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Aliases & Descriptions for C10orf4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| F26C11.1-like 2 | | FRA10A 2, 5 | | FRA10AC1 2, 5 | | OTTHUMP00000020120 2 |
| | | Descriptions |
|---|
| FRA10AC1 protein 2 | | chromosome 10 open reading frame 4 2 | | fragile site 10q23.3 2 | rare folic acid-type fragile site, FRA(10)(q23.3), candidate gene 1 2 |
|
| | Search outside databases for aliases for C10orf4 genePrevious GC identifers: GC10M094322 GC10M094661 GC10M095559 GC10M095092 |
Summaries for C10orf4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for C10orf4 |
Genomic Location for C10orf4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the C10orf4 gene 
Entrez Gene cytogenetic band: 10q23.33 Ensembl cytogenetic band: 10q23.33 HGNC cytogenetic band: 10q24.1C10orf4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M095418:
(about GC identifiers)
Start:
|
95,418,319 bp from pter |
End:
|
95,452,319 bp from pter |
Size:
|
34,001 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for C10orf4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: F10C1_HUMAN, Q70Z53 (See
protein sequence)Recommended Name: Protein FRA10AC1 Size: 315 amino acids; 37584 Da
Subcellular location: Nucleus
Miscellaneous: Expansion of a polymorphic CGG repeat within the 5'-UTR of this gene FRA10AC1 may be the cause of folate-sensitive fragile site FRA10A expression which is characterized by chromosomal breakage under specific cell culture conditions. No distinct phenotype has been associated with expression of FRA10A. Nevertheless, some studies have proposed that this fragile site expression might be associated with mental retardation, tumorigenesis, or neurological disorders. However, these associations can be attributed to ascertainment bias
Sequence caution: Sequence=AAK55529.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;
Secondary accessions: Q70Z49 Q70Z50 Q70Z51 Q70Z52 Q8N293 Q8WVH5 Q96JQ8Alternative splicing: 5 isoforms: Q70Z53-1 Q70Z53-2 Q70Z53-3 Q70Z53-4 Q70Z53-5 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_660289.2
ENSEMBL proteins: ENSP00000360484 ENSP00000360480 ENSP00000377660 ENSP00000360488
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for C10orf4: Assays for C10orf4: | Protein
Domains/ Families for C10orf4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q70Z53
ProtoNet protein and cluster: Q70Z53 | Gene Function for C10orf4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_145246
Applied Biosystems Silencer® siRNAs for C10orf4
Sigma-Aldrich siRNA for C10orf4  Sigma-Aldrich shRNA for C10orf4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145246                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_145246                                  untagged cDNA clones in CMV expression vector (see all 6): NM_145246 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_145246
1 MGI phenotypic allele for 5730455O13Rik (no phenotypes)
1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for C10orf4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/7 Interacting proteins for C10orf4 (Q70Z531, 2) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
|
Drugs & Compounds for C10orf4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for C10orf4
|
Transcripts for C10orf4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_145246
Sigma-Aldrich siRNA for C10orf4  Sigma-Aldrich shRNA for C10orf4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_145246 REFSEQ mRNAs for C10orf4 gene: NM_145246.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_145246               OriGene GFP tagged cDNA clone in CMV expression vector: NM_145246                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_145246                                  untagged cDNA clones in CMV expression vector (see all 6): NM_145246  Additional cDNA sequence: AJ431721.1 AK090955.1 AK308861.1 AK309016.1 BC018007.1 CR621041.1 CR625507.1 16 DOTS entries: DT.100020279 DT.92431978 DT.75103180 DT.109530 DT.92431981 DT.95364390 DT.92431988 DT.97784317 DT.92431983 DT.92431984 DT.100773690 DT.40232197 DT.97839923 DT.121218817 DT.40123084 DT.92431985 24/144 AceView cDNA sequences (see all 144
):NM_203441 BF515647 CR621041 AI971005 NM_203439 AI358056 AV682295 AI668922 AA883221 AI674617 AI018610 BM720498 NM_145246 AA327710 AA045804 AI872052 BQ006958 AW131098 BG218978 CD557606 AA505135 NM_203438 CR625507 AA843806
highest scoring ESTs for C10orf4:AA296219 AA375304 AI804930 AJ431721 AJ431722 AJ431723 AJ431724 AJ431725 AK090955 AL702137 Unigene Cluster for C10orf4: Chromosome 10 open reading frame 4 Hs.658192 [show with all ESTs]Unigene Representative Sequence: NM_145246
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf4 (see all 8
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for C10orf4
4 Ensembl transcripts including schematic representations: ENST00000371430
ENST00000371426
ENST00000394100
ENST00000359204
|
Expression for C10orf4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| C10orf4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for C10orf4
1 / 2 / 3 3 probe-sets matching C10orf4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CAATTTGAAA
SOURCE GeneReport for Unigene cluster: Hs.658192 UniProtKB/Swiss-Prot: F10C1_HUMAN, Q70Z53Tissue specificity: Ubiquitously expressed with higher expression in brain, heart, skeletal muscle, kidney and liver |
Orthologs for C10orf4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for C10orf4 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for C10orf4
ENSEMBL Gene Tree for C10orf4 | Paralogs for C10orf4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for C10orf4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for C10orf4 (up to first 250kb)
|
Disorders & Mutations for C10orf4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608866
|
Medical News for C10orf4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for C10orf4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for C10orf4 gene:- Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein. (PubMed id 15203205)1, 3, 4 Sarafidou T.... Gecz J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)3, 4 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PubMed id 11483580)3, 4 Yu Y....He F. (2001)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)3 Stelzl U....Wanker E.E. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for C10orf4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing C10orf4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing C10orf4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C10orf4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for C10orf4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for C10orf4:

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Incremental update: 13 Oct 2009
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