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C10orf67 Gene

protein-coding   GIFtS: 38

GC10M023645
chromosome 10 open reading frame 67
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC46732 1, 2
RP11-792P23.2 2
Descriptions
chromosome 10 open reading frame 67 2
hypothetical protein LOC256815 2
External Ids
HGNC: 287161
Entrez Gene: 2568152
UniProtKB: Q8IYJ23
Ensembl: ENSG000001791337
Search outside databases for aliases for C10orf67 gene

Previous GC identifer: GC10M023609

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf67 gene  

Entrez Gene cytogenetic band: 10p12.2   Ensembl cytogenetic band:  10p12.2   HGNC cytogenetic band: 10p12.31

C10orf67 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M023645:     (about GC identifiers)

Start:
23,596,130 bp from pter
End:
23,673,780 bp from pter
Size:
77,651 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_008705.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ067_HUMAN, Q8IYJ2 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf67  
Size: 184 amino acids; 21463 Da
Secondary accessions: A8MUP9 Q5SWD4

REFSEQ proteins: NP_714925.2  

ENSEMBL proteins: 
ENSP00000382702 ENSP00000321464 ENSP00000365683 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for C10orf67: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for C10orf67

Assays for C10orf67: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8IYJ2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (C10orf67)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153714

              Applied Biosystems Silencer® siRNAs for C10orf67

              Sigma-Aldrich siRNA for C10orf67  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_153714
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_153714
                                 untagged cDNA clone in CMV expression vector: NM_153714 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_153714

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf67

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (C10orf67)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153714

              Sigma-Aldrich siRNA for C10orf67  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_153714  

REFSEQ mRNAs for C10orf67 gene: 

NM_153714.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_153714  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_153714
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_153714
                                 untagged cDNA clone in CMV expression vector: NM_153714 

Additional cDNA sequence: BC035732.1 

3 DOTS entries:

DT.97823306  DT.121220425  DT.70100540 

6 AceView cDNA sequences:

AI301009 NM_153714 BM805554 BC035732 CA944707 AW024692 

highest scoring ESTs for C10orf67:

BC035732 BM805554 AW024692 CA944707 NM_153714 AW242462 BE893425 AI301009 BG542843 BI757288 

Unigene Cluster for C10orf67:

Chromosome 10 open reading frame 67
Hs.522360  [show with all ESTs]
Unigene Representative Sequence: BC035732


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000399803  ENST00000323327  ENST00000376500  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf67 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C10orf67

1 / 2 / 3

4 probe-sets matching C10orf67 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
53978_at2, 3 U95-C 1 0.94 1.00 1.00 1.00 AW024692 0.60 1.00 0.82 1

1553843_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1553844_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1553845_x_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
GeneDecks  C10orf67 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AACAGCAGCA

SOURCE GeneReport for Unigene cluster: Hs.522360
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for C10orf67 gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC6082781   -- hypothetical protein LOC608278 79.55(n)
75.76(a)
608278  XM_845253.1  XP_850346.1 
chimpanzee
(Pan troglodytes)
LOC7413331   -- similar to Chromosome 10 open reading frame 67 99.46(n)
98.91(a)
741333  XM_001155518.1  XP_001155518.1 
cow
(Bos taurus)
LOC6158711   -- similar to Chromosome 10 open reading frame 67 81.29(n)
76.32(a)
615871  XM_867790.2  XP_872883.2 
mouse
(Mus musculus)
4921504E06Rik5 2 RIKEN cDNA 4921504E06 gene   -- BX649213 
About this table        Species with no ortholog for C10orf67

ENSEMBL Gene Tree for C10orf67
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/153 NCBI SNPs in C10orf67 are shown (see all 153 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 57)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs98880001,2
A,C,F,H23646397(+) gcaccG/Actcct 1 -- ut314Minor allele frequency- A:0.41EU EA WA 386
rs42973641,2
A,C,F,H23646176(+) aacagT/Cgcctg 1 -- ut317Minor allele frequency- C:0.49EU EA WA NA 536
rs46032061,2
A,C,F,H23647198(+) gctggT/Cagctg 1 -- ut31 ese37Minor allele frequency- C:0.41EU EA WA NA 556
rs47488601,2
C,F,H23645722(+) acagcA/Gaataa 1 -- ut31 ese37Minor allele frequency- G:0.47EU EA WA NA 556
rs40726881,2
C,F,H23647331(-) CTGACA/GAAAGC 1 -- ut31 ese311Minor allele frequency- G:0.03EU EA WA NA 980
rs43266951,2
C,F,H23645936(+) ggtggG/Agcttc 1 -- ut313Minor allele frequency- A:0.16EA WA 288
--
rs47488651,2
A,C23674110(+) TTTCTC/TCTCTC 1 -- ng31 trp30--------
--
rs92997811,2
A,C23674332(+) CGTTGC/TGCAGG 1 -- ng310--------
--
rs92997821,2
A,C23674340(+) AGGCTA/GGTCTA 1 -- ng310--------
--
rs108284331,2
A23675081(+) ATAGCA/GTATCA 1 -- ng310--------
About this table

HapMap Linkage Disequilibrium images for C10orf67 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Genome Epidemiology Navigator: C10orf67 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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4 PubMed articles for C10orf67 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 256815 HGNC: 28716 AceView: C10orf67 Ensembl:ENSG00000179133 euGenes: HUgn256815
ECgene: C10orf67 H-InvDB: C10orf67
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for C10orf67:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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