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Aliases for C10orf54 Gene

Aliases for C10orf54 Gene

  • Chromosome 10 Open Reading Frame 54 2 3 5
  • V-Set Domain-Containing Immunoregulatory Receptor 3 4
  • V-Domain Ig Suppressor Of T Cell Activation 2 3
  • Stress-Induced Secreted Protein-1 3 4
  • Sisp-1 3 4
  • SISP1 3 4
  • VISTA 3 4
  • Stress Induced Secreted Protein 1 2
  • Platelet Receptor GI24 3
  • Platelet Receptor Gi24 4
  • Death Domain1alpha 3
  • DD1alpha 3
  • PP2135 3
  • B7-H5 3
  • B7H5 3
  • GI24 3

External Ids for C10orf54 Gene

Previous GeneCards Identifiers for C10orf54 Gene

  • GC10M073178
  • GC10U900642
  • GC10M073507
  • GC10M067501

Summaries for C10orf54 Gene

GeneCards Summary for C10orf54 Gene

C10orf54 (Chromosome 10 Open Reading Frame 54) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions.

UniProtKB/Swiss-Prot for C10orf54 Gene

  • Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).

Gene Wiki entry for C10orf54 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf54 Gene

Genomics for C10orf54 Gene

Regulatory Elements for C10orf54 Gene

Promoters for C10orf54 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C10orf54 on UCSC Golden Path with GeneCards custom track

Genomic Location for C10orf54 Gene

Chromosome:
10
Start:
71,747,556 bp from pter
End:
71,773,580 bp from pter
Size:
26,025 bases
Orientation:
Minus strand

Genomic View for C10orf54 Gene

Genes around C10orf54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf54 Gene

Proteins for C10orf54 Gene

  • Protein details for C10orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7M9-VISTA_HUMAN
    Recommended name:
    V-type immunoglobulin domain-containing suppressor of T-cell activation
    Protein Accession:
    Q9H7M9
    Secondary Accessions:
    • A1L0X9
    • A4ZYV1
    • A8MVH5
    • Q6UXF3
    • Q8WUG3
    • Q8WYZ8

    Protein attributes for C10orf54 Gene

    Size:
    311 amino acids
    Molecular mass:
    33908 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL55778.1; Type=Erroneous termination; Positions=84; Note=Translated as Ser.; Evidence={ECO:0000305}; Sequence=AAL55778.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAB15739.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for C10orf54 Gene

Proteomics data for C10orf54 Gene at MOPED

Post-translational modifications for C10orf54 Gene

Other Protein References for C10orf54 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for C10orf54 (VISTA/B7-H5/PD-1H)
  • Cell Signaling Technology (CST) Antibodies for C10orf54 (VISTA)

No data available for DME Specific Peptides for C10orf54 Gene

Domains & Families for C10orf54 Gene

Gene Families for C10orf54 Gene

Protein Domains for C10orf54 Gene

Suggested Antigen Peptide Sequences for C10orf54 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7M9

UniProtKB/Swiss-Prot:

VISTA_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with C10orf54: view

Function for C10orf54 Gene

Molecular function for C10orf54 Gene

UniProtKB/Swiss-Prot Function:
Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).

Phenotypes for C10orf54 Gene

MGI mutant phenotypes for C10orf54:
inferred from 1 alleles
GenomeRNAi human phenotypes for C10orf54:
genes like me logo Genes that share phenotypes with C10orf54: view

Animal Models for C10orf54 Gene

MGI Knock Outs for C10orf54:
  • Vsir tm1.1(KOMP)Vlcg

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C10orf54 Gene

Localization for C10orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf54 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C10orf54 Gene COMPARTMENTS Subcellular localization image for C10orf54 gene
Compartment Confidence
plasma membrane 5
nucleus 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for C10orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IBA --
genes like me logo Genes that share ontologies with C10orf54: view

