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PYROXD2 Gene

protein-coding   GIFtS: 40

GC10M100134
pyridine nucleotide-disulphide oxidoreductase domain 2
(Previous name: chromosome 10 open reading frame 33 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C10orf33)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
C10orf33 2, 3
EC 1.-.-.- 3
FLJ12197 2
FLJ23849 1, 2
FP3420 2
MGC13047 2
OTTHUMP00000020249 2
Descriptions
chromosome 10 open reading frame 33 1
pyridine nucleotide-disulphide oxidoreductase domain 2 2
External Ids
HGNC: 235171
Entrez Gene: 847952
UniProtKB: Q8N2H33
Ensembl: ENSG000001199437
Search outside databases for aliases for PYROXD2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: PYRD2_HUMAN, Q8N2H3
Function: Probable oxidoreductase (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.2   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24.2

PYROXD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M100134:     (about GC identifiers)

Start:
100,133,314 bp from pter
End:
100,164,931 bp from pter
Size:
31,618 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PYRD2_HUMAN, Q8N2H3 (See protein sequence)
Recommended Name: Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2  
Size: 581 amino acids; 63068 Da
Secondary accessions: Q5TAA9 Q9BRQ1

REFSEQ proteins: NP_116098.2  

ENSEMBL proteins: 
ENSP00000359607 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (PYROXD2)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for PYROXD2: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (PYROXD2), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for PYROXD2

Assays for PYROXD2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR013027 FAD_pyr_nucl-diS_OxRdtase


   GeneDecks  PYROXD2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8N2H3

ProtoNet protein and cluster: Q8N2H3

UniProtKB/Swiss-Prot: PYRD2_HUMAN, Q8N2H3
Similarity: Belongs to the carotenoid/retinoid oxidoreductase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PYROXD2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032709

              Applied Biosystems Silencer® siRNAs for PYROXD2

              Sigma-Aldrich siRNA for PYROXD2  
                     Sigma-Aldrich shRNA for PYROXD2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for PYROXD2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032709
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032709
                                 untagged cDNA clone in CMV expression vector: NM_032709 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_032709

UniProtKB/Swiss-Prot: PYRD2_HUMAN, Q8N2H3
Function: Probable oxidoreductase (By similarity)
Enzyme Number (IUBMB): EC 1.-.-.- 

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016491 oxidoreductase activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0055114 oxidation reduction IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PYROXD2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PYROXD2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032709

              Sigma-Aldrich siRNA for PYROXD2  
                     Sigma-Aldrich shRNA for PYROXD2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_032709  

REFSEQ mRNAs for PYROXD2 gene: 

NM_032709.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_032709  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032709
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032709
                                 untagged cDNA clone in CMV expression vector: NM_032709 

Additional cDNA sequence: 

AK022259.1 AK074429.1 AK075265.1 AK123713.1 AK225637.1 AK295699.1 BC006131.1 BC035712.1 
BC050574.1 CR597626.1 CR620799.1 

10 DOTS entries:

DT.410149  DT.97839792  DT.100758181  DT.40131826  DT.101982390  DT.121290374  DT.100019759  DT.100662346 
DT.101979638  DT.424805 

24/218 AceView cDNA sequences (see all 218 ):

CR593063 BE048783 CR625584 CD673355 BM758873 BX282181 BG388727 BC035712 
CR620028 BU629693 CA488995 BC000175 BX451587 AI219272 BE747083 BU196145 
AW674329 BX092521 AA649872 BG757528 AW675059 NM_182639 Z40097 NM_182637 

Unigene Cluster for PYROXD2:

Pyridine nucleotide-disulphide oxidoreductase domain 2
Hs.238303  [show with all ESTs]
Unigene Representative Sequence: BC050574


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for PYROXD2

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b
SP1:                                                                                      -                 -                 -                     
SP2:                                                                                                        -                                       
SP3:                                                                                      -                                                         
SP4:              -                                                                                                                                 
SP5:                                                                                                                                                

