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C10orf26 Gene

protein-coding   GIFtS: 43

GC10P104525
chromosome 10 open reading frame 26
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for C10orf26

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ20154 1, 2
FLJ20367 2
MGC125648 2
OPAL1 2, 5
OTTHUMP00000020381 2
Descriptions
chromosome 10 open reading frame 26 2
hypothetical protein LOC54838 2
outcome predictor in acute leukemia 1 2
External Ids
HGNC: 235101
Entrez Gene: 548382
UniProtKB: Q9NX943
Ensembl: ENSG000001662727
Search outside databases for aliases for C10orf26 gene

Previous GC identifer: GC10P104200

Summaries
for C10orf26

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 Gene Wiki entry for C10orf26

Genomic Location
for C10orf26

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf26 gene  

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.33

C10orf26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P104525:     (about GC identifiers)

Start:
 104,493,717 bp from pter
End:
 104,566,011 bp from pter
Size:
 72,295 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  

Proteins
for C10orf26

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: OPA1L_HUMAN, Q9NX94 (See protein sequence)
Recommended Name: Outcome predictor in acute leukemia 1  
Size: 342 amino acids; 37828 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q1EG70 Q2HIY7 Q5F2G6

REFSEQ proteins (2 alternative transcripts): 
NP_001077382.1  NP_060257.4  


ENSEMBL proteins: 
ENSP00000358905 ENSP00000376960 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for C10orf26: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for C10orf26

Assays for C10orf26: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
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Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for C10orf26

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9NX94

Gene Function
for C10orf26

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (C10orf26)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001083913

              Applied Biosystems Silencer® siRNAs for C10orf26

              Sigma-Aldrich siRNA for C10orf26  
                     Sigma-Aldrich shRNA for C10orf26  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001083913
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001083913
                                 untagged cDNA clones in CMV expression vector (see all 5): AK000161 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001083913

Pathways & Interactions
for C10orf26

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for C10orf26

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf26

Transcripts
for C10orf26

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (C10orf26)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001083913

              Sigma-Aldrich siRNA for C10orf26  
                     Sigma-Aldrich shRNA for C10orf26  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001083913  NM_017787  

REFSEQ mRNAs for C10orf26 gene (2 alternative transcripts): 

NM_001083913.1   NM_017787.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001083913  NM_017787  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001083913
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001083913
                                 untagged cDNA clones in CMV expression vector (see all 5): AK000161 

Additional cDNA sequence: AY656174.1 

17 DOTS entries:

DT.452085  DT.100719087  DT.100746187  DT.95174728  DT.121299845  DT.97819468  DT.100028914  DT.75146340 
DT.100691519  DT.121299713  DT.97844370  DT.100665971  DT.75129198  DT.91810671  DT.97823601  DT.97825263 
DT.91957907 

24/261 AceView cDNA sequences (see all 261 ):

AI200433 NM_017787 AA187617 AA983333 AI554618 CA389094 BM708561 BM714825 
AI459545 CF121236 AW519132 AW468609 H25348 BX100578 AA234055 AA954841 
BM838772 BC063659 F24405 AW519142 CA426767 CR591598 AW419058 BF195955 

highest scoring ESTs for C10orf26:

AA125860 AA125861 AA187443 AA234055 AA310172 AA340597 AA430020 AA445968 AA555192 AA565298 

Unigene Clusters for C10orf26:

Chromosome 10 open reading frame 26
Hs.500897  [show with all ESTs], Hs.693257
Unigene Representative Sequences: NM_017787, AY656174


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000369889  ENST00000393281  

Expression
for C10orf26

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf26 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C10orf26

1 / 2 / 3

3 probe-sets matching C10orf26 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

38652_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AF070644 0.60 1.00 0.82 1

