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Aliases for C10orf54 Gene

Aliases for C10orf54 Gene

  • Chromosome 10 Open Reading Frame 54 2 3 5
  • V-Set Domain-Containing Immunoregulatory Receptor 3 4
  • V-Domain Ig Suppressor Of T Cell Activation 2 3
  • Stress-Induced Secreted Protein-1 3 4
  • PDCD1 Homolog 2 3
  • Sisp-1 3 4
  • SISP1 3 4
  • VISTA 3 4
  • V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation 3
  • Stress Induced Secreted Protein 1 2
  • Platelet Receptor GI24 3
  • Platelet Receptor Gi24 4
  • Death Domain1alpha 3
  • DD1alpha 3
  • PP2135 3
  • B7-H5 3
  • PD-1H 3
  • B7H5 3
  • GI24 3

External Ids for C10orf54 Gene

Previous GeneCards Identifiers for C10orf54 Gene

  • GC10M073178
  • GC10U900642
  • GC10M073507
  • GC10M067501

Summaries for C10orf54 Gene

GeneCards Summary for C10orf54 Gene

C10orf54 (Chromosome 10 Open Reading Frame 54) is a Protein Coding gene. Diseases associated with C10orf54 include Solar Retinopathy and Parasagittal Meningioma. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and NF-kappaB Signaling.

UniProtKB/Swiss-Prot for C10orf54 Gene

  • Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).

Gene Wiki entry for C10orf54 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf54 Gene

Genomics for C10orf54 Gene

Regulatory Elements for C10orf54 Gene

Enhancers for C10orf54 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C10orf54 on UCSC Golden Path with GeneCards custom track

Promoters for C10orf54 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C10orf54 Gene

Chromosome:
10
Start:
71,747,556 bp from pter
End:
71,773,580 bp from pter
Size:
26,025 bases
Orientation:
Minus strand

Genomic View for C10orf54 Gene

Genes around C10orf54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf54 Gene

Proteins for C10orf54 Gene

  • Protein details for C10orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7M9-VISTA_HUMAN
    Recommended name:
    V-type immunoglobulin domain-containing suppressor of T-cell activation
    Protein Accession:
    Q9H7M9
    Secondary Accessions:
    • A1L0X9
    • A4ZYV1
    • A8MVH5
    • Q6UXF3
    • Q8WUG3
    • Q8WYZ8

    Protein attributes for C10orf54 Gene

    Size:
    311 amino acids
    Molecular mass:
    33908 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL55778.1; Type=Erroneous termination; Positions=84; Note=Translated as Ser.; Evidence={ECO:0000305}; Sequence=AAL55778.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAB15739.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for C10orf54 Gene

Post-translational modifications for C10orf54 Gene

Other Protein References for C10orf54 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for C10orf54 (VISTA/B7-H5/PD-1H)
  • Cell Signaling Technology (CST) Antibodies for C10orf54 (VISTA)
  • Abcam antibodies for GI24

No data available for DME Specific Peptides for C10orf54 Gene

Domains & Families for C10orf54 Gene

Gene Families for C10orf54 Gene

Protein Domains for C10orf54 Gene

Suggested Antigen Peptide Sequences for C10orf54 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7M9

UniProtKB/Swiss-Prot:

VISTA_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with C10orf54: view

Function for C10orf54 Gene

Molecular function for C10orf54 Gene

UniProtKB/Swiss-Prot Function:
Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).
genes like me logo Genes that share phenotypes with C10orf54: view

Animal Models for C10orf54 Gene

MGI Knock Outs for C10orf54:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for C10orf54 (VISTA/B7-H5/PD-1H)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C10orf54 Gene

Localization for C10orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf54 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C10orf54 Gene COMPARTMENTS Subcellular localization image for C10orf54 gene
Compartment Confidence
plasma membrane 5
nucleus 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for C10orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0005911 cell-cell junction IBA --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C10orf54: view

Pathways & Interactions for C10orf54 Gene

genes like me logo Genes that share pathways with C10orf54: view

Pathways by source for C10orf54 Gene

1 Cell Signaling Technology pathway for C10orf54 Gene
1 R&D Systems pathway for C10orf54 Gene

Gene Ontology (GO) - Biological Process for C10orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002725 negative regulation of T cell cytokine production IEA --
GO:0016337 single organismal cell-cell adhesion IBA --
GO:0030509 BMP signaling pathway IEA --
GO:0030513 positive regulation of BMP signaling pathway IEA --
GO:0048863 stem cell differentiation IEA --
genes like me logo Genes that share ontologies with C10orf54: view

