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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C10orf71 Gene

protein-coding   GIFtS: 35
GCID: GC10P050507

Chromosome 10 Open Reading Frame 71

  Search for C10orf71
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 10 Open Reading Frame 711 2
Uncharacterized Protein C10orf712

External Ids:    HGNC: 269731   Entrez Gene: 1184612   Ensembl: ENSG000001773547   UniProtKB: Q711Q03   

Export aliases for C10orf71 gene to outside databases

Previous GC identifers: GC10P049851 GC10P050177 GC10P044771


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C10orf71 Gene: 
C10orf71 (chromosome 10 open reading frame 71) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C10orf71 gene promoter:
         Max1   LHX3b/Lhx3b   ATF-2   POU6F1 (c2)   Arnt   E47   SEF-1 (1)   LHX3a/Lhx3a   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C10orf71

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf71


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.23

C10orf71 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf71 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P050507:  view genomic region     (about GC identifiers)

Start:
50,507,187 bp from pter      End:
50,535,537 bp from pter
Size:
28,351 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CJ071_HUMAN, Q711Q0 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf71  
Size: 1435 amino acids; 156477 Da
Sequence caution: Sequence=CAC85340.1; Type=Frameshift; Positions=1282, 1418;
Secondary accessions: A0AVL8
Alternative splicing: 2 isoforms:  Q711Q0-1   Q711Q0-3   

Explore the universe of human proteins at neXtProt for C10orf71: NX_Q711Q0

Explore proteomics data for C10orf71 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q711Q0

  • C10orf71 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C10orf71 Protein Expression
    REFSEQ proteins: NP_001128668.1  
    ENSEMBL proteins: 
     ENSP00000363259   ENSP00000318713  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q711Q0


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C10orf71

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C10orf71 (CJ071)

    Search CenterWatch for drugs/clinical trials and news about C10orf71 / CJ071

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C10orf71 gene (2 alternative transcripts): 
    NM_199459.3  NM_001135196.1  

    Unigene Cluster for C10orf71:

    Chromosome 10 open reading frame 71
    Hs.585480  [show with all ESTs]
    Unigene Representative Sequence: NM_001135196
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374144(uc021pqa.1) ENST00000470615 ENST00000323868(uc021pqc.1)

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    Additional mRNA sequence: 

    AJ237663.1 AJ311357.1 AJ311358.1 AK056949.1 AL833265.1 BC126413.1 BC143808.1 BC143809.1 

    4 DOTS entries:

    DT.102821694  DT.87015659  DT.121216672  DT.92064808 

    18 AceView cDNA sequences:

    F21334 NM_199459 F35761 AK127811 F18952 AA192638 AK056949 AL833265 
    F31558 AJ237663 AJ311357 F22065 F01180 F33176 AA211775 F30552 
    F17031 AA213852 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See C10orf71 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C10orf71

    SOURCE GeneReport for Unigene cluster: Hs.585480
        SABiosciences Custom PCR Arrays for C10orf71
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf71

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C10orf71 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 3425401B19Rik1 , 5 RIKEN cDNA 3425401B19 gene1, 5 75.39(n)1
    67.33(a)1
      14 (19.40 cM)5
    1005045181  NM_001195097.11  NP_001182026.11 
     326591195 
    chicken
    (Gallus gallus)
    Aves C6H10orf711 chromosome 6 open reading frame, human C10orf71 49.61(n)
    35.1(a)
      423784  XM_421655.3  XP_421655.3 
    lizard
    (Anolis carolinensis)
    Reptilia C10ORF716
    Uncharacterized protein
    28(a)
    1 ↔ 1
    GL343297.1(823290-827564)
    zebrafish
    (Danio rerio)
    Actinopterygii C13H10orf71 (1 of 2)6
    C12H10orf71 (2 of 2)6
    chromosome 10 open reading frame 71
    7(a)
    10(a)
    1 ↔ many
    1 ↔ many
    13(31148896-31159671)
    12(2645050-2650806)


    ENSEMBL Gene Tree for C10orf71 (if available)
    TreeFam Gene Tree for C10orf71 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/686 SNPs in C10orf71 are shown (see all 686)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719725421,2
    C--44792244(+) CAAGC-/TATATATATATATATATAT
    ATATATATATATATATATATA
    TATAT
    1 -- int10--------
    rs1470958671,2
    --50509085(+) AGACCC/TTTACT 1 -- int10--------
    rs1845675221,2
    --50509127(+) CCTATC/TCCTCC 1 -- int10--------
    rs1885891451,2
    --50509149(+) GAAATC/TTCAAG 1 -- int10--------
    rs79047711,2
    C,F,A,H--50509169(+) CTGCTG/AGTGGC 1 -- int14Minor allele frequency- A:0.01NS EA 420
    rs79048861,2
    C,F,H--50509238(+) TTACTG/AGAGGG 1 -- int15Minor allele frequency- A:0.04NS EA WA 538
    rs124151541,2
    C,F,H--50509314(+) TCCATC/TGAGGC 1 -- int114Minor allele frequency- T:0.12EA NA NS WA 992
    rs618485731,2
    C,F--50509440(+) TCAGAC/TACCCC 1 -- int14Minor allele frequency- T:0.07NA EA 244
    rs741309281,2
    C,F--50509444(+) ACACCC/TCCTCA 1 -- int12Minor allele frequency- T:0.03WA 120
    rs1147206981,2
    C,F--50509706(+) GAACTC/AAGCTG 1 -- int11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for C10orf71 (50507187 - 50535537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for C10orf71:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2736540CNV Deletion23290073
    esv2255118CNV Deletion18987734
    esv2736529CNV Deletion23290073
    nsv895365CNV Loss21882294
    nsv895375CNV Gain21882294
    nsv895369CNV Gain21882294
    nsv895376CNV Gain21882294
    nsv7203OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C10orf71 for disorders           About MalaCards

    C10orf71 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C10orf71

    Export disorders for C10orf71 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C10orf71 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C10orf71)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Genome-wide association study identifies novel loci as sociated with concentrations of four plasma phospholipid fatty acids in the de n ovo lipogenesis pathway: results from the Cohorts for Heart and Aging Research i n Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (2013)
    4. Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)4 Fellay J....Goldstein D.B. (2009)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 118461 HGNC: 26973 AceView: C10orf71 Ensembl:ENSG00000177354 euGenes: HUgn118461
    ECgene: C10orf71 H-InvDB: C10orf71

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C10orf71 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C10orf71 gene:
    Search GeneIP for patents involving C10orf71

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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