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ZCCHC24 Gene

protein-coding GIFtS: 43

GC10M080813

zinc finger, CCHC domain containing 24
(Previous name: chromosome 10 open reading frame 56 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C10orf56)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C10orf56 ^², ³
FLJ90798 ^¹, ²
OTTHUMP00000019923 ^²

Descriptions
chromosome 10 open reading frame 56 ^¹
zinc finger, CCHC domain containing 24 ^²

External Ids
HGNC: 26911¹
Entrez Gene: 219654²
UniProtKB: Q8N2G6³
Ensembl: ENSG00000165424⁷

Search outside databases for aliases for ZCCHC24 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.3 Ensembl cytogenetic band: 10q22.3 HGNC cytogenetic band: 10q22.3

ZCCHC24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M080813: (about GC identifiers)

Start:	80,812,087 bp from pter
End:	80,875,389 bp from pter
Size:	63,303 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZCH24_HUMAN, Q8N2G6 (See protein sequence)

Recommended Name: Zinc finger CCHC domain-containing protein 24

Size: 241 amino acids; 26955 Da

Sequence caution: Sequence=AAH39249.1; Type=Frameshift; Positions=33;

Secondary accessions: Q5U5T9 Q8TAG0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_699198.2

ENSEMBL proteins:

ENSP00000361411 ENSP00000361410 ENSP00000361408

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: ZCCHC24

Antibodies for ZCCHC24:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ZCCHC24

Assays for ZCCHC24:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8N2G6

ProtoNet protein and cluster: Q8N2G6

1 Blocks protein family: IPB001878 C2HC-type zinc-finger signature

UniProtKB/Swiss-Prot: ZCH24_HUMAN, Q8N2G6

Similarity: Contains 1 CCHC-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZCCHC24)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (C10orf56)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153367

Applied Biosystems Silencer® siRNAs for ZCCHC24

Sigma-Aldrich siRNA for ZCCHC24

Sigma-Aldrich shRNA for ZCCHC24

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_153367
Myc/DDK tagged cDNA clone in CMV expression vector: NM_153367
untagged cDNA clone in CMV expression vector: NM_153367

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_153367

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/8 Interacting proteins for ZCCHC24 (ENSP00000361410³) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C10orf58	ENSP00000361261³	STRING (score=.712)
DYDC2	ENSP00000361272³	STRING (score=.712)
SFTPA2B	ENSP00000361390³	STRING (score=.712)
TSPAN14	ENSP00000361229³	STRING (score=.712)
SFTPA1B	ENSP00000361382³	STRING (score=.706)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZCCHC24

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZCCHC24)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (C10orf56)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153367

Sigma-Aldrich siRNA for ZCCHC24

Sigma-Aldrich shRNA for ZCCHC24

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_153367

REFSEQ mRNAs for ZCCHC24 gene:

NM_153367.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_153367

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_153367
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_153367
                                 untagged cDNA clone in CMV expression vector: NM_153367

Additional cDNA sequence:

AK024784.1 AK075279.1 AK293361.1 AK303734.1 AK308876.1 AL049949.1 BC016959.1 BC028617.1

BC032450.1 BC039249.1 BC053564.1 BX648607.1

4 DOTS entries:

DT.417554 DT.102844128 DT.100029577 DT.91867043

24/279 AceView cDNA sequences (see all 279 ):

BQ672480 AI341629 BU628686 AI625576 BU177436 AW664457 AI741748 AI753816

BM679684 BP365768 H48519 BG054590 BF725996 AI027147 BC016959 T34455

BF725995 Z41445 BG057063 AI269859 CA395644 AA122266 BM708259 BQ575746

Unigene Cluster for ZCCHC24:

Zinc finger, CCHC domain containing 24

Hs.523080 [show with all ESTs]

Unigene Representative Sequence: BC028617

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000372336 ENST00000372335 ENST00000372333

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZCCHC24 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZCCHC24

¹ / ²

5 probe-sets matching ZCCHC24 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34303_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
212419_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
212423_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
212419_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212423_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGTATTAAA

SOURCE GeneReport for Unigene cluster: Hs.523080

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZCCHC24 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZCCHC24¹	--	zinc finger, CCHC domain containing 24	94.88(n) 97.93(a)	610507 XM_848028.1 XP_853121.1
chimpanzee (Pan troglodytes)	ZCCHC24¹	--	zinc finger, CCHC domain containing 24	99.31(n) 99.59(a)	450547 XM_507867.2 XP_507867.2
rat (Rattus norvegicus)	Zcchc24¹	--	zinc finger, CCHC domain containing 24	91.42(n) 97.1(a)	361104 XM_341390.3 XP_341391.2
mouse (Mus musculus)	Zcchc24^{1, 5}	14⁵	zinc finger, CCHC domain containing 24^{1, 5}	91.98(n)¹ 97.51(a)¹	71918¹ XM_975187.2¹ XP_980281.1¹ AI852699⁵ AK009861⁵ (see all 10)
chicken (Gallus gallus)	C10orf56¹	--	chromosome 10 open reading frame 56	82.98(n) 91.21(a)	423722 XM_421599.2 XP_421599.2

