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Aliases for C10orf67 Gene

Aliases for C10orf67 Gene

  • Chromosome 10 Open Reading Frame 67 2 3 5
  • Long Intergenic Non-Protein Coding RNA 1552 2 3
  • LINC01552 3 4
  • Uncharacterized Protein C10orf67, Mitochondrial 3
  • Chromosome 10 Open Reading Frame 115 2
  • Uncharacterized Protein C10orf67 3
  • BA215C7.4 3
  • C10orf115 3

External Ids for C10orf67 Gene

Previous HGNC Symbols for C10orf67 Gene

  • LINC01552
  • C10orf115

Previous GeneCards Identifiers for C10orf67 Gene

  • GC10M023609
  • GC10M023645
  • GC10M023556

Summaries for C10orf67 Gene

GeneCards Summary for C10orf67 Gene

C10orf67 (Chromosome 10 Open Reading Frame 67) is a Protein Coding gene.

Additional gene information for C10orf67 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf67 Gene

Genomics for C10orf67 Gene

Regulatory Elements for C10orf67 Gene

Enhancers for C10orf67 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H023412 1.4 FANTOM5 Ensembl ENCODE 15.8 -67.3 -67318 0 KLF1 JUN INSM2 ZEB1 RFX5 FOSL1 ZNF366 FOS KLF8 ZNF639 C10orf67 OTUD1 LOC105376453 ENSG00000227537 MIR1254-2
GH10H023511 1.6 FANTOM5 Ensembl ENCODE 10.3 -167.4 -167399 1 PKNOX1 ATF1 ZNF766 ATF7 FOS ZNF518A ZNF592 ATF4 SMARCA4 STAT3 OTUD1 C10orf67 LOC105376453 KIAA1217 GC10M023494 GC10P023457
GH10H023448 1.3 FANTOM5 Ensembl ENCODE 10.8 -104.0 -104030 1 JUN ZNF175 CEBPG ZNF316 ZNF366 ATF7 ETV6 MAFK CREM MAFG OTUD1 C10orf67 LOC105376453 GC10P023457 GC10P023441
GH10H023413 1.3 FANTOM5 Ensembl ENCODE 10.7 -68.7 -68690 0 PKNOX1 CBFB ZBED1 CEBPB JUNB BATF BCL11A IKZF1 ETV6 PRDM10 OTUD1 C10orf67 LOC105376453 MIR1254-2
GH10H023431 1.2 FANTOM5 Ensembl ENCODE 11.1 -87.5 -87515 1 KLF1 POLR2A STAT3 CEBPB OTUD1 C10orf67 LOC105376453 MIR1254-2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C10orf67 on UCSC Golden Path with GeneCards custom track

Promoters for C10orf67 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000025567 816 1200 ZSCAN4 INSM2 ZNF76 KLF17 BMI1 ZNF2 GLIS2 ZNF366 ZNF391 EGR2

Genomic Location for C10orf67 Gene

Chromosome:
10
Start:
23,201,916 bp from pter
End:
23,345,216 bp from pter
Size:
143,301 bases
Orientation:
Minus strand

Genomic View for C10orf67 Gene

Genes around C10orf67 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf67 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf67 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf67 Gene

Proteins for C10orf67 Gene

  • Protein details for C10orf67 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYJ2-CJ067_HUMAN
    Recommended name:
    Uncharacterized protein C10orf67, mitochondrial
    Protein Accession:
    Q8IYJ2
    Secondary Accessions:
    • A8MUP9
    • Q5QP74
    • Q5SWD4

    Protein attributes for C10orf67 Gene

    Size:
    551 amino acids
    Molecular mass:
    63656 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35732.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C10orf67 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C10orf67 Gene

Post-translational modifications for C10orf67 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C10orf67 Gene

Domains & Families for C10orf67 Gene

Gene Families for C10orf67 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C10orf67 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf67: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C10orf67 Gene

