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FAM178A Gene

protein-coding GIFtS: 41

GC10P102663

family with sequence similarity 178, member A
(Previous name: chromosome 10 open reading frame 6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C10orf6)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C10orf6 ^², ³, ⁵
FLJ10512 ^¹
FLJ25012 ^¹
MGC90157 ^²
OTTHUMP00000020300 ^²

Descriptions
chromosome 10 open reading frame 6 ^¹
family with sequence similarity 178, member A ^²
hypothetical protein LOC55719 ^²

External Ids
HGNC: 17814¹
Entrez Gene: 55719²
UniProtKB: Q8IX21³
Ensembl: ENSG00000119906⁷

Search outside databases for aliases for FAM178A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.31 Ensembl cytogenetic band: 10q24.31 HGNC cytogenetic band: 10q24.31

FAM178A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P102663: (about GC identifiers)

Start:	102,662,316 bp from pter
End:	102,714,881 bp from pter
Size:	52,566 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: F178A_HUMAN, Q8IX21 (See protein sequence)

Recommended Name: Protein FAM178A

Size: 1173 amino acids; 131873 Da

Miscellaneous: Localized in the locus associated with inherited infantile onset spinocerebellar

ataxia (IOSCA). No mutation were found associated with IOSCA compared to control subjects. The

expression level in the brain was not different between the 2 populations

Secondary accessions: A8K950 Q5W0L8 Q9NPE8

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001129595.1 NP_060591.3

ENSEMBL proteins:

ENSP00000359292 ENSP00000359294 ENSP00000238961

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for FAM178A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FAM178A

Assays for FAM178A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8IX21

UniProtKB/Swiss-Prot: F178A_HUMAN, Q8IX21

Similarity: Belongs to the FAM178 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM178A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_144592

Applied Biosystems Silencer® siRNAs for FAM178A

Sigma-Aldrich siRNA for FAM178A

Sigma-Aldrich shRNA for FAM178A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001136123
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001136123
untagged cDNA clones in CMV expression vector (see all 3): BC015131

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001136123

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for FAM178A (Q8IX21²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
-- Q9WMX2² MINT-7048256
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM178A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM178A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_144592

Sigma-Aldrich siRNA for FAM178A

Sigma-Aldrich shRNA for FAM178A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001136123 NM_018121

REFSEQ mRNAs for FAM178A gene (2 alternative transcripts):

NM_001136123.1 NM_018121.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001136123 NM_018121

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001136123
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001136123
                                 untagged cDNA clones in CMV expression vector (see all 3): BC015131

Additional cDNA sequence:

AF460991.1 AF460992.1 AK001374.1 AK024283.1 AK292565.1 AL832343.1 AL832383.1 AL833126.1

BC015131.1 BC020915.1 BC030565.1 BC047715.1 BC064526.1 BC073832.1 CR612065.1 CR614509.1

13 DOTS entries:

DT.447779 DT.100024753 DT.403630 DT.428704 DT.121266513 DT.121266531 DT.91816894 DT.92067167

DT.95176762 DT.100669050 DT.121266456 DT.121266517 DT.100644001

24/203 AceView cDNA sequences (see all 203 ):

AF460992 BM478882 AI187130 W87812 AU127141 BU633328 AI951781 AA737563

BM463515 AA721345 AA327526 BC047715 CB045246 BQ050508 BC015131 AA757128

BM699473 AK057741 CF528436 CF528701 CK826320 AI523516 AA379912 AI681455

Unigene Cluster for FAM178A:

Family with sequence similarity 178, member A

Hs.447458 [show with all ESTs]

Unigene Representative Sequence: NM_018121

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAM178A (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20a	·	20b	^
SP1:																													-		-		-																-
SP2:																													-		-		-																-
SP3:																																	-
SP4:							-		-
SP5:

ExUns:	21a	·	21b	·	21c	^	22a	·	22b	·	22c
SP1:	-				-
SP2:	-
SP3:
SP4:
SP5:	-				-

About this scheme

ECgene alternative splicing isoforms for FAM178A

3 Ensembl transcripts including schematic representations:

ENST00000370269 ENST00000370271 ENST00000238961

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FAM178A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FAM178A

¹ / ²

11 probe-sets matching FAM178A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33192_g_at²	U95-A	1	1.00	1.00	0.93	1.16	--	--	--	--	--
33191_at²	U95-A	1	1.00	1.00	0.95	0.82	--	--	--	--	--
54377_at²	U95-B	1	1.00	1.00	0.72	1.09	--	--	--	--	--
62945_at²	U95-C	1	0.94	1.00	0.83	0.93	--	--	--	--	--
203481_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
235590_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
203482_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
203481_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235590_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553909_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203482_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACAGTGTCG

SOURCE GeneReport for Unigene cluster: Hs.447458
UniProtKB/Swiss-Prot: F178A_HUMAN, Q8IX21
Tissue specificity: Widely expressed. Expressed at higher level in skeletal muscle and at slightly
lower level in brain, liver and heart, than in lung, kidney, spleen and thymus

