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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C10orf54 Gene

protein-coding GIFtS: 45
GCID: GC10M073507

chromosome 10 open reading frame 54

Search for C10orf54
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 10 Open Reading Frame 54¹ ²		SISP1¹ ²
B7-H5¹ ²		PP2135²
B7H5¹ ²		Platelet Receptor Gi24²
GI24¹ ²		Stress Induced Secreted Protein 1²

External Ids:	HGNC: 30085¹	Entrez Gene: 64115²	Ensembl: ENSG00000107738⁷	UniProtKB: Q9H7M9³

Export aliases for C10orf54 gene to outside databases

Previous GC identifers: GC10M073178 GC10U900642 GC10M067501

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for C10orf54

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C10orf54 gene promoter:
ATF-2 NRSF form 1 Nkx5-1 NRSF form 2 GATA-1 E47 CRE-BP1 c-Myb Pax-4a Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C10orf54 promoter sequence

Search SABiosciences Chromatin IP Primers for C10orf54

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf54

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.1

C10orf54 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf54 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M073507: view genomic region (about GC identifiers)

Start:	73,507,313 bp from pter	End:	73,533,337 bp from pter
Size:	26,025 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GI24_HUMAN, Q9H7M9 (See protein sequence)

Recommended Name: Platelet receptor Gi24 precursor

Size: 311 amino acids; 33908 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Sequence caution: Sequence=AAL55778.1; Type=Erroneous termination; Positions=84; Note=Translated as Ser;

Sequence=AAL55778.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the

N-terminal part; Sequence=BAB15739.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A8MVH5 Q6UXF3 Q8WUG3 Q8WYZ8

Explore the universe of human proteins at neXtProt for C10orf54: NX_Q9H7M9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H7M9

C10orf54 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_071436.1

ENSEMBL proteins:

ENSP00000378409

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

C10orf54 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C10orf54 for domains About GeneDecksing

4 InterPro domains/families:

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q9H7M9

ProtoNet protein and cluster: Q9H7M9

1 Blocks protein family: IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: GI24_HUMAN, Q9H7M9

Similarity: Contains 1 Ig-like (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--

C10orf54 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out 4632428N05Rik^tm1Lex for C10orf54
     1 MGI phenotypic allele

for 4632428N05Rik (no phenotypes)

C10orf54 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C10orf54

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for C10orf54 (Q9H7M9^{2, 3} ENSP00000378409⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD3	P84022²^,³	MINT-61732 I2D: score=3
PLSCR1	O15162³, ENSP00000345494⁴	I2D: score=4 STRING: ENSP00000345494
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C10orf54
Search CenterWatch for drugs/clinical trials and news about C10orf54 / GI24

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C10orf54 gene:

NM_022153.1

Unigene Cluster for C10orf54:

Chromosome 10 open reading frame 54

Hs.47382 [show with all ESTs]

Unigene Representative Sequence: NM_022153

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394957(uc001jsd.3 uc001jse.3) ENST00000470317 ENST00000481568

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Additional cDNA sequence:

AB073653.1 AF193048.1 AK024449.1 AY265805.1 AY358379.1 BC020568.1 BC111048.1 BC127257.1

EF506490.1

16 DOTS entries:

DT.95352283 DT.95238640 DT.75102935 DT.101983591 DT.100882368 DT.100882366 DT.121260659 DT.95238639

DT.40265648 DT.100793214 DT.115109 DT.100030892 DT.100882362 DT.105753 DT.95216541 DT.97846813

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C10orf54 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

C10orf54 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Primordial germ cell-like cells (Reconstitution of mo...)

Syncytiotrophoblast-like cells (Generation of syncyt...)

See C10orf54 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C10orf54

SOURCE GeneReport for Unigene cluster: Hs.47382

SABiosciences Custom PCR Arrays for C10orf54

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf54

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C10orf54 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	4632428N05Rik^{1 , 5}	RIKEN cDNA 4632428N05 gene^{1, 5}	79.65(n)¹ 77.92(a)¹		10 (30.26 cM)⁵ 74048¹ NM_028732.4¹ NP_083008.1¹ 60346851⁵
chicken (Gallus gallus)	Aves	C10orf54⁶	Uncharacterized protein	57(a)	1 ↔ 1	6(12990618-12993771)
lizard (Anolis carolinensis)	Reptilia	C10orf54⁶	--	58(a)	1 ↔ 1	3(48449463-48464786)
zebrafish (Danio rerio)	Actinopterygii	zgc:153073¹	zgc:153073	51.99(n) 43.24(a)		570830 NM_001077581.1 NP_001071049.1

ENSEMBL Gene Tree for C10orf54 (if available)
TreeFam Gene Tree for C10orf54 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61026199^1,2	F,	--	67500915(+)	`GCCTAC/ACCATC`	2	--	int¹		1	WA	118
rs74928616^1,2	F,	--	67501040(+)	`ATCTCC/GCAGAG`	2	--	int¹		1	WA	118
rs57444011^1,2	C,F,	--	67501278(+)	`AGTTAC/TAACAC`	2	--	int¹		1	WA	118
rs79904170^1,2		--	67501395(+)	`TATCTC/TGGCAC`	2	--	int¹		1	NA	120
rs115700945^1,2	C,F,	--	67501439(+)	`CCTCTC/TAACAC`	2	--	int¹		1	WA	118
rs77559756^1,2	C,F,	--	67501750(+)	`GCTCGG/CTGGTG`	2	--	int¹		1	NA	120
rs77500667^1,2	C,F,	--	67502085(+)	`TTCAGC/TCTCTC`	2	--	int¹		2	WA NA	238
rs74720353^1,2	C,F,	--	67502088(+)	`NNNNTC/TTCCCT`	2	--	int¹		2	WA NA	238
rs3747856^1,2	C,H,	--	67502238(+)	`TGCCAC/TGAATC`	2	--	int¹ ese³		5	EA NS	1912
rs77870539^1,2		--	67502567(+)	`GAGAAG/CAGAGG`	2	--	int¹		2	CSA WA	120

HapMap Linkage Disequilibrium report for C10orf54 (73507313 - 73533337 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C10orf54
1 CNV: 29865

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C10orf54 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with C10orf54)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{1, 2} Wan D....Gu J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)¹ Imboden M....Probst-Hensch N.M. (2012)
Evolution of the B7 family: co-evolution of B7H6 and N Kp30, identification of a new B7 family member, B7H7, and of B7's historical rel ationship with the MHC. (PubMed id 22488247)¹ Flajnik M.F....Ohta Y. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
GI24 enhances tumor invasiveness by regulating cell s urface membrane-type 1 matrix metalloproteinase. (PubMed id 20666777)¹ Sakr M.A....Sato H. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64115	HGNC: 30085	Ensembl:ENSG00000107738	euGenes: HUgn64115	ECgene: C10orf54
H-InvDB: C10orf54

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C10orf54	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C10orf54 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C10orf54 gene:
Search GeneIP for patents involving C10orf54

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C10orf54
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	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C10orf54
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	GenScript Custom Purified and Recombinant Proteins Services for C10orf54		GenScript cDNA clones with any tag delivered in your preferred vector for C10orf54
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	Browse SwitchGear 3'UTR luciferase reporter plasmids for C10orf54
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C10orf54

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C10orf54 gene at Home site.

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C10orf54 Gene

chromosome 10 open reading frame 54

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C10orf54 Gene

chromosome 10 open reading frame 54

Aliasesfor C10orf54 gene

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Genomic Viewsfor C10orf54 gene

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