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C10orf88 Gene

protein-coding   GIFtS: 47
GCID: GC10M124681

Chromosome 10 Open Reading Frame 88

  Search for C10orf88
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 10 Open Reading Frame 881 2
Uncharacterized Protein C10orf882

External Ids:    HGNC: 258221   Entrez Gene: 800072   Ensembl: ENSG000001199657   UniProtKB: Q9H8K73   

Export aliases for C10orf88 gene to outside databases

Previous GC identifers: GC10M124230 GC10M118307


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C10orf88 Gene:
C10orf88 (chromosome 10 open reading frame 88) is a protein-coding gene. GO annotations related to this gene include identical protein binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the C10orf88 gene promoter:
         STAT5B   FOXF2   HTF   LCR-F1   HNF-1A   MEF-2A   HNF-1   FOXJ2 (long isoform)   FOXJ2   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C10orf88

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C10orf88


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13

C10orf88 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf88 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M124681:  view genomic region     (about GC identifiers)

Start:
124,690,419 bp from pter      End:
124,713,919 bp from pter
Size:
23,501 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CJ088_HUMAN, Q9H8K7 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf88  
Size: 445 amino acids; 49249 Da
Secondary accessions: Q0P6C6 Q8N597

Explore the universe of human proteins at neXtProt for C10orf88: NX_Q9H8K7

Explore proteomics data for C10orf88 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C10orf88 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079218.2  
    ENSEMBL proteins: 
     ENSP00000419126  

    C10orf88 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for C10orf88

     
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    C10orf88 Antibody Products:

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    Cloud-Clone Corp. ELISAs for C10orf88
    Cloud-Clone Corp. CLIAs for C10orf88
    Search eBioscience for ELISAs for C10orf88 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028043 DUF4506

    Graphical View of Domain Structure for InterPro Entry Q9H8K7

    ProtoNet protein and cluster: Q9H8K7


    Find genes that share domains with C10orf88           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042802identical protein binding IEA--
         
    Find genes that share ontologies with C10orf88           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C10orf88
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C10orf88
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C10orf88

    miRNA
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    miRTarBase miRNAs that target C10orf88:
    hsa-mir-98-5p (MIRT027573), hsa-mir-101-3p (MIRT027285), hsa-mir-331-3p (MIRT043328)

    Block miRNA regulation of human, mouse, rat C10orf88 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate C10orf88:
    hsa-miR-1290 hsa-miR-1243 hsa-miR-101 hsa-miR-1278 hsa-miR-876-5p hsa-miR-380 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidC10orf88 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for C10orf88
    Predesigned siRNA for gene silencing in human, mouse, rat C10orf88

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: C10orf88 (NM_024942)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C10orf88
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C10orf88

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf88


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    golgi apparatus1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C10orf88
    Interactions:

        Search GeneGlobe Interaction Network for C10orf88

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for C10orf88 (Q9H8K73 ENSP000004191264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLTCQ006103, ENSP000002691224I2D: score=4 STRING: ENSP00000269122
    PLEKHO1Q53GL03, ENSP000003581204I2D: score=2 STRING: ENSP00000358120
    IMMTQ168913I2D: score=4 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C10orf88 (CJ088)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C10orf88 gene: 
    NM_024942.3  

    Unigene Cluster for C10orf88:

    Chromosome 10 open reading frame 88
    Hs.501286  [show with all ESTs]
    Unigene Representative Sequence: NM_024942
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368891(uc001lgw.2 uc001lgx.2) ENST00000481909 ENST00000462191
    ENST00000470158
    miRNA
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    Block miRNA regulation of human, mouse, rat C10orf88 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate C10orf88:
    hsa-miR-1290 hsa-miR-1243 hsa-miR-101 hsa-miR-1278 hsa-miR-876-5p hsa-miR-380 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidC10orf88 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C10orf88
    Predesigned siRNA for gene silencing in human, mouse, rat C10orf88
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    OriGene clones in human, mouse for C10orf88 (see all 7)
    OriGene ORF clones in mouse, rat for C10orf88
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C10orf88 (NM_024942)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C10orf88
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C10orf88
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for C10orf88
    OriGene qSTAR qPCR primer pairs in human, mouse for C10orf88
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C10orf88
      QuantiTect SYBR Green Assays in human, mouse, rat C10orf88
      QuantiFast Probe-based Assays in human, mouse, rat C10orf88

