C10orf35 Gene
protein-coding GIFtS : 45
GCID: GC10 P071390
chromosome 10 open reading frame 35
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Aliasesfor C10orf35 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome 10 Open Reading Frame 35 1 2 Uncharacterized Protein C10orf352
Export aliases for C10orf35 gene to outside databases Previous GC identifers: GC10P070734 GC10P071060 GC10P065379
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Summariesfor C10orf35 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor C10orf35 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.1 NT_030059.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the C10orf35 gene promoter: Tal-1 AP-4 Tal-1beta E47 S8 PPAR-gamma1 NRF-2 PPAR-gamma2 Pax-4a ITF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for C10orf35 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat C10orf35
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.2 C10orf35 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P071390: view genomic region
(about GC identifiers )
Start:
71,390,003 bp from pter
End:
71,393,355 bp from pter
Size:
3,353 bases
Orientation:
plus strand
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Proteinsfor C10orf35 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CJ035_HUMAN, Q96D05 (See
protein sequence )Recommended Name: Uncharacterized protein C10orf35 Size : 121 amino acids; 13238 Da
Subcellular location : Membrane; Single-pass membrane protein (Potential)Alternative splicing : 2 isoforms : Q96D05-1 Q96D05-2 Explore the universe of human proteins at neXtProt for C10orf35: NX_Q96D05 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96D05 C10orf35 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_660349.1 ENSEMBL proteins: ENSP00000362376 ENSP00000398621 Human Recombinant Protein Products for C10orf35: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
C10orf35 for ontologies About GeneDecksing C10orf35 Antibody Products: Assay Products for C10orf35:
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Protein
Domains / Familiesfor C10orf35 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q96D05
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Functionfor C10orf35 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
-- --
C10orf35 for ontologies About GeneDecksing Phenotypes: 2 GenomeRNAi human phenotypes for C10orf35 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C10orf35 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C10orf35OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C10orf35 (NM_145306 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C10orf35 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C10orf35
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf35
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Pathways & Interactionsfor C10orf35 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C10orf35 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)5/6 Interacting proteins for C10orf35 (Q96D05 3 ENSP00000362376 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table
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Drugs & Compoundsfor C10orf35 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for C10orf35 Search CenterWatch for drugs/clinical trials and news about C10orf35 / CJ035
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Transcriptsfor C10orf35 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
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shRNA from
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Tagged/untagged cDNA clones from
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Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for C10orf35 gene: NM_145306.2 Unigene Cluster for C10orf35:
Chromosome 10 open reading frame 35 Hs.522992 [show with all ESTs ] Unigene Representative Sequence: BC013587 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000491890 ENST00000373279 (uc001jpq.4 ) ENST00000421716 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C10orf35 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C10orf35OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C10orf35 (NM_145306 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C10orf35 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C10orf35
Additional cDNA sequence: BC013587.1
2 DOTS entries : DT.114028 DT.87015864
24/65 AceView cDNA sequences (see all 65 ):
AI420512 AA335913 BX095713 BM707732 CA942743 CA942977 BU733254 BF437055 BQ884216 BG055477 AW089957 AA338814 AI968970 BI193763 AA426015 AI368631 BF591892 BV204557 AI197950 BC013587 BE904302 AA293851 AI288193 AA452165 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf35 About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c SP1 :     -   -             SP2 :                   SP3 :       -             SP4 :     -   -            
ECgene alternative splicing isoforms for C10orf35
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Expression for C10orf35 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section C10orf35 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCGACGTCTCAbout this image C10orf35 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See C10orf35 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for C10orf35 SOURCE GeneReport for Unigene cluster: Hs.522992 SABiosciences Custom PCR Arrays for C10orf35 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C10orf35Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat C10orf35 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C10orf35 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C10orf35 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf35
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Orthologsfor C10orf35 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for C10orf35 gene from 3/12 species (see all 12 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
2010107G23Rik1 , 5
RIKEN cDNA 2010107G23 gene1, 5
85.56(n) 1 93.33(a) 1
 
10 (32.34 cM) 5 69894 1 NM_027251.3 1 NP_081527.1 1 62107655 5
lizard (Anolis carolinensis)
Reptilia
C10orf356
--
75(a)
1 ↔ 1
GL343215.1(2434248-2434463)
African clawed frog (Xenopus laevis)
Amphibia
Xl.71132
Xenopus laevis transcribed sequences
73.24(n)
 
AW634674.1
ENSEMBL Gene Tree for C10orf35 (if available)TreeFam Gene Tree for C10orf35 (if available)
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Paralogsfor C10orf35 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor C10orf35 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 10 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for C10orf35 (71390003 - 71393355 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for C10orf35 1 CNV : 6879
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C10orf35
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Disorders
/ Diseasesfor C10orf35 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
C10orf35 for disorders About GeneDecksing 1 disease for C10orf35 : About MalaCards alzheimer's disease Human Genome Epidemiology (HuGE) Navigator: C10orf35 (2 documents) Export disorders for C10orf35 gene to outside databases
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Publicationsfor C10orf35 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for C10orf35 gene integrated from 9 sources : (articles sorted by number of sources associating them with C10orf35) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054) 1 , 2 Deloukas P.... Rogers J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976) 2 Daub H.... Mann M. (2008) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451) 1 Grupe A....Goate A. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Protein-protein interaction panel using mouse full-length cDNAs. (PubMed id 11591653) 1 Suzuki H....Hayashizaki Y. (2001)
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External Searches for C10orf35 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing C10orf35 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing C10orf35 gene
(According to HUGE )
About This Section --
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Specialized Databases showing C10orf35 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for C10orf35 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for C10orf35 gene: Search GeneIP for patents involving C10orf35 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor C10orf35 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for C10orf35 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for C10orf35 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C10orf35 OriGene Protein Over-expression Lysate for C10orf35 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for C10orf35 OriGene 3'-UTR Clone for C10orf35 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C10orf35 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C10orf35 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for C10orf35 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for C10orf35 OriGene Custom Protein Services for C10orf35 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C10orf35 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C10orf35 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat C10orf35 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat C10orf35 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C10orf35 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C10orf35
C10orf35 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf35
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C10orf35
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Aliases for C10orf35
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