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C10orf57 Gene

protein-coding GIFtS: 41

GC10P081828

chromosome 10 open reading frame 57
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ13263 ^¹, ²
OTTHUMP00000019950 ^²
bA369J21.6 ^¹, ²

Descriptions
chromosome 10 open reading frame 57 ^²
hypothetical protein LOC80195 ^²

External Ids
HGNC: 25804¹
Entrez Gene: 80195²
UniProtKB: Q8TBM7³
Ensembl: ENSG00000122378⁷

Search outside databases for aliases for C10orf57 gene

Previous GC identifer: GC10P081504

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C10orf57 gene

Entrez Gene cytogenetic band: 10q22.3 Ensembl cytogenetic band: 10q23.1 HGNC cytogenetic band: 10q23.1

C10orf57 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P081828: (about GC identifiers)

Start:	81,828,406 bp from pter
End:	81,842,286 bp from pter
Size:	13,881 bases
Orientation:	plus strand

1 alternative location:

Chr10+ 82,157,565-82,182,733

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ057_HUMAN, Q8TBM7 (See protein sequence)

Recommended Name: Transmembrane protein C10orf57

Size: 123 amino acids; 14243 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q53HP4 Q6IA45 Q9H8S6

REFSEQ proteins: NP_079401.2

ENSEMBL proteins:

ENSP00000361262 ENSP00000378012 ENSP00000361259 ENSP00000361254 ENSP00000361261

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for C10orf57:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for C10orf57
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for C10orf57

Assays for C10orf57:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8TBM7

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf57)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025125

Applied Biosystems Silencer® siRNAs for C10orf57

Sigma-Aldrich siRNA for C10orf57

Sigma-Aldrich shRNA for C10orf57

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for C10orf57
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_025125
Myc/DDK tagged cDNA clone in CMV expression vector: NM_025125
untagged cDNA clone in CMV expression vector: NM_025125

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_025125

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/8 Interacting proteins for C10orf57 (ENSP00000361261³) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DYDC2	ENSP00000361272³	STRING (score=.712)
SFTPA2B	ENSP00000361390³	STRING (score=.712)
TSPAN14	ENSP00000361229³	STRING (score=.712)
ZCCHC24	ENSP00000361410³	STRING (score=.712)
SFTPA1B	ENSP00000361382³	STRING (score=.706)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf57

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf57)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025125

Sigma-Aldrich siRNA for C10orf57

Sigma-Aldrich shRNA for C10orf57

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_025125

REFSEQ mRNAs for C10orf57 gene:

NM_025125.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_025125

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_025125
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_025125
                                 untagged cDNA clone in CMV expression vector: NM_025125

Additional cDNA sequence:

AF147339.1 AK023325.1 AK222536.1 AK300490.1 AK309425.1 AK309980.1 AK310160.1 AK311563.1

AL832397.1 AL832483.1 BC022252.1 BX537803.1 CR457310.1 CR606165.1 CR622847.1 DQ786319.1

13 DOTS entries:

DT.214964 DT.92432105 DT.95315410 DT.100036036 DT.100705708 DT.100799475 DT.92432103 DT.95274605

DT.100748205 DT.121256554 DT.444343 DT.92432101 DT.92432106

24/222 AceView cDNA sequences (see all 222 ):

BM714638 AA190897 CR622847 Z41201 BM693871 AW014014 BM724886 BM717322

BM829225 AA868251 BG742982 AW517839 BG698076 AI206962 BC022252 BF445609

T51718 NM_025125 AA732874 AL832397 BM672194 BM679174 AI083554 AW197647

highest scoring ESTs for C10orf57:

AA029276 AA236326 AA319331 AA337239 AA359636 AA364612 AA365326 AA424411 AA424456 AA424816

Unigene Cluster for C10orf57:

Chromosome 10 open reading frame 57

Hs.169982 [show with all ESTs]

Unigene Representative Sequence: AL832397

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf57

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c
SP1:			-		-		-						-
SP2:					-		-						-
SP3:					-		-		-				-
SP4:													-
SP5:

About this scheme

ECgene alternative splicing isoforms for C10orf57

5 Ensembl transcripts including schematic representations:

ENST00000372188 ENST00000394504 ENST00000372185 ENST00000372181 ENST00000372187

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf57 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf57

¹ / ² / ³

5 probe-sets matching C10orf57 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65850_at²^{, 3}	U95-C	3	1.00	0.48	1.00	1.00	AA029276	1.00	1.00	1.00	1
218174_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	NM_025125	0.60	1.00	0.82	1
222545_s_at²^{, 3}	U133-B	3	1.00	0.42	--	--	AA029276	1.00	1.00	1.00	1
218174_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
222545_s_at²	U133Plus2	3	1.00	0.42	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAATTCAAA

