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C10orf28 Gene

protein-coding GIFtS: 44

GC10P099905

chromosome 10 open reading frame 28
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ25458 ^²
FLJ37160 ^²
GIDRP86 ^¹, ²
OTTHUMP00000020241 ^²
PSORT ^¹, ²

Descriptions
Putative mitochondrial space protein 32.1 ^², ³
chromosome 10 open reading frame 28 ^²
growth inhibition and differentiation related protein 86 ^²

External Ids
HGNC: 23512¹
Entrez Gene: 27291²
UniProtKB: Q7Z5L2³
Ensembl: ENSG00000166024⁷

Search outside databases for aliases for C10orf28 gene

Previous GC identifer: GC10P099559

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C10orf28 gene

Entrez Gene cytogenetic band: 10q24.2 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q24.2

C10orf28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P099905: (about GC identifiers)

Start:	99,884,371 bp from pter
End:	99,994,644 bp from pter
Size:	110,274 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GIDRP_HUMAN, Q7Z5L2 (See protein sequence)

Recommended Name: Growth inhibition and differentiation-related protein 88

Size: 792 amino acids; 87884 Da

Sequence caution: Sequence=AAC05748.1; Type=Frameshift; Positions=304;

Secondary accessions: O60598 Q5W0B4 Q5W0B5 Q86VT9 Q8N9H0

Alternative splicing: 3 isoforms: Q7Z5L2-1 Q7Z5L2-2 Q7Z5L2-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055287.4

ENSEMBL proteins:

ENSP00000298999 ENSP00000314018 ENSP00000359618 ENSP00000359616

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GIDRP88)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for C10orf28:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GIDRP88), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for C10orf28

Assays for C10orf28:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q7Z5L2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf28)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014472

Applied Biosystems Silencer® siRNAs for C10orf28

Sigma-Aldrich siRNA for C10orf28

Sigma-Aldrich shRNA for C10orf28

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014472
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014472
untagged cDNA clones in CMV expression vector (see all 3): AF050198

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014472

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Interacting proteins for C10orf28 (ENSP00000314018³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DNAJB1	ENSP00000254322³	STRING (score=.807)
--	ENSP00000366911³	STRING (score=.776)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf28

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf28)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014472

Sigma-Aldrich siRNA for C10orf28

Sigma-Aldrich shRNA for C10orf28

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014472

REFSEQ mRNAs for C10orf28 gene:

NM_014472.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014472

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014472
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014472
                                 untagged cDNA clones in CMV expression vector (see all 3): AF050198

Additional cDNA sequence:

AF050198.1 AF525304.1 AK058187.1 AK094479.1 AK292546.1 BC009231.2 BC047908.1 BC098175.1

BC098268.1 BC098359.1 BC099848.1

11 DOTS entries:

DT.97775359 DT.201397 DT.100023351 DT.121212795 DT.121212819 DT.102824855 DT.121212808 DT.121212788

DT.99932165 DT.121212769 DT.121212803

24/47 AceView cDNA sequences (see all 47 ):

BM717339 AI453689 BQ605320 BF112221 AI963584 BC009231 BQ277147 AK058187

BX474900 BX646236 AI344204 AW273890 BM993056 AU130441 AI654913 CA427577

BU680170 CB528783 BM969188 BQ574807 AI868416 AW025970 BC047908 AU130447

highest scoring ESTs for C10orf28:

AI344204 AA887876 AF050198 AF525304 AI453689 AI654913 AI868416 AI917413 AI963584 AK058187

Unigene Cluster for C10orf28:

Chromosome 10 open reading frame 28

Hs.419800 [show with all ESTs]

Unigene Representative Sequence: AF525304

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf28 (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b
SP1:					-				-		-						-
SP2:					-		-		-		-
SP3:					-		-		-		-						-
SP4:					-		-		-		-		-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for C10orf28

4 Ensembl transcripts including schematic representations:

ENST00000298999 ENST00000314594 ENST00000370586 ENST00000370584

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf28 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf28

¹ / ² / ³

6 probe-sets matching C10orf28 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31338_at²^{, 3}	U95-A	1	1.00	1.00	0.03	0.28	AF050198	0.80	1.00	0.91	1
57686_at²^{, 3}	U95-C	1	1.00	1.00	1.00	1.00	AI344204	1.00	1.00	1.00	1
210455_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF050198	0.80	1.00	0.91	1
228374_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW025970	0.80	1.00	0.91	1
210455_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228374_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks C10orf28 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGTAAGAGG

SOURCE GeneReport for Unigene cluster: Hs.419800
Expression variation in blood from EXPOLDB for C10orf28
UniProtKB/Swiss-Prot: GIDRP_HUMAN, Q7Z5L2
Tissue specificity: Expressed in placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for C10orf28 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC486829¹	--	similar to growth inhibition and differentiation related more	85.19(n) 76.87(a)	486829 XM_543958.2 XP_543958.2
chimpanzee (Pan troglodytes)	LOC450661¹	--	growth inhibition and differentiation related protein more	99.27(n) 98.2(a)	450661 XM_001165410.1 XP_001165410.1
cow (Bos taurus)	LOC616788¹	--	similar to growth inhibition and differentiation related more	82.66(n) 71.93(a)	616788 XM_868897.1 XP_873990.1
rat (Rattus norvegicus)	RGD1307934¹	--	similar to DNA segment, Chr 19, ERATO Doi 386, expressed	73.44(n) 55.41(a)	293953 XM_219870.4 XP_219870.4
mouse (Mus musculus)	D19Ertd386e^{1, 5}	19 (41.00 cM)⁵	DNA segment, Chr 19, ERATO Doi 386, expressed^{1, 5}	78.69(n)¹ 66.01(a)¹	52013¹ NM_177464.3¹ NP_803415.1¹ AI450607⁵ AI661445⁵ (see all 15)

