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NPL2 Gene

protein-coding   GIFtS: 34

GC10P099335
N-acetylneuraminate pyruvate lyase 2 (putative)
(Previous name: chromosome 10 open reading frame 65 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C10orf65)
Services    

Aliases &
Descriptions
for NPL2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
C10orf65 2
DHDPS2 1, 2
FLJ37472 1, 2
OTTHUMP00000059366 2
Descriptions
DHDPS-like protein 2
Dihydrodipicolinate synthase-like, mitochondrial 2
N-acetylneuraminate pyruvate lyase 2 (putative) 2
chromosome 10 open reading frame 65 1
dihydrodipicolinate synthetase homolog 2 2
External Ids
HGNC: 251551
Entrez Gene: 1128172
UniProtKB: A8MT094
Search outside databases for aliases for NPL2 gene

Summaries
for NPL2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for NPL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   HGNC cytogenetic band: 10q24.1

NPL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P099335:     (about GC identifiers)

Start:
 99,334,108 bp from pter
End:
 99,362,549 bp from pter
Size:
 28,442 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  

Proteins
for NPL2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/TrEMBL: A8MT09 (See protein sequence)
Recommended Name: Putative uncharacterized protein NPL2  
Size: 83 amino acids; 8836 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should
be considered as preliminary data

REFSEQ proteins (2 alternative transcripts): 
NP_001128142.1  NP_612422.2  

Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005739 mitochondrion IEA--
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Antibodies for NPL2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for NPL2

Assays for NPL2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for NPL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro domains/families:
 IPR013785 Aldolase_TIM
 IPR002220 DHDPS


   GeneDecks  NPL2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry A8MT09

ProtoNet protein and cluster: A8MT09

Gene Function
for NPL2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (NPL2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001134670

              Applied Biosystems Silencer® siRNAs for NPL2

              Sigma-Aldrich siRNA for NPL2  
                     Sigma-Aldrich shRNA for NPL2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for NPL2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001134670
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001134670
                                 untagged cDNA clones in CMV expression vector (see all 4): BC011916 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_138413

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016829 lyase activity IEA--
About this table

Pathways & Interactions
for NPL2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008152 metabolic process IEA--
About this table

Drugs & Compounds
for NPL2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NPL2

Transcripts
for NPL2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (NPL2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001134670

              Sigma-Aldrich siRNA for NPL2  
                     Sigma-Aldrich shRNA for NPL2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001134670  NM_138413  

REFSEQ mRNAs for NPL2 gene (2 alternative transcripts): 

NM_001134670.1   NM_138413.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001134670  NM_138413  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001134670
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001134670
                                 untagged cDNA clones in CMV expression vector (see all 4): BC011916 

Additional cDNA sequence: 

AK289440.1 BC011916.2 BC045550.1 BC057821.1 

4 DOTS entries:

DT.95372143  DT.101980393  DT.99933316  DT.95151648 

24/36 AceView cDNA sequences (see all 36 ):

BC011916 BX097583 BX281317 BM006098 AK094791 BI764563 BP334104 BM005711 
BI252088 BG166577 BC057821 BI765630 NM_138413 BF569272 BI761505 BI549804 
R89840 BI547728 BI759683 BC045550 BI763832 BE384660 CA430030 AA757672 

Unigene Cluster for NPL2:

N-acetylneuraminate pyruvate lyase 2 (putative)
Hs.180346  [show with all ESTs]
Unigene Representative Sequence: NM_138413


GeneLoc Exon Structure

Expression
for NPL2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NPL2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for NPL2

1 / 2

3 probe-sets matching NPL2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
50566_at2 U95-B 2 1.00 0.50 1.00 1.00 -- -- -- -- --

239093_at2 U133-B 2 1.00 0.50 -- -- -- -- -- -- --

239093_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  NPL2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ATCTCGCCTC

SOURCE GeneReport for Unigene cluster: Hs.180346

Orthologs
for NPL2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for NPL2 gene from 5/12 species (see all 12 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LOC6087551   -- hypothetical protein LOC608755 90.95(n)
92.9(a)		 608755  XM_845865.1  XP_850958.1 
chimpanzee
(Pan troglodytes)		 LOC7428841   -- similar to Chromosome 10 open reading frame 65 99.59(n)
99.69(a)		 742884  XM_001164461.1  XP_001164461.1 
cow
(Bos taurus)		 C10orf651   -- dihydrodipicolinate synthase-like 89.78(n)
90.18(a)		 506001  NM_001075237.1  NP_001068705.1 
rat
(Rattus norvegicus)		 RGD13104751   -- similar to RIKEN cDNA 0610010D20 87.23(n)
88.47(a)		 293949  XM_215248.4  XP_215248.2 
mouse
(Mus musculus)		 Npl25
0610010D20Rik1		 195
 N-acetylneuraminate pyruvate lyase 2 (putative)5
RIKEN cDNA 0610010D20 gene1		 87.02(n)1
89.41(a)1		 674321  NM_026152.11  NP_080428.11 
 AK0024575  AK0108575  (see all 6)
About this table        Species with no ortholog for NPL2

Paralogs
for NPL2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for NPL2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/130 NCBI SNPs in NPL2 are shown (see all 130 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 68)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs111892951,2
A,C,F,H99362117(+) CTGGAG/AGCCAG 2 -- ut314Minor allele frequency- A:0.39EU EA WA 396
rs9330571,2
A,C,F,H99361719(-) TTCCTG/TTCTGA 2 -- ut3116Minor allele frequency- N:0.00EU EA WA NA 1476
--
rs19776401,2
A,C,F99362043(-) CCGGCT/CGGGTG 2 -- ut313Minor allele frequency- C:0.10NA 128
--
rs18122861,2
A99361851(-) GAGAAC/TCGCTT 2 -- ut310--------
--
rs19776411,2
A99361966(-) AGTTCA/GAGACC 2 -- ut310--------
--
rs20180171,2
A99361904(-) CTGGGC/TGTGGT 2 -- ut310--------
rs122617521,2
C,F99361334(+) CGCGCC/ACCCTT 2 A/A syn11Minor allele frequency- A:0.24NA 78
rs10109311,2
A,C,F,H99350782(+) aagcaC/Ttcacc 1 -- int18Minor allele frequency- T:0.22EU EA WA 838
rs70787591,2
A,C,F,H99336758(+) TCCTCG/ATTTTA 1 -- int18Minor allele frequency- A:0.45EU EA WA 830
rs11059991,2
A,C,F,H99350523(+) TTGAGG/TGACTT 1 -- int112Minor allele frequency- T:0.44EU EA WA NA 1046
About this table

HapMap Linkage Disequilibrium images for NPL2 (up to first 250kb)

Disorders & Mutations
for NPL2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for NPL2

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for NPL2

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for NPL2 gene:

Search for NPL2

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing NPL2

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 112817 HGNC: 25155 AceView: C10orf65 euGenes: HUgn112817 ECgene: NPL2
H-InvDB: NPL2

Other Databases showing NPL2

(According to HUGE)
About This Section

   --

Specialized Databases showing NPL2

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for NPL2

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for NPL2

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for NPL2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NPL2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for NPL2 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for NPL2 Browse small molecules at Sigma-Aldrich
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