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C10orf76 Gene

protein-coding   GIFtS: 41
GCID: GC10M103595

Chromosome 10 Open Reading Frame 76

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 10 Open Reading Frame 761 2
UPF0668 Protein C10orf762

External Ids:    HGNC: 257881   Entrez Gene: 795912   Ensembl: ENSG000001200297   UniProtKB: Q5T2E63   

Export aliases for C10orf76 gene to outside databases

Previous GC identifers: GC10M103270 GC10M097236


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C10orf76 Gene:
C10orf76 (chromosome 10 open reading frame 76) is a protein-coding gene. Diseases associated with C10orf76 include alzheimer's disease, and malaria.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C10orf76 gene promoter:
         ER-alpha   RP58   Pax-5   Lmo2   LCR-F1   C/EBPalpha   E2F-1   E2F   ARP-1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C10orf76

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C10orf76


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.32

C10orf76 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf76 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M103595:  view genomic region     (about GC identifiers)

Start:
103,605,356 bp from pter      End:
103,815,950 bp from pter
Size:
210,595 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CJ076_HUMAN, Q5T2E6 (See protein sequence)
Recommended Name: UPF0668 protein C10orf76  
Size: 689 amino acids; 78710 Da
Secondary accessions: Q2TB87 Q9H8Z9
Alternative splicing: 3 isoforms:  Q5T2E6-1   Q5T2E6-2   Q5T2E6-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for C10orf76: NX_Q5T2E6

Explore proteomics data for C10orf76 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C10orf76 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078817.2  
    ENSEMBL proteins: 
     ENSP00000359050   ENSP00000413473   ENSP00000312408  

    C10orf76 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for C10orf76

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    C10orf76 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for C10orf76
    Cloud-Clone Corp. CLIAs for C10orf76


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013636 DUF1741
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q5T2E6

    ProtoNet protein and cluster: Q5T2E6

    UniProtKB/Swiss-Prot: CJ076_HUMAN, Q5T2E6
    Similarity: Belongs to the UPF0668 family


    C10orf76 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    C10orf76 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for 9130011E15Rik):
     mortality/aging 

    C10orf76 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C10orf76
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C10orf76
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C10orf76

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate C10orf76 (see all 43):
    hsa-miR-15a hsa-miR-146a hsa-miR-30d hsa-miR-766 hsa-miR-3916 hsa-miR-424 hsa-miR-30a hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidC10orf76 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for C10orf76
    Predesigned siRNA for gene silencing in human, mouse, rat C10orf76

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for C10orf76

    Clone
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    OriGene ORF clones in mouse, rat for C10orf76
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    GenScript: all cDNA clones in your preferred vector: C10orf76 (NM_024541)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C10orf76
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C10orf76

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf76


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CJ076_HUMAN, Q5T2E6: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    C10orf76 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C10orf76
    Interactions:

        Search GeneGlobe Interaction Network for C10orf76

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for C10orf76 (ENSP000003590504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C10orf76 (CJ076)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C10orf76 gene: 
    NM_024541.2  

    Unigene Cluster for C10orf76:

    Chromosome 10 open reading frame 76
    Hs.16004  [show with all ESTs]
    Unigene Representative Sequence: NM_024541
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495001 ENST00000370033(uc009xwx.1 uc009xwy.1) ENST00000456149
    ENST00000470043 ENST00000311122(uc001kui.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat C10orf76 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate C10orf76 (see all 43):
    hsa-miR-15a hsa-miR-146a hsa-miR-30d hsa-miR-766 hsa-miR-3916 hsa-miR-424 hsa-miR-30a hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidC10orf76 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C10orf76
    Predesigned siRNA for gene silencing in human, mouse, rat C10orf76
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    OriGene clones in human, mouse for C10orf76 (see all 8)
    OriGene ORF clones in mouse, rat for C10orf76
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C10orf76 (NM_024541)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C10orf76
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C10orf76
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for C10orf76
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C10orf76
      QuantiTect SYBR Green Assays in human, mouse, rat C10orf76
      QuantiFast Probe-based Assays in human, mouse, rat C10orf76

    Additional mRNA sequence: 

