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Aliases for C10orf54 Gene

Aliases for C10orf54 Gene

  • Chromosome 10 Open Reading Frame 54 2 3
  • Stress Induced Secreted Protein 1 2 3
  • Stress-Induced Secreted Protein-1 3 4
  • Sisp-1 3 4
  • SISP1 3 4
  • B7H5 3 6
  • Platelet Receptor Gi24 3
  • PP2135 3
  • B7-H5 3
  • GI24 3

External Ids for C10orf54 Gene

Previous GeneCards Identifiers for C10orf54 Gene

  • GC10M073178
  • GC10U900642
  • GC10M073507
  • GC10M067501

Summaries for C10orf54 Gene

GeneCards Summary for C10orf54 Gene

C10orf54 (Chromosome 10 Open Reading Frame 54) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C10orf54 Gene

  • May stimulate MMP14-mediated MMP2 activation.

Gene Wiki entry for C10orf54 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf54 Gene

Genomics for C10orf54 Gene

Regulatory Elements for C10orf54 Gene

Genomic Location for C10orf54 Gene

71,747,556 bp from pter
71,773,580 bp from pter
26,025 bases
Minus strand

Genomic View for C10orf54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C10orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf54 Gene

Proteins for C10orf54 Gene

  • Protein details for C10orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Platelet receptor Gi24
    Protein Accession:
    Secondary Accessions:
    • A1L0X9
    • A4ZYV1
    • A8MVH5
    • Q6UXF3
    • Q8WUG3
    • Q8WYZ8

    Protein attributes for C10orf54 Gene

    311 amino acids
    Molecular mass:
    33908 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAL55778.1; Type=Erroneous termination; Positions=84; Note=Translated as Ser.; Evidence={ECO:0000305}; Sequence=AAL55778.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAB15739.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for C10orf54 Gene

Proteomics data for C10orf54 Gene at MOPED

Post-translational modifications for C10orf54 Gene

  • At the cell surface, may be cleaved by MMP14.
  • Glycosylation at Asn49, Asn91, Asn108, and Asn128
  • Modification sites at PhosphoSitePlus

Other Protein References for C10orf54 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C10orf54 Gene

Domains for C10orf54 Gene

Gene Families for C10orf54 Gene

  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for C10orf54 Gene

Suggested Antigen Peptide Sequences for C10orf54 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H7M9
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with C10orf54: view

Function for C10orf54 Gene

Molecular function for C10orf54 Gene

UniProtKB/Swiss-Prot Function: May stimulate MMP14-mediated MMP2 activation.

Gene Ontology (GO) - Molecular Function for C10orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with C10orf54: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C10orf54 Gene

Localization for C10orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf54 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for C10orf54 Gene COMPARTMENTS Subcellular localization image for C10orf54 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C10orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C10orf54: view

Pathways for C10orf54 Gene

SuperPathways for C10orf54 Gene

No Data Available

Interacting Proteins for C10orf54 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9H7M9-GI24_HUMAN ENSP00000378409 for C10orf54 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for C10orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002725 negative regulation of T cell cytokine production IEA --
GO:0030509 BMP signaling pathway IEA --
GO:0030513 positive regulation of BMP signaling pathway IEA --
GO:0048863 stem cell differentiation IEA --
GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation IEA --
genes like me logo Genes that share ontologies with C10orf54: view

No data available for Pathways by source for C10orf54 Gene

Transcripts for C10orf54 Gene

mRNA/cDNA for C10orf54 Gene

(9) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C10orf54 Gene

Chromosome 10 open reading frame 54:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf54 Gene

No ASD Table

Relevant External Links for C10orf54 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C10orf54 Gene

mRNA expression in normal human tissues for C10orf54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C10orf54 Gene

This gene is overexpressed in Whole Blood (29.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C10orf54 Gene

SOURCE GeneReport for Unigene cluster for C10orf54 Gene Hs.47382

genes like me logo Genes that share expressions with C10orf54: view

No data available for mRNA Expression by UniProt/SwissProt for C10orf54 Gene

Orthologs for C10orf54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf54 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C10H10orf54 35
  • 99.36 (n)
  • 99.36 (a)
C10orf54 36
  • 99 (a)
(Bos Taurus)
Mammalia C28H10orf54 35
  • 86.99 (n)
  • 82.58 (a)
MGC151567 36
  • 82 (a)
(Canis familiaris)
Mammalia C10orf54 36
  • 80 (a)
(Mus musculus)
Mammalia 4632428N05Rik 35
  • 79.65 (n)
  • 77.92 (a)
4632428N05Rik 16
4632428N05Rik 36
  • 77 (a)
(Monodelphis domestica)
Mammalia C10orf54 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia C10orf54 36
  • 62 (a)
(Rattus norvegicus)
Mammalia MGC112715 35
  • 77.35 (n)
  • 76.05 (a)
(Gallus gallus)
Aves C10ORF54 35
  • 64.81 (n)
  • 61.32 (a)
C10orf54 36
  • 56 (a)
(Anolis carolinensis)
Reptilia C10orf54 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf54 35
  • 57.5 (n)
  • 52.42 (a)
(Danio rerio)
Actinopterygii C13H10orf54 36
  • 38 (a)
zgc:153073 35
  • 52.12 (n)
  • 43.63 (a)
Species with no ortholog for C10orf54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf54 Gene

Gene Tree for C10orf54 (if available)
Gene Tree for C10orf54 (if available)

Paralogs for C10orf54 Gene

Selected SIMAP similar genes for C10orf54 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with C10orf54: view

No data available for Paralogs for C10orf54 Gene

Variants for C10orf54 Gene

Sequence variations from dbSNP and Humsavar for C10orf54 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_028036 -

Structural Variations from Database of Genomic Variants (DGV) for C10orf54 Gene

Variant ID Type Subtype PubMed ID
nsv831910 CNV Loss 17160897
nsv470963 CNV Loss 18288195
nsv895716 CNV Loss 21882294
esv1096295 CNV Deletion 17803354

Relevant External Links for C10orf54 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf54 Gene

Disorders for C10orf54 Gene

Relevant External Links for C10orf54

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with C10orf54: view

No data available for UniProtKB/Swiss-Prot for C10orf54 Gene

Publications for C10orf54 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for C10orf54 Gene

Sources for C10orf54 Gene

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