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ENKUR Gene

protein-coding GIFtS: 35

GC10M025311

enkurin, TRPC channel interacting protein
(Previous name: chromosome 10 open reading frame 63 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C10orf63)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C10orf63 ^², ³
DKFZp781F21103 ^²
MGC26778 ^¹, ²
OTTHUMP00000019326 ^²
enkurin ^¹, ²

Descriptions
chromosome 10 open reading frame 63 ^¹
enkurin, TRPC channel interacting protein ^²

External Ids
HGNC: 28388¹
Entrez Gene: 219670²
UniProtKB: Q8TC29³
Ensembl: ENSG00000151023⁷

Search outside databases for aliases for ENKUR gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ENKUR:

Enkurin interacts with transient receptor potential canonical (TRPC) cation channels (see TRPC1;

MIM 602343) and functions as an adaptor protein, tethering signal transduction proteins to TRPC

channels (Sutton et al., 2004 [PubMed 15385169]).[supplied by OMIM]

UniProtKB/Swiss-Prot: ENKUR_HUMAN, Q8TC29

Function: Adapter that functions to localize a calcium-sensitive signal transduction machinery in

sperm to a calcium-permeable ion channel (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1 Ensembl cytogenetic band: 10p12.1 HGNC cytogenetic band: 10p12.31

ENKUR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M025311: (about GC identifiers)

Start:	25,310,923 bp from pter
End:	25,345,091 bp from pter
Size:	34,169 bases
Orientation:	minus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ENKUR_HUMAN, Q8TC29 (See protein sequence)

Recommended Name: Enkurin

Size: 256 amino acids; 29454 Da

Subunit: Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3 (By

similarity)

Subcellular location: Cell projection, cilium, flagellum. Note=Sperm acrosomal crescent and

flagellar principal piece

REFSEQ proteins: NP_659447.1

ENSEMBL proteins:

ENSP00000365545 ENSP00000365541 ENSP00000331044

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (C10orf63)
	Human Recombinant Proteins from Abnova (C10orf63)

OriGene Purified Recombinant Human Protein: ENKUR

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005929	cilium	IEA	--
GO:0019861	flagellum	IEA	--

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Antibodies for ENKUR:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (C10orf63), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (C10orf63)
	Novus Biologicals Antibody for C10orf63

Assays for ENKUR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8TC29

UniProtKB/Swiss-Prot: ENKUR_HUMAN, Q8TC29

Domain: Residues 160-255 contains the TRPC2 binding site (By similarity)

Domain: The IQ motif is involved in calmodulin binding (By similarity)

Similarity: Contains 1 IQ domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ENKUR)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145010

Applied Biosystems Silencer® siRNAs for ENKUR

Sigma-Aldrich siRNA for ENKUR

Sigma-Aldrich shRNA for ENKUR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ENKUR
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_145010
Myc/DDK tagged cDNA clone in CMV expression vector: NM_145010
untagged cDNA clone in CMV expression vector: NM_145010

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_145010

UniProtKB/Swiss-Prot: ENKUR_HUMAN, Q8TC29

Function: Adapter that functions to localize a calcium-sensitive signal transduction machinery in

sperm to a calcium-permeable ion channel (By similarity)

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005516	calmodulin binding	IEA	--
GO:0017124	SH3 domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ENKUR

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ENKUR)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145010

Sigma-Aldrich siRNA for ENKUR

Sigma-Aldrich shRNA for ENKUR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_145010

REFSEQ mRNAs for ENKUR gene:

NM_145010.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_145010

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145010
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145010
                                 untagged cDNA clone in CMV expression vector: NM_145010

24/31 AceView cDNA sequences (see all 31 ):

BX096158 BC064597 NM_145010 AK095021 AI139823 BQ185147 AK124767 BQ067464

BU683627 CA312597 CD688045 AI797509 AW514416 BC026165 BQ187957 AW150986

BG772575 AI986131 BM979174 BM976420 AW119023 AI972161 BU685488 AY454125

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ENKUR

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7
SP1:																	-		-
SP2:
SP3:							-		-				-

About this scheme

ECgene alternative splicing isoforms for ENKUR

3 Ensembl transcripts including schematic representations:

ENST00000376366 ENST00000376363 ENST00000331161

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ENKUR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ENKUR

/ ²

2 probe-sets matching ENKUR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
237314_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
237314_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ENKUR gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC487104¹	--	similar to enkurin	89.9(n) 88.19(a)	487104 XM_544232.1 XP_544232.1
chimpanzee (Pan troglodytes)	LOC466270¹	--	enkurin	99.34(n) 98.82(a)	466270 XM_521670.2 XP_521670.2
cow (Bos taurus)	LOC516469¹	--	similar to enkurin	90.68(n) 89.37(a)	516469 XM_594624.3 XP_594624.3
rat (Rattus norvegicus)	RGD1309839¹	--	similar to hypothetical protein MGC26778	82.68(n) 85.43(a)	291354 XM_225627.4 XP_225627.3
mouse (Mus musculus)	Enkur⁵ 4933434I06Rik¹	2⁵	enkurin, TRPC channel interacting protein⁵ RIKEN cDNA 4933434I06 gene¹	83.73(n)¹ 87.8(a)¹	71233¹ NM_027728.2¹ NP_082004.1¹ AI615414⁵ AK017056⁵ (see all 13)

