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Aliases for C10orf35 Gene

Aliases for C10orf35 Gene

  • Chromosome 10 Open Reading Frame 35 2 3 5

External Ids for C10orf35 Gene

Previous GeneCards Identifiers for C10orf35 Gene

  • GC10P070734
  • GC10P071060
  • GC10P071390
  • GC10P065379

Summaries for C10orf35 Gene

GeneCards Summary for C10orf35 Gene

C10orf35 (Chromosome 10 Open Reading Frame 35) is a Protein Coding gene. Diseases associated with C10orf35 include Uterine Benign Neoplasm.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf35 Gene

Genomics for C10orf35 Gene

Regulatory Elements for C10orf35 Gene

Enhancers for C10orf35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G069445 1.6 Ensembl ENCODE dbSUPER 10.5 -180.7 -180651 9.0 FOXA2 PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 ZNF766 CBX5 ZNF143 TSPAN15 CCAR1 DDX50 DDX21 C10orf35 TYSND1 TACR2 AIFM2 GC10M069447 ATP5G1P7
GH10G069898 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +270.1 270064 4.5 PKNOX1 ZNF76 RAD21 YY1 GATA2 CREM EGR2 SMARCA5 ZBTB11 USF2 C10orf35 H2AFY2 LOC105378347 LOC102723350
GH10G069315 1.7 FANTOM5 ENCODE dbSUPER 9.8 -311.5 -311546 7.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 SIN3A ZNF2 ZNF207 FOS HK1 DDX21 ENSG00000231748 HKDC1 TYSND1 C10orf35 DDX50 RPS15AP28 TACR2
GH10G069425 1.5 Ensembl ENCODE dbSUPER 10.7 -204.1 -204133 2.0 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 FOS ZHX2 MXD4 REST TSPAN15 C10orf35 ENSG00000231748 HK1 TACR2 GC10M069433
GH10G069865 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 +237.6 237647 4.6 CTCF SIN3A RBBP5 CHD7 RAD21 ZNF23 ZFHX2 GATA2 ZMIZ1 EGR2 C10orf35 COL13A1 LOC105378347 LOC102723350
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C10orf35 on UCSC Golden Path with GeneCards custom track

Promoters for C10orf35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029271 157 801 ATF1 ARNT SIN3A GLI4 ZNF2 ZBTB7B GLIS2 ELK1 KLF7 ZNF548

Genomic Location for C10orf35 Gene

Chromosome:
10
Start:
69,630,243 bp from pter
End:
69,633,599 bp from pter
Size:
3,357 bases
Orientation:
Plus strand

Genomic View for C10orf35 Gene

Genes around C10orf35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf35 Gene

Proteins for C10orf35 Gene

  • Protein details for C10orf35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D05-CJ035_HUMAN
    Recommended name:
    Uncharacterized protein C10orf35
    Protein Accession:
    Q96D05

    Protein attributes for C10orf35 Gene

    Size:
    121 amino acids
    Molecular mass:
    13238 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C10orf35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C10orf35 Gene

Post-translational modifications for C10orf35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C10orf35 Gene

No data available for DME Specific Peptides for C10orf35 Gene

Domains & Families for C10orf35 Gene

Protein Domains for C10orf35 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf35: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C10orf35 Gene

Function for C10orf35 Gene

Gene Ontology (GO) - Molecular Function for C10orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C10orf35: view
genes like me logo Genes that share phenotypes with C10orf35: view

Animal Model Products

CRISPR Products

miRNA for C10orf35 Gene

miRTarBase miRNAs that target C10orf35

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C10orf35 Gene

Localization for C10orf35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf35 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf35 gene
Compartment Confidence
plasma membrane 2
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C10orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C10orf35: view

Pathways & Interactions for C10orf35 Gene

SuperPathways for C10orf35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C10orf35 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf35 Gene

Drugs & Compounds for C10orf35 Gene

No Compound Related Data Available

Transcripts for C10orf35 Gene

Unigene Clusters for C10orf35 Gene

Chromosome 10 open reading frame 35:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf35 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2:
SP3: -
SP4: - -

Relevant External Links for C10orf35 Gene

GeneLoc Exon Structure for
C10orf35
ECgene alternative splicing isoforms for
C10orf35

Expression for C10orf35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C10orf35 Gene

mRNA differential expression in normal tissues according to GTEx for C10orf35 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.3) and Brain - Cerebellum (x4.6).

Protein differential expression in normal tissues from HIPED for C10orf35 Gene

This gene is overexpressed in Bone (41.3), Fetal Brain (8.5), and Frontal cortex (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C10orf35 Gene



Protein tissue co-expression partners for C10orf35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C10orf35 Gene:

C10orf35

SOURCE GeneReport for Unigene cluster for C10orf35 Gene:

Hs.522992

Evidence on tissue expression from TISSUES for C10orf35 Gene

  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with C10orf35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf35 Gene

Orthologs for C10orf35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10orf35 35
  • 100 (a)
OneToOne
C10H10orf35 34
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia C28H10ORF35 35
  • 94 (a)
OneToOne
C28H10orf35 34
  • 89.44 (n)
dog
(Canis familiaris)
Mammalia C10orf35 35
  • 93 (a)
OneToOne
C4H10orf35 34
  • 90 (n)
mouse
(Mus musculus)
Mammalia 2010107G23Rik 34 16 35
  • 85.56 (n)
rat
(Rattus norvegicus)
Mammalia RGD1305587 34
  • 85.28 (n)
oppossum
(Monodelphis domestica)
Mammalia C10orf35 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf35 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C10orf35 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf35 34
  • 64.1 (n)
Str.16059 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7113 34
Species where no ortholog for C10orf35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C10orf35 Gene

ENSEMBL:
Gene Tree for C10orf35 (if available)
TreeFam:
Gene Tree for C10orf35 (if available)

Paralogs for C10orf35 Gene

No data available for Paralogs for C10orf35 Gene

Variants for C10orf35 Gene

Sequence variations from dbSNP and Humsavar for C10orf35 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000455268 -- 69,633,867(+) CTCTG(G/T)CCAGA downstream-variant-500B
rs1002035953 -- 69,632,415(+) ATCGC(A/G)CCATT intron-variant
rs1002698837 -- 69,629,685(+) AAACA(C/T)CAGGA upstream-variant-2KB
rs1002930281 -- 69,633,379(+) CAGCT(A/G)GATGC utr-variant-3-prime
rs1003210981 -- 69,632,032(+) GACTT(C/G)ACAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf35 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV gain+loss 17666407
nsv509356 CNV insertion 20534489
nsv7032 CNV insertion 18451855

Variation tolerance for C10orf35 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C10orf35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf35 Gene

Disorders for C10orf35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C10orf35 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
uterine benign neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C10orf35

Genetic Association Database (GAD)
C10orf35
Human Genome Epidemiology (HuGE) Navigator
C10orf35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C10orf35
genes like me logo Genes that share disorders with C10orf35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C10orf35 Gene

Publications for C10orf35 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (PMID: 24509480) . … Morris A.P. (Nat. Genet. 2014) 3 64

Products for C10orf35 Gene

Sources for C10orf35 Gene

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