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C10orf32 Gene

protein-coding GIFtS: 34

GC10P104608

chromosome 10 open reading frame 32
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp686B2219 ^²
FLJ40752 ^¹, ²
MGC27171 ^²
OTTHUMP00000020385 ^²
OTTHUMP00000020386 ^²
RP11-753C18.6 ^²

Descriptions
chromosome 10 open reading frame 32 ^²
hypothetical protein LOC119032 ^²

External Ids
HGNC: 23516¹
Entrez Gene: 119032²
UniProtKB: Q96B45³
Ensembl: ENSG00000166275⁷

Search outside databases for aliases for C10orf32 gene

Previous GC identifers: GC10P104278 GC10P104604

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C10orf32 gene

Entrez Gene cytogenetic band: 10q24.32 Ensembl cytogenetic band: 10q24.32 HGNC cytogenetic band: 10q24.33

C10orf32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P104608: (about GC identifiers)

Start:	104,603,970 bp from pter
End:	104,651,641 bp from pter
Size:	47,672 bases
Orientation:	plus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ032_HUMAN, Q96B45 (See protein sequence)

Recommended Name: UPF0693 protein C10orf32

Size: 105 amino acids; 11564 Da

Secondary accessions: B2R488 B3KUW4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001129672.1 NP_653192.2

ENSEMBL proteins:

ENSP00000358895 ENSP00000299353 ENSP00000347370 ENSP00000342331 ENSP00000358899

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: C10orf32

Antibodies for C10orf32:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for C10orf32

Assays for C10orf32:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q96B45

UniProtKB/Swiss-Prot: CJ032_HUMAN, Q96B45

Similarity: Belongs to the UPF0693 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf32)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_144591

Applied Biosystems Silencer® siRNAs for C10orf32

Sigma-Aldrich siRNA for C10orf32

Sigma-Aldrich shRNA for C10orf32

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for C10orf32
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001136200
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001136200
untagged cDNA clones in CMV expression vector (see all 2): NM_001136200

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_144591

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf32

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf32)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_144591

Sigma-Aldrich siRNA for C10orf32

Sigma-Aldrich shRNA for C10orf32

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001136200 NM_144591

REFSEQ mRNAs for C10orf32 gene (2 alternative transcripts):

NM_001136200.1 NM_144591.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001136200 NM_144591

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001136200
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001136200
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001136200

24/261 AceView cDNA sequences (see all 261 ):

BE907345 BQ708132 AA976545 AI126419 AA476377 BX452092 BU189046 CA312126

CA777536 AK098071 BQ186811 AI628634 AV762757 AA234980 BX279728 AI652047

CA444341 BF196047 AW161513 AI580507 AV650805 N42402 AW301647 BM887676

highest scoring ESTs for C10orf32:

AI126419 AI219645 BI259247 DB577059 AI026812 AI458532 AI652047 AW020576 AW957869 BC015994

GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations:

ENST00000369879 ENST00000299353 ENST00000355230 ENST00000339834 ENST00000369883

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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C10orf32 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf32

¹ / ² / ³

9 probe-sets matching C10orf32 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
63640_s_at²^{, 3}	U95-C	1	1.00	1.00	0.86	1.42	AI126419	0.80	0.70	0.75	1
65742_at²^{, 3}	U95-C	1	1.00	1.00	0.90	0.91	AI652047	0.60	0.62	0.61	1
78696_at²^{, 3}	U95-E	1	1.00	1.00	0.88	1.08	W15483	0.60	0.62	0.61	1
71574_at²	U95-D	2	1.00	0.50	0.92	0.84	--	--	--	--	--
64102_at²^{, 3}	U95-C	2	0.94	0.50	0.85	0.78	AI563922	0.20	0.10	0.16	2
225334_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI147621	0.40	0.50	0.45	1
223652_at²^{, 3}	U133-B	2	0.91	0.46	--	--	AF226730	0.20	0.12	0.17	2
225334_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223652_at²	U133Plus2	2	0.91	0.46	--	--	--	--	--	--	--

GeneDecks C10orf32 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: AGTCTGTTGT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for C10orf32 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC477808¹	--	hypothetical LOC477808	92.7(n) 98.1(a)	477808 XM_535001.2 XP_535001.2
chimpanzee (Pan troglodytes)	LOC450702¹	--	similar to Chromosome 10 open reading frame 32	100(n) 100(a)	450702 XM_508006.2 XP_508006.2
cow (Bos taurus)	LOC613274¹	--	hypothetical protein LOC613274	91.75(n) 97.14(a)	613274 XM_863865.2 XP_868958.2
rat (Rattus norvegicus)	RGD1311783¹	--	similar to RIKEN cDNA 2010012O05	88.25(n) 95.24(a)	294012 XM_215266.4 XP_215266.4
mouse (Mus musculus)	2010012O05Rik^{1, 5}	19⁵	RIKEN cDNA 2010012O05 gene^{1, 5}	90.16(n)¹ 96.19(a)¹	66439¹ NM_025563.3¹ NP_079839.1¹ AI413851⁵ AI467257⁵ (see all 10)

