V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

C10orf2 Gene

protein-coding   GIFtS: 56

GC10P102738
chromosome 10 open reading frame 2
(Previous name: infantile onset spinocerebellar ataxia (autosomal recessive) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: IOSCA, SCA8)
Services    

Aliases &
Descriptions
for C10orf2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ATXN8 1, 2
EC 3.6.1.- 3
FLJ21832 1, 2
IOSCA 2, 5
OTTHUMP00000020296 2
PEO 1, 2
PEO1 1, 2, 5
PEOA3 2, 5
SANDO 2, 5
SCA8 2
TWINKLE 1, 5
TWINL 1, 2
twinkle 2
Descriptions
Progressive external ophthalmoplegia 1 protein 3
T7 gp4-like protein with intramitochondrial nucleoid
localization 3
T7-like mitochondrial DNA helicase 3
ataxin 8 2
chromosome 10 open reading frame 2 2
gp4-like protein with intramitochondrial nucleoid
localization 2
infantile onset spinocerebellar ataxia (autosomal
recessive) 1
External Ids
HGNC: 11601
Entrez Gene: 566522
UniProtKB: Q96RR13
Ensembl: ENSG000001078157
Search outside databases for aliases for C10orf2 gene

Previous GC identifers: GC10P101640 GC10P101981 GC10P102878

Summaries
for C10orf2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for C10orf2:
Twinkle is a mitochondrial protein with structural similarity to the phage T7 primase/helicase
(GP4) and other hexameric ring helicases. The twinkle protein colocalizes with mtDNA in
mitochondrial nucleoids, and its name derives from the unusual localization pattern reminiscent of
twinkling stars (Spelbrink et al., 2001 [PubMed 11431692]).[supplied by OMIM]

UniProtKB/Swiss-Prot: PEO1_HUMAN, Q96RR1
Function: Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine
nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of
mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery,
which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA)
molecules. May be a key regulator of mtDNA copy number in mammals (By similarity)

Gene Wiki entry for C10orf2 (PEO1)

Genomic Location
for C10orf2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.3-q24.3   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24

C10orf2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P102738:     (about GC identifiers)

Start:
 102,737,302 bp from pter
End:
 102,744,148 bp from pter
Size:
 6,847 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  

Proteins
for C10orf2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: PEO1_HUMAN, Q96RR1 (See protein sequence)
Recommended Name: Twinkle protein, mitochondrial precursor  
Size: 684 amino acids; 77154 Da
Subunit: Forms multimers in vitro, including hexamers. Interacts with POLG in vitro
Subcellular location: Mitochondrion matrix, mitochondrion nucleoid. Note=Colocalizes with mtDNA in
mitochondrial nucleoids, a nucleoproteins complex consisting of a number of copies of proteins
associated with mtDNA, probably involved in mtDNA maintenance and expression
Secondary accessions: Q6MZX2 Q6PJP5 Q96RR0
Alternative splicing: 3 isoforms:  Q96RR1-1   Q96RR1-2   Q96RR1-3   

REFSEQ proteins: NP_068602.2  

ENSEMBL proteins: 
ENSP00000309595 ENSP00000359248 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Twinkle)
Human Recombinant Proteins from Abnova (PEO1)
              OriGene Purified Recombinant Human Protein: C10orf2 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005739 mitochondrion IEA--
GO:0042645 mitochondrial nucleoid IDA18063578
About this table

Antibodies for C10orf2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for C10orf2
Browse R&D Systems for Antibodies
Antibodies from Abcam (Twinkle), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (PEO1)
Novus Biologicals Antibody for C10orf2

Assays for C10orf2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for C10orf2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR007694 DNA_helicase_DnaB-like_C


   GeneDecks  C10orf2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q96RR1

ProtoNet protein and cluster: Q96RR1

UniProtKB/Swiss-Prot: PEO1_HUMAN, Q96RR1
Similarity: Contains 1 SF4 helicase domain

Gene Function
for C10orf2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (C10orf2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021830

              Applied Biosystems Silencer® siRNAs for C10orf2

              Sigma-Aldrich siRNA for C10orf2  
                     Sigma-Aldrich shRNA Panels and shRNA for C10orf2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for C10orf2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021830
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021830
                                 untagged cDNA clones in CMV expression vector (see all 2): AF292004 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_021830

UniProtKB/Swiss-Prot: PEO1_HUMAN, Q96RR1
Function: Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine
nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of
mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery,
which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA)
molecules. May be a key regulator of mtDNA copy number in mammals (By similarity)
Enzyme Number (IUBMB): EC 3.6.1.- 

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0002020 protease binding IPI14739292
GO:0003678 DNA helicase activity IEA--
GO:0005524 ATP binding IEA--
GO:0016787 hydrolase activity IEA--
About this table

