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C10orf46 Gene

protein-coding   GIFtS: 46

GC10M120434
chromosome 10 open reading frame 46
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ40409 1, 2
MGC33215 1, 2
OTTHUMP00000046870 2
cullin 2
Descriptions
chromosome 10 open reading frame 46 2
External Ids
HGNC: 237271
Entrez Gene: 1433842
UniProtKB: Q86Y373
Ensembl: ENSG000001518937
Search outside databases for aliases for C10orf46 gene

Previous GC identifer: GC10M120108

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf46 gene  

Entrez Gene cytogenetic band: 10q26.11   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q26.13

C10orf46 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M120434:     (about GC identifiers)

Start:
120,430,484 bp from pter
End:
120,504,748 bp from pter
Size:
74,265 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ046_HUMAN, Q86Y37 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf46  
Size: 369 amino acids; 41064 Da
Sequence caution: Sequence=AAU89709.1; Type=Frameshift; Positions=296;
Secondary accessions: Q5XPL7 Q8IY11 Q8N7S4
Alternative splicing: 3 isoforms:  Q86Y37-1   Q86Y37-2   Q86Y37-4   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_722517.3  

    ENSEMBL proteins: 
    ENSP00000358147 ENSP00000358152 ENSP00000342487 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (C10orf46)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031461 cullin-RING ubiquitin ligase complex IEA--
    About this table

    Antibodies for C10orf46: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for C10orf46
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (C10orf46)
    Novus Biologicals Antibodies for C10orf46

    Assays for C10orf46: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR016157 Cullin_CS
     IPR001373 Cullin_N


       GeneDecks  C10orf46 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q86Y37

    ProtoNet protein and cluster: Q86Y37

    UniProtKB/Swiss-Prot: CJ046_HUMAN, Q86Y37
    Similarity: Belongs to the cullin family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (C10orf46)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (C10orf46)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153810

                  Applied Biosystems Silencer® siRNAs for C10orf46

                  Sigma-Aldrich siRNA and siRNA Panels for C10orf46  
                         Sigma-Aldrich shRNA for C10orf46  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for C10orf46
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_153810
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_153810
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_153810 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_153810

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031625 ubiquitin protein ligase binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511 ubiquitin-dependent protein catabolic process IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for C10orf46
    1 Novoseek chemical compound relationship for C10orf46 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 7.90 3 16636053 (2), 18562529 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (C10orf46)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (C10orf46)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153810

                  Sigma-Aldrich siRNA and siRNA Panels for C10orf46  
                         Sigma-Aldrich shRNA for C10orf46  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_153810  

    REFSEQ mRNAs for C10orf46 gene: 

    NM_153810.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_153810  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_153810
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_153810
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_153810 

    Additional cDNA sequence: 

    AJ544771.1 AK026985.1 AK057742.1 AK131008.1 AK301182.1 AY743663.1 

    11 DOTS entries:

    DT.115696  DT.80100935  DT.100776827  DT.91709045  DT.100776831  DT.100776832  DT.40110811  DT.75172355 
    DT.91740587  DT.95370475  DT.100751365 

    24/344 AceView cDNA sequences (see all 344 ):

    BM450022 BM021295 BU623515 AA830160 BM021064 CK904202 AA281799 BC038294 
    AA477325 BF447218 AA648460 AA292403 BF588549 BM556972 BF195693 BU619567 
    AA404669 AA280585 AI795966 AA569396 AI265943 BE889163 BU623607 W31635 

    highest scoring ESTs for C10orf46:

    AA936352 AI394046 AA057479 AA758084 AI014959 AI184559 AI217826 AI222487 AI347164 AI365096 

    Unigene Cluster for C10orf46:

    Chromosome 10 open reading frame 46
    Hs.719193  [show with all ESTs]
    Unigene Representative Sequence: NM_153810


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf46

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                                -                                   -                           
    SP2:                                -                             -     -                           
    SP3:                                                              -     -           -               
    SP4:                                                                                                
    SP5:                                                                                                

    About this scheme

    ECgene alternative splicing isoforms for C10orf46

    3 Ensembl transcripts including schematic representations:
    ENST00000369151  ENST00000369156  ENST00000340214  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    C10orf46 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for C10orf46

    1 / 2 / 3

    10 probe-sets matching C10orf46 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    91053_at2, 3 U95-E 1 1.00 1.00 0.66 0.87 AI394046 1.00 1.00 1.00 1