Pathways & Interactions for C10orf54 Gene

genes like me logo Genes that share pathways with C10orf54: view

Pathways by source for C10orf54 Gene

1 R&D Systems pathway for C10orf54 Gene

Interacting Proteins for C10orf54 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000378409%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000345494%0d%0a
Selected Interacting proteins: Q9H7M9-VISTA_HUMAN ENSP00000378409 for C10orf54 Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for C10orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002725 negative regulation of T cell cytokine production IEA --
GO:0030513 positive regulation of BMP signaling pathway IEA --
GO:0048863 stem cell differentiation IEA --
GO:2000738 positive regulation of stem cell differentiation IEA --
genes like me logo Genes that share ontologies with C10orf54: view

No data available for SIGNOR curated interactions for C10orf54 Gene

Drugs & Compounds for C10orf54 Gene

No Compound Related Data Available

Transcripts for C10orf54 Gene

mRNA/cDNA for C10orf54 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C10orf54 Gene

Chromosome 10 open reading frame 54:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf54 Gene

No ASD Table

Relevant External Links for C10orf54 Gene

GeneLoc Exon Structure for
C10orf54
ECgene alternative splicing isoforms for
C10orf54

Expression for C10orf54 Gene

mRNA expression in normal human tissues for C10orf54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C10orf54 Gene

This gene is overexpressed in Whole Blood (x29.2).

Protein differential expression in normal tissues from HIPED for C10orf54 Gene

This gene is overexpressed in Liver (15.8), Testis (13.4), Monocytes (11.5), Peripheral blood mononuclear cells (8.0), and Placenta (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C10orf54 Gene



SOURCE GeneReport for Unigene cluster for C10orf54 Gene Hs.47382

mRNA Expression by UniProt/SwissProt for C10orf54 Gene

Q9H7M9-VISTA_HUMAN
Tissue specificity: Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues.
genes like me logo Genes that share expression patterns with C10orf54: view

Protein tissue co-expression partners for C10orf54 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for C10orf54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf54 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C28H10orf54 35
  • 86.99 (n)
  • 82.58 (a)
MGC151567 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4632428N05Rik 35
  • 79.65 (n)
  • 77.92 (a)
Vsir 16
4632428N05Rik 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf54 35
  • 99.36 (n)
  • 99.36 (a)
C10orf54 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia MGC112715 35
  • 77.35 (n)
  • 76.05 (a)
dog
(Canis familiaris)
Mammalia C10orf54 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C10orf54 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf54 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10ORF54 35
  • 64.81 (n)
  • 61.32 (a)
C10orf54 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C10orf54 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf54 35
  • 57.5 (n)
  • 52.42 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:153073 35
  • 52.12 (n)
  • 43.63 (a)
C13H10orf54 36
  • 38 (a)
OneToOne
Species with no ortholog for C10orf54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf54 Gene

ENSEMBL:
Gene Tree for C10orf54 (if available)
TreeFam:
Gene Tree for C10orf54 (if available)

Paralogs for C10orf54 Gene

(1) SIMAP similar genes for C10orf54 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with C10orf54: view

No data available for Paralogs for C10orf54 Gene

Variants for C10orf54 Gene

Sequence variations from dbSNP and Humsavar for C10orf54 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_028036 -

Structural Variations from Database of Genomic Variants (DGV) for C10orf54 Gene

Variant ID Type Subtype PubMed ID
nsv831910 CNV Loss 17160897
nsv470963 CNV Loss 18288195
nsv895716 CNV Loss 21882294
esv1096295 CNV Deletion 17803354

Variation tolerance for C10orf54 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.55; 86.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf54 Gene

HapMap Linkage Disequilibrium report
C10orf54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf54 Gene

Disorders for C10orf54 Gene

Relevant External Links for C10orf54

Genetic Association Database (GAD)
C10orf54
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C10orf54

No disorders were found for C10orf54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf54 Gene

Publications for C10orf54 Gene

  1. VISTA is an immune checkpoint molecule for human T cells. (PMID: 24691993) Lines J.L. … Noelle R. (Cancer Res. 2014) 2 3 4 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  3. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. (PMID: 26228159) Yoon K.W. … Lee S.W. (Science 2015) 3
  4. Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M. … Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012) 3
  5. Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC. (PMID: 22488247) Flajnik M.F. … Ohta Y. (Immunogenetics 2012) 3

Products for C10orf54 Gene

Sources for C10orf54 Gene

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