About this table Species with no ortholog for C10orf32

ENSEMBL Gene Tree for C10orf32

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/69 NCBI SNPs in C10orf32 are shown (see all 69 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 45)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4917985^1,2	A,C,F,H	104614062(+)	`AAGCTG/AGATGT`	2	--	ut3¹		11		NA EU EA WA	948
	rs9527^1,2	A,C,F,H	104613568(-)	`GGCAAG/AAGGCT`	2	--	ut3¹ ese³		9		MN NA EU EA WA	932
--	rs4919691^1,2	A,C,F,H	104614465(+)	`AATGTG/TAGAAC`	2	--	ut3¹ ese³		7		EA NA EU	516
	rs12219246^1,2	A,F,H	104603345(+)	`TAGGCA/GACAGA`	1	--	ng5¹		4		EU EA WA	418
	rs17115171^1,2	C,F,H	104614662(+)	`TGTGAT/CAATAC`	2	--	ut3¹		15		NA EU EA WA	1396
	rs7090993^1,2	F,H	104613379(+)	`TGAGAA/GTGATT`	2	--	int¹ ut3¹		4		EU EA WA	414
--	rs10883788^1,2	A,C	104612943(+)	`TGGGCA/GTGGTG`	2	--	int¹ ut3¹		0	--	--	--	--
--	rs11554411^1,2	C	104612648(+)	`AGGACA/CAGTTG`	2	Q/K	mis¹		0	--	--	--	--
--	rs17523050^1,2	F	104603935(+)	`TTCCTT/CTTCCC`	1	--	ng5¹ trp³		2		MN EA	356
--	rs12219247^1,2	A	104603351(+)	`ACAGAA/GCAAGA`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for C10orf32 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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7 PubMed articles for C10orf32 gene:

The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)³ Adams M.D....White O. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 119032	HGNC: 23516	AceView: AS3MTandC10orf32	Ensembl:ENSG00000166275	euGenes: HUgn119032
ECgene: C10orf32	H-InvDB: C10orf32

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for C10orf32
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for C10orf32:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf32-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for C10orf32		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for C10orf32		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for C10orf32

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for C10orf32

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C10orf32 Gene

protein-coding GIFtS: 34

Aliases &
Descriptions
for C10orf32

Summaries
for C10orf32

Genomic Location
for C10orf32

Proteins
for C10orf32

Protein Domains/
Families
for C10orf32

Gene Function
for C10orf32

Pathways & Interactions
for C10orf32

Drugs & Compounds
for C10orf32

Transcripts
for C10orf32

Expression
for C10orf32

Orthologs
for C10orf32

Paralogs
for C10orf32

SNPs/Variants
for C10orf32

Disorders & Mutations
for C10orf32

Medical News
for C10orf32

Publications
for C10orf32

Search for C10orf32

Genome Databases showing C10orf32

Other Databases showing C10orf32

Specialized Databases showing C10orf32

Licensable Technologies
for C10orf32

Services
for C10orf32

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf32 Gene

protein-coding GIFtS: 34

Aliases & Descriptionsfor C10orf32

Summariesfor C10orf32

Genomic Locationfor C10orf32

Proteinsfor C10orf32

Protein Domains/Familiesfor C10orf32

Gene Functionfor C10orf32

Pathways & Interactionsfor C10orf32

Drugs & Compoundsfor C10orf32

Transcriptsfor C10orf32

Expression for C10orf32

Orthologsfor C10orf32

Paralogsfor C10orf32

SNPs/Variantsfor C10orf32

Disorders & Mutationsfor C10orf32

Medical Newsfor C10orf32

Publicationsfor C10orf32

Search for C10orf32

Genome Databases showing C10orf32

Other Databases showing C10orf32

Specialized Databases showing C10orf32

Licensable Technologiesfor C10orf32

Servicesfor C10orf32

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf32

Summaries
for C10orf32

Genomic Location
for C10orf32

Proteins
for C10orf32

Protein Domains/
Families
for C10orf32

Gene Function
for C10orf32

Pathways & Interactions
for C10orf32

Drugs & Compounds
for C10orf32

Transcripts
for C10orf32

Expression
for C10orf32

Orthologs
for C10orf32

Paralogs
for C10orf32

SNPs/Variants
for C10orf32

Disorders & Mutations
for C10orf32

Medical News
for C10orf32

Publications
for C10orf32

Licensable Technologies
for C10orf32

Services
for C10orf32