About this table Species with no ortholog for C10orf28

ENSEMBL Gene Tree for C10orf28

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for C10orf28 gene

R3HCC1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/410 NCBI SNPs in C10orf28 are shown (see all 410 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 142)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3750595^1,2	A,C,F,H	99994896(+)	`TCTTGC/ATTTCT`	1	--	ng3¹		9	EA EU WA	2320
	rs6584168^1,2	A,C,F,H	99883743(+)	`acactT/Ggagat`	1	--	ng5¹		4	EU EA WA	416
--	rs7090206^1,2	A,C,F,H	99882732(+)	`ccaccG/Tctggg`	1	--	ng5¹		4	EU EA WA	354
	rs1048757^1,2	A,C,F,H	99994431(+)	`GAACTC/GCAAAG`	1	--	ut3¹		14	EA MN EU WA NA	2866
	rs7922159^1,2	C,F,H	99958575(+)	`ATAAAA/CCTAAG`	1	K/N	mis¹		8	EU EA WA	838
	rs11189513^1,2	C,F,H	99959558(+)	`TTCTCA/GCACAG`	1	H/R	mis¹ ese³		13	EA NA EU WA	1124
	rs1952061^1,2	C,F,H	99981398(-)	`CAGTAC/TGAAAT`	1	R/H	mis¹ ese³		9	EU EA WA NA	912
	rs1048754^1,2	A,C,F	99994350(+)	`TGGTTG/AGAGAG`	1	--	ut3¹ ese³		1	EA	1486
	rs7072474^1,2	A,F,H	99883043(+)	`attgtG/Actctg`	1	--	ng5¹		4	EU EA WA	408
	rs17108974^1,2	C,F,H	99883943(+)	`TGTCAT/GAGAAA`	1	--	ng5¹		11	NA EU EA WA	980

About this table

HapMap Linkage Disequilibrium images for C10orf28 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

8 PubMed articles for C10orf28 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The development of a genetic profile of placental gene expression during the first trimester of pregnancy: a potential tool for identifying novel secreted markers. (PubMed id 10867487)^{3, 4} Page N.M.... Lowry P.J. (2000)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)³ Bonaldo M.F....Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 27291	HGNC: 23512	AceView: C10orf28	Ensembl:ENSG00000166024	euGenes: HUgn27291
ECgene: C10orf28	H-InvDB: C10orf28

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for C10orf28
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for C10orf28:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf28-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for C10orf28		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for C10orf28		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search OriGene for C10orf28

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for C10orf28

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C10orf28 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for C10orf28

Summaries
for C10orf28

Genomic Location
for C10orf28

Proteins
for C10orf28

Protein Domains/
Families
for C10orf28

Gene Function
for C10orf28

Pathways & Interactions
for C10orf28

Drugs & Compounds
for C10orf28

Transcripts
for C10orf28

Expression
for C10orf28

Orthologs
for C10orf28

Paralogs
for C10orf28

SNPs/Variants
for C10orf28

Disorders & Mutations
for C10orf28

Medical News
for C10orf28

Publications
for C10orf28

Search for C10orf28

Genome Databases showing C10orf28

Other Databases showing C10orf28

Specialized Databases showing C10orf28

Licensable Technologies
for C10orf28

Services
for C10orf28

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf28 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor C10orf28

Summariesfor C10orf28

Genomic Locationfor C10orf28

Proteinsfor C10orf28

Protein Domains/Familiesfor C10orf28

Gene Functionfor C10orf28

Pathways & Interactionsfor C10orf28

Drugs & Compoundsfor C10orf28

Transcriptsfor C10orf28

Expression for C10orf28

Orthologsfor C10orf28

Paralogsfor C10orf28

SNPs/Variantsfor C10orf28

Disorders & Mutationsfor C10orf28

Medical Newsfor C10orf28

Publicationsfor C10orf28

Search for C10orf28

Genome Databases showing C10orf28

Other Databases showing C10orf28

Specialized Databases showing C10orf28

Licensable Technologiesfor C10orf28

Servicesfor C10orf28

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf28

Summaries
for C10orf28

Genomic Location
for C10orf28

Proteins
for C10orf28

Protein Domains/
Families
for C10orf28

Gene Function
for C10orf28

Pathways & Interactions
for C10orf28

Drugs & Compounds
for C10orf28

Transcripts
for C10orf28

Expression
for C10orf28

Orthologs
for C10orf28

Paralogs
for C10orf28

SNPs/Variants
for C10orf28

Disorders & Mutations
for C10orf28

Medical News
for C10orf28

Publications
for C10orf28

Licensable Technologies
for C10orf28

Services
for C10orf28