(C/T)TGGAC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs11558415 - 126,505,029(-) CAGAT(C/G)ATTGA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs12412320 - 126,461,527(+) GTGGG(G/T)TCCTC reference, missense
rs1436789 -- 126,644,442(-) TTCAC(A/G)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf90 Gene

Variant ID Type Subtype PubMed ID
nsv525054 CNV Loss 19592680
esv2677894 CNV Deletion 23128226
nsv7602 CNV Loss 18451855
nsv521809 CNV Loss 19592680
esv2743062 CNV Deletion 23290073

Variation tolerance for C10orf90 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf90 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf90 Gene

Disorders for C10orf90 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C10orf90 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • actinomycetoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C10orf90

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C10orf90: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C10orf90 Gene

Publications for C10orf90 Gene

  1. An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. (PMID: 20154723) Li Z. … Cai W.W. (Oncogene 2010) 2 3 67
  2. FATS is a transcriptional target of p53 and associated with antitumor activity. (PMID: 20843368) Zhang X. … Li Z. (Mol. Cancer 2010) 2 3
  3. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PMID: 23319000) Luykx J.J. … Ophoff R.A. (Mol. Psychiatry 2013) 3
  4. FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage. (PMID: 24240685) Yan S. … Li Z. (Oncogene 2013) 3
  5. Expression level of novel tumor suppressor gene FATS is associated with the outcome of node positive breast cancer. (PMID: 22040499) Zhang J. … Li Z. (Chin. Med. J. 2011) 3

Products for C10orf90 Gene

Sources for C10orf90 Gene