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BEND7 Gene

protein-coding GIFtS: 38

GC10M013521

BEN domain containing 7
(Previous name: chromosome 10 open reading frame 30 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C10orf30)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C10orf30 ^², ³
FLJ40283 ^¹, ²
MGC35247 ^²
OTTHUMP00000019143 ^²
OTTHUMP00000019144 ^²

Descriptions
BEN domain containing 7 ^²
chromosome 10 open reading frame 30 ^¹

External Ids
HGNC: 23514¹
Entrez Gene: 222389²
UniProtKB: Q8N7W2³
Ensembl: ENSG00000165626⁷

Search outside databases for aliases for BEND7 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p14

BEND7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M013521: (about GC identifiers)

Start:	13,520,490 bp from pter
End:	13,610,539 bp from pter
Size:	90,050 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_077569.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BEND7_HUMAN, Q8N7W2 (See protein sequence)

Recommended Name: BEN domain-containing protein 7

Size: 519 amino acids; 57549 Da

Sequence caution: Sequence=CAI12222.1; Type=Erroneous gene model prediction; Sequence=CAI12223.1;

Type=Erroneous gene model prediction; Sequence=CAI12224.1; Type=Erroneous gene model prediction;

Sequence=CAI12660.1; Type=Erroneous gene model prediction; Sequence=CAI12661.1; Type=Erroneous

gene model prediction; Sequence=CAI12662.1; Type=Erroneous gene model prediction;

Secondary accessions: Q5SYY7 Q5SYY8 Q5SYY9 Q8N5T7

Alternative splicing: 2 isoforms: Q8N7W2-1 Q8N7W2-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001094382.1 NP_689964.2

ENSEMBL proteins:

ENSP00000367868 ENSP00000380107 ENSP00000380108 ENSP00000345773

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for BEND7:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for BEND7

Assays for BEND7:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8N7W2

ProtoNet protein and cluster: Q8N7W2

UniProtKB/Swiss-Prot: BEND7_HUMAN, Q8N7W2

Similarity: Contains 1 BEN domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BEND7)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001100912

Applied Biosystems Silencer® siRNAs for BEND7

Sigma-Aldrich siRNA for BEND7

Sigma-Aldrich shRNA for BEND7

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BEND7
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001100912
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001100912
untagged cDNA clones in CMV expression vector (see all 2): NM_001100912

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_152751

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for BEND7 (Q8N7W2²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
-- Q9WMX2² MINT-7050494
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BEND7

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BEND7)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001100912

Sigma-Aldrich siRNA for BEND7

Sigma-Aldrich shRNA for BEND7

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001100912 NM_152751

REFSEQ mRNAs for BEND7 gene (2 alternative transcripts):

NM_001100912.1 NM_152751.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001100912 NM_152751

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001100912
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001100912
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001100912

Additional cDNA sequence:

AK097602.1 AL832195.1 BC029597.1 BC031618.1

8 DOTS entries:

DT.413388 DT.413387 DT.100023435 DT.97828462 DT.101954149 DT.121303332 DT.40273352 DT.97789392

24/91 AceView cDNA sequences (see all 91 ):

BM720457 AA584736 AI369211 AW449649 AA256670 AI621046 BE504219 AL598920

CA431003 F13072 W15426 BU753600 AW771348 AA887433 AW236121 BM724953

BM680177 AL044899 AI912800 BE047472 BM090563 AI439140 BM679988 CD300572

Unigene Cluster for BEND7:

BEN domain containing 7

Hs.498740 [show with all ESTs]

Unigene Representative Sequence: AL832195

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for BEND7

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10
SP1:									-												-
SP2:					-

About this scheme

ECgene alternative splicing isoforms for BEND7

4 Ensembl transcripts including schematic representations:

ENST00000378605 ENST00000396898 ENST00000396900 ENST00000341083

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BEND7 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BEND7

¹ / ²

5 probe-sets matching BEND7 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
87653_at²	U95-E	1	1.00	1.00	0.73	0.77	--	--	--	--	--
65155_at²	U95-C	1	1.00	1.00	0.78	1.24	--	--	--	--	--
227341_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
227341_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553327_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BEND7 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.498740