No data available for SIGNOR curated interactions for C10orf54 Gene

Drugs & Compounds for C10orf54 Gene

No Compound Related Data Available

Transcripts for C10orf54 Gene

mRNA/cDNA for C10orf54 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C10orf54 Gene

Chromosome 10 open reading frame 54:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for C10orf54 (VISTA/B7-H5/PD-1H)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf54 Gene

No ASD Table

Relevant External Links for C10orf54 Gene

GeneLoc Exon Structure for
C10orf54
ECgene alternative splicing isoforms for
C10orf54

Expression for C10orf54 Gene

mRNA expression in normal human tissues for C10orf54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C10orf54 Gene

This gene is overexpressed in Whole Blood (x29.2).

Protein differential expression in normal tissues from HIPED for C10orf54 Gene

This gene is overexpressed in Liver (15.8), Testis (13.4), Monocytes (11.5), Peripheral blood mononuclear cells (8.0), and Placenta (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C10orf54 Gene



Protein tissue co-expression partners for C10orf54 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C10orf54 Gene:

C10orf54

SOURCE GeneReport for Unigene cluster for C10orf54 Gene:

Hs.47382

mRNA Expression by UniProt/SwissProt for C10orf54 Gene:

Q9H7M9-VISTA_HUMAN
Tissue specificity: Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues.
genes like me logo Genes that share expression patterns with C10orf54: view

Primer Products

Orthologs for C10orf54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf54 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C28H10orf54 34
  • 86.99 (n)
  • 82.58 (a)
MGC151567 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4632428N05Rik 34
  • 79.65 (n)
  • 77.92 (a)
Vsir 16
4632428N05Rik 35
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf54 34
  • 99.36 (n)
  • 99.36 (a)
C10orf54 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia MGC112715 34
  • 77.35 (n)
  • 76.05 (a)
dog
(Canis familiaris)
Mammalia C10orf54 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C10orf54 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf54 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10ORF54 34
  • 64.81 (n)
  • 61.32 (a)
C10orf54 35
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C10orf54 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf54 34
  • 57.5 (n)
  • 52.42 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:153073 34
  • 52.12 (n)
  • 43.63 (a)
C13H10orf54 35
  • 38 (a)
OneToOne
Species where no ortholog for C10orf54 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf54 Gene

ENSEMBL:
Gene Tree for C10orf54 (if available)
TreeFam:
Gene Tree for C10orf54 (if available)

Paralogs for C10orf54 Gene

(1) SIMAP similar genes for C10orf54 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with C10orf54: view

No data available for Paralogs for C10orf54 Gene

Variants for C10orf54 Gene

Sequence variations from dbSNP and Humsavar for C10orf54 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_028036 -

Structural Variations from Database of Genomic Variants (DGV) for C10orf54 Gene

Variant ID Type Subtype PubMed ID
esv1096295 CNV deletion 17803354
nsv1127122 CNV deletion 24896259
nsv1137935 CNV deletion 24896259
nsv1147297 CNV deletion 26484159
nsv470963 CNV loss 18288195
nsv831910 CNV loss 17160897

Variation tolerance for C10orf54 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.55; 86.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf54 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf54 Gene

Disorders for C10orf54 Gene

MalaCards: The human disease database

(6) MalaCards diseases for C10orf54 Gene - From: DISEASES

Disorder Aliases PubMed IDs
solar retinopathy
  • solar retinitis
parasagittal meningioma
cerebral convexity meningioma
  • cerebral hemispheric convexity meningioma
trichorhinophalangeal syndrome, type i
  • trichorhinophalangeal syndrome type i
chorioretinal scar
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C10orf54

Genetic Association Database (GAD)
C10orf54
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C10orf54
genes like me logo Genes that share disorders with C10orf54: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C10orf54 Gene

Publications for C10orf54 Gene

  1. VISTA is an immune checkpoint molecule for human T cells. (PMID: 24691993) Lines J.L. … Noelle R. (Cancer Res. 2014) 2 3 4 65
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 65
  3. Characterization of programmed death-1 homologue-1 (PD-1H) expression and function in normal and HIV infected individuals. (PMID: 25279955) Bharaj P. … Shankar P. (PLoS ONE 2014) 2 3 65
  4. Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M. … Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012) 3 46 65
  5. GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. (PMID: 20666777) Sakr M.A. … Sato H. (Cancer Sci. 2010) 3 4 65

Products for C10orf54 Gene

Sources for C10orf54 Gene

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