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C10orf47 Gene

protein-coding GIFtS: 38

GC10P011905

chromosome 10 open reading frame 47
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC35403 ^¹, ²
OTTHUMP00000035224 ^²

Descriptions
chromosome 10 open reading frame 47 ^²
hypothetical protein LOC254427 ^²

External Ids
HGNC: 23728¹
Entrez Gene: 254427²
UniProtKB: Q86WR7³
Ensembl: ENSG00000148426⁷

Search outside databases for aliases for C10orf47 gene

Previous GC identifer: GC10P011869

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14 Ensembl cytogenetic band: 10p14 HGNC cytogenetic band: 10p14

C10orf47 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P011905: (about GC identifiers)

Start:	11,905,403 bp from pter
End:	11,954,282 bp from pter
Size:	48,880 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_077569.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ047_HUMAN, Q86WR7 (See protein sequence)

Recommended Name: Uncharacterized protein C10orf47

Size: 435 amino acids; 45802 Da

Secondary accessions: Q5W0J9 Q5W0K0 Q5W0K1 Q5W0K2 Q6PJC8 Q8N317

Alternative splicing: 2 isoforms: Q86WR7-1 Q86WR7-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_694988.3

ENSEMBL proteins:

ENSP00000368506 ENSP00000368498 ENSP00000277570 ENSP00000368500

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for C10orf47:

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	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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	Search Novus for antibodies for C10orf47

Assays for C10orf47:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q86WR7

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf47)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_153256

Applied Biosystems Silencer® siRNAs for C10orf47

Sigma-Aldrich siRNA for C10orf47

Sigma-Aldrich shRNA for C10orf47

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for C10orf47
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_153256
Myc/DDK tagged cDNA clone in CMV expression vector: NM_153256
untagged cDNA clones in CMV expression vector (see all 2): BC017269

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_153256

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf47

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf47)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_153256

Sigma-Aldrich siRNA for C10orf47

Sigma-Aldrich shRNA for C10orf47

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_153256

REFSEQ mRNAs for C10orf47 gene:

NM_153256.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_153256

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_153256
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_153256
                                 untagged cDNA clones in CMV expression vector (see all 2): BC017269

Additional cDNA sequence:

BC007547.1 BC017269.2 BC029134.1 BC040040.1 BC048800.1 CR621861.1

2 DOTS entries:

DT.207634 DT.100754953

24/63 AceView cDNA sequences (see all 63 ):

BM768240 BC029134 AW130973 NM_153256 CR621861 CA432416 BC048800 BC040040

AA251971 BE465736 CD109834 CA422643 AI985781 BU676600 BM919494 AI032517

AW182452 BU621175 AW150989 AI335619 AW474326 BC017269 AA968424 BU856973

highest scoring ESTs for C10orf47:

AA701297 AI640157 AA251971 AA954229 AA968424 AI032517 AI288965 AI335619 AI636121 AI651429

Unigene Cluster for C10orf47:

Chromosome 10 open reading frame 47

Hs.435775 [show with all ESTs]

Unigene Representative Sequence: BC048800

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000379208 ENST00000379200 ENST00000277570 ENST00000379202

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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C10orf47 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf47

¹ / ² / ³

7 probe-sets matching C10orf47 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57746_at²^{, 3}	U95-C	1	1.00	1.00	0.93	1.15	AI640157	1.00	1.00	1.00	1
73491_at²^{, 3}	U95-E	1	1.00	1.00	0.96	0.87	AA701297	1.00	1.00	1.00	1
58725_at²^{, 3}	U95-C	1	0.88	1.00	0.27	1.02	AI056660	0.60	1.00	0.82	1
230051_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF589207	0.80	1.00	0.91	1
229801_at²^{, 3}	U133-B	1	0.82	1.00	--	--	AI640157	1.00	1.00	1.00	1
230051_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229801_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks C10orf47 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAAGTTCAGA

SOURCE GeneReport for Unigene cluster: Hs.435775

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for C10orf47 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC607757¹	--	hypothetical protein LOC607757	71.33(n) 61.07(a)	607757 XM_844547.1 XP_849640.1
chimpanzee (Pan troglodytes)	LOC736008¹	--	similar to chromosome 10 open reading frame 47	97.7(n) 96.55(a)	736008 XM_001135699.1 XP_001135699.1
mouse (Mus musculus)	5430407P10Rik^{1, 5}	2⁵	RIKEN cDNA 5430407P10 gene^{1, 5}	71.16(n)¹ 63.02(a)¹	227545¹ NM_144883.3¹ NP_659132.2¹ AI317549⁵ AK077380⁵ (see all 15)
chicken (Gallus gallus)	C10orf47¹	--	chromosome 10 open reading frame 47	54.37(n) 46.84(a)	419101 XM_417289.2 XP_417289.2