SOURCE GeneReport for Unigene cluster: Hs.169982

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for C10orf57 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC610526¹	--	similar to Protein C10orf57 homolog	85.37(n) 83.74(a)	610526 XM_848047.1 XP_853140.1
chimpanzee (Pan troglodytes)	LOC450551¹	--	hypothetical LOC450551	99.6(n) 100(a)	450551 XM_507871.2 XP_507871.2
cow (Bos taurus)	C28H10orf57¹	--	chromosome 10 open reading frame 57 ortholog	80.58(n) 76.52(a)	505854 NM_001075228.1 NP_001068696.1
rat (Rattus norvegicus)	RGD1305689¹	--	similar to DNA segment, Chr 14, ERATO Doi 449, expressed	84.02(n) 80.17(a)	290529 NM_001008297.1 NP_001008298.1
mouse (Mus musculus)	D14Ertd449e⁵ ENSMUSG00000021867¹	14 (6.00 cM)⁵	DNA segment, Chr 14, ERATO Doi 449, expressed⁵ predicted gene, ENSMUSG00000021867¹	84.02(n)¹ 83.47(a)¹	100039257¹ XM_001472657.1¹ XP_001472707.1¹ AA960404⁵ AK002342⁵ (see all 14)

About this table Species with no ortholog for C10orf57

ENSEMBL Gene Tree for C10orf57

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for C10orf57 gene

C1orf93²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/105 NCBI SNPs in C10orf57 are shown (see all 105 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 23)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs3156^1,2	A,C,F,H	81842039(-)	`TCTACT/CAGAGA`	1	--	ut3¹		5		MN EU EA WA	598
--	rs3842235^1,2	C,F	81828205(-)	`CTCCTCT/-GTCAC`	1	--	ng5¹		2		MN EA	1252
--	rs7901689^1,2	F,H	81828071(+)	`gtctaG/Actatg`	1	--	ng5¹		4		EU EA WA	416
	rs1046707^1,2	A,C	81841100(+)	`CACTTC/TCACTA`	1	--	ut3¹		0	--	--	--	--
	rs12248116^1,2	H	81826471(+)	`GAAAGC/TTGAGA`	1	--	ng5¹		4		EU EA WA	420
--	rs10430708^1,2	A	81828051(+)	`attcaC/Ttcatt`	1	--	ng5¹		0	--	--	--	--
--	rs6421346^1,2	C	81827898(+)	`caggcA/Gccacc`	1	--	ng5¹		0	--	--	--	--
--	rs10887487^1,2	A	81842680(+)	`GCACTA/GTTAGG`	1	--	ng3¹		0	--	--	--	--
	rs1932574^1,2	A,C,F,H	81831672(+)	`CTCCTG/TTGCAA`	1	L/L	syn¹		6		EU WA EA	660
	rs7085612^1,2	A,C,F,H	81829452(+)	`TGGTAA/Gttttg`	1	--	int¹		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for C10orf57 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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7 PubMed articles for C10orf57 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{2, 3, 4} Ota T....Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Lineage-specific gene duplication and loss in human and great ape evolution. (PubMed id 15252450)³ Fortna A....Sikela J.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)³ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 80195	HGNC: 25804	AceView: C10orf57	Ensembl:ENSG00000122378	euGenes: HUgn80195
ECgene: C10orf57	H-InvDB: C10orf57

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for C10orf57
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for C10orf57:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf57-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for C10orf57		Antibodies for C10orf57
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for C10orf57		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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C10orf57 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for C10orf57

Summaries
for C10orf57

Genomic Location
for C10orf57

Proteins
for C10orf57

Protein Domains/
Families
for C10orf57

Gene Function
for C10orf57

Pathways & Interactions
for C10orf57

Drugs & Compounds
for C10orf57

Transcripts
for C10orf57

Expression
for C10orf57

Orthologs
for C10orf57

Paralogs
for C10orf57

SNPs/Variants
for C10orf57

Disorders & Mutations
for C10orf57

Medical News
for C10orf57

Publications
for C10orf57

Search for C10orf57

Genome Databases showing C10orf57

Other Databases showing C10orf57

Specialized Databases showing C10orf57

Licensable Technologies
for C10orf57

Services
for C10orf57

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf57 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor C10orf57

Summariesfor C10orf57

Genomic Locationfor C10orf57

Proteinsfor C10orf57

Protein Domains/Familiesfor C10orf57

Gene Functionfor C10orf57

Pathways & Interactionsfor C10orf57

Drugs & Compoundsfor C10orf57

Transcriptsfor C10orf57

Expression for C10orf57

Orthologsfor C10orf57

Paralogsfor C10orf57

SNPs/Variantsfor C10orf57

Disorders & Mutationsfor C10orf57

Medical Newsfor C10orf57

Publicationsfor C10orf57

Search for C10orf57

Genome Databases showing C10orf57

Other Databases showing C10orf57

Specialized Databases showing C10orf57

Licensable Technologiesfor C10orf57

Servicesfor C10orf57

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf57

Summaries
for C10orf57

Genomic Location
for C10orf57

Proteins
for C10orf57

Protein Domains/
Families
for C10orf57

Gene Function
for C10orf57

Pathways & Interactions
for C10orf57

Drugs & Compounds
for C10orf57

Transcripts
for C10orf57

Expression
for C10orf57

Orthologs
for C10orf57

Paralogs
for C10orf57

SNPs/Variants
for C10orf57

Disorders & Mutations
for C10orf57

Medical News
for C10orf57

Publications
for C10orf57

Licensable Technologies
for C10orf57

Services
for C10orf57