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C10orf35 Gene

protein-coding GIFtS: 40

GC10P071060

chromosome 10 open reading frame 35
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
OTTHUMP00000019727 ^²

Descriptions
chromosome 10 open reading frame 35 ^²
hypothetical protein LOC219738 ^²

External Ids
HGNC: 23519¹
Entrez Gene: 219738²
UniProtKB: Q96D05³
Ensembl: ENSG00000171224⁷

Search outside databases for aliases for C10orf35 gene

Previous GC identifer: GC10P070734

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C10orf35 gene

Entrez Gene cytogenetic band: 10q21.3 Ensembl cytogenetic band: 10q21.3 HGNC cytogenetic band: 10q22.2

C10orf35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P071060: (about GC identifiers)

Start:	71,060,009 bp from pter
End:	71,063,361 bp from pter
Size:	3,353 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ035_HUMAN, Q96D05 (See protein sequence)

Recommended Name: Uncharacterized protein C10orf35

Size: 121 amino acids; 13238 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

REFSEQ proteins: NP_660349.1

ENSEMBL proteins:

ENSP00000378495 ENSP00000362376

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for C10orf35:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for C10orf35

Assays for C10orf35:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q96D05

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf35)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145306

Applied Biosystems Silencer® siRNAs for C10orf35

Sigma-Aldrich siRNA for C10orf35

Sigma-Aldrich shRNA for C10orf35

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for C10orf35
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_145306
Myc/DDK tagged cDNA clone in CMV expression vector: NM_145306
untagged cDNA clone in CMV expression vector: NM_145306

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_145306

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf35

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf35)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145306

Sigma-Aldrich siRNA for C10orf35

Sigma-Aldrich shRNA for C10orf35

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_145306

REFSEQ mRNAs for C10orf35 gene:

NM_145306.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_145306

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145306
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145306
                                 untagged cDNA clone in CMV expression vector: NM_145306

Additional cDNA sequence: BC013587.1

2 DOTS entries:

DT.114028 DT.87015864

24/65 AceView cDNA sequences (see all 65 ):

BX095713 AA335913 AI420512 BM707732 BF437055 CA942743 CA942977 BU733254

BQ884216 AA426015 AI368631 AA084096 AA452165 BG055477 BM714109 BE904302

BC013587 AA947931 BF568253 BM459665 AW089957 BI193763 AA740545 BF591892

highest scoring ESTs for C10orf35:

H49529 AA031975 AA084096 AA293851 AA338814 AA338815 AA398343 AA428101 AA452165 AA682907

Unigene Cluster for C10orf35:

Chromosome 10 open reading frame 35

Hs.522992 [show with all ESTs]

Unigene Representative Sequence: BC013587

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf35

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c
SP1:					-		-
SP2:
SP3:							-
SP4:					-		-

About this scheme

ECgene alternative splicing isoforms for C10orf35

2 Ensembl transcripts including schematic representations:

ENST00000395055 ENST00000373279

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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C10orf35 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf35

¹ / ² / ³

5 probe-sets matching C10orf35 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
48736_f_at²^{, 3}	U95-C	1	1.00	1.00	0.91	1.17	H49529	1.00	1.00	1.00	1
48734_at²^{, 3}	U95-C	1	1.00	1.00	0.85	1.28	AA452165	0.80	1.00	0.91	1
48735_i_at²^{, 3}	U95-C	1	1.00	1.00	0.95	0.59	H49529	1.00	1.00	1.00	1
226313_at²^{, 3}	U133-B	1	1.00	1.00	--	--	H49529	1.00	1.00	1.00	1
226313_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks C10orf35 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCGACGTCTC

SOURCE GeneReport for Unigene cluster: Hs.522992

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for C10orf35 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC479235¹	--	hypothetical LOC479235	90(n) 92.5(a)	479235 XM_536377.2 XP_536377.1
chimpanzee (Pan troglodytes)	LOC746867¹	--	similar to Chromosome 10 open reading frame 35	99.17(n) 100(a)	746867 XM_001169572.1 XP_001169572.1
cow (Bos taurus)	C28H10ORF35¹	--	chromosome 10 open reading frame 35 ortholog	88.89(n) 93.33(a)	510161 XM_001251032.1 XP_001251033.1
rat (Rattus norvegicus)	RGD1305587¹	--	similar to RIKEN cDNA 2010107G23	85.28(n) 93.33(a)	294499 XM_215413.2 XP_215413.2
mouse (Mus musculus)	2010107G23Rik^{1, 5}	10⁵	RIKEN cDNA 2010107G23 gene^{1, 5}	85.56(n)¹ 93.33(a)¹	69894¹ NM_027251.3¹ NP_081527.1¹ AA545165⁵ AK035688⁵ (see all 8)