202808_at2, 3 U133-A 1 1.00 1.00 -- -- AK000161 0.80 1.00 0.91 1

202808_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.500897 Hs.693257

Expression variation in blood from EXPOLDB for C10orf26

Orthologs
for C10orf26

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for C10orf26 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LOC6085671   -- hypothetical protein LOC608567 91.31(n)
93.2(a)		 608567  XM_858176.1  XP_863269.1 
cow
(Bos taurus)		 LOC7826511   -- similar to Outcome predictor in acute leukemia 1 homolog 90.82(n)
91.32(a)		 782651  XM_001251287.1  XP_001251288.1 
rat
(Rattus norvegicus)		 RGD13057931   -- similar to hypothetical protein FLJ20154 88.98(n)
90.4(a)		 309456  XM_219958.4  XP_219958.4 
mouse
(Mus musculus)		 D19Wsu162e1, 5 19 (50.00 cM)5
 DNA segment, Chr 19, Wayne State University 162, expressed1, 5 87.48(n)1
88.14(a)1		 2261781  NM_146099.21  NP_666211.21 
 AA4084435  AI5738495  (see all 21)
chicken
(Gallus gallus)		 C10orf261   -- chromosome 10 open reading frame 26 75.59(n)
75.08(a)		 423867  XM_421732.2  XP_421732.1 
About this table        Species with no ortholog for C10orf26

ENSEMBL Gene Tree for C10orf26

Paralogs
for C10orf26

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for C10orf26 gene
WBP12  

Pseudogenes
4 related pseudogenes


SNPs/Variants
for C10orf26

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/464 NCBI SNPs in C10orf26 are shown (see all 464 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 101)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs2848581,2
A,C,F,H,O104563926(-) TCAACG/AGCAGG 2 -- ut31 ese311Minor allele frequency- A:0.47MN EA NA EU WA 2426
rs2848571,2
A,C,F,H,O104564053(-) GAACAT/CAGACC 2 -- ut31 ese313Minor allele frequency- C:0.46MN EA NA EU WA 2648
rs13399191,2
A,C,F,H,O104524438(-) CCATGT/CAAGTC 2 -- ng51 int112Minor allele frequency- C:0.34EU EA WA NA 1054
rs2848561,2
A,C,F,H,O104564319(-) AGGCAA/TGAAAA 2 -- ut31 ese38Minor allele frequency- T:0.48MN EU EA WA NA 734
--
rs68921,2
A,C,F,H,O104565860(-) CACAAT/CAACTG 2 -- ut3115Minor allele frequency- C:0.21EA NA MN CSAM EU WA 2652
rs2848601,2
A,C,F,H104562953(-) AGAGGA/GCTGAC 2 S/P mis1 ese315Minor allele frequency- C:0.01EU EA WA NA MN 2704
--
rs22974511,2
A,C,F,H104493449(+) CTCTCT/AGCGGG 1 -- ng519Minor allele frequency- A:0.25EA EU WA 2318
rs111914011,2
A,C,F,H104563393(+) GTTTTA/GAAAGC 2 -- ut31 ese311Minor allele frequency- G:0.16NA EU EA WA 980
--
rs22974501,2
C,F,H,O104493164(+) GGCAGT/CTGAGA 1 -- ng5112Minor allele frequency- C:0.48EA NA EU WA 2482
rs4997701,2
A,C,F,H104524897(+) ACTTTC/GGATTT 2 -- ng51 int1 tfbs37Minor allele frequency- G:0.37EU EA WA NA 508
About this table

HapMap Linkage Disequilibrium images for C10orf26 (up to first 250kb)

Disorders & Mutations
for C10orf26

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 611129

Medical News
for C10orf26

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for C10orf26

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10 PubMed articles for C10orf26 gene:

Search for C10orf26

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing C10orf26

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 54838 HGNC: 23510 AceView: C10orf26 Ensembl:ENSG00000166272 euGenes: HUgn54838
ECgene: C10orf26 H-InvDB: C10orf26

Other Databases showing C10orf26

(According to HUGE)
About This Section

   --

Specialized Databases showing C10orf26

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for C10orf26

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for C10orf26

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for C10orf26:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for C10orf26-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for C10orf26 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for C10orf26 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for C10orf26

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