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C10orf18 Gene

protein-coding GIFtS: 41

GC10P005766

chromosome 10 open reading frame 18
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp781E1986 ^²
FLJ20360 ^¹, ²
KIAA2006 ^³
OTTHUMP00000019009 ^²
bA318E3.2 ^¹, ²

Descriptions
chromosome 10 open reading frame 18 ^²
hypothetical protein LOC54906 ^²

External Ids
HGNC: 23484¹
Entrez Gene: 54906²
UniProtKB: Q5VWN6³
Ensembl: ENSG00000108021⁷

Search outside databases for aliases for C10orf18 gene

Previous GC identifer: GC10U900558

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C10orf18 gene

Entrez Gene cytogenetic band: 10p15.1 Ensembl cytogenetic band: 10p15.1 HGNC cytogenetic band: 10p15.1

C10orf18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P005766: (about GC identifiers)

Start:	5,766,807 bp from pter
End:	5,846,949 bp from pter
Size:	80,143 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_077569.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ018_HUMAN, Q5VWN6 (See protein sequence)

Recommended Name: Uncharacterized protein C10orf18

Size: 2430 amino acids; 268843 Da

Secondary accessions: Q2YD91 Q5VWN5 Q6ZRQ8 Q8IVG4 Q9BUZ7 Q9H5J9 Q9H7A4 Q9H996 Q9NXA1

Alternative splicing: 2 isoforms: Q5VWN6-1 Q5VWN6-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_060252.3

ENSEMBL proteins:

ENSP00000263123 ENSP00000328426 ENSP00000369623

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for C10orf18:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for C10orf18

Assays for C10orf18:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5VWN6

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf18)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_017782

Applied Biosystems Silencer® siRNAs for C10orf18

Sigma-Aldrich siRNA for C10orf18

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_017782
Myc/DDK tagged cDNA clone in CMV expression vector: NM_017782
untagged cDNA clones in CMV expression vector (see all 3): BC016688

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017782

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for C10orf18 (Q5VWN6²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
-- Q9WMX2² MINT-7047372
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf18

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf18)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_017782

Sigma-Aldrich siRNA for C10orf18

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_017782

REFSEQ mRNAs for C10orf18 gene:

NM_017782.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_017782

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017782
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_017782
                                 untagged cDNA clones in CMV expression vector (see all 3): BC016688

Additional cDNA sequence:

AB095927.1 AK000367.1 AK022966.1 AK024762.1 AK027014.1 AK091392.1 AK126513.1 AK128051.1

AK128055.1 AK128151.1 AK225352.1 AK309877.1 AL832762.1 BC001759.1 BC016688.1 BC071976.1

BC110339.1 BX649177.1 CR592483.1 CR936780.1

13 DOTS entries:

DT.213838 DT.100794665 DT.101984231 DT.75171366 DT.100794669 DT.92070658 DT.40214500 DT.100794663

DT.70103688 DT.75157942 DT.95364199 DT.101960764 DT.95348857

24/217 AceView cDNA sequences (see all 217 ):

AI807640 AW006863 AK128151 CA389021 CD656097 AI569072 BF512655 BM842535

BX112201 AK128051 BF448595 AI351702 BU189725 BM720849 AU139357 BQ186407

AA314386 BX480880 AA424604 H65579 AI376972 AI695207 BG944317 AI888798

highest scoring ESTs for C10orf18:

AL043619 AA129415 AA281119 AA397887 AA420977 AA437229 AA442293 AA495765 AA514752 AA707521

Unigene Cluster for C10orf18:

Chromosome 10 open reading frame 18

Hs.699500 [show with all ESTs]

Unigene Representative Sequence: NM_017782

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000263123 ENST00000328090 ENST00000380270

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C10orf18 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf18

¹ / ² / ³

6 probe-sets matching C10orf18 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
48942_at²^{, 3}	U95-B	1	1.00	1.00	0.90	0.59	AI400585	0.60	1.00	0.82	1
65613_at²^{, 3}	U95-C	1	1.00	1.00	0.72	1.43	AL043619	1.00	1.00	1.00	1
238795_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA424537	0.40	1.00	0.76	1
218331_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_017782	0.20	1.00	0.72	1
238795_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
218331_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks C10orf18 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTAATGTCAG

SOURCE GeneReport for Unigene cluster: Hs.699500

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for C10orf18 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC478015¹	--	similar to retinoblastoma-associated protein 140	76.89(n) 65.39(a)	478015 XM_535198.2 XP_535198.2
chimpanzee (Pan troglodytes)	LOC450282¹	--	similar to chromosome 10 open reading frame 18	98.86(n) 97.82(a)	450282 XM_507637.2 XP_507637.2
cow (Bos taurus)	LOC785666¹	--	similar to Uncharacterized protein C10orf18 homolog more	72.74(n) 60.82(a)	785666 XM_001253614.1 XP_001253615.1
rat (Rattus norvegicus)	RGD1564456¹	--	similar to chromosome 10 open reading frame 18	74.32(n) 60.19(a)	361269 XM_341552.3 XP_341553.3
mouse (Mus musculus)	BC016423⁵	13	cDNA sequence BC016423	--	BG083311

