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RNLS Gene

protein-coding   GIFtS: 49

GC10M090024
renalase, FAD-dependent amine oxidase
(Previous name: chromosome 10 open reading frame 59 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C10orf59)
Services    

Aliases &
Descriptions
for RNLS

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
C10orf59 2, 3
EC 1.4.-.- 3
FLJ11218 1, 2
OTTHUMP00000020034 2
OTTHUMP00000020035 2
RENALASE 2
renalase 1, 2
Descriptions
chromosome 10 open reading frame 59 1
renalase, FAD-dependent amine oxidase 2
External Ids
HGNC: 256411
Entrez Gene: 553282
UniProtKB: Q5VYX03
Ensembl: ENSG000001847197
Search outside databases for aliases for RNLS gene

Summaries
for RNLS

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for RNLS:
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood
from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM]

UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0
Function: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood
and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as
dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing
cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular
tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular
risk

Genomic Location
for RNLS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

RNLS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M090024:     (about GC identifiers)

Start:
 90,023,601 bp from pter
End:
 90,332,988 bp from pter
Size:
 309,388 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  

Proteins
for RNLS

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0 (See protein sequence)
Recommended Name: Renalase precursor  
Size: 342 amino acids; 37847 Da
Cofactor: FAD
Subcellular location: Secreted
Secondary accessions: Q9BS33 Q9NUP8
Alternative splicing: 2 isoforms:  Q5VYX0-1   Q5VYX0-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001026879.2  NP_060833.1  


    ENSEMBL proteins: 
    ENSP00000332530 ENSP00000361015 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Renalase)
    Human Recombinant Proteins from Abnova (C10orf59)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    About this table

    Antibodies for RNLS: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    R&D Systems Antibodies for RNLS (Renalase)
    Antibodies from Abcam (Renalase), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (C10orf59)
    Novus Biologicals Antibodies for C10orf59

    Assays for RNLS: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for RNLS

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR002938 mOase_FAD_bd


       GeneDecks  RNLS for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q5VYX0

    ProtoNet protein and cluster: Q5VYX0

    1 Blocks protein family: IPB002938 Monooxygenase

    UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0
    Similarity: Belongs to the renalase family

    Gene Function
    for RNLS

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (RNLS)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001031709

                  Applied Biosystems Silencer® siRNAs for RNLS

                  Sigma-Aldrich siRNA for RNLS  
                         Sigma-Aldrich shRNA for RNLS  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RNLS
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001031709
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001031709
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001031709 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001031709

    UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0
    Function: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood
    and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as
    dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing
    cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular
    tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular
    risk
    Enzyme Number (IUBMB): EC 1.4.-.- 

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497 monooxygenase activity IEA--
    About this table

    Pathways & Interactions
    for RNLS

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114 oxidation reduction IEA--
    About this table

    Drugs & Compounds
    for RNLS

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RNLS
    1 Novoseek chemical compound relationship for RNLS gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    amine 75.55 13 18299506 (3), 15841207 (2), 15687836 (1), 17565281 (1) (see all 7)
    About this table


    Transcripts
    for RNLS

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (RNLS)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001031709

                  Sigma-Aldrich siRNA for RNLS  
                         Sigma-Aldrich shRNA for RNLS  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001031709  NM_018363  

    REFSEQ mRNAs for RNLS gene (2 alternative transcripts): 

    NM_001031709.2   NM_018363.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001031709  NM_018363  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001031709
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001031709
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001031709 

    Additional cDNA sequence: 

    AK002080.1 AK296262.1 BC005364.1 BX648154.1 

    8 DOTS entries:

    DT.101208  DT.92392573  DT.91759114  DT.95154169  DT.101955364  DT.91759112  DT.95367269  DT.91659451 

    24/44 AceView cDNA sequences (see all 44 ):

    NM_018363 BX097218 BM695006 AK002080 CA407528 BM978857 AA232650 BX097852 
    BC005364 BI758544 AI828824 BG197548 CA446666 BI832528 BE464707 BX648154 
    BG194028 AI983739 BU753507 AA609946 AI093491 BI832374 AA854849 BX472150 

    Unigene Cluster for RNLS:

    Renalase, FAD-dependent amine oxidase
    Hs.149849  [show with all ESTs]
    Unigene Representative Sequence: AK002080


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RNLS

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                -                 -     -     -         
    SP2:                                -                 -                     
    SP3:                                                                        

    About this scheme

    ECgene alternative splicing isoforms for RNLS

    2 Ensembl transcripts including schematic representations:
    ENST00000331772  ENST00000371947  

    Expression
    for RNLS

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RNLS expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RNLS

    1 / 2

    5 probe-sets matching RNLS gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    47868_at2 U95-B 1 1.00 1.00 1.00 1.00 -- -- -- -- --

