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C10orf54 Gene

protein-coding GIFtS: 46

GC10M073178

chromosome 10 open reading frame 54
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
GI24 ^²
OTTHUMP00000019774 ^²
PP2135 ^²
SISP1 ^²

Descriptions
chromosome 10 open reading frame 54 ^²
platelet receptor Gi24 ^²
stress induced secreted protein 1 ^²

External Ids
HGNC: 30085¹
Entrez Gene: 64115²
UniProtKB: Q9H7M9³
Ensembl: ENSG00000107738⁷

Search outside databases for aliases for C10orf54 gene

Previous GC identifer: GC10U900642

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for C10orf54

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C10orf54 gene

Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC chromosome: 10

C10orf54 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M073178: (about GC identifiers)

Start:	73,177,319 bp from pter
End:	73,203,343 bp from pter
Size:	26,025 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GI24_HUMAN, Q9H7M9 (See protein sequence)

Recommended Name: Platelet receptor Gi24 precursor

Size: 311 amino acids; 33922 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: Q6UXF3 Q8WUG3 Q8WYZ8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_071436.1

ENSEMBL proteins:

ENSP00000378409 ENSP00000378412 ENSP00000263569

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GI24)
	Human Recombinant Proteins from Abnova (C10orf54)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for C10orf54:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for C10orf54
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GI24), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (C10orf54)
	Novus Biologicals Antibody for C10orf54

Assays for C10orf54:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9H7M9

ProtoNet protein and cluster: Q9H7M9

1 Blocks protein family: IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: GI24_HUMAN, Q9H7M9

Similarity: Contains 1 Ig-like (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf54)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (C10orf54)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_022153

Applied Biosystems Silencer® siRNAs for C10orf54

Sigma-Aldrich siRNA for C10orf54

Sigma-Aldrich shRNA for C10orf54

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for C10orf54
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_022153
Myc/DDK tagged cDNA clone in CMV expression vector: NM_022153
untagged cDNA clones in CMV expression vector (see all 2): BC020568

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_022153

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for C10orf54 (Q9H7M9²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
SMAD3 P84022² MINT-61732
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf54

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf54)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (C10orf54)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_022153

Sigma-Aldrich siRNA for C10orf54

Sigma-Aldrich shRNA for C10orf54

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_022153

REFSEQ mRNAs for C10orf54 gene:

NM_022153.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_022153

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022153
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022153
                                 untagged cDNA clones in CMV expression vector (see all 2): BC020568

Additional cDNA sequence:

AB073653.1 AF193048.1 AK024449.1 AY265805.1 AY358379.1 BC020568.1 BC111048.1 BC127257.1

CR595858.1 CR598635.1 CR599757.1 CR600781.1 CR604197.1 CR610409.1 CR611971.1 CR612511.1

CR614217.1 CR614300.1 CR621313.1 CR624628.1 CR626183.1 EF506490.1

16 DOTS entries:

DT.95352283 DT.95238640 DT.75102935 DT.101983591 DT.100882368 DT.100882366 DT.95238639 DT.40265648

DT.121260659 DT.115109 DT.100030892 DT.100882362 DT.105753 DT.40249652 DT.91941547 DT.95216541

highest scoring ESTs for C10orf54:

AA157962 AK024449 AY265805 AY358379 BC020568 BF347928 BM147376 BM811349 BM914488 BM919384

Unigene Cluster for C10orf54:

Chromosome 10 open reading frame 54

Hs.47382 [show with all ESTs]

Unigene Representative Sequence: NM_022153

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000394957 ENST00000394960 ENST00000263569

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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C10orf54 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf54

¹ / ² / ³

7 probe-sets matching C10orf54 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
50642_at²^{, 3}	U95-B	1	1.00	1.00	0.93	0.99	AA157962	0.60	1.00	0.82	1
82205_at²^{, 3}	U95-E	1	1.00	1.00	0.97	0.93	AI343963	0.40	1.00	0.76	1
49349_at²^{, 3}	U95-B	1	1.00	1.00	0.99	1.08	W72919	0.60	1.00	0.82	1
225373_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE271644	0.40	1.00	0.76	1
225372_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK024449	0.60	1.00	0.82	1
225373_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225372_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks C10orf54 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.47382

