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Aliases for C10orf76 Gene

Aliases for C10orf76 Gene

  • Chromosome 10 Open Reading Frame 76 2 3 5

External Ids for C10orf76 Gene

Previous GeneCards Identifiers for C10orf76 Gene

  • GC10M103270
  • GC10M103595
  • GC10M097236

Summaries for C10orf76 Gene

GeneCards Summary for C10orf76 Gene

C10orf76 (Chromosome 10 Open Reading Frame 76) is a Protein Coding gene. GO annotations related to this gene include binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf76 Gene

Genomics for C10orf76 Gene

Regulatory Elements for C10orf76 Gene

Enhancers for C10orf76 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F102024 0.5 Ensembl 12.2 +31.2 31232 0.8 ZFHX2 MAX NR2F6 MYC EGR2 C10orf76 HPS6 KCNIP2 PPRC1 ENSG00000222430
GH10F102009 1 Ensembl ENCODE 11.6 +46.3 46294 0.7 ELF3 TBL1XR1 WRNIP1 ARID4B ZSCAN9 ZNF2 RAD21 RFX5 SLC30A9 SCRT2 KCNIP2 C10orf76 HPS6 KCNIP2-AS1 MGEA5 FGF8 POLL DPCD ENSG00000222430
GH10F101966 0.5 Ensembl ENCODE 11.2 +87.1 87149 5.1 BCOR TBP PKNOX1 TBL1XR1 ZMYM3 CEBPG RELA ZNF664 ZNF324 ZNF335 HPS6 KCNIP2 C10orf76 NPM3 C10orf95 ENSG00000222430
GH10F102492 0.6 ENCODE 11.1 -436.7 -436740 0.9 ATF1 MLX ARNT ARID4B FEZF1 ZNF48 YY1 KLF7 ZNF548 ZNF263 PPRC1 PDCD11 C10orf76 GBF1 LDB1 SFXN2 ACTR1A ENSG00000273262
GH10F102916 0.2 ENCODE 11.1 -862.4 -862417 4.3 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 AS3MT PPRC1 PDCD11 C10orf76 GBF1 ENSG00000260461 LDB1 MARCKSL1P1 WBP1L CNNM2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C10orf76 on UCSC Golden Path with GeneCards custom track

Promoters for C10orf76 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000006525 532 1801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for C10orf76 Gene

Chromosome:
10
Start:
101,845,599 bp from pter
End:
102,056,232 bp from pter
Size:
210,634 bases
Orientation:
Minus strand

Genomic View for C10orf76 Gene

Genes around C10orf76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf76 Gene

Proteins for C10orf76 Gene

  • Protein details for C10orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2E6-CJ076_HUMAN
    Recommended name:
    UPF0668 protein C10orf76
    Protein Accession:
    Q5T2E6
    Secondary Accessions:
    • Q2TB87
    • Q9H8Z9

    Protein attributes for C10orf76 Gene

    Size:
    689 amino acids
    Molecular mass:
    78710 Da
    Quaternary structure:
    • Interacts with PI4KB.

    Alternative splice isoforms for C10orf76 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C10orf76 Gene

Post-translational modifications for C10orf76 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C10orf76 Gene

Domains & Families for C10orf76 Gene

Protein Domains for C10orf76 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C10orf76 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T2E6

UniProtKB/Swiss-Prot:

CJ076_HUMAN :
  • Belongs to the UPF0668 family.
Family:
  • Belongs to the UPF0668 family.
genes like me logo Genes that share domains with C10orf76: view

No data available for Gene Families for C10orf76 Gene

Function for C10orf76 Gene

Gene Ontology (GO) - Molecular Function for C10orf76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23572552
genes like me logo Genes that share ontologies with C10orf76: view
genes like me logo Genes that share phenotypes with C10orf76: view

Animal Models for C10orf76 Gene

MGI Knock Outs for C10orf76:

Animal Model Products

miRNA for C10orf76 Gene

miRTarBase miRNAs that target C10orf76

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C10orf76 Gene

Localization for C10orf76 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf76 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C10orf76 Gene COMPARTMENTS Subcellular localization image for C10orf76 gene
Compartment Confidence
plasma membrane 3
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C10orf76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C10orf76: view

Pathways & Interactions for C10orf76 Gene

SuperPathways for C10orf76 Gene

No Data Available

Interacting Proteins for C10orf76 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359050%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000359050 Q5T2E6-CJ076_HUMAN for C10orf76 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C10orf76 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf76 Gene

