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C10orf140 Gene

protein-coding   GIFtS: 37

GC10M021843
chromosome 10 open reading frame 140
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp761J229 2
DLN-1 2
DLN1 3
FLJ45187 1, 2
Descriptions
chromosome 10 open reading frame 140 2
hypothetical protein LOC387640 2
External Ids
HGNC: 326971
Entrez Gene: 3876402
UniProtKB: Q1XH103
Ensembl: ENSG000001805927
Search outside databases for aliases for C10orf140 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.31   Ensembl cytogenetic band:  10p12.31   HGNC cytogenetic band: 10p12.31

C10orf140 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M021843:     (about GC identifiers)

Start:
21,842,413 bp from pter
End:
21,854,617 bp from pter
Size:
12,205 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_008705.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DLN1_HUMAN, Q1XH10 (See protein sequence)
Recommended Name: Protein DLN-1  
Size: 827 amino acids; 90476 Da
Secondary accessions: B1ANA5 Q6ZMX4 Q8N3C3

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_997254.3  

    ENSEMBL proteins: 
    ENSP00000326863 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
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    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for C10orf140: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for C10orf140

    Assays for C10orf140: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR003380 Transform_Ski


       GeneDecks  C10orf140 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q1XH10

    ProtoNet protein and cluster: Q1XH10

    UniProtKB/Swiss-Prot: DLN1_HUMAN, Q1XH10
    Similarity: Belongs to the DACH/dachshund family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (C10orf140)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FLJ45187)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_207371

                  Applied Biosystems Silencer® siRNAs for C10orf140

                  Sigma-Aldrich siRNA for C10orf140  
                         Sigma-Aldrich shRNA for C10orf140  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_207371
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_207371
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_207371 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_207371

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for C10orf140

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (C10orf140)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FLJ45187)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_207371

                  Sigma-Aldrich siRNA for C10orf140  
                         Sigma-Aldrich shRNA for C10orf140  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_207371  

    REFSEQ mRNAs for C10orf140 gene: 

    NM_207371.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_207371  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_207371
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_207371
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_207371 

    Additional cDNA sequence: 

    AB234866.1 AK055656.1 AK127130.1 AK131456.1 AK299717.1 AL834446.1 BC142633.1 

    3 DOTS entries:

    DT.101974978  DT.40257672  DT.75153595 

    7 AceView cDNA sequences:

    NM_207371 AL834446 AK131456 BE250228 AA723015 BI497298 AI363206 

    Unigene Cluster for C10orf140:

    Chromosome 10 open reading frame 140
    Hs.350848  [show with all ESTs]
    Unigene Representative Sequence: NM_207371


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000317413  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    C10orf140 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for C10orf140

    1 / 2

    2 probe-sets matching C10orf140 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    1559265_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1559266_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.350848
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for C10orf140 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4870951   -- similar to dachshund b 94.67(n)
    94.97(a)
    487095  XM_544223.2  XP_544223.2 
    chimpanzee
    (Pan troglodytes)
    LOC7403631   -- hypothetical protein LOC740363 99.2(n)
    99.28(a)
    740363  XM_001154654.1  XP_001154654.1 
    rat
    (Rattus norvegicus)
    LOC6807701   -- similar to dachshund b 74.4(n)
    67.86(a)
    680770  XM_001058786.1  XP_001058786.1 
    mouse
    (Mus musculus)
    2810030E01Rik1, 5 25
    RIKEN cDNA 2810030E01 gene1, 5 85.38(n)1
    83.17(a)1
    726681  NM_028317.11  NP_082593.11 
     AK0128435  AK0177575  (see all 15)
    chicken
    (Gallus gallus)
    LOC4205101   -- hypothetical LOC420510 76.24(n)
    72.47(a)
    420510  XM_418611.2  XP_418611.2 
    About this table        Species with no ortholog for C10orf140

    ENSEMBL Gene Tree for C10orf140
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for C10orf140 gene
    C17orf962  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    UniProtKB/Swiss-Prot: DLN1_HUMAN, Q1XH10
    Polymorphism: The poly-Ala region of C10orf140 is highly polymorphic and the number of Ala can vary


    10/73 NCBI SNPs in C10orf140 are shown (see all 73 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 25)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs9467111,2
    A,C,F,H21846838(+) TCCTCA/CGCCAG 1 -- ut51 tfbs313Minor allele frequency- C:0.17EU EA WA NS 1292
    rs70796721,2
    A,F,H21842660(+) AAACAC/GAAGTT 1 -- ut314Minor allele frequency- G:0.05EU EA WA 418
    --
    rs412773781,2
    C,F21846864(+) CAAGGC/TATCCT 1 -- ut511Minor allele frequency- T:0.05NS 40
    --
    rs454994941,2
    F21843378(+) TATGAG/CGCAGC 1 -- ut311Minor allele frequency- C:0.18NS 34
    --
    rs454598031,2
    F21852772(+) GAGCCA/GATCAC 1 -- ut511Minor allele frequency- G:0.10NS 40
    --
    rs110127311,2
    C21856596(+) AGACAA/CCCGTG 1 -- ng310--------
    rs110127301,2
    A,C,F,H21851493(+) GCTAAG/ATTTAT 1 -- int15Minor allele frequency- A:0.30EU EA WA NS 456
    rs37585951,2
    F,H21852817(-) TCCCGC/GTTTTT 1 -- int15Minor allele frequency- G:0.02EA EU WA 1906
    --
    rs118151111,2
    A21853964(+) CCAGTC/GTCAGC 1 -- int10--------
    rs123565641,2
    H21853607(+) AAAAAG/AAATGG 1 -- int14Minor allele frequency- A:0.00EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for C10orf140 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    6 PubMed articles for C10orf140 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 387640 HGNC: 32697 AceView: FLJ45187 Ensembl:ENSG00000180592 euGenes: HUgn387640
    ECgene: C10orf140 H-InvDB: C10orf140
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for C10orf140:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Search Novus for antibodies for C10orf140

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