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C10orf68 Gene

protein-coding   GIFtS: 31

GC10P032896
chromosome 10 open reading frame 68
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for C10orf68

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ13031 1, 2
MGC149767 2
dJ1104A8.1 2
Descriptions
chromosome 10 open reading frame 68 2
External Ids
HGNC: 257791
Entrez Gene: 797412
UniProtKB: Q9H9433
Ensembl: ENSG000001500767
Search outside databases for aliases for C10orf68 gene

Previous GC identifers: GC10P032860 GC10P032740 GC10P032775

Summaries
for C10orf68

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for C10orf68

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf68 gene  

Entrez Gene cytogenetic band: 10p11.22   Ensembl cytogenetic band:  10p11.22   HGNC cytogenetic band: 10p11.23

C10orf68 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P032896:     (about GC identifiers)

Start:
 32,896,657 bp from pter
End:
 33,211,798 bp from pter
Size:
 315,142 bases
Orientation:
 plus strand

Proteins
for C10orf68

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: CJ068_HUMAN, Q9H943 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf68  
Size: 628 amino acids; 71506 Da
Secondary accessions: Q8N7T7
Alternative splicing: 2 isoforms:  Q9H943-1   Q9H943-2   

REFSEQ proteins: NP_078964.2  

ENSEMBL proteins: 
ENSP00000364170 ENSP00000364177 ENSP00000364165 ENSP00000364168 ENSP00000303710 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for C10orf68: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for C10orf68

Assays for C10orf68: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for C10orf68

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9H943

Gene Function
for C10orf68

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (C10orf68)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024688

              Applied Biosystems Silencer® siRNAs for C10orf68

              Sigma-Aldrich siRNA for C10orf68  
                     Sigma-Aldrich shRNA for C10orf68  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024688
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024688
                                 untagged cDNA clone in CMV expression vector: NM_024688 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_024688

Pathways & Interactions
for C10orf68

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for C10orf68

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf68

Transcripts
for C10orf68

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (C10orf68)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024688

              Sigma-Aldrich siRNA for C10orf68  
                     Sigma-Aldrich shRNA for C10orf68  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_024688  

REFSEQ mRNAs for C10orf68 gene: 

NM_024688.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_024688  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024688
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024688
                                 untagged cDNA clone in CMV expression vector: NM_024688 

24/48 AceView cDNA sequences (see all 48 ):

AK057324 AI018457 AI243111 AA421130 BC042672 BI825699 BC022020 BX952720 
BM554024 NM_145023 AA400069 NM_024688 BQ441383 AU130596 AW665864 AK097668 
AA861428 BX098451 AK023093 BI828912 AA973049 BI520023 AA401505 AA609088 

highest scoring ESTs for C10orf68:

AA401575 AA416799 AA416800 AK023093 AA400267 AA400069 AA401505 AI018457 AK097668 AU152515 


GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations:
ENST00000375030  ENST00000375037  ENST00000375025  ENST00000375028  ENST00000302316  

Expression
for C10orf68

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf68 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C10orf68

1 / 2 / 3

4 probe-sets matching C10orf68 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

49014_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA401575 0.60 0.62 0.61 1

220749_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024688 0.40 0.50 0.45 1

220749_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1553215_s_at2 U133Plus2 2 0.91 0.46 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

Orthologs
for C10orf68

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for C10orf68 gene from 2 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 LOC4660361   -- hypothetical LOC466036 98.41(n)
97.13(a)		 466036  XM_521438.2  XP_521438.2 
cow
(Bos taurus)		 LOC7868911   -- similar to C10orf68 protein 60.48(n)
34.03(a)		 786891  XM_001254446.1  XP_001254447.1 
About this table        Species with no ortholog for C10orf68

ENSEMBL Gene Tree for C10orf68

Paralogs
for C10orf68

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for C10orf68

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/1681 NCBI SNPs in C10orf68 are shown (see all 1681 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 388)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs25040111,2
A,C,F,H,O33177557(-) CGGACA/GTATCT 1 M/T mis111Minor allele frequency- G:0.19NA EU EA WA 978
rs22757471,2
A,C,F,H,O33211956(+) TTCATA/GTTAAA 1 -- ng315Minor allele frequency- G:0.22EA NA WA 1728
rs14185381,2
A,C,F,H33183402(+) ATACAA/GTTGGA 1 V/I mis19Minor allele frequency- G:0.04MN EU EA WA 1020
rs44486271,2
A,C,F,H33163830(+) TCATGC/GAGGTA 1 G/A mis18Minor allele frequency- G:0.02EU EA WA 838
rs17625261,2
A,C,F,H33014975(-) CTTTAC/TTTGTA 1 I/V mis1 ese311Minor allele frequency- T:0.13NA EU EA WA 978
rs122448321,2
C,F,H32912126(+) TACAAC/TAGTAT 1 -- ut51 ese34Minor allele frequency- T:0.13EU EA WA 420
rs110091231,2
A,F,H33212251(+) ATATTG/ATCTTA 1 -- ng314Minor allele frequency- A:0.11EU EA WA 374
rs122174141,2
F33205428(+) GACTCG/ATGTGG 1 -- ut31 ese33Minor allele frequency- A:0.19NA EA 272
rs70781241,2
H33055733(+) AAAAGA/GAAAAA 1 K/E mis1 trp34Minor allele frequency- G:0.00EU EA WA 410
rs14145481,2
A,C,F,H,O33058357(+) CAAACC/GAAGAA 1 T/T syn112Minor allele frequency- G:0.07MN NA EU EA WA 1160
About this table

HapMap Linkage Disequilibrium images for C10orf68 (up to first 250kb)

Disorders & Mutations
for C10orf68

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 Human Genome Epidemiology Navigator: C10orf68 (1 document)

Medical News
for C10orf68

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for C10orf68

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

3 PubMed articles for C10orf68 gene:

Search for C10orf68

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing C10orf68

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 79741 HGNC: 25779 AceView: C10orf68 Ensembl:ENSG00000150076 euGenes: HUgn79741
ECgene: C10orf68 H-InvDB: C10orf68

Other Databases showing C10orf68

(According to HUGE)
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   --

Specialized Databases showing C10orf68

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for C10orf68

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for C10orf68

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for C10orf68:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for C10orf68-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
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 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for C10orf68 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for C10orf68 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for C10orf68

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