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C10orf4 Gene

protein-coding   GIFtS: 53

GC10M095418
chromosome 10 open reading frame 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
F26C11.1-like 2
FRA10A 2, 5
FRA10AC1 2, 5
OTTHUMP00000020120 2
Descriptions
FRA10AC1 protein 2
chromosome 10 open reading frame 4 2
fragile site 10q23.3 2
rare folic acid-type fragile site, FRA(10)(q23.3),
candidate gene 1 2
External Ids
HGNC: 11621
Entrez Gene: 1189242
UniProtKB: Q70Z533
Ensembl: ENSG000001486907
Search outside databases for aliases for C10orf4 gene

Previous GC identifers: GC10M094322 GC10M094661 GC10M095559 GC10M095092

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for C10orf4
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf4 gene  

Entrez Gene cytogenetic band: 10q23.33   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q24.1

C10orf4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M095418:     (about GC identifiers)

Start:
95,418,319 bp from pter
End:
95,452,319 bp from pter
Size:
34,001 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F10C1_HUMAN, Q70Z53 (See protein sequence)
Recommended Name: Protein FRA10AC1  
Size: 315 amino acids; 37584 Da
Subcellular location: Nucleus
Miscellaneous: Expansion of a polymorphic CGG repeat within the 5'-UTR of this gene FRA10AC1 may be
the cause of folate-sensitive fragile site FRA10A expression which is characterized by chromosomal
breakage under specific cell culture conditions. No distinct phenotype has been associated with
expression of FRA10A. Nevertheless, some studies have proposed that this fragile site expression
might be associated with mental retardation, tumorigenesis, or neurological disorders. However,
these associations can be attributed to ascertainment bias
Sequence caution: Sequence=AAK55529.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;
Secondary accessions: Q70Z49 Q70Z50 Q70Z51 Q70Z52 Q8N293 Q8WVH5 Q96JQ8
Alternative splicing: 5 isoforms:  Q70Z53-1   Q70Z53-2   Q70Z53-3   Q70Z53-4   Q70Z53-5   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_660289.2  

    ENSEMBL proteins: 
    ENSP00000360484 ENSP00000360480 ENSP00000377660 ENSP00000360488 


    Human Recombinant Proteins 
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    Browse R&D Systems for human recombinant proteins
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    Recombinant Proteins from Abcam (C10orf4)
    Human Recombinant Proteins from Abnova (C10orf4)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for C10orf4: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for C10orf4
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (C10orf4), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (C10orf4)
    Novus Biologicals Antibodies for C10orf4

    Assays for C10orf4: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR019129 Folate-sensitive_fs_Fra10Ac1


       GeneDecks  C10orf4 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q70Z53

    ProtoNet protein and cluster: Q70Z53

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (C10orf4)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (C10orf4)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_145246

                  Applied Biosystems Silencer® siRNAs for C10orf4

                  Sigma-Aldrich siRNA for C10orf4  
                         Sigma-Aldrich shRNA for C10orf4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for C10orf4
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_145246
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_145246
                                     untagged cDNA clones in CMV expression vector (see all 6): NM_145246 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_145246

    1 MGI phenotypic allele for 5730455O13Rik (no phenotypes)

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI16169070
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/7 Interacting proteins for C10orf4 (Q70Z531, 2) via UniProtKB, MINT, and/or STRING (see all 7 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K12Q128521, 2EBI-710176, EBI-710223 MINT-64738 EBI-710176, EBI-710223 MINT-64738
    MAP3K12Q128521, 2EBI-710176, EBI-710223 MINT-64738 EBI-710176, EBI-710223 MINT-64738
    ADPRHL2Q9NX462MINT-64739
    C21orf33P300422MINT-64737
    GDPD2Q9HCC82MINT-64741
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for C10orf4

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (C10orf4)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (C10orf4)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_145246

                  Sigma-Aldrich siRNA for C10orf4  
                         Sigma-Aldrich shRNA for C10orf4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_145246  

    REFSEQ mRNAs for C10orf4 gene: 

    NM_145246.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_145246  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_145246
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_145246
                                     untagged cDNA clones in CMV expression vector (see all 6): NM_145246 

    Additional cDNA sequence: 

    AJ431721.1 AK090955.1 AK308861.1 AK309016.1 BC018007.1 CR621041.1 CR625507.1 

    16 DOTS entries:

    DT.100020279  DT.92431978  DT.75103180  DT.109530  DT.92431981  DT.95364390  DT.92431988  DT.97784317 
    DT.92431983  DT.92431984  DT.100773690  DT.40232197  DT.97839923  DT.121218817  DT.40123084  DT.92431985 

    24/144 AceView cDNA sequences (see all 144 ):

    NM_203441 BF515647 CR621041 AI971005 NM_203439 AI358056 AV682295 AI668922 
    AA883221 AI674617 AI018610 BM720498 NM_145246 AA327710 AA045804 AI872052 
    BQ006958 AW131098 BG218978 CD557606 AA505135 NM_203438 CR625507 AA843806 

    highest scoring ESTs for C10orf4:

