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FAM171A1 Gene

protein-coding GIFtS: 43

GC10M015294

family with sequence similarity 171, member A1
(Previous name: chromosome 10 open reading frame 38 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C10orf38)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
Astroprincin ^³
C10orf38 ^², ³
FLJ12884 ^¹, ²
MGC130014 ^²
MGC130015 ^²
OTTHUMP00000019205 ^²

Descriptions
chromosome 10 open reading frame 38 ^¹
family with sequence similarity 171, member A1 ^²
hypothetical protein LOC221061 ^²

External Ids
HGNC: 23522¹
Entrez Gene: 221061²
UniProtKB: Q5VUB5³
Ensembl: ENSG00000148468⁷

Search outside databases for aliases for FAM171A1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p13

FAM171A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M015294: (about GC identifiers)

Start:	15,293,648 bp from pter
End:	15,453,064 bp from pter
Size:	159,417 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_077569.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F1711_HUMAN, Q5VUB5 (See protein sequence)

Recommended Name: Protein FAM171A1 precursor

Size: 890 amino acids; 97854 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: Q32M49 Q8N4I0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001010924.1

ENSEMBL proteins:

ENSP00000380001 ENSP00000367356 ENSP00000367354

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FAM171A1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for FAM171A1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FAM171A1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FAM171A1

Assays for FAM171A1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q5VUB5

ProtoNet protein and cluster: Q5VUB5

UniProtKB/Swiss-Prot: F1711_HUMAN, Q5VUB5

Similarity: Belongs to the FAM171 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM171A1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001010924

Applied Biosystems Silencer® siRNAs for FAM171A1

Sigma-Aldrich siRNA for FAM171A1

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010924
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010924
untagged cDNA clone in CMV expression vector: NM_001010924

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001010924

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Interacting proteins for FAM171A1 (ENSP00000367356³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C12orf29	ENSP00000329885³	STRING (score=.712)
C9orf167	ENSP00000350102³	STRING (score=.712)
COTL1	ENSP00000262428³	STRING (score=.704)
--	ENSP00000347976³	STRING (score=.712)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM171A1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM171A1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001010924

Sigma-Aldrich siRNA for FAM171A1

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001010924

REFSEQ mRNAs for FAM171A1 gene:

NM_001010924.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001010924

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010924
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010924
                                 untagged cDNA clone in CMV expression vector: NM_001010924

Additional cDNA sequence:

AK022946.1 AL050367.1 AY683003.1 BC034232.1 BC089427.1 BC109302.1 BC109303.1

8 DOTS entries:

DT.315902 DT.121263523 DT.100035970 DT.121263471 DT.100764189 DT.121263494 DT.121263518 DT.434859

24/147 AceView cDNA sequences (see all 147 ):

AI375870 BM672283 AA029582 AI022579 BM052992 CK903935 BE677452 AW612421

AW235877 AA709074 BM052713 AI524316 AU130409 AK022946 AW593463 AW513072

BE378106 AA404359 AI378812 AI565123 CB143172 BE883250 AW263996 BI913133

Unigene Cluster for FAM171A1:

Family with sequence similarity 171, member A1

Hs.66762 [show with all ESTs]

Unigene Representative Sequence: AY683003

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM171A1

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b
SP1:			-								-
SP2:
SP3:																					-		-
SP4:

About this scheme

ECgene alternative splicing isoforms for FAM171A1

3 Ensembl transcripts including schematic representations:

ENST00000396781 ENST00000378116 ENST00000378114

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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FAM171A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FAM171A1

¹ / ²

3 probe-sets matching FAM171A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36821_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
212771_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
212771_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FAM171A1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTAACGTGG

SOURCE GeneReport for Unigene cluster: Hs.66762

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM171A1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC607108¹	--	hypothetical protein LOC607108	87.7(n) 92.2(a)	607108 XM_843699.1 XP_848792.1
chimpanzee (Pan troglodytes)	LOC450322¹	--	similar to Chromosome 10 open reading frame 38	99.53(n) 99.65(a)	450322 XM_529297.2 XP_529297.2
cow (Bos taurus)	C13H10ORF38¹	--	chromosome 10 open reading frame 38 ortholog	84.75(n) 89.83(a)	534850 XM_614764.3 XP_614764.3
rat (Rattus norvegicus)	Fam171a1¹	--	family with sequence similarity 171, member A1	84.69(n) 89.54(a)	680259 XM_001056358.1 XP_001056358.1
mouse (Mus musculus)	Fam171a1^{1, 5}	2⁵	family with sequence similarity 171, member A1^{1, 5}	86.63(n)¹ 92.13(a)¹	269233¹ NM_001081161.1¹ NP_001074630.1¹ AA409679⁵ AI551141⁵ (see all 14)