    Additional mRNA sequence: 

    AK023552.1 BC032645.1 

    5 DOTS entries:

    DT.100678416  DT.208144  DT.100774647  DT.302128  DT.95107259 

    Selected AceView cDNA sequences (see all 72):

    BU429606 AI640465 AW137174 AA758647 AU142809 AI091567 AI083986 AI623607 
    CB044034 BI821345 BQ014253 BU663125 AA847212 BU175280 BM353644 AA609770 
    BX487999 CA447682 AI225214 BX424522 BE766129 BI463402 BX475334 BX443360 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf88    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
    SP1:                                                  -                           
    SP2:                                                  -                           
    SP3:                                -                 -                           
    SP4:                                                                    -         


    ECgene alternative splicing isoforms for C10orf88

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C10orf88 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGGACAAA
    C10orf88 Expression
    About this image


    C10orf88 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Long Bone
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Pelvic Girdle
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
    C10orf88 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C10orf88 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501286
        Custom PCR Arrays for C10orf88
    Primer
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    OriGene qPCR primer pairs and template standards for C10orf88
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    QuantiFast Probe-based Assays in human, mouse, rat C10orf88
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf88

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C10orf88 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2310057M21Rik1 , 5 RIKEN cDNA 2310057M21 gene1, 5 78.9(n)1
    70.95(a)1
      7 (73.88 cM)5
    682771  NM_026655.31  NP_080931.11 
     1313427185 
    chicken
    (Gallus gallus)
    Aves C6H10ORF881 chromosome 6 open reading frame, human C10orf88 59.81(n)
    51.83(a)
      427084  XM_424678.4  XP_424678.4 
    lizard
    (Anolis carolinensis)
    Reptilia C10orf886
    chromosome 10 open reading frame 88
    40(a)
    1 ↔ 1
    3(59905509-59916324)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004853091 uncharacterized LOC100485309 48.94(n)
    37.23(a)
      100485309  XM_002944426.2  XP_002944472.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:rp71-19m20.11 si:rp71-19m20.1 48.16(n)
    36.12(a)
      570641  XM_694146.5  XP_699238.2 


    ENSEMBL Gene Tree for C10orf88 (if available)
    TreeFam Gene Tree for C10orf88 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C10orf88 gene

    Find genes that share paralogs with C10orf88           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for C10orf88
    PGOHUM00000238960 PGOHUM00000237817


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C10orf88 (see all 433)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466345101,2
    --124689921(+) TGTGAC/TCTTGC 1 -- int10--------
    rs1904607721,2
    --124690077(+) CAGACC/TACAAC 1 -- int10--------
    rs771738931,2
    F--124690273(+) GTTCCA/GTATAC 1 -- int11Minor allele frequency- G:0.02WA 118
    rs176534391,2
    C,F,H--124690291(+) CCTTTG/ATAGTA 1 -- int114Minor allele frequency- A:0.03NA NS EA 1342
    rs1807787351,2
    --124690318(+) ACAACA/CTATAA 1 -- int10--------
    rs1410659991,2
    C--124690368(+) AAAGAC/TGGGGT 1 -- int10--------
    rs1498212211,2
    --124690372(+) ATGGGA/GTCTTT 1 -- int10--------
    rs611824421,2
    C--124690512(+) GAGGG-/G/GG  
            
    TTAAA
    2 -- ut310--------
    rs1426126241,2
    C--124690512(+) AGTGA-/GGGGGTT 1 -- ut310--------
    rs1850983671,2
    --124690537(+) TCTAAA/TAAAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for C10orf88 (124690419 - 124713919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for C10orf88:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832010CNV Gain17160897
    esv6242OTHER Inversion19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C10orf88
    DNA2.0 Custom Variant and Variant Library Synthesis for C10orf88

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with C10orf88           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: C10orf88 (1 document)

    Export disorders for C10orf88 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C10orf88 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with C10orf88)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Genome-wide association study of circulating vitamin D levels. (PubMed id 20418485)1 Ahn J....Albanes D. (Hum. Mol. Genet. 2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (J. Proteome Res. 2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80007 HGNC: 25822 AceView: C10orf88 Ensembl:ENSG00000119965 euGenes: HUgn80007
    ECgene: C10orf88 H-InvDB: C10orf88

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C10orf88 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C10orf88 gene:
    Search GeneIP for patents involving C10orf88

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