Function for C10orf67 Gene

Phenotypes From GWAS Catalog for C10orf67 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C10orf67
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C10orf67 Gene

Localization for C10orf67 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf67 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf67 gene
Compartment Confidence
mitochondrion 4
peroxisome 2
nucleus 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C10orf67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with C10orf67: view

Pathways & Interactions for C10orf67 Gene

SuperPathways for C10orf67 Gene

No Data Available

Interacting Proteins for C10orf67 Gene

Gene Ontology (GO) - Biological Process for C10orf67 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf67 Gene

Drugs & Compounds for C10orf67 Gene

No Compound Related Data Available

Transcripts for C10orf67 Gene

mRNA/cDNA for C10orf67 Gene

(13) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C10orf67 Gene

Chromosome 10 open reading frame 67:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C10orf67
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf67 Gene

No ASD Table

Relevant External Links for C10orf67 Gene

GeneLoc Exon Structure for
C10orf67
ECgene alternative splicing isoforms for
C10orf67

Expression for C10orf67 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C10orf67 Gene

mRNA differential expression in normal tissues according to GTEx for C10orf67 Gene

This gene is overexpressed in Testis (x12.7), Pituitary (x4.7), and Lung (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C10orf67 Gene



Protein tissue co-expression partners for C10orf67 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C10orf67 Gene:

C10orf67

SOURCE GeneReport for Unigene cluster for C10orf67 Gene:

Hs.522360

Evidence on tissue expression from TISSUES for C10orf67 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with C10orf67: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf67 Gene

Orthologs for C10orf67 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf67 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf67 33
  • 99.64 (n)
C10orf67 34
  • 40 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C10orf67 34
  • 35 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10orf67 34
  • 17 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C10orf67 34
  • 16 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4921504E06Rik 34
  • 14 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf67 34
  • 12 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10orf67 34
  • 11 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C10orf67 34
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C2H10orf67 34
  • 8 (a)
OneToOne
Species where no ortholog for C10orf67 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf67 Gene

ENSEMBL:
Gene Tree for C10orf67 (if available)
TreeFam:
Gene Tree for C10orf67 (if available)

Paralogs for C10orf67 Gene

No data available for Paralogs for C10orf67 Gene

Variants for C10orf67 Gene

Sequence variations from dbSNP and Humsavar for C10orf67 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000002483 -- 23,266,310(+) TTCTG(A/G)GCCCC nc-transcript-variant, reference, synonymous-codon
rs1000013786 -- 23,347,126(+) TATTT(A/G)TATAA intron-variant, upstream-variant-2KB
rs1000018063 -- 23,226,783(+) AACAC(A/T)AACTA intron-variant
rs1000020202 -- 23,293,837(+) CTTGG(A/G)AGCTT intron-variant
rs1000026871 -- 23,266,717(+) GGAGG(G/T)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf67 Gene

Variant ID Type Subtype PubMed ID
nsv1069463 CNV deletion 25765185
nsv1143495 CNV deletion 24896259
nsv550213 CNV loss 21841781
nsv550213 CNV loss 21841781
nsv6043 CNV insertion 18451855
nsv825301 CNV gain 20364138
nsv825302 CNV gain 20364138
nsv831810 CNV gain 17160897
nsv951256 CNV duplication 24416366

Variation tolerance for C10orf67 Gene

Gene Damage Index Score: 3.94; 59.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf67 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf67

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf67 Gene

Disorders for C10orf67 Gene

Relevant External Links for C10orf67

Genetic Association Database (GAD)
C10orf67
Human Genome Epidemiology (HuGE) Navigator
C10orf67
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C10orf67
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C10orf67

No disorders were found for C10orf67 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf67 Gene

Publications for C10orf67 Gene

  1. Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. (PMID: 27812135) Thiébaut R … Ollendorff V (PloS one 2016) 2 3 60
  2. Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2. (PMID: 18723019) Franke A … Schreiber S (Gastroenterology 2008) 3 45 60
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for C10orf67 Gene

Sources for C10orf67 Gene

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