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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C10orf35 Gene

protein-coding   GIFtS: 45
GCID: GC10P071390

Chromosome 10 Open Reading Frame 35

Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 10 Open Reading Frame 351 2
Uncharacterized Protein C10orf352

External Ids:    HGNC: 235191   Entrez Gene: 2197382   Ensembl: ENSG000001712247   UniProtKB: Q96D053   

Export aliases for C10orf35 gene to outside databases

Previous GC identifers: GC10P070734 GC10P071060 GC10P065379


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C10orf35 Gene: 
C10orf35 (chromosome 10 open reading frame 35) is a protein-coding gene. Diseases associated with C10orf35 include alzheimer's disease.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C10orf35 gene promoter:
         Tal-1   AP-4   Tal-1beta   E47   S8   PPAR-gamma1   NRF-2   PPAR-gamma2   Pax-4a   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C10orf35

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.2

C10orf35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf35 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P071390:  view genomic region     (about GC identifiers)

Start:
71,390,003 bp from pter      End:
71,393,355 bp from pter
Size:
3,353 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CJ035_HUMAN, Q96D05 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf35  
Size: 121 amino acids; 13238 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Alternative splicing: 2 isoforms:  Q96D05-1   Q96D05-2   

Explore the universe of human proteins at neXtProt for C10orf35: NX_Q96D05

Explore proteomics data for C10orf35 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96D05

  • C10orf35 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C10orf35 Protein Expression
    REFSEQ proteins: NP_660349.1  
    ENSEMBL proteins: 
     ENSP00000362376   ENSP00000398621  

    Human Recombinant Protein Products for C10orf35: 
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    Cloud-Clone Corp. Proteins for C10orf35 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    C10orf35 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96D05


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    C10orf35 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for C10orf35:
     Decreased TP53 protein express  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C10orf35 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf35


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C10orf35

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/6 Interacting proteins for C10orf35 (Q96D053 ENSP000003623764) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC39A11Q8N1S53, ENSP000002555594I2D: score=4 STRING: ENSP00000255559
    ARL6IP5O759153I2D: score=3 
    MS4A10Q96PG23I2D: score=3 
    NIPA2Q8N8Q93I2D: score=2 
    CAMLGP490693I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C10orf35 (CJ035)

    Search CenterWatch for drugs/clinical trials and news about C10orf35 / CJ035

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C10orf35 gene: 
    NM_145306.2  

    Unigene Cluster for C10orf35:

    Chromosome 10 open reading frame 35
    Hs.522992  [show with all ESTs]
    Unigene Representative Sequence: BC013587
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491890 ENST00000373279(uc001jpq.4) ENST00000421716

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate C10orf35:
    hsa-miR-642a hsa-miR-3121-3p hsa-miR-18b*
    SwitchGear 3'UTR luciferase reporter plasmidC10orf35 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for C10orf35
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C10orf35
    Clone
    Products:
         
    OriGene clones in human, mouse for C10orf35 (see all 7)
    OriGene ORF clones in mouse, rat for C10orf35
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C10orf35 (NM_145306)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C10orf35
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C10orf35
    Sirion Biotech Customized lentivirus for stable overexpression of C10orf35 
                         Customized lentivirus expression plasmids for stable overexpression of C10orf35 
    Primer
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    OriGene qPCR primer pairs and template standards for C10orf35
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C10orf35
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C10orf35

    Additional mRNA sequence: BC013587.1 

    2 DOTS entries:

    DT.114028  DT.87015864 

    24/65 AceView cDNA sequences (see all 65):

    BM707732 CA942977 BU733254 CA942743 BF437055 AI420512 BX095713 BQ884216 
    AA335913 AA398343 AA947931 AA426015 AI694330 AA452165 AA452397 AI368631 
    BV204557 BE904302 AA682907 BI521387 AI968970 AA740545 BM714109 BM676116 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf35    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:              -     -                                 
    SP2:                                                      
    SP3:                    -                                 
    SP4:              -     -                                 


    ECgene alternative splicing isoforms for C10orf35

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C10orf35 expression in normal human tissues (normalized intensities)      C10orf35 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGACGTCTC
    C10orf35 Expression
    About this image


    C10orf35 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             sperm   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Brain (Nervous System)
             medial temporal gyrus   

    See C10orf35 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C10orf35

    SOURCE GeneReport for Unigene cluster: Hs.522992
        SABiosciences Custom PCR Arrays for C10orf35
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C10orf35 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2010107G23Rik1 , 5 RIKEN cDNA 2010107G23 gene1, 5 85.56(n)1
    93.33(a)1
      10 (32.34 cM)5
    698941  NM_027251.31  NP_081527.11 
     621076555 
    lizard
    (Anolis carolinensis)
    Reptilia C10ORF356
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343215.1(2427255-2437270)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.71132 Xenopus laevis transcribed sequences 73.24(n)    AW634674.1 


    ENSEMBL Gene Tree for C10orf35 (if available)
    TreeFam Gene Tree for C10orf35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/146 SNPs in C10orf35 are shown (see all 146)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437778791,2
    --71388023(+) CAAAGC/TCTTGC 1 -- us2k10--------
    rs1481388591,2
    --71388057(+) CAGACA/GGTAGG 1 -- us2k10--------
    rs1412242081,2
    C--71388249(+) CTCTCA/GACTCT 1 -- us2k10--------
    rs741393141,2
    C,F--71388275(+) CTGGAG/CTGTAT 1 -- us2k13Minor allele frequency- C:0.05WA CSA 122
    rs26160961,2
    C,F,A,H--71388285(-) TGCCAA/GAGAGA 1 -- us2k110Minor allele frequency- G:0.45NA WA CSA EA 371
    rs1453035271,2
    --71388289(+) TCTGGC/TAGCAG 1 -- us2k10--------
    rs1886841751,2
    --71388362(+) CAGCCC/TACAGA 1 -- us2k10--------
    rs1166069561,2
    C,F--71388369(+) CAGAGG/ATTACC 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1920450871,2
    --71388434(+) AGGCAA/GTGTTT 1 -- us2k10--------
    rs1842363821,2
    --71388443(+) TTCTCA/GGCCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C10orf35 (71390003 - 71393355 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C10orf35:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509356CNV Insertion20534489
    nsv7032CNV Insertion18451855
    esv32737CNV Gain+Loss17666407

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for C10orf35:    About MalaCards
    alzheimer's disease    


    C10orf35 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): C10orf35
    Human Genome Epidemiology (HuGE) Navigator: C10orf35 (2 documents)

    Export disorders for C10orf35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C10orf35 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with C10orf35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Genome-wide association study of Alzheimer's disease w ith psychotic symptoms. (PubMed id 22005930)4 Hollingworth P....Williams J. (2012)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219738 HGNC: 23519 AceView: C10orf35 Ensembl:ENSG00000171224 euGenes: HUgn219738
    ECgene: C10orf35 H-InvDB: C10orf35

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C10orf35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C10orf35 gene:
    Search GeneIP for patents involving C10orf35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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