About this table Species with no ortholog for C10orf35

ENSEMBL Gene Tree for C10orf35

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/55 NCBI SNPs in C10orf35 are shown (see all 55 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 62)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs2616095^1,2	A,C,F,H	71058517(-)	`ATGTCG/ATTGAT`	1	--	ng5¹		3		EU EA	300
	rs1132075^1,2	A,C,F,H	71063031(+)	`TTCCCG/AAGATA`	1	--	ut3¹ ese³		12		MN NA EU EA WA	1164
	rs899022^1,2	A,C,F,H	71063502(-)	`CTGCGA/TTCCTA`	1	--	ng3¹		16		EU EA WA NA	1472
--	rs2812577^1,2	A,C	71058590(+)	`TGTGCA/GCATTG`	1	--	ng5¹		0	--	--	--	--
	rs10998884^1,2	A,C	71059679(+)	`CAAACA/GTAACA`	1	--	ng5¹		0	--	--	--	--
	rs2616094^1,2	A,C	71058661(-)	`GTGCAC/TGCATG`	1	--	ng5¹		0	--	--	--	--
--	rs2812576^1,2	A,C	71058496(+)	`CATGCA/CCAGAT`	1	--	ng5¹		0	--	--	--	--
	rs2616096^1,2	A,C	71058291(-)	`TGCCAA/GAGAGA`	1	--	ng5¹		0	--	--	--	--
	rs2812578^1,2	A,C	71058821(+)	`GAGCAC/TGTACT`	1	--	ng5¹		0	--	--	--	--
	rs2616093^1,2	A	71059872(-)	`GATGGA/GGCGTG`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for C10orf35 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for C10orf35 gene:

The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Protein-protein interaction panel using mouse full-length cDNAs. (PubMed id 11591653)³ Suzuki H....Hayashizaki Y. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 219738	HGNC: 23519	AceView: C10orf35	Ensembl:ENSG00000171224	euGenes: HUgn219738
ECgene: C10orf35	H-InvDB: C10orf35

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for C10orf35
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for C10orf35:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf35-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for C10orf35		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for C10orf35		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for C10orf35

Search Tocris compounds for C10orf35

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for C10orf35

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C10orf35 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for C10orf35

Summaries
for C10orf35

Genomic Location
for C10orf35

Proteins
for C10orf35

Protein Domains/
Families
for C10orf35

Gene Function
for C10orf35

Pathways & Interactions
for C10orf35

Drugs & Compounds
for C10orf35

Transcripts
for C10orf35

Expression
for C10orf35

Orthologs
for C10orf35

Paralogs
for C10orf35

SNPs/Variants
for C10orf35

Disorders & Mutations
for C10orf35

Medical News
for C10orf35

Publications
for C10orf35

Search for C10orf35

Genome Databases showing C10orf35

Other Databases showing C10orf35

Specialized Databases showing C10orf35

Licensable Technologies
for C10orf35

Services
for C10orf35

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf35 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor C10orf35

Summariesfor C10orf35

Genomic Locationfor C10orf35

Proteinsfor C10orf35

Protein Domains/Familiesfor C10orf35

Gene Functionfor C10orf35

Pathways & Interactionsfor C10orf35

Drugs & Compoundsfor C10orf35

Transcriptsfor C10orf35

Expression for C10orf35

Orthologsfor C10orf35

Paralogsfor C10orf35

SNPs/Variantsfor C10orf35

Disorders & Mutationsfor C10orf35

Medical Newsfor C10orf35

Publicationsfor C10orf35

Search for C10orf35

Genome Databases showing C10orf35

Other Databases showing C10orf35

Specialized Databases showing C10orf35

Licensable Technologiesfor C10orf35

Servicesfor C10orf35

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf35

Summaries
for C10orf35

Genomic Location
for C10orf35

Proteins
for C10orf35

Protein Domains/
Families
for C10orf35

Gene Function
for C10orf35

Pathways & Interactions
for C10orf35

Drugs & Compounds
for C10orf35

Transcripts
for C10orf35

Expression
for C10orf35

Orthologs
for C10orf35

Paralogs
for C10orf35

SNPs/Variants
for C10orf35

Disorders & Mutations
for C10orf35

Medical News
for C10orf35

Publications
for C10orf35

Licensable Technologies
for C10orf35

Services
for C10orf35