    60297_at2, 3 U95-C 1 1.00 1.00 0.20 0.85 AI525959 0.20 1.00 0.72 1

    65779_at2, 3 U95-C 1 1.00 1.00 0.06 1.44 AA044726 0.60 1.00 0.82 1

    75328_at2, 3 U95-D 1 0.56 1.00 0.78 0.86 AA936352 1.00 1.00 1.00 1

    227257_s_at2, 3 U133-B 1 1.00 1.00 -- -- AW973842 0.60 1.00 0.82 1

    225192_at2, 3 U133-B 1 1.00 1.00 -- -- AA044726 0.60 1.00 0.82 1

    227258_at2, 3 U133-B 1 1.00 1.00 -- -- AW629460 0.80 1.00 0.91 1

    227257_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    225192_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    227258_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.719193
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for C10orf46 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    LOC4507711   -- hypothetical LOC450771 99.64(n)
    99.46(a)
    450771  XM_001152975.1  XP_001152975.1 
    cow
    (Bos taurus)
    LOC7842281   -- similar to chromosome 10 open reading frame 46 76.71(n)
    71.08(a)
    784228  XM_001252600.1  XP_001252601.1 
    rat
    (Rattus norvegicus)
    RGD13081271   -- similar to 2700078E11Rik protein 89.09(n)
    93.81(a)
    365493  NM_001014248.1  NP_001014270.1 
    mouse
    (Mus musculus)
    2700078E11Rik1, 5 195
    RIKEN cDNA 2700078E11 gene1, 5 90.15(n)1
    94.58(a)1
    788321  NM_030197.11  NP_084473.11 
     AI4503465  AI6395715  (see all 17)
    chicken
    (Gallus gallus)
    C10orf461   -- chromosome 10 open reading frame 46 85.67(n)
    85.67(a)
    423926  NM_001031238.1  NP_001026409.1 
    About this table        Species with no ortholog for C10orf46

    ENSEMBL Gene Tree for C10orf46
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/357 NCBI SNPs in C10orf46 are shown (see all 357 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 130)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs44439921,2
    A,C,F,H120434870(+) GGGGAA/CAATCC 1 -- ut31 ese37Minor allele frequency- C:0.06EU EA WA NA 546
    rs43194311,2
    A,C,F,H120505172(+) TTACGC/TTTGTA 1 -- ng31 tfbs37Minor allele frequency- T:0.28EU EA WA NA 544
    rs111985911,2
    C,F,H120505882(+) AGGAAG/AGCAAA 1 -- ng31 trp36Minor allele frequency- A:0.38EU WA EA 636
    --
    rs176628951,2
    C,F,H120432872(+) CCATAT/CACTGT 1 -- ut31 ese311Minor allele frequency- C:0.06NA EU EA WA 980
    rs170979601,2
    F,H120430939(+) CAAAAC/TGCACT 1 -- ut31 ese37Minor allele frequency- T:0.08NA EU EA WA 544
    --
    rs170979621,2
    F120434080(+) CTGACA/CACCTT 1 -- ut313Minor allele frequency- C:0.01NA 142
    rs127837811,2
    H120431562(+) AAAGGT/GCCTAT 1 -- ut314Minor allele frequency- G:0.00EU EA WA 418
    rs127665091,2
    H120431412(+) TCTTGT/GGGCCA 1 -- ut31 ese34Minor allele frequency- G:0.00EU EA WA 402
    rs127824931,2
    H120431709(+) TCCAAA/CCAATG 1 -- ut314Minor allele frequency- C:0.00EU EA WA 408
    rs124401,2
    F,H120436104(-) TTGGCT/CTATAG 1 A/A syn14Minor allele frequency- C:0.03EU EA WA 416
    About this table

    HapMap Linkage Disequilibrium images for C10orf46 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    1 Novoseek disease relationship for C10orf46 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.00 1 11673459 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/138 PubMed articles for C10orf46 gene (see all 138 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 143384 HGNC: 23727 AceView: C10orf46 Ensembl:ENSG00000151893 euGenes: HUgn143384
    ECgene: C10orf46 H-InvDB: C10orf46
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for C10orf46:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for C10orf46 Antibodies for C10orf46
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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     Antibodies for C10orf46

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