About this table Species with no ortholog for FAM171A1

ENSEMBL Gene Tree for FAM171A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FAM171A1 gene

FAM171B² FAM171A2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1092 NCBI SNPs in FAM171A1 are shown (see all 1092 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 325)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4750633^1,2	A,C,F,H	15454302(+)	`gctaaG/Agaggg`	1	--	ng3¹		4	EU EA WA	418
	rs3814165^1,2	C,F,H	15296200(-)	`TTTTTC/TCCTTA`	1	P/S	mis¹ trp³		13	EA NA EU WA NS	1092
	rs17156419^1,2	F,H	15294578(+)	`GTTCCC/TAGAAT`	1	--	ut3¹ ese³		7	NA EU EA WA	562
--	rs11259633^1,2	C,F	15453570(+)	`CCACCG/AGGTGC`	1	--	ng3¹		1	NS	30
	rs3814169^1,2	F,H	15294158(-)	`TGACAA/GCAGAC`	1	--	ut3¹ ese³		4	EA WA	1798
	rs12254516^1,2	H	15303036(+)	`GTGCAC/AAAGAC`	1	L/V	mis¹ ese³		4	EU EA WA	420
--	rs45475991^1,2	F	15293542(+)	`AAAGT-/AGTGCTGG`	1	--	ng5¹		1	NS	36
	rs3814168^1,2	C,F,H	15295298(-)	`CAGAAC/TTACCC`	1	N/N	syn¹ ese³		10	EA EU WA NS	2372
	rs3814167^1,2	F,H	15295841(-)	`ATCCCG/AGCTCA`	1	P/P	syn¹ ese³		5	EA EU WA	1910
	rs3740127^1,2	F,H	15366049(-)	`GCGCTC/TATCGA`	1	L/L	syn¹		5	EA EU WA	1912

About this table

HapMap Linkage Disequilibrium images for FAM171A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for FAM171A1 gene:

The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)⁴ Chen R.... Zou H. (2009)
Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)⁴ Han G.... Gu J. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 221061	HGNC: 23522	AceView: C10orf38	Ensembl:ENSG00000148468	euGenes: HUgn221061
ECgene: FAM171A1	H-InvDB: FAM171A1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FAM171A1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FAM171A1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FAM171A1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FAM171A1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for FAM171A1

Search Tocris compounds for FAM171A1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for FAM171A1

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FAM171A1 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for FAM171A1

Summaries
for FAM171A1

Genomic Location
for FAM171A1

Proteins
for FAM171A1

Protein Domains/
Families
for FAM171A1

Gene Function
for FAM171A1

Pathways & Interactions
for FAM171A1

Drugs & Compounds
for FAM171A1

Transcripts
for FAM171A1

Expression
for FAM171A1

Orthologs
for FAM171A1

Paralogs
for FAM171A1

SNPs/Variants
for FAM171A1

Disorders & Mutations
for FAM171A1

Medical News
for FAM171A1

Publications
for FAM171A1

Search for FAM171A1

Genome Databases showing FAM171A1

Other Databases showing FAM171A1

Specialized Databases showing FAM171A1

Licensable Technologies
for FAM171A1

Services
for FAM171A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FAM171A1 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor FAM171A1

Summariesfor FAM171A1

Genomic Locationfor FAM171A1

Proteinsfor FAM171A1

Protein Domains/Familiesfor FAM171A1

Gene Functionfor FAM171A1

Pathways & Interactionsfor FAM171A1

Drugs & Compoundsfor FAM171A1

Transcriptsfor FAM171A1

Expression for FAM171A1

Orthologsfor FAM171A1

Paralogsfor FAM171A1

SNPs/Variantsfor FAM171A1

Disorders & Mutationsfor FAM171A1

Medical Newsfor FAM171A1

Publicationsfor FAM171A1

Search for FAM171A1

Genome Databases showing FAM171A1

Other Databases showing FAM171A1

Specialized Databases showing FAM171A1

Licensable Technologiesfor FAM171A1

Servicesfor FAM171A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FAM171A1

Summaries
for FAM171A1

Genomic Location
for FAM171A1

Proteins
for FAM171A1

Protein Domains/
Families
for FAM171A1

Gene Function
for FAM171A1

Pathways & Interactions
for FAM171A1

Drugs & Compounds
for FAM171A1

Transcripts
for FAM171A1

Expression
for FAM171A1

Orthologs
for FAM171A1

Paralogs
for FAM171A1

SNPs/Variants
for FAM171A1

Disorders & Mutations
for FAM171A1

Medical News
for FAM171A1

Publications
for FAM171A1

Licensable Technologies
for FAM171A1

Services
for FAM171A1