    AK023176.1 AK057007.1 AK097972.1 AK126113.1 BC032118.2 BC054882.1 

    6 DOTS entries:

    DT.100021296  DT.97840443  DT.307260  DT.99998928  DT.121255202  DT.121255197 

    Selected AceView cDNA sequences (see all 114):

    AW839004 C01041 BI063656 AA866129 AU131451 BM464011 CA306941 BQ083281 
    BM855182 CD632134 CA307159 BQ447201 AA359293 BI063967 AI565077 AK097972 
    CD632131 AI424158 BM993023 BM694887 AW028345 BU595486 BP354202 BC054882 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf76    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e
    SP1:                                -     -           -     -                                             
    SP2:                                                                                                      
    SP3:                                                  -     -                                             
    SP4:                                                                                                      
    SP5:                                                  -     -     -                                       


    ECgene alternative splicing isoforms for C10orf76

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C10orf76 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGATGTA
    C10orf76 Expression
    About this image

    C10orf76 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C10orf76 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16004
        Custom PCR Arrays for C10orf76
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf76

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for C10orf76 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 9130011E15Rik1 , 5 RIKEN cDNA 9130011E15 gene1, 5 91.39(n)1
    98.55(a)1
      19 (38.75 cM)5
    716171  NM_198296.21  NP_938038.21 
     458181445 
    chicken
    (Gallus gallus)
    Aves C6H10ORF761 chromosome 6 open reading frame, human C10orf76 82.54(n)
    96.37(a)
      423850  XM_421719.4  XP_421719.2 
    lizard
    (Anolis carolinensis)
    Reptilia C10orf766
    chromosome 10 open reading frame 76
    95(a)
    1 ↔ 1
    GL343239.1(1548352-1706551)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.329182 Xenopus laevis transcribed sequence with moderate similarity more 80.81(n)    BJ062912.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc637332 hypothetical protein MGC63733 78.03(n)   393591  BC056810.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83791 CG8379 55.59(n)
    49.54(a)
      41060  NM_206463.3  NP_996185.1 


    ENSEMBL Gene Tree for C10orf76 (if available)
    TreeFam Gene Tree for C10orf76 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C10orf76 (see all 3304)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1885116511,2
    --97450465(+) TCCCCC/TGGGCC 1 -- us2k10--------
    rs1876242371,2
    --103605704(+) TATACC/TAGTGC 1 -- ut310--------
    rs10442581,2
    C,F,H--103605714(-) GGAGCA/GAACAG 1 -- ut3123Minor allele frequency- G:0.19NS EA NA CSA WA 2763
    rs1166132231,2
    C,F--103605796(+) CTGTTG/AGGAAA 1 -- ut311Minor allele frequency- A:0.06WA 118
    rs1920970571,2
    --103605814(+) GTGGTC/TCCATG 1 -- ut310--------
    rs413002291,2
    C,F--103605987(+) TCCCAG/AGCACT 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs2001405411,2
    C--103606121(+) GAGGAC/GGGGGG 1 -- ut310--------
    rs115963871,2
    C,F,H--103606122(+) AGGAGG/TGGGGG 1 -- ut31 trp38Minor allele frequency- T:0.02NS 1522
    rs1841926741,2
    --103606142(+) GTGGGA/GGAGCT 1 -- ut310--------
    rs1384913171,2
    --103606268(+) GTGACC/TCTATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for C10orf76 (103605356 - 103815950 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for C10orf76:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270180CNV Insertion20981092
    esv1400220CNV Insertion17803354
    esv273373CNV Insertion20981092
    nsv513016CNV Insertion21212237
    nsv895969CNV Loss21882294
    nsv895968CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C10orf76
    DNA2.0 Custom Variant and Variant Library Synthesis for C10orf76

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for C10orf76:    
    About MalaCards
    alzheimer's disease    malaria


    C10orf76 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Human Genome Epidemiology (HuGE) Navigator: C10orf76 (1 document)

    Export disorders for C10orf76 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C10orf76 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with C10orf76)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PubMed id 23870195)1 Wojczynski M.K....Reilly M.P. (BMC Med. Genet. 2013)
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79591 HGNC: 25788 AceView: C10orf76 Ensembl:ENSG00000120029 euGenes: HUgn79591
    ECgene: C10orf76 H-InvDB: C10orf76

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C10orf76 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C10orf76 gene:
    Search GeneIP for patents involving C10orf76

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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