Pathways & Interactions
for C10orf2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



5/10 Interacting proteins for C10orf2 (Q96RR12 ENSP000003095953) via UniProtKB, MINT, and/or STRING (see all 10 )
InteractantInteraction Details
GeneCardExternal ID(s)
POLGENSP000002681243STRING (score=.967)
SLC25A4ENSP000002814563STRING (score=.958)
POLG2ENSP000003176183STRING (score=.917)
TYMPENSP000002520293STRING (score=.898)
PRIM1ENSP000003504913STRING (score=.857)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006260 DNA replication IEA--
GO:0008219 cell death IEA--
About this table

Drugs & Compounds
for C10orf2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf2

Transcripts
for C10orf2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (C10orf2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021830

              Sigma-Aldrich siRNA for C10orf2  
                     Sigma-Aldrich shRNA Panels and shRNA for C10orf2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_021830  

REFSEQ mRNAs for C10orf2 gene: 

NM_021830.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_021830  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021830
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021830
                                 untagged cDNA clones in CMV expression vector (see all 2): AF292004 

Additional cDNA sequence: 

AF292004.1 AF292005.1 AK022959.1 AK025485.1 AK297068.1 AK308098.1 BC013349.2 BC033762.1 
BX640829.1 CR593649.1 CR626239.1 

10 DOTS entries:

DT.97846893  DT.121293577  DT.210174  DT.95288120  DT.121293557  DT.92454503  DT.95353221  DT.92454510 
DT.95070218  DT.100715950 

24/200 AceView cDNA sequences (see all 200 ):

BQ643363 BQ057593 AF292004 BQ924236 BC013349 AW196505 F10278 CB159220 
BE277526 AI651203 BM800014 AI863792 BI089876 BQ059754 NM_021830 BQ643111 
BM980922 BE743851 BQ058029 BU838941 CA450490 BQ066500 F12667 BF795117 

Unigene Cluster for C10orf2:

Chromosome 10 open reading frame 2
Hs.22678  [show with all ESTs]
Unigene Representative Sequence: BX640829


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf2

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
SP1:              -     -                             -     -               
SP2:                                                  -     -               
SP3:                                                        -               
SP4:              -     -                                                   
SP5:                    -     -                                             

About this scheme

ECgene alternative splicing isoforms for C10orf2

2 Ensembl transcripts including schematic representations:
ENST00000311916  ENST00000370228  

Expression
for C10orf2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C10orf2

1 / 2

3 probe-sets matching C10orf2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
43019_at2 U95-B 1 1.00 1.00 1.00 1.00 -- -- -- -- --

218590_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

218590_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  C10orf2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TACTAGAATT

SOURCE GeneReport for Unigene cluster: Hs.22678

UniProtKB/Swiss-Prot: PEO1_HUMAN, Q96RR1
Tissue specificity: High relative levels in skeletal muscle, testis and pancreas. Lower levels of
expression in the heart, brain, placenta, lung, liver, kidney, spleen, thymus, prostate, ovary,
small intestine, colon and leukocytes. Expression is coregulated with MRPL43

Orthologs
for C10orf2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for C10orf2 gene from 5/12 species (see all 12 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 PEO11   -- progressive external ophthalmoplegia 1 87.96(n)
87.87(a)		 486845  XM_543974.1  XP_543974.1 
chimpanzee
(Pan troglodytes)		 PEO11   -- progressive external ophthalmoplegia 1 98.84(n)
98.36(a)		 745279  XM_001150920.1  XP_001150920.1 
cow
(Bos taurus)		 C26H10ORF21   -- chromosome 10 open reading frame 2 ortholog 88.53(n)
89.02(a)		 538467  XM_580526.3  XP_580526.3 
rat
(Rattus norvegicus)		 Peo11   -- progressive external ophthalmoplegia 1 (human) 84.41(n)
86.36(a)		 309441  XM_219939.4  XP_219939.1 
mouse
(Mus musculus)		 Peo11, 5 19 (47.00 cM)5
 progressive external ophthalmoplegia 1 (human)1, 5 84.87(n)1
87.12(a)1		 2261531  NM_153796.31  NP_722491.21 
 AF5032915  AI8466815  (see all 15)
About this table        Species with no ortholog for C10orf2