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BEND7 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BEND7¹	--	BEN domain containing 7	86.95(n) 88.86(a)	487127 XM_544255.2 XP_544255.2
chimpanzee (Pan troglodytes)	BEND7¹	--	BEN domain containing 7	99.64(n) 99.73(a)	450314 XM_507664.2 XP_507664.2
rat (Rattus norvegicus)	Bend7¹	--	BEN domain containing 7	85.7(n) 87.74(a)	361275 XM_341560.3 XP_341561.3
mouse (Mus musculus)	Bend7^{1, 5}	2⁵	BEN domain containing 7^{1, 5}	85.52(n)¹ 86.35(a)¹	209645¹ NM_178663.3¹ NP_848778.1¹ AK003761⁵ AK030428⁵ (see all 14)
chicken (Gallus gallus)	C10orf30¹	--	chromosome 10 open reading frame 30	77.43(n) 78.57(a)	419037 XM_417230.2 XP_417230.2

About this table Species with no ortholog for BEND7

ENSEMBL Gene Tree for BEND7

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/444 NCBI SNPs in BEND7 are shown (see all 444 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 186)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1890876^1,2	A,C,F,H,O	13522737(-)	`TCAGAC/TGGACA`	2	--	int¹ ng5¹		11		NA EU EA WA	916
	rs3814659^1,2	A,C,F,H	13584870(+)	`ACCCCG/AGCTCT`	2	--	ut5¹ ese³		11		NA EA EU WA	908
	rs4750356^1,2	A,C,F,H	13520795(+)	`GGGATA/GCAGCG`	1	--	ut3¹ ese³		11		NA EU EA WA	976
	rs3814660^1,2	C,F,H	13585136(+)	`GCATAA/CCTTTG`	2	--	ng3¹		4		EU EA WA	416
--	rs7096196^1,2	A,C	13585590(+)	`agcgcA/Gcgcct`	2	--	ng3¹		0	--	--	--	--
	rs1890877^1,2	A,C	13586080(+)	`GGCAGA/GTGGGG`	2	--	ng3¹		0	--	--	--	--
--	rs7083941^1,2	A,C	13520240(+)	`gatttC/Tggctc`	1	--	ng5¹		0	--	--	--	--
	rs12247033^1,2	H	13562946(+)	`TCCGGT/CTGTCA`	2	S/N	mis¹ ese³		4		EU EA WA	406
--	rs4748033^1,2	A	13520323(+)	`CCCACC/GACCAG`	1	--	ng5¹		0	--	--	--	--
	rs11594305^1,2	H	13534637(+)	`CATGGT/GTAGCT`	2	T/N	mis¹		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for BEND7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for BEND7 gene:

The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)⁴ Sjoeblom T.... Velculescu V.E. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 222389	HGNC: 23514	AceView: C10orf30	Ensembl:ENSG00000165626	euGenes: HUgn222389
ECgene: BEND7	H-InvDB: BEND7

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for BEND7
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BEND7:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BEND7-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BEND7		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for BEND7		Browse small molecules at Sigma-Aldrich
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	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Novus for antibodies for BEND7

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BEND7 Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for BEND7

Summaries
for BEND7

Genomic Location
for BEND7

Proteins
for BEND7

Protein Domains/
Families
for BEND7

Gene Function
for BEND7

Pathways & Interactions
for BEND7

Drugs & Compounds
for BEND7

Transcripts
for BEND7

Expression
for BEND7

Orthologs
for BEND7

Paralogs
for BEND7

SNPs/Variants
for BEND7

Disorders & Mutations
for BEND7

Medical News
for BEND7

Publications
for BEND7

Search for BEND7

Genome Databases showing BEND7

Other Databases showing BEND7

Specialized Databases showing BEND7

Licensable Technologies
for BEND7

Services
for BEND7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BEND7 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor BEND7

Summariesfor BEND7

Genomic Locationfor BEND7

Proteinsfor BEND7

Protein Domains/Familiesfor BEND7

Gene Functionfor BEND7

Pathways & Interactionsfor BEND7

Drugs & Compoundsfor BEND7

Transcriptsfor BEND7

Expression for BEND7

Orthologsfor BEND7

Paralogsfor BEND7

SNPs/Variantsfor BEND7

Disorders & Mutationsfor BEND7

Medical Newsfor BEND7

Publicationsfor BEND7

Search for BEND7

Genome Databases showing BEND7

Other Databases showing BEND7

Specialized Databases showing BEND7

Licensable Technologiesfor BEND7

Servicesfor BEND7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BEND7

Summaries
for BEND7

Genomic Location
for BEND7

Proteins
for BEND7

Protein Domains/
Families
for BEND7

Gene Function
for BEND7

Pathways & Interactions
for BEND7

Drugs & Compounds
for BEND7

Transcripts
for BEND7

Expression
for BEND7

Orthologs
for BEND7

Paralogs
for BEND7

SNPs/Variants
for BEND7

Disorders & Mutations
for BEND7

Medical News
for BEND7

Publications
for BEND7

Licensable Technologies
for BEND7

Services
for BEND7