About this scheme

ECgene alternative splicing isoforms for PYROXD2

1 Ensembl transcript including schematic representation:
ENST00000370575  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PYROXD2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for PYROXD2

1 / 2

7 probe-sets matching PYROXD2 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
57817_at2 U95-C 1 1.00 1.00 0.75 1.05 -- -- -- -- --

51785_s_at2 U95-C 1 1.00 1.00 0.74 1.09 -- -- -- -- --

58857_at*2 U95-B 1 0.94 1.00 0.20 0.87 -- -- -- -- --

232942_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

228384_s_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

232942_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

228384_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  PYROXD2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GACTGGTTCT

SOURCE GeneReport for Unigene cluster: Hs.238303
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for PYROXD2 gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC4777901   -- similar to F37C4.6 88.93(n)
90.66(a)
477790  XM_534984.2  XP_534984.2 
cow
(Bos taurus)
C26H10orf331   -- chromosome 10 open reading frame 33 ortholog 86.46(n)
85.89(a)
519120  NM_001034532.1  NP_001029704.1 
rat
(Rattus norvegicus)
RGD13032321   -- Phytn_dehydro and Pyr_redox domain containing protein more 84.05(n)
86.06(a)
309381  NM_001004261.1  NP_001004261.1 
mouse
(Mus musculus)
Pyroxd25
4833409A17Rik1
195
pyridine nucleotide-disulphide oxidoreductase domain more5
RIKEN cDNA 4833409A17 gene1
84.17(n)1
84.51(a)1
745801  NM_029011.21  NP_083287.21 
 AK0146685  AK0384145  (see all 13)
chicken
(Gallus gallus)
C10orf331   -- chromosome 10 open reading frame 33 73.39(n)
75.05(a)
425345  XM_423118.2  XP_423118.2 
About this table        Species with no ortholog for PYROXD2

ENSEMBL Gene Tree for PYROXD2
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/298 NCBI SNPs in PYROXD2 are shown (see all 298 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 181)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs21478961,2
A,C,F,H,O100138166(-) GTACAC/TGCCCT 1 T/M mis1 ese320Minor allele frequency- G:0.01EA NA EU WA 2962
rs22742441,2
A,C,F,H100165208(-) CCTCAT/CCTGTA 1 -- ng314Minor allele frequency- C:0.41EU EA WA 412
rs22742431,2
A,C,F,H100165257(-) GCTCCA/GCTCTG 1 -- ng314Minor allele frequency- G:0.41EU EA WA 412
rs22964411,2
C,F,H100134772(-) ACTTCG/ACCCGC 1 T/A mis1 ese310Minor allele frequency- A:0.43MN EU EA WA NA 1086
rs22742451,2
A,C,F100165072(-) CTCCCG/AACGGC 1 -- ng315Minor allele frequency- A:0.40EA NA 1708
rs22742461,2
A,C,F100165050(-) CCAGGG/ACAGCA 1 -- ng311Minor allele frequency- A:0.40EA 1456
--
rs79052651,2
A,C100133183(+) gaagtC/Gctggg 1 -- ng510--------
rs111895961,2
H100157730(+) AGTCTC/GTGCAG 1 Q/H mis1 ese34Minor allele frequency- G:0.00EU EA WA 406
rs22964371,2
F100164913(-) AACTCC/GCTGCC 1 -- ut51 ese31Minor allele frequency- G:0.02EA 1492
--
rs178561701,2
H100140355(+) GGAAGG/ACAGGC 1 P/S mis14Minor allele frequency- A:0.00EU EA WA 418
About this table

HapMap Linkage Disequilibrium images for PYROXD2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

6 PubMed articles for PYROXD2 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 84795 HGNC: 23517 AceView: HPS1andC10orf33 Ensembl:ENSG00000119943 euGenes: HUgn84795
ECgene: PYROXD2 H-InvDB: PYROXD2
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for PYROXD2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for PYROXD2-related products

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 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


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 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for PYROXD2 Browse small molecules at Sigma-Aldrich
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