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM178A gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC612816¹	--	hypothetical LOC612816	92.18(n) 90.75(a)	612816 XM_845474.1 XP_850567.1
chimpanzee (Pan troglodytes)	LOC450860¹	--	similar to chromosome 10 open reading frame 6	99.6(n) 99.06(a)	450860 XM_001168969.1 XP_001168969.1
cow (Bos taurus)	C26H10ORF6¹	--	chromosome 10 open reading frame 6 ortholog	90.73(n) 88.76(a)	541239 XM_615238.3 XP_615238.3
rat (Rattus norvegicus)	Fam178a¹	--	family with sequence similarity 178, member A	88(n) 86.05(a)	499360 XM_574673.2 XP_574673.2
mouse (Mus musculus)	Fam178a^{1, 5}	19⁵	family with sequence similarity 178, member A^{1, 5}	88(n)¹ 85.7(a)¹	226151¹ NM_001081225.1¹ NP_001074694.1¹ AA117346⁵ AI448845⁵ (see all 27)

About this table Species with no ortholog for FAM178A

ENSEMBL Gene Tree for FAM178A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/239 NCBI SNPs in FAM178A are shown (see all 239 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 62)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs927302^1,2	A,F,H,O	102712906(-)	`CCCCCC/GACAAC`	1	--	ut3¹ trp³		8		EA NA MN EU WA	658
	rs10883563^1,2	A,C,F,H	102674370(+)	`AATTTC/ATGGGG`	2	Y/S	mis¹ ese³		9		EU EA WA NA	866
	rs11190772^1,2	C,F,H	102711713(+)	`CCTTTC/TATAGA`	1	--	ut3¹ ese³		4		EU EA WA	418
	rs1324218^1,2	H	102661955(+)	`TTGCAG/AGCAGC`	1	--	ng5¹ tfbs³		7		NA EA EU WA	669
	rs7901307^1,2	A	102662507(+)	`GAGGCG/TCGCGC`	2	--	ut5¹		0	--	--	--	--
	rs12780429^1,2	C,F,H	102697516(+)	`CTGAGA/GCAGTG`	2	R/R	syn¹		5		EU EA WA NA	496
	rs11190754^1,2	C,F	102673741(+)	`AATAAA/GTTCCC`	2	K/K	syn¹ ese³		1		NA	28
	rs1056295^1,2	A,C,F,H,O	102705173(+)	`TATAAT/CACATT`	1	--	int¹		8		MN EU EA WA NA	744
--	rs7078599^1,2	A,C,F,H	102671852(+)	`ttgatA/Tcaagg`	1	--	int¹		8		EU EA WA	838
	rs2273654^1,2	A,C,F,H	102679207(-)	`AAAATA/GCATTA`	1	--	int¹		8		EU EA WA NA	780

About this table

HapMap Linkage Disequilibrium images for FAM178A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610348

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for FAM178A gene:

cDNA cloning, expression profile and genomic structure of a novel human transcript on chromosome 10q24, and its analyses as a candidate gene for infantile onset spinocerebellar ataxia. (PubMed id 12459258)^{1, 2, 3, 4} Nikali K.... Peltonen L. (2002)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)⁴ Matsuoka S.... Elledge S.J. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55719	HGNC: 17814	AceView: C10orf6	Ensembl:ENSG00000119906	euGenes: HUgn55719
ECgene: FAM178A	H-InvDB: FAM178A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FAM178A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FAM178A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FAM178A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FAM178A		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FAM178A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Tocris compounds for FAM178A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for FAM178A

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FAM178A Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for FAM178A

Summaries
for FAM178A

Genomic Location
for FAM178A

Proteins
for FAM178A

Protein Domains/
Families
for FAM178A

Gene Function
for FAM178A

Pathways & Interactions
for FAM178A

Drugs & Compounds
for FAM178A

Transcripts
for FAM178A

Expression
for FAM178A

Orthologs
for FAM178A

Paralogs
for FAM178A

SNPs/Variants
for FAM178A

Disorders & Mutations
for FAM178A

Medical News
for FAM178A

Publications
for FAM178A

Search for FAM178A

Genome Databases showing FAM178A

Other Databases showing FAM178A

Specialized Databases showing FAM178A

Licensable Technologies
for FAM178A

Services
for FAM178A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FAM178A Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor FAM178A

Summariesfor FAM178A

Genomic Locationfor FAM178A

Proteinsfor FAM178A

Protein Domains/Familiesfor FAM178A

Gene Functionfor FAM178A

Pathways & Interactionsfor FAM178A

Drugs & Compoundsfor FAM178A

Transcriptsfor FAM178A

Expression for FAM178A

Orthologsfor FAM178A

Paralogsfor FAM178A

SNPs/Variantsfor FAM178A

Disorders & Mutationsfor FAM178A

Medical Newsfor FAM178A

Publicationsfor FAM178A

Search for FAM178A

Genome Databases showing FAM178A

Other Databases showing FAM178A

Specialized Databases showing FAM178A

Licensable Technologiesfor FAM178A

Servicesfor FAM178A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FAM178A

Summaries
for FAM178A

Genomic Location
for FAM178A

Proteins
for FAM178A

Protein Domains/
Families
for FAM178A

Gene Function
for FAM178A

Pathways & Interactions
for FAM178A

Drugs & Compounds
for FAM178A

Transcripts
for FAM178A

Expression
for FAM178A

Orthologs
for FAM178A

Paralogs
for FAM178A

SNPs/Variants
for FAM178A

Disorders & Mutations
for FAM178A

Medical News
for FAM178A

Publications
for FAM178A

Licensable Technologies
for FAM178A

Services
for FAM178A