    		223824_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    		220564_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    		223824_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		220564_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  RNLS for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CTAGAATGGA

    SOURCE GeneReport for Unigene cluster: Hs.149849

    UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0
    Tissue specificity: Secreted into the blood by the kidney. Highly expressed in the kidney,
    expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration
    is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects

    Orthologs
    for RNLS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for RNLS gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LOC6104481   -- hypothetical protein LOC610448 79.53(n)
    76.85(a)    		 610448  XM_847958.1  XP_853051.1 
    chimpanzee
    (Pan troglodytes)    		 LOC4505811   -- similar to chromosome 10 open reading frame 59 99.22(n)
    98.25(a)    		 450581  XM_507898.2  XP_507898.2 
    cow
    (Bos taurus)    		 LOC5347781   -- similar to renalase 89.57(n)
    84.8(a)    		 534778  XM_614663.3  XP_614663.3 
    rat
    (Rattus norvegicus)    		 RGD13098041   -- similar to hypothetical protein FLJ11218 82.48(n)
    78.53(a)    		 361751  NM_001014167.1  NP_001014189.1 
    mouse
    (Mus musculus)    		 Rnls5
    6530404N21Rik1    		 195
    		 renalase, FAD-dependent amine oxidase5
    RIKEN cDNA 6530404N21 gene1    		 81.09(n)1
    71.35(a)1    		 677951  XM_001481318.11  XP_001481368.11 
     AK0148665  AK0183225  (see all 8)
    About this table        Species with no ortholog for RNLS

    ENSEMBL Gene Tree for RNLS

    Paralogs
    for RNLS

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for RNLS

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1280 NCBI SNPs in RNLS are shown (see all 1280 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 473)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs22965451,2
    		A,C,F,H,O90332817(+) GAGTCC/GTCAGC 2 E/D D/E mis1 ese318Minor allele frequency- G:0.43EA EU WA NA 3128
    rs25761781,2
    		A,C,F,H,O90333378(-) ATCGCT/CGGTAA 2 -- ng31 ese37Minor allele frequency- C:0.37EU EA WA NA 554
    rs21144061,2
    		A,C,F,H,O90023573(+) AAAAAA/GAATGC 1 -- ng517Minor allele frequency- G:0.23EU EA WA NA 560
    rs10489561,2
    		A,C,F,H90034769(-) TTTGTA/GTGCCA 2 -- ut31 int1 ese39Minor allele frequency- G:0.47NA EU EA WA 714
    rs107495711,2
    		A,C,F,H90034325(+) GGAGAG/ACCCAT 2 -- int1 ng5116Minor allele frequency- A:0.15EA NA EU WA 1470
    rs79220581,2
    		A,C,F,H90024019(+) taaccA/Gtcatc 1 -- ut31 ese38Minor allele frequency- G:0.19EU EA WA 836
    rs107495681,2
    		C,F,H90024468(+) CATACG/AGCAAT 1 -- ut31 ese34Minor allele frequency- A:0.20EU EA WA 420
    --
    rs65861241,2
    		A,C90023613(+) ATTATA/GGTTTT 1 -- ut313Minor allele frequency- G:0.01NA 142
    rs171092901,2
    		F,H90334141(+) GTATGA/GAAGAT 2 -- ng31 ese38Minor allele frequency- N:0.01NA EU EA WA 628
    rs49334751,2
    		H90034451(+) AAAGTA/CCTGTG 2 -- int1 ng514Minor allele frequency- C:0.00EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for RNLS (up to first 250kb)

    Disorders & Mutations
    for RNLS

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 609360

    3 Novoseek disease relationships for RNLS gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal failure chronic 52.56 2 15841207 (1), 17846919 (1)
    renal disease 42.69 6 18277152 (4), 17565281 (1), 18299506 (1)
    cardiovascular diseases 37.56 1 18277152 (1)
    About this table

    Medical News
    for RNLS

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for RNLS

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/17 PubMed articles for RNLS gene (see all 17 ):

    Search for RNLS

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RNLS

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 55328 HGNC: 25641 AceView: C10orf59 Ensembl:ENSG00000184719 euGenes: HUgn55328
    ECgene: RNLS H-InvDB: RNLS

    Other Databases showing RNLS

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing RNLS

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for RNLS

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for RNLS

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RNLS:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RNLS-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for RNLS Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for RNLS Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

     Recombinant Proteins (C10orf59)
     Antibodies (C10orf59)
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     Custom Service for Rabbit Pab from Full-length Protein
      
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     Recombinant Proteins
    (Renalase)
     Antibodies (Renalase)
     Search OriGene for RNLS
     Search Tocris compounds for RNLS




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for C10orf59

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