Transcripts for C10orf76 Gene

Unigene Clusters for C10orf76 Gene

Chromosome 10 open reading frame 76:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf76 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - -
SP2:
SP3: - -
SP4:
SP5: - - -

Relevant External Links for C10orf76 Gene

GeneLoc Exon Structure for
C10orf76
ECgene alternative splicing isoforms for
C10orf76

Expression for C10orf76 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C10orf76 Gene

Protein differential expression in normal tissues from HIPED for C10orf76 Gene

This gene is overexpressed in Cervix (16.5), Peripheral blood mononuclear cells (9.1), and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C10orf76 Gene



Protein tissue co-expression partners for C10orf76 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C10orf76 Gene:

C10orf76

SOURCE GeneReport for Unigene cluster for C10orf76 Gene:

Hs.16004
genes like me logo Genes that share expression patterns with C10orf76: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C10orf76 Gene

Orthologs for C10orf76 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C10orf76 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C10orf76 35
  • 100 (a)
OneToOne
C26H10orf76 34
  • 95.21 (n)
dog
(Canis familiaris)
Mammalia C10orf76 35
  • 100 (a)
OneToOne
C28H10orf76 34
  • 94.82 (n)
chimpanzee
(Pan troglodytes)
Mammalia C10orf76 35
  • 100 (a)
OneToOne
C10H10orf76 34
  • 99.9 (n)
oppossum
(Monodelphis domestica)
Mammalia C10orf76 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf76 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9130011E15Rik 34 16 35
  • 91.39 (n)
rat
(Rattus norvegicus)
Mammalia RGD1564887 34
  • 91.39 (n)
chicken
(Gallus gallus)
Aves C10orf76 35
  • 96 (a)
OneToOne
C6H10ORF76 34
  • 82.54 (n)
lizard
(Anolis carolinensis)
Reptilia C10orf76 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488528 34
  • 79.25 (n)
Str.10588 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.32918 34
zebrafish
(Danio rerio)
Actinopterygii C22H10orf76 (1 of 2) 35
  • 85 (a)
OneToMany
C22H10orf76 (2 of 2) 35
  • 82 (a)
OneToMany
zgc:63733 34
  • 74.94 (n)
zgc63733 34
fruit fly
(Drosophila melanogaster)
Insecta CG8379 34 35
  • 55.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012485 34
  • 50.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08708 34
  • 42.72 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC20F10.02c 34
  • 38.32 (n)
Species where no ortholog for C10orf76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf76 Gene

ENSEMBL:
Gene Tree for C10orf76 (if available)
TreeFam:
Gene Tree for C10orf76 (if available)

Paralogs for C10orf76 Gene

No data available for Paralogs for C10orf76 Gene

Variants for C10orf76 Gene

Sequence variations from dbSNP and Humsavar for C10orf76 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10128116 -- 101,957,856(+) CCAAG(A/G)TCTTT intron-variant
rs1044258 -- 101,845,957(-) GGAGC(A/G)AACAG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1044260 -- 101,845,840(-) CTCCC(C/T)GGGAA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs10509753 -- 101,907,129(+) GACGA(A/C)CTGAC intron-variant
rs10509754 -- 101,961,940(+) GTACC(A/G)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf76 Gene

Variant ID Type Subtype PubMed ID
esv1400220 CNV insertion 17803354
esv3309100 CNV mobile element insertion 20981092
esv3329487 CNV insertion 20981092
esv3338570 CNV insertion 20981092
esv3346415 CNV insertion 20981092
esv3414712 CNV insertion 20981092
esv3450028 CNV duplication 20981092
esv3624392 CNV loss 21293372
nsv472440 CNV novel sequence insertion 20440878
nsv479391 CNV novel sequence insertion 20440878
nsv513016 CNV insertion 21212237

Variation tolerance for C10orf76 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf76 Gene

Disorders for C10orf76 Gene

Relevant External Links for C10orf76

Human Genome Epidemiology (HuGE) Navigator
C10orf76
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C10orf76

No disorders were found for C10orf76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf76 Gene

Publications for C10orf76 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger A.L. … DeRisi J.L. (MBio 2013) 3 4 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  5. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski M.K. … Reilly M.P. (BMC Med. Genet. 2013) 3 64

Products for C10orf76 Gene

Sources for C10orf76 Gene

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