About this table Species with no ortholog for C10orf18

ENSEMBL Gene Tree for C10orf18

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for C10orf18 gene

C3orf63²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/431 NCBI SNPs in C10orf18 are shown (see all 431 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 163)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11255072^1,2	A,C,F,H	5846254(+)	`ACCCAC/TGAGGC`	1	--	ut3¹		8	EU EA WA	830
	rs2797501^1,2	A,C,F,H	5844537(+)	`AAATAA/GTGGAA`	1	S/N	mis¹ ese³		15	NA EU EA WA	1394
	rs11920^1,2	A,C,F,H	5845864(+)	`GCAGTC/AAAGTA`	1	--	ut3¹		13	MN NA EU EA WA	1350
	rs2254067^1,2	A,C,F,H	5821634(-)	`TTGACC/AACCTC`	1	G/C	mis¹ ese³		8	EU EA WA	830
	rs2669142^1,2	A,C,F,H	5830426(-)	`GAAACG/ACTGGC`	1	A/V	mis¹ ese³		11	EU EA WA NA	978
	rs11596406^1,2	A,C,F,H	5766259(+)	`CAAGGG/ATAAAC`	1	--	ng5¹		4	EU EA WA	418
	rs2797491^1,2	C,F,H,O	5828614(+)	`TGAACC/GTACAA`	1	R/P	mis¹ ese³		16	EU EA WA NA	1470
	rs9424204^1,2	A,C,F,H	5766382(+)	`ATTTCG/CAAAAT`	1	--	ng5¹		4	EU EA	390
	rs11259192^1,2	A,C,F,H	5766827(+)	`CGCCGG/ATCAGA`	1	--	ut5¹ ese³		8	EU EA WA	838
	rs4748636^1,2	C,F,H	5822028(+)	`TAAAGC/ACCAGT`	1	D/A	mis¹ ese³		8	EU EA WA	826

About this table

HapMap Linkage Disequilibrium images for C10orf18 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

8 PubMed articles for C10orf18 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)⁴ Olsen J.V....Mann M. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)⁴ Deloukas P.... Rogers J. (2004)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54906	HGNC: 23484	AceView: C10orf18	Ensembl:ENSG00000108021	euGenes: HUgn54906
ECgene: C10orf18	H-InvDB: C10orf18

(According to HUGE)
About This Section

HUGE: KIAA2006

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for C10orf18
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for C10orf18:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf18-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for C10orf18		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for C10orf18

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for C10orf18

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C10orf18 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for C10orf18

Summaries
for C10orf18

Genomic Location
for C10orf18

Proteins
for C10orf18

Protein Domains/
Families
for C10orf18

Gene Function
for C10orf18

Pathways & Interactions
for C10orf18

Drugs & Compounds
for C10orf18

Transcripts
for C10orf18

Expression
for C10orf18

Orthologs
for C10orf18

Paralogs
for C10orf18

SNPs/Variants
for C10orf18

Disorders & Mutations
for C10orf18

Medical News
for C10orf18

Publications
for C10orf18

Search for C10orf18

Genome Databases showing C10orf18

Other Databases showing C10orf18

Specialized Databases showing C10orf18

Licensable Technologies
for C10orf18

Services
for C10orf18

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf18 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor C10orf18

Summariesfor C10orf18

Genomic Locationfor C10orf18

Proteinsfor C10orf18

Protein Domains/Familiesfor C10orf18

Gene Functionfor C10orf18

Pathways & Interactionsfor C10orf18

Drugs & Compoundsfor C10orf18

Transcriptsfor C10orf18

Expression for C10orf18

Orthologsfor C10orf18

Paralogsfor C10orf18

SNPs/Variantsfor C10orf18

Disorders & Mutationsfor C10orf18

Medical Newsfor C10orf18

Publicationsfor C10orf18

Search for C10orf18

Genome Databases showing C10orf18

Other Databases showing C10orf18

Specialized Databases showing C10orf18

Licensable Technologiesfor C10orf18

Servicesfor C10orf18

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf18

Summaries
for C10orf18

Genomic Location
for C10orf18

Proteins
for C10orf18

Protein Domains/
Families
for C10orf18

Gene Function
for C10orf18

Pathways & Interactions
for C10orf18

Drugs & Compounds
for C10orf18

Transcripts
for C10orf18

Expression
for C10orf18

Orthologs
for C10orf18

Paralogs
for C10orf18

SNPs/Variants
for C10orf18

Disorders & Mutations
for C10orf18

Medical News
for C10orf18

Publications
for C10orf18

Licensable Technologies
for C10orf18

Services
for C10orf18