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UCMA Gene

protein-coding   GIFtS: 35

GC10M013304
upper zone of growth plate and cartilage matrix associated
(Previous name: chromosome 10 open reading frame 49 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C10orf49)
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Aliases &
Descriptions
for UCMA

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
C10orf49 2, 3
OTTHUMP00000043627 2
Descriptions
chromosome 10 open reading frame 49 1
unique cartilage matrix-associated protein 2
upper zone of growth plate and cartilage matrix associated 2
External Ids
HGNC: 252051
Entrez Gene: 2210442
UniProtKB: Q8WVF23
Ensembl: ENSG000001656237
Search outside databases for aliases for UCMA gene

Summaries
for UCMA

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UCMA_HUMAN, Q8WVF2
Function: May be involved in the negative control of osteogenic differentiation of
osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone
interface (By similarity)

Genomic Location
for UCMA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

UCMA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M013304:     (about GC identifiers)

Start:
 13,303,773 bp from pter
End:
 13,316,337 bp from pter
Size:
 12,565 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000010.9  NT_077569.2  

Proteins
for UCMA

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: UCMA_HUMAN, Q8WVF2 (See protein sequence)
Recommended Name: Unique cartilage matrix-associated protein precursor  
Size: 138 amino acids; 16563 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Post-translational modifications:

  • Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment
    found in almost the entire cartilage matrix, and affecting osteoblast differentiation (By
    similarity)1
  • Sulfated on tyrosine residues (By similarity)1


    • REFSEQ proteins: NP_660357.2  

    ENSEMBL proteins: 
    ENSP00000367952 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005578 proteinaceous extracellular matrix IEA--
    About this table

    Antibodies for UCMA: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
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    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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    Search Novus for antibodies for UCMA

    Assays for UCMA: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
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    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for UCMA

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8WVF2

    UniProtKB/Swiss-Prot: UCMA_HUMAN, Q8WVF2
    Similarity: Belongs to the UCMA family

    Gene Function
    for UCMA

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (UCMA)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145314

                  Applied Biosystems Silencer® siRNAs for UCMA

                  Sigma-Aldrich siRNA for UCMA  
                         Sigma-Aldrich shRNA for UCMA  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for UCMA
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_145314
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_145314
                                     untagged cDNA clone in CMV expression vector: NM_145314 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_145314

    UniProtKB/Swiss-Prot: UCMA_HUMAN, Q8WVF2
    Function: May be involved in the negative control of osteogenic differentiation of
    osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone
    interface (By similarity)

    Pathways & Interactions
    for UCMA

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045668 negative regulation of osteoblast differentiation IEA--
    About this table

    Drugs & Compounds
    for UCMA

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for UCMA

    Transcripts
    for UCMA

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (UCMA)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145314

                  Sigma-Aldrich siRNA for UCMA  
                         Sigma-Aldrich shRNA for UCMA  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_145314  

    REFSEQ mRNAs for UCMA gene: 

    NM_145314.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_145314  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_145314
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_145314
                                     untagged cDNA clone in CMV expression vector: NM_145314 

    Additional cDNA sequence: BC018068.1 

    1 DOTS entry:

    DT.100008722 

    17 AceView cDNA sequences:

    BF111669 AI123014 BI492502 BC018068 AI275700 BX096251 BG709040 NM_145314 
    AA993036 AA628504 BG187136 AI808049 AA621553 AI761841 BI492556 AW021545 
    BG714828 

    Unigene Cluster for UCMA:

    Upper zone of growth plate and cartilage matrix associated
    Hs.112998  [show with all ESTs]
    Unigene Representative Sequence: BG709040


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000378681  

    Expression
    for UCMA

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    UCMA expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for UCMA

    1 / 2

    3 probe-sets matching UCMA gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		46501_at2 U95-B 1 1.00 1.00 1.00 1.00 -- -- -- -- --

    		236800_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    		236800_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CCTTTCCTTC

    SOURCE GeneReport for Unigene cluster: Hs.112998

    UniProtKB/Swiss-Prot: UCMA_HUMAN, Q8WVF2
    Tissue specificity: Predominantly expressed in resting chondrocytes

    Orthologs
    for UCMA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for UCMA gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LOC4780021   -- hypothetical LOC478002 82.24(n)
    80.29(a)    		 478002  XM_535186.2  XP_535186.2 
    chimpanzee
    (Pan troglodytes)    		 LOC7366811   -- hypothetical protein LOC736681 98.79(n)
    97.1(a)    		 736681  XM_001140953.1  XP_001140953.1 
    cow
    (Bos taurus)    		 LOC6159241   -- hypothetical LOC615924 82.22(n)
    78.52(a)    		 615924  XM_867865.2  XP_872958.1 
    rat
    (Rattus norvegicus)    		 RGD13089771   -- similar to RIKEN cDNA 1110017I16 83.45(n)
    82.48(a)    		 291312  XM_214510.3  XP_214510.2 
    mouse
    (Mus musculus)    		 Ucma5
    1110017I16Rik1    		 25
    		 upper zone of growth plate and cartilage matrix associated5
    RIKEN cDNA 1110017I16 gene1    		 85.8(n)1
    83.48(a)1    		 685271  NM_026754.21  NP_081030.11 
     AK0037505  AL9286625  (see all 11)
    About this table        Species with no ortholog for UCMA

    ENSEMBL Gene Tree for UCMA

    Paralogs
    for UCMA

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for UCMA

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/139 NCBI SNPs in UCMA are shown (see all 139 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 85)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs23999561,2
    		A,C,F,H13317622(+) AGGGCG/AGGTAT 1 -- ng318Minor allele frequency- A:0.39EU EA WA 778
    rs20938471,2
    		C,F,H13316540(+) TGGGAC/TGGTCT 1 -- ng318Minor allele frequency- T:0.21EU EA WA 786
    rs171529801,2
    		C,F,H13316757(+) GTCAAG/CAAGGG 1 -- ng3111Minor allele frequency- C:0.11NA EU EA WA 980
    --
    rs118159451,2
    		C,F,H13303564(+) CCAGCG/ATTTCA 1 -- ng513Minor allele frequency- A:0.03EU EA 272
    rs22817951,2
    		C,F,H13303620(+) CTAGCA/GTATTC 1 -- ng5118Minor allele frequency- G:0.24EA NS EU WA 2854
    --
    rs109063221,2
    		A,C13303512(+) atataC/Tatata 1 -- ng510--------
    rs122626371,2
    		F,H13317890(+) TACCTG/AAAGCT 1 -- ng314Minor allele frequency- A:0.01EU EA WA 402
    --
    rs112582691,2
    		F,H13303563(+) CCCAGC/TGTTTC 1 -- ng514Minor allele frequency- T:0.01EU EA WA 394
    --
    rs23999551,2
    		A,C13317577(+) AACAGC/TAAGGC 1 -- ng31 tfbs30--------
    rs78944361,2
    		H13303925(+) AAAGAG/AGTGAA 1 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 390
    About this table

    HapMap Linkage Disequilibrium images for UCMA (up to first 250kb)

    Disorders & Mutations
    for UCMA

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for UCMA

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for UCMA

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		6 PubMed articles for UCMA gene:

    Search for UCMA

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UCMA

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 221044 HGNC: 25205 AceView: C10orf49 Ensembl:ENSG00000165623 euGenes: HUgn221044
    ECgene: UCMA H-InvDB: UCMA

    Other Databases showing UCMA

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing UCMA

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for UCMA

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for UCMA

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for UCMA:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for UCMA-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for UCMA Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for UCMA Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for UCMA

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