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C10orf71 Gene

protein-coding   GIFtS: 40
GCID: GC10P050507

Chromosome 10 Open Reading Frame 71

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 10 Open Reading Frame 711 2
Uncharacterized Protein C10orf712

External Ids:    HGNC: 269731   Entrez Gene: 1184612   Ensembl: ENSG000001773547   UniProtKB: Q711Q03   

Export aliases for C10orf71 gene to outside databases

Previous GC identifers: GC10P049851 GC10P050177 GC10P044771


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C10orf71 Gene:
C10orf71 (chromosome 10 open reading frame 71) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C10orf71 gene promoter:
         Max1   LHX3b/Lhx3b   ATF-2   POU6F1 (c2)   Arnt   E47   SEF-1 (1)   LHX3a/Lhx3a   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C10orf71

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C10orf71


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.23

C10orf71 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf71 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P050507:  view genomic region     (about GC identifiers)

Start:
50,507,187 bp from pter      End:
50,535,537 bp from pter
Size:
28,351 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CJ071_HUMAN, Q711Q0 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf71  
Size: 1435 amino acids; 156477 Da
Sequence caution: Sequence=CAC85340.1; Type=Frameshift; Positions=1282, 1418;
Secondary accessions: A0AVL8
Alternative splicing: 2 isoforms:  Q711Q0-1   Q711Q0-3   

Explore the universe of human proteins at neXtProt for C10orf71: NX_Q711Q0

Explore proteomics data for C10orf71 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C10orf71 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001128668.1  
    ENSEMBL proteins: 
     ENSP00000363259   ENSP00000318713  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027838 DUF4585

    Graphical View of Domain Structure for InterPro Entry Q711Q0

    ProtoNet protein and cluster: Q711Q0


    Find genes that share domains with C10orf71           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for C10orf71

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C10orf71
    Interactions:

        Search GeneGlobe Interaction Network for C10orf71

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C10orf71 (CJ071)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C10orf71 gene (2 alternative transcripts): 
    NM_199459.3  NM_001135196.1  

    Unigene Cluster for C10orf71:

    Chromosome 10 open reading frame 71
    Hs.585480  [show with all ESTs]
    Unigene Representative Sequence: NM_001135196
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374144(uc021pqa.1) ENST00000470615 ENST00000323868(uc021pqc.1)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidC10orf71 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat C10orf71

    Additional mRNA sequence: 

    AJ237663.1 AJ311357.1 AJ311358.1 AK056949.1 AL833265.1 BC126413.1 BC143808.1 BC143809.1 

    4 DOTS entries:

    DT.102821694  DT.87015659  DT.121216672  DT.92064808 

    18 AceView cDNA sequences:

    F35761 NM_199459 F21334 AL833265 AA192638 F18952 F31558 AK127811 
    AJ237663 AK056949 AJ311357 F30552 F01180 AA211775 F22065 F33176 
    F17031 AA213852 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    C10orf71 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C10orf71 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.585480
        Custom PCR Arrays for C10orf71
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C10orf71 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 3425401B19Rik1 , 5 RIKEN cDNA 3425401B19 gene1, 5 75.39(n)1
    67.4(a)1
      14 (19.40 cM)5
    1005045181  NM_001195097.11  NP_001182026.11 
     326591195 
    chicken
    (Gallus gallus)
    Aves C6H10ORF711 chromosome 6 open reading frame, human C10orf71 50.37(n)
    36.26(a)
      423784  XM_421655.4  XP_421655.3 
    lizard
    (Anolis carolinensis)
    Reptilia C10orf716
    chromosome 10 open reading frame 71
    30(a)
    1 ↔ 1
    GL343297.1(823290-827564)
    zebrafish
    (Danio rerio)
    Actinopterygii C10orf71 (1 of 2)6
    C10orf71 (2 of 2)6
    chromosome 10 open reading frame 71
    13(a)
    10(a)
    many → 1
    many → 1
    12(2645050-2650806) ENSDARG00000086945
    13(31148896-31159671) ENSDARG00000086970


    ENSEMBL Gene Tree for C10orf71 (if available)
    TreeFam Gene Tree for C10orf71 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C10orf71 (see all 686)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719725421,2
    C--44792244(+) CAAGC-/TATATATATATATATATAT
    ATATATATATATATATATATA
    TATAT
    1 -- int10--------
    rs1470958671,2
    --50509085(+) AGACCC/TTTACT 1 -- int10--------
    rs1845675221,2
    --50509127(+) CCTATC/TCCTCC 1 -- int10--------
    rs1885891451,2
    --50509149(+) GAAATC/TTCAAG 1 -- int10--------
    rs79047711,2
    C,F,A,H--50509169(+) CTGCTG/AGTGGC 1 -- int14Minor allele frequency- A:0.01NS EA 420
    rs79048861,2
    C,F,H--50509238(+) TTACTG/AGAGGG 1 -- int15Minor allele frequency- A:0.04NS EA WA 538
    rs124151541,2
    C,F,H--50509314(+) TCCATC/TGAGGC 1 -- int114Minor allele frequency- T:0.12EA NA NS WA 992
    rs618485731,2
    C,F--50509440(+) TCAGAC/TACCCC 1 -- int14Minor allele frequency- T:0.07NA EA 244
    rs741309281,2
    C,F--50509444(+) ACACCC/TCCTCA 1 -- int12Minor allele frequency- T:0.03WA 120
    rs1147206981,2
    C,F--50509706(+) GAACTC/AAGCTG 1 -- int11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for C10orf71 (50507187 - 50535537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for C10orf71:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736540CNV Deletion23290073
    esv2255118CNV Deletion18987734
    esv2736529CNV Deletion23290073
    nsv895365CNV Loss21882294
    nsv895375CNV Gain21882294
    nsv895369CNV Gain21882294
    nsv895376CNV Gain21882294
    nsv7203OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with C10orf71           About GenesLikeMe

    Genetic Association Database (GAD): C10orf71

    Export disorders for C10orf71 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C10orf71 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C10orf71)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (Circ Cardiovasc Genet 2013)
    4. Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)4 Fellay J....Goldstein D.B. (PLoS Genet. 2009)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 118461 HGNC: 26973 AceView: C10orf71 Ensembl:ENSG00000177354 euGenes: HUgn118461
    ECgene: C10orf71 H-InvDB: C10orf71

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C10orf71 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C10orf71 gene:
    Search GeneIP for patents involving C10orf71

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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