    AA296219 AA375304 AI804930 AJ431721 AJ431722 AJ431723 AJ431724 AJ431725 AK090955 AL702137 

    Unigene Cluster for C10orf4:

    Chromosome 10 open reading frame 4
    Hs.658192  [show with all ESTs]
    Unigene Representative Sequence: NM_145246


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf4 (see all 8 )

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:                                                  -                                                                                 
    SP2:        -     -                                                                                                                     
    SP3:                                                                                      -     -     -     -     -                     
    SP4:              -                                                                                                                     
    SP5:                                                                                                              -                     

    About this scheme

    ECgene alternative splicing isoforms for C10orf4

    4 Ensembl transcripts including schematic representations:
    ENST00000371430  ENST00000371426  ENST00000394100  ENST00000359204  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    C10orf4 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for C10orf4

    1 / 2 / 3

    3 probe-sets matching C10orf4 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    45634_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI804930 0.80 1.00 0.91 1

    226398_s_at2, 3 U133-B 1 1.00 1.00 -- -- AI804930 0.80 1.00 0.91 1

    226398_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CAATTTGAAA

    SOURCE GeneReport for Unigene cluster: Hs.658192

    UniProtKB/Swiss-Prot: F10C1_HUMAN, Q70Z53
    Tissue specificity: Ubiquitously expressed with higher expression in brain, heart, skeletal muscle,
    kidney and liver

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for C10orf4 gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4777761   -- similar to FRA10AC1 protein isoform FRA10AC1-1 93.08(n)
    92.65(a)
    477776  XM_534970.2  XP_534970.2 
    chimpanzee
    (Pan troglodytes)
    LOC4506181   -- FRA10AC1 protein 99.68(n)
    99.68(a)
    450618  XM_507931.2  XP_507931.2 
    cow
    (Bos taurus)
    C26H10ORF41   -- chromosome 10 open reading frame 4 ortholog 92.91(n)
    92.06(a)
    615724  NM_001076392.1  NP_001069860.1 
    rat
    (Rattus norvegicus)
    RGD13094821   -- similar to chromosome 10 open reading frame 4; similar more 88.04(n)
    86.98(a)
    365458  NM_001014246.1  NP_001014268.1 
    mouse
    (Mus musculus)
    5730455O13Rik1, 5 195
    RIKEN cDNA 5730455O13 gene1, 5 86.35(n)1
    86.67(a)1
    705671  NM_001081075.11  NP_001074544.11 
     AA8401435  AI4482935  (see all 13)
    About this table        Species with no ortholog for C10orf4

    ENSEMBL Gene Tree for C10orf4
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/212 NCBI SNPs in C10orf4 are shown (see all 212 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 121)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs22754381,2
    A,C,F,H,O95444671(+) ACTTTG/CTATGT 1 R/T mis113Minor allele frequency- C:0.38EA EU WA NA 2546
    rs7268171,2
    A,C,F,H,O95449807(+) CACAGC/TGTTCA 1 R/H mis1 ese320Minor allele frequency- N:0.00NS EA NA EU WA 2912
    rs108823111,2
    A,C,F,H95453461(+) TACAAT/ATTGAC 1 -- ng319Minor allele frequency- A:0.36EU EA WA NA 738
    rs111875801,2
    C,F,H95418997(+) AGACAT/CACATA 1 -- ut31 ese34Minor allele frequency- C:0.07EU EA WA 396
    rs107486101,2
    C,F,H95452225(-) CCTGTC/GCTGCA 1 -- ut51 ese32Minor allele frequency- G:0.04EA 174
    rs115921421,2
    A,C,F95453002(+) TTTGCG/CTTTTC 1 -- ng313Minor allele frequency- C:0.37NA 140
    rs111875831,2
    C,F,H95431262(+) CAGAAG/AATAAT 1 F/S mis1 ese38Minor allele frequency- A:0.06EU EA WA 832
    rs111876021,2
    A,F,H95454123(+) CCTACT/GCTGGG 1 -- ng313Minor allele frequency- G:0.29EA WA 268
    rs133768971,2
    F,H95452672(+) TCCTCT/CCAGAG 1 -- ng31 tfbs34Minor allele frequency- C:0.01EU EA WA 398
    --
    rs49193981,2
    A,C95419152(+) GTTTCC/TACAAA 1 -- ut31 ese30--------
    About this table

    HapMap Linkage Disequilibrium images for C10orf4 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 608866

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    8 PubMed articles for C10orf4 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 118924 HGNC: 1162 AceView: C10orf4 Ensembl:ENSG00000148690 euGenes: HUgn118924
    ECgene: C10orf4 H-InvDB: C10orf4
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for C10orf4:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for C10orf4 Antibodies for C10orf4
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