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for C10orf54 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC609741¹	--	similar to Platelet receptor Gi24 precursor	83.4(n) 82.59(a)	609741 XM_847067.1 XP_852160.1
chimpanzee (Pan troglodytes)	LOC735593¹	--	similar to FLJ00041 protein	98.4(n) 97.95(a)	735593 XM_001135701.1 XP_001135701.1
cow (Bos taurus)	MGC151567¹	--	hypothetical protein LOC783068	86.99(n) 82.58(a)	783068 XM_001251233.1 XP_001251234.1
rat (Rattus norvegicus)	MGC112715¹	--	platelet receptor Gi24	77.35(n) 76.05(a)	690899 XM_001073575.1 XP_001073575.1
mouse (Mus musculus)	4632428N05Rik^{1, 5}	10⁵	RIKEN cDNA 4632428N05 gene^{1, 5}	79.65(n)¹ 77.92(a)¹	74048¹ NM_028732.3¹ NP_083008.1¹ AA764293⁵ AI842456⁵ (see all 24)

About this table Species with no ortholog for C10orf54

ENSEMBL Gene Tree for C10orf54

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/11 PubMed articles for C10orf54 gene (see all 11 ):

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{2, 3, 4} Clark H.F....Gray A. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{3, 4} Wan D....Gu J. (2004)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)³ Colland F....Gauthier J.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 64115	HGNC: 30085	Ensembl:ENSG00000107738	euGenes: HUgn64115	ECgene: C10orf54
H-InvDB: C10orf54

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for C10orf54
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for C10orf54:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf54-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for C10orf54		Antibodies for C10orf54
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for C10orf54		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (C10orf54)
	Antibodies (C10orf54)
	Chimera RNAi (C10orf54)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (GI24)
	Antibodies (GI24)

Search OriGene for C10orf54

Search Tocris compounds for C10orf54

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for C10orf54

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C10orf54 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for C10orf54

Summaries
for C10orf54

Genomic Location
for C10orf54

Proteins
for C10orf54

Protein Domains/
Families
for C10orf54

Gene Function
for C10orf54

Pathways & Interactions
for C10orf54

Drugs & Compounds
for C10orf54

Transcripts
for C10orf54

Expression
for C10orf54

Orthologs
for C10orf54

Paralogs
for C10orf54

SNPs/Variants
for C10orf54

Disorders & Mutations
for C10orf54

Medical News
for C10orf54

Publications
for C10orf54

Search for C10orf54

Genome Databases showing C10orf54

Other Databases showing C10orf54

Specialized Databases showing C10orf54

Licensable Technologies
for C10orf54

Services
for C10orf54

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf54 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor C10orf54

Summariesfor C10orf54

Genomic Locationfor C10orf54

Proteinsfor C10orf54

Protein Domains/Familiesfor C10orf54

Gene Functionfor C10orf54

Pathways & Interactionsfor C10orf54

Drugs & Compoundsfor C10orf54

Transcriptsfor C10orf54

Expression for C10orf54

Orthologsfor C10orf54

Paralogsfor C10orf54

SNPs/Variantsfor C10orf54

Disorders & Mutationsfor C10orf54

Medical Newsfor C10orf54

Publicationsfor C10orf54

Search for C10orf54

Genome Databases showing C10orf54

Other Databases showing C10orf54

Specialized Databases showing C10orf54

Licensable Technologiesfor C10orf54

Servicesfor C10orf54

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf54

Summaries
for C10orf54

Genomic Location
for C10orf54

Proteins
for C10orf54

Protein Domains/
Families
for C10orf54

Gene Function
for C10orf54

Pathways & Interactions
for C10orf54

Drugs & Compounds
for C10orf54

Transcripts
for C10orf54

Expression
for C10orf54

Orthologs
for C10orf54

Paralogs
for C10orf54

SNPs/Variants
for C10orf54

Disorders & Mutations
for C10orf54

Medical News
for C10orf54

Publications
for C10orf54

Licensable Technologies
for C10orf54

Services
for C10orf54