ENSEMBL Gene Tree for C10orf2

Paralogs
for C10orf2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for C10orf2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/43 NCBI SNPs in C10orf2 are shown (see all 43 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 42)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs37404881,2
A,C,F,H102744023(+) CATAGA/TAGGAA 1 -- ut31 ese313Minor allele frequency- T:0.42EU EA WA NS 1020
rs37404891,2
A,C,F102744228(+) TTGGGA/GATGGA 1 -- ng315Minor allele frequency- G:0.38NS 186
--
rs115421311,2
C,F102743778(+) AGATTC/GAAGGC 1 -- ut31 ese35Minor allele frequency- G:0.04NS 186
--
rs115421261,2
H102739427(+) CAGTGA/GGTATG 1 E/G mis1 ese34Minor allele frequency- G:0.00EU EA WA 404
rs37404871,2
A,C,F,H102740773(+) TTTAGA/CGGAGC 1 -- int1 ese310Minor allele frequency- C:0.49EA EU WA NS 2086
rs38247831,2
A,C,F,H102740841(+) TAATCG/ATCTTG 1 -- int114Minor allele frequency- A:0.50EA EU WA NS 2508
--
rs37404861,2
A,C,F102740613(+) TGGCGT/CAGGAT 1 -- int15Minor allele frequency- C:0.40NS 184
--
rs49195111,2
A,C,F102742735(+) TCACCG/ATGTTA 1 -- int15Minor allele frequency- A:0.39NS 144
--
rs37404851,2
A,C,F102740611(+) GATGGC/TGTAGG 1 -- int15Minor allele frequency- T:0.40NS 182
--
rs626262931,2
--102743104(+) AAGAAC/GAAGGC 1 N/K mis15Minor allele frequency- G:0.00NS 190
About this table

HapMap Linkage Disequilibrium images for C10orf2 (up to first 250kb)

Disorders & Mutations
for C10orf2

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 606075   disorders: 609286  607459  251880  271245  

UniProtKB/Swiss-Prot: PEO1_HUMAN, Q96RR1

  • Defects in PEO1 are the cause of progressive external ophthalmoplegia with mitochondrial
    DNA deletions autosomal dominant type 3 (PEOA3) [MIM:609286]. Progressive external ophthalmoplegia
    is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid.
    In a minority of cases, it is associated with skeletal myopathy, which predominantly involves
    axial or proximal muscles and which causes abnormal fatigability and even permanent muscle
    weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic
    ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this
    disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal
    neuropathy, ataxia, depression, hypogonadism, and parkinsonism
  • Defects in PEO1 are a cause of sensory ataxic neuropathy dysarthria and ophthalmoparesis
    (SANDO) [MIM:607459]. SANDO is a clinically heterogeneous systemic disorder with variable features
    resulting from mitochondrial dysfunction. It shares phenotypic characteristics with autosomal
    recessive progressive external ophthalmoplegia and mitochondrial neurogastrointestinal
    encephalopathy syndrome. The clinical triad of symptoms consists of sensory ataxic, neuropathy,
    dysarthria, and ophthalmoparesis
  • Defects in PEO1 are a cause of hepatocerebral mitochondrial DNA deletions syndrome
    autosomal recessive (ARHCMDS) [MIM:251880]. Clinical features include liver dysfunction,
    peripheral neuropathy, severe trunk hypotonia, psychomotor retardation
  • Defects in PEO1 are the cause of spinocerebellar ataxia infantile-onset (IOSCA)
    [MIM:271245]. IOSCA is a severe neurodegenerative disorder due to progressive atrophy of the
    cerebellum, brain stem and spinal cord, and sensory axonal neuropathy. It is an autosomal
    recessive cerebellar ataxia (ARCA) characterized by very early onset ataxia (between 1 and 2
    years), athetosis and reduced tendon reflexes. Other features such as ophthalmoplegia, hearing
    loss and sensory neuropathy with progressive loss of myelinated fibers in sural nerves appear
    later in the disease course. Some patients show reduced mental capacity

    • 2 Novoseek disease relationships for C10orf2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    chronic progressive external ophthalmoplegia 93.67 3 14557557 (1), 18575922 (1), 17357142 (1)
    mitochondrial diseases 83.25 1 16401742 (1)
    About this table

    GeneTests: C10orf2
    Infantile-Onset Spinocerebellar Ataxia

    Human Gene Mutation Database: C10orf2
    Human Genome Epidemiology Navigator: C10orf2 (5 documents)

    Medical News
    for C10orf2

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for C10orf2

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/52 PubMed articles for C10orf2 gene (see all 52 ):

    Search for C10orf2

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C10orf2

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 56652 HGNC: 1160 AceView: PEO1 Ensembl:ENSG00000107815 euGenes: HUgn56652
    ECgene: C10orf2 H-InvDB: C10orf2

    Other Databases showing C10orf2

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing C10orf2

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    GeneReviewshttp://www.genetests.org/query?gene=C10orf2

    Licensable Technologies
    for C10orf2

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for C10orf2

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for C10orf2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for C10orf2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for C10orf2 Antibodies for C10orf2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for C10orf2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (PEO1)
     Antibodies (PEO1)
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Twinkle)
     Antibodies (Twinkle)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for C10orf2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for C10orf2

    GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    C10orf2 Gene at Home site.
    Version 2.41.1
    server4.xennexinc.com