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C10orf62 Gene

protein-coding   GIFtS: 37

GC10P099339
chromosome 10 open reading frame 62
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MERIT40 5
NBA1 5
OTTHUMP00000020214 2
bA548K23.1 1, 2
Descriptions
chromosome 10 open reading frame 62 2
hypothetical protein LOC414157 2
External Ids
HGNC: 232941
Entrez Gene: 4141572
UniProtKB: Q5T6813
Ensembl: ENSG000002039427
Search outside databases for aliases for C10orf62 gene

Previous GC identifer: GC10U900455

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf62 gene  

Entrez Gene cytogenetic band: 10q24.2   Ensembl cytogenetic band:  10q24.1   HGNC chromosome: 10

C10orf62 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P099339:     (about GC identifiers)

Start:
99,339,474 bp from pter
End:
99,340,681 bp from pter
Size:
1,208 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ062_HUMAN, Q5T681 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf62  
Size: 223 amino acids; 25128 Da
Secondary accessions: Q49A70 Q8N3Y6

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001009997.1  

    ENSEMBL proteins: 
    ENSP00000359674 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for C10orf62: 
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    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for C10orf62

    Assays for C10orf62: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5T681

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (C10orf62)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC037252

                  Applied Biosystems Silencer® siRNAs for C10orf62

                  Sigma-Aldrich siRNA for C10orf62  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for C10orf62
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001009997
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001009997
                                     untagged cDNA clones in CMV expression vector (see all 2): BC037252 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001009997

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for C10orf62

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (C10orf62)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC037252

                  Sigma-Aldrich siRNA for C10orf62  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001009997  

    REFSEQ mRNAs for C10orf62 gene: 

    NM_001009997.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001009997  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001009997
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001009997
                                     untagged cDNA clones in CMV expression vector (see all 2): BC037252 

    Additional cDNA sequence: 

    BC037252.1 BC043281.1 

    1 DOTS entry:

    DT.109482 

    highest scoring ESTs for C10orf62:

    AA758803 AA398195 AA399278 AA729781 AA889586 AA889597 AA922590 AW117336 BC037252 BC043281 

    Unigene Cluster for C10orf62:

    Chromosome 10 open reading frame 62
    Hs.662302  [show with all ESTs]
    Unigene Representative Sequence: BC043281


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000370640  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    C10orf62 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for C10orf62

    1 / 2 / 3

    3 probe-sets matching C10orf62 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    59774_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA758803 0.40 0.67 0.55 1

    240235_at2, 3 U133-B 1 0.91 1.00 -- -- AA889586 0.20 0.50 0.38 1

    240235_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    GeneDecks  C10orf62 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGTGGGGTCT

    SOURCE GeneReport for Unigene cluster: Hs.662302
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for C10orf62 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4868231   -- hypothetical LOC486823 78.84(n)
    68.95(a)
    486823  XM_543952.2  XP_543952.2 
    chimpanzee
    (Pan troglodytes)
    LOC7429181   -- similar to chromosome 10 open reading frame 62 98.95(n)
    97.76(a)
    742918  XM_001164501.1  XP_001164501.1 
    rat
    (Rattus norvegicus)
    MGC938611   -- hypothetical protein LOC685807 70.99(n)
    57.21(a)
    685807  XM_001064999.1  XP_001064999.1 
    mouse
    (Mus musculus)
    4933411K16Rik1, 5 195
    RIKEN cDNA 4933411K16 gene1, 5 70.63(n)1
    57.14(a)1
    667651  XM_894441.21  XP_899534.11 
     AI5965665  AK0063745  (see all 7)
    About this table        Species with no ortholog for C10orf62

    ENSEMBL Gene Tree for C10orf62
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

      --
    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 612766

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    7 PubMed articles for C10orf62 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 414157 HGNC: 23294 Ensembl:ENSG00000203942 euGenes: HUgn414157 ECgene: C10orf62
    H-InvDB: C10orf62
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for C10orf62:
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     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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