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C10orf67 Gene

protein-coding   GIFtS: 36
GCID: GC10M023556

Chromosome 10 Open Reading Frame 67

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 10 Open Reading Frame 671 2
Uncharacterized Protein C10orf672

External Ids:    HGNC: 287161   Entrez Gene: 2568152   Ensembl: ENSG000001791337   UniProtKB: Q8IYJ23   

Export aliases for C10orf67 gene to outside databases

Previous GC identifers: GC10M023609 GC10M023645 GC10M023265


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C10orf67 Gene:
C10orf67 (chromosome 10 open reading frame 67) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the C10orf67 gene promoter:
         TBP   AML1a   POU6F1 (c2)   E47   POU2F1   Nkx6-1   POU2F1a   Hand1   Cart-1   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C10orf67

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C10orf67


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.2   Ensembl cytogenetic band:  10p12.2   HGNC cytogenetic band: 10p12.31

C10orf67 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf67 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M023556:  view genomic region     (about GC identifiers)

Start:
23,556,124 bp from pter      End:
23,633,774 bp from pter
Size:
77,651 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CJ067_HUMAN, Q8IYJ2 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf67  
Size: 185 amino acids; 21594 Da
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Sequence caution: Sequence=AAH35732.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MUP9 Q5SWD4

Explore the universe of human proteins at neXtProt for C10orf67: NX_Q8IYJ2

Explore proteomics data for C10orf67 at MOPED


See C10orf67 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_714925.2  
ENSEMBL proteins: 
 ENSP00000365683   ENSP00000321464  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8IYJ2


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for C10orf67

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion3
nucleus2
peroxisome2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C10orf67
Interactions:

    Search GeneGlobe Interaction Network for C10orf67

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C10orf67 (CJ067)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C10orf67 gene: 
NM_153714.2  

Unigene Cluster for C10orf67:

Chromosome 10 open reading frame 67
Hs.522360  [show with all ESTs]
Unigene Representative Sequence: BC035732
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000376500 ENST00000323327(uc010qcx.2)
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Additional mRNA sequence: BC035732.1 

3 DOTS entries:

DT.97823306  DT.121220425  DT.70100540 

6 AceView cDNA sequences:

BC035732 BM805554 CA944707 NM_153714 AI301009 AW024692 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C10orf67 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AACAGCAGCA
C10orf67 Expression
About this image

C10orf67 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C10orf67 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.522360
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for C10orf67 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 4921504E06Rik5 RIKEN cDNA 4921504E06 gene   --   2 (13.40 cM) 19462837 
chicken
(Gallus gallus)
Aves C10orf676
chromosome 10 open reading frame 67
11(a)
1 ↔ 1
2(17250380-17288284)
lizard
(Anolis carolinensis)
Reptilia C10orf676
chromosome 10 open reading frame 67
33(a)
1 ↔ 1
6(15889314-15892564)
zebrafish
(Danio rerio)
Actinopterygii C2H10orf676
chromosome 10 open reading frame 67
8(a)
1 ↔ 1
2(29441590-29476797) ENSDARG00000076896


ENSEMBL Gene Tree for C10orf67 (if available)
TreeFam Gene Tree for C10orf67 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C10orf67 (see all 674)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1136101601,2
C,F--23605037(+) GGCTCA/GTACTA 1 -- ds50012Minor allele frequency- G:0.03CSA NA 121
rs1845641191,2
--23605178(+) GCTGAA/CAAAGG 1 -- ds50010--------
rs1120317881,2
C,F--23605245(+) GCTGGC/TATAGG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
rs1888822811,2
--23605335(+) GAGCTC/TCTAGG 1 -- ds50010--------
rs1932993091,2
--23605348(+) TGGGCA/GCCCCC 1 -- ds50010--------
rs1177213751,2
F--23605351(+) GCGCCC/TCCAAG 1 -- ds50011Minor allele frequency- T:0.03EA 120
rs1405819461,2
C--23605376(+) TCTCCA/GTCTTG 1 -- ds50010--------
rs1445337061,2
--23605401(+) GTGAGC/TGAGGG 1 -- ds50010--------
rs1174676211,2
F--23605447(+) AGTCCC/AACCAT 1 -- ds50011Minor allele frequency- A:0.02NA 120
rs1160700941,2
F--23605458(+) TTGGTG/AGGTCC 1 -- ds50011Minor allele frequency- A:0.04WA 118

HapMap Linkage Disequilibrium report for C10orf67 (23556124 - 23633774 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for C10orf67:    About this table    
Variant IDTypeSubtypePubMed ID
nsv6043CNV Insertion18451855

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with C10orf67           About GenesLikeMe

Genetic Association Database (GAD): C10orf67
Human Genome Epidemiology (HuGE) Navigator: C10orf67 (1 document)

Export disorders for C10orf67 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C10orf67 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C10orf67)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2. (PubMed id 18723019)1, 4 Franke A....Schreiber S. (Gastroenterology 2008)
  2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 256815 HGNC: 28716 AceView: C10orf67 Ensembl:ENSG00000179133 euGenes: HUgn256815
ECgene: C10orf67 H-InvDB: C10orf67

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C10orf67 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C10orf67 gene:
Search GeneIP for patents involving C10orf67

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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