About this table Species with no ortholog for ENKUR

ENSEMBL Gene Tree for ENKUR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/130 NCBI SNPs in ENKUR are shown (see all 130 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs902903^1,2	A,C,F,H,O	25310447(+)	`GTCCTC/GTCCTG`	1	--	ng5¹		14		NA NS EU EA WA	1030
	rs2307047^1,2	A,C,F,H	25311276(+)	`CCTCAG/ATACTA`	1	--	ut3¹ ese³		8		EA EU NA	2150
	rs33980615^1,2	C	25313750(+)	`CAGCCC/TCTGCT`	1	R/G	mis¹		0	--	--	--	--
	rs1492608^1,2	A,C,F,H,O	25331829(+)	`GTCTCG/ATGATT`	1	--	int¹		13		NA EU EA WA	1140
	rs7073171^1,2	A,C,F,H	25321606(+)	`gggcaC/Tgtggc`	1	--	int¹		4		EU EA WA	412
	rs4345864^1,2	A,C,F,H	25329079(+)	`AGATAT/GCTAAT`	1	--	int¹		4		EU EA WA	418
	rs2279547^1,2	A,C,F,H	25313994(+)	`GCCACA/GGTAAC`	1	--	int¹		9		EA EU WA NA	1820
--	rs10764515^1,2	A,C,F,H	25317923(+)	`CTATCG/ATCACA`	1	--	int¹		3		EU EA	300
	rs11014341^1,2	A,C,F,H	25331256(+)	`CCACAG/ATCCTC`	1	--	int¹		8		EU EA WA	840
	rs7099168^1,2	C,F,H	25331728(+)	`ATAGTC/ACAAAC`	1	--	int¹		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for ENKUR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611025

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for ENKUR gene:

Enkurin is a novel calmodulin and TRPC channel binding protein in sperm. (PubMed id 15385169)^{2, 3, 4} Sutton K.A....Florman H.M. (2004)
Canonical transient receptor potential 5. (PubMed id 17217053)^{1, 2, 3} Beech D.J. (2007)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 219670	HGNC: 28388	AceView: C10orf63	Ensembl:ENSG00000151023	euGenes: HUgn219670
ECgene: ENKUR	H-InvDB: ENKUR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ENKUR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ENKUR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ENKUR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ENKUR		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ENKUR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (C10orf63)
	Antibodies (C10orf63)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (C10orf63)
	Antibodies (C10orf63)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ENKUR

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for C10orf63

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ENKUR Gene

protein-coding GIFtS: 35

Aliases &
Descriptions
for ENKUR

Summaries
for ENKUR

Genomic Location
for ENKUR

Proteins
for ENKUR

Protein Domains/
Families
for ENKUR

Gene Function
for ENKUR

Pathways & Interactions
for ENKUR

Drugs & Compounds
for ENKUR

Transcripts
for ENKUR

Expression
for ENKUR

Orthologs
for ENKUR

Paralogs
for ENKUR

SNPs/Variants
for ENKUR

Disorders & Mutations
for ENKUR

Medical News
for ENKUR

Publications
for ENKUR

Search for ENKUR

Genome Databases showing ENKUR

Other Databases showing ENKUR

Specialized Databases showing ENKUR

Licensable Technologies
for ENKUR

Services
for ENKUR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ENKUR Gene

protein-coding GIFtS: 35

Aliases & Descriptionsfor ENKUR

Summariesfor ENKUR

Genomic Locationfor ENKUR

Proteinsfor ENKUR

Protein Domains/Familiesfor ENKUR

Gene Functionfor ENKUR

Pathways & Interactionsfor ENKUR

Drugs & Compoundsfor ENKUR

Transcriptsfor ENKUR

Expression for ENKUR

Orthologsfor ENKUR

Paralogsfor ENKUR

SNPs/Variantsfor ENKUR

Disorders & Mutationsfor ENKUR

Medical Newsfor ENKUR

Publicationsfor ENKUR

Search for ENKUR

Genome Databases showing ENKUR

Other Databases showing ENKUR

Specialized Databases showing ENKUR

Licensable Technologiesfor ENKUR

Servicesfor ENKUR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ENKUR

Summaries
for ENKUR

Genomic Location
for ENKUR

Proteins
for ENKUR

Protein Domains/
Families
for ENKUR

Gene Function
for ENKUR

Pathways & Interactions
for ENKUR

Drugs & Compounds
for ENKUR

Transcripts
for ENKUR

Expression
for ENKUR

Orthologs
for ENKUR

Paralogs
for ENKUR

SNPs/Variants
for ENKUR

Disorders & Mutations
for ENKUR

Medical News
for ENKUR

Publications
for ENKUR

Licensable Technologies
for ENKUR

Services
for ENKUR