About this table Species with no ortholog for C10orf47

ENSEMBL Gene Tree for C10orf47

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/367 NCBI SNPs in C10orf47 are shown (see all 367 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 117)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10795903^1,2	A,C,F,H	11953354(+)	`GAACCC/AAAAGT`	1	--	ut3¹ ese³		4		EU EA WA	418
	rs4750127^1,2	A,C,F,H	11954168(+)	`ACTGCG/ATCTTT`	1	--	ut3¹ ese³		4		EU EA WA	418
--	rs12253600^1,2	A,C,F,H	11952437(+)	`CACCCC/TGTTTC`	1	--	ut3¹ ese³		4		EU EA WA	388
	rs11257370^1,2	A,C	11953913(+)	`TAGAAA/TTGCAA`	1	--	ut3¹		0	--	--	--	--
	rs4747947^1,2	A,C	11904280(+)	`TTAGTC/TTTCTG`	1	--	ng5¹		0	--	--	--	--
	rs4750123^1,2	A,C	11905310(+)	`TCGGGC/TGGCGC`	1	--	ng5¹		0	--	--	--	--
	rs10906024^1,2	A,H	11903746(+)	`aatttC/Aaccac`	1	--	ng5¹ tfbs³		4		EU EA WA	420
--	rs10795897^1,2	A,C	11903813(+)	`AATTCC/TTTAAA`	1	--	ng5¹		0	--	--	--	--
--	rs10160172^1,2	C	11904968(+)	`agatgC/Ggagta`	1	--	ng5¹		0	--	--	--	--
--	rs4750122^1,2	C	11905297(+)	`AAGGAG/TTGCGA`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for C10orf47 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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7 PubMed articles for C10orf47 gene:

The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Phosphoproteome of resting human platelets. (PubMed id 18088087)⁴ Zahedi R.P.... Sickmann A. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS Spectra. (PubMed id 17924679)⁴ Yu L.-R.... Veenstra T.D. (2007)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)³ Beausoleil S.A....Gygi S.P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 254427	HGNC: 23728	AceView: C10orf47	Ensembl:ENSG00000148426	euGenes: HUgn254427
ECgene: C10orf47	H-InvDB: C10orf47

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for C10orf47
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for C10orf47:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf47-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for C10orf47		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for C10orf47		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search OriGene for C10orf47

Search Tocris compounds for C10orf47

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for C10orf47

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C10orf47 Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for C10orf47

Summaries
for C10orf47

Genomic Location
for C10orf47

Proteins
for C10orf47

Protein Domains/
Families
for C10orf47

Gene Function
for C10orf47

Pathways & Interactions
for C10orf47

Drugs & Compounds
for C10orf47

Transcripts
for C10orf47

Expression
for C10orf47

Orthologs
for C10orf47

Paralogs
for C10orf47

SNPs/Variants
for C10orf47

Disorders & Mutations
for C10orf47

Medical News
for C10orf47

Publications
for C10orf47

Search for C10orf47

Genome Databases showing C10orf47

Other Databases showing C10orf47

Specialized Databases showing C10orf47

Licensable Technologies
for C10orf47

Services
for C10orf47

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf47 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor C10orf47

Summariesfor C10orf47

Genomic Locationfor C10orf47

Proteinsfor C10orf47

Protein Domains/Familiesfor C10orf47

Gene Functionfor C10orf47

Pathways & Interactionsfor C10orf47

Drugs & Compoundsfor C10orf47

Transcriptsfor C10orf47

Expression for C10orf47

Orthologsfor C10orf47

Paralogsfor C10orf47

SNPs/Variantsfor C10orf47

Disorders & Mutationsfor C10orf47

Medical Newsfor C10orf47

Publicationsfor C10orf47

Search for C10orf47

Genome Databases showing C10orf47

Other Databases showing C10orf47

Specialized Databases showing C10orf47

Licensable Technologiesfor C10orf47

Servicesfor C10orf47

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf47

Summaries
for C10orf47

Genomic Location
for C10orf47

Proteins
for C10orf47

Protein Domains/
Families
for C10orf47

Gene Function
for C10orf47

Pathways & Interactions
for C10orf47

Drugs & Compounds
for C10orf47

Transcripts
for C10orf47

Expression
for C10orf47

Orthologs
for C10orf47

Paralogs
for C10orf47

SNPs/Variants
for C10orf47

Disorders & Mutations
for C10orf47

Medical News
for C10orf47

Publications
for C10orf47

Licensable Technologies
for C10orf47

Services
for C10orf47