About this table Species with no ortholog for ZCCHC24

ENSEMBL Gene Tree for ZCCHC24

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/449 NCBI SNPs in ZCCHC24 are shown (see all 449 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 179)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6480934^1,2	A,C,F,H	80812215(+)	`GACGTC/TGGAGC`	1	--	ut3¹ ese³		7	EU EA WA NA	562
	rs4980069^1,2	A,C,F,H	80815272(+)	`CTGCTA/GGAACA`	1	--	ut3¹ ese³		12	EA NA EU WA	1050
	rs1046444^1,2	A,C,F,H	80815707(-)	`ACCAGC/GCAGGC`	1	--	ut3¹ ese³		5	MN EU EA WA	592
	rs7085536^1,2	A,C,F,H	80812054(+)	`CCTACA/GTGCTT`	1	--	ng5¹		7	EU EA WA NA	562
	rs1063119^1,2	A,C,F,H	80815541(-)	`AATCCG/AGACCC`	1	--	ut3¹ ese³		5	MN EU EA WA	588
	rs4979863^1,2	A,C,F,H	80814703(+)	`AGGAGC/TGCACG`	1	--	ut3¹		4	EU EA WA	412
	rs6858^1,2	A,C,F,H	80812371(-)	`AGCGGG/ACTTAT`	1	--	ut3¹ ese³		6	MN EU EA WA	790
	rs16937130^1,2	C,F,H	80814837(+)	`TCAGGG/CTTCTC`	1	--	ut3¹ ese³		11	NA EU EA WA	966
	rs11002951^1,2	C,F,H	80812251(+)	`GCCCAC/TGGGTT`	1	--	ut3¹ ese³		7	EU EA WA NA	562
	rs1046445^1,2	C,F,H	80815648(-)	`CTCTCG/AGAAAT`	1	--	ut3¹ ese³		9	MN EU EA WA	1016

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HapMap Linkage Disequilibrium images for ZCCHC24 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for ZCCHC24 gene:

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 219654	HGNC: 26911	AceView: C10orf56	Ensembl:ENSG00000165424	euGenes: HUgn219654
ECgene: ZCCHC24	H-InvDB: ZCCHC24

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ZCCHC24
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZCCHC24:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZCCHC24-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZCCHC24		Browse antibodies at Sigma-Aldrich
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Search Tocris compounds for ZCCHC24

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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ZCCHC24 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for ZCCHC24

Summaries
for ZCCHC24

Genomic Location
for ZCCHC24

Proteins
for ZCCHC24

Protein Domains/
Families
for ZCCHC24

Gene Function
for ZCCHC24

Pathways & Interactions
for ZCCHC24

Drugs & Compounds
for ZCCHC24

Transcripts
for ZCCHC24

Expression
for ZCCHC24

Orthologs
for ZCCHC24

Paralogs
for ZCCHC24

SNPs/Variants
for ZCCHC24

Disorders & Mutations
for ZCCHC24

Medical News
for ZCCHC24

Publications
for ZCCHC24

Search for ZCCHC24

Genome Databases showing ZCCHC24

Other Databases showing ZCCHC24

Specialized Databases showing ZCCHC24

Licensable Technologies
for ZCCHC24

Services
for ZCCHC24

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZCCHC24 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor ZCCHC24

Summariesfor ZCCHC24

Genomic Locationfor ZCCHC24

Proteinsfor ZCCHC24

Protein Domains/Familiesfor ZCCHC24

Gene Functionfor ZCCHC24

Pathways & Interactionsfor ZCCHC24

Drugs & Compoundsfor ZCCHC24

Transcriptsfor ZCCHC24

Expression for ZCCHC24

Orthologsfor ZCCHC24

Paralogsfor ZCCHC24

SNPs/Variantsfor ZCCHC24

Disorders & Mutationsfor ZCCHC24

Medical Newsfor ZCCHC24

Publicationsfor ZCCHC24

Search for ZCCHC24

Genome Databases showing ZCCHC24

Other Databases showing ZCCHC24

Specialized Databases showing ZCCHC24

Licensable Technologiesfor ZCCHC24

Servicesfor ZCCHC24

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZCCHC24

Summaries
for ZCCHC24

Genomic Location
for ZCCHC24

Proteins
for ZCCHC24

Protein Domains/
Families
for ZCCHC24

Gene Function
for ZCCHC24

Pathways & Interactions
for ZCCHC24

Drugs & Compounds
for ZCCHC24

Transcripts
for ZCCHC24

Expression
for ZCCHC24

Orthologs
for ZCCHC24

Paralogs
for ZCCHC24

SNPs/Variants
for ZCCHC24

Disorders & Mutations
for ZCCHC24

Medical News
for ZCCHC24

Publications
for ZCCHC24

Licensable Technologies
for ZCCHC24

Services
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