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C10orf25 Gene

protein-coding   GIFtS: 29

GC10M044809
chromosome 10 open reading frame 25
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ30567 1, 2
OTTHUMP00000019499 2
Descriptions
chromosome 10 open reading frame 25 2
hypothetical protein LOC220979 2
External Ids
HGNC: 235091
Entrez Gene: 2209792
UniProtKB: Q5T7423
Ensembl: ENSG000001655117
Search outside databases for aliases for C10orf25 gene

Previous GC identifers: GC10M044777 GC10U900614

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf25 gene  

Entrez Gene cytogenetic band: 10q11.21   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.21

C10orf25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M044809:     (about GC identifiers)

Start:
44,813,152 bp from pter
End:
44,816,342 bp from pter
Size:
3,191 bases
Orientation:
minus strand
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ025_HUMAN, Q5T742 (See protein sequence)
Recommended Name: Uncharacterized protein C10orf25 precursor  
Size: 122 amino acids; 14442 Da
Subcellular location: Secreted (Potential)
Secondary accessions: A1L424 Q96NM5

REFSEQ proteins: NP_001034469.1  

ENSEMBL proteins: 
ENSP00000298298 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
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Antibodies for C10orf25: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for C10orf25

Assays for C10orf25: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5T742

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_145022

              Applied Biosystems Silencer® siRNAs for C10orf25

              Sigma-Aldrich siRNA for C10orf25  
                     Sigma-Aldrich shRNA for C10orf25  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001039380
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001039380
                                 untagged cDNA clone in CMV expression vector: NM_001039380 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001039380

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf25

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_145022

              Sigma-Aldrich siRNA for C10orf25  
                     Sigma-Aldrich shRNA for C10orf25  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001039380  

REFSEQ mRNAs for C10orf25 gene: 

NM_001039380.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001039380  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001039380
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001039380
                                 untagged cDNA clone in CMV expression vector: NM_001039380 

highest scoring ESTs for C10orf25:

R25159 NM_145022 AA421539 AA397684 AA417215 AI198849 AK055129 BC062568 BI768372 BI824686 


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000298298  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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C10orf25 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C10orf25

1 / 2 / 3

4 probe-sets matching C10orf25 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
86187_at2, 3 U95-E 1 1.00 1.00 0.66 1.35 AA421539 0.60 0.60 0.60 1

42583_at2, 3 U95-B 3 1.00 0.96 0.88 0.66 AA393328 0.20 0.33 0.27 2

43825_at2, 3 U95-B 1 0.69 1.00 0.08 0.28 R25159 0.40 1.00 0.76 1

1552422_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  C10orf25 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GATGTTACTG
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for C10orf25 gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
LOC4504261   -- similar to chromosome 10 open reading frame 25 89.88(n)
87.5(a)
450426  XM_507761.2  XP_507761.2 
About this table        Species with no ortholog for C10orf25

ENSEMBL Gene Tree for C10orf25
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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8 NCBI SNPs in C10orf25 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs122690281,2
A,C,F,H44816126(+) TCAAAA/TTTTGT 1 N/I mis18Minor allele frequency- T:0.44EU EA WA 836
rs112393081,2
F,H44813039(+) CTCCAC/ACCTTC 1 -- ng514Minor allele frequency- A:0.08EU EA WA 418
--
rs49489391,2
A,C44812709(+) ctggaA/Gccagg 1 -- ng510--------
rs413016091,2
--44816132(+) TTTGTA/GGAAAG 1 P/L mis10--------
--
rs576441661,2
--44813597(+) TTTTAA/GAAGTT 1 -- ut310--------
--
rs112393071,2
--44812768(+) TTGGGC/TGAGTT 1 -- ng510--------
--
rs732834701,2
--44816188(+) CTCGAC/GCACAC 1 W/C mis10--------
--
rs360527931,2
--44816201(+) GGGGC-/GGGTTA 1 R/P fra10--------
About this table
The following additional 30 SNP(s) have been found in Applied Biosystems data source:
(Click for Applied Biosystems TaqMan ® Genotyping Assay)


 rs11239306 rs12416304 rs6593454 rs3814568 rs11239303 rs3740090 rs11239309
 rs58731194 rs35625805 rs3740093 rs2210497 rs4245615 rs11239314 rs11593886
 rs4948648 rs35795993 rs4948650 rs11494 rs3814569 rs7080655 rs7918812
 rs2297492 rs11239310 rs6593453 rs11471 rs7068660 rs4948649 rs3740091
 rs4948940 rs17157326

HapMap Linkage Disequilibrium images for C10orf25 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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4 PubMed articles for C10orf25 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 220979 HGNC: 23509 Ensembl:ENSG00000165511 euGenes: HUgn220979 ECgene: C10orf25
H-InvDB: C10orf25
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for C10orf25:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for C10orf25-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for C10orf25 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for C10orf25 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for C10orf25

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