C10orf137 Gene
protein-coding GIFtS: 48
GCID: GC10P127408
|
|
chromosome 10 open reading frame 137
| |
Aliases
for C10orf137 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 10 Open Reading Frame 1371 2 | | EDRF11 2 | | DKFZp586F10191 | | FLJ216171 | | Erythroid Differentiation-Related Factor 12 |
Export aliases for C10orf137 gene to outside databasesPrevious GC identifers: GC10P126983 GC10P127398 GC10P121097 |
Summaries
for C10orf137 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for C10orf137:
This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroidtranscription factor GATA-1 and may regulate the expression of alpha-globin. Alternatively spliced transcript variantsencoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jan 2011)
UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1Function: Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of theglobin gene
|
Genomic Views
for C10orf137 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C10orf137 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 LHX3b/Lhx3b oct-B3 oct-B2 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for C10orf137
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C10orf137 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.13 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q26.2C10orf137 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P127408: view genomic region
(about GC identifiers)
Start:
|
127,408,084 bp from pter |
End:
|
127,452,712 bp from pter |
Size:
|
44,629 bases |
Orientation:
|
plus strand |
|
Proteins
for C10orf137 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1 (See
protein sequence)Recommended Name: Erythroid differentiation-related factor 1 Size: 1238 amino acids; 138528 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAG37462.1; Type=Erroneous initiation; Sequence=CAH73214.1; Type=Erroneous gene modelprediction;
Secondary accessions: B2RC65 Q3KR40 Q4G190 Q5VZQ4 Q8IZ74 Q9Y3W4Alternative splicing: 4 isoforms: Q3B7T1-1 Q3B7T1-3 Q3B7T1-4 Q3B7T1-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C10orf137: NX_Q3B7T1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q3B7T1
C10orf137 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001189367.1 NP_056423.2
ENSEMBL proteins: ENSP00000396544 ENSP00000431902 ENSP00000349244 ENSP00000357805 ENSP00000336727 ENSP00000432229 ENSP00000357803 ENSP00000432102
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
C10orf137 for ontologies About GeneDecksing
C10orf137 Antibody Products:
Assay Products for C10orf137: |
Protein
Domains /
Families
for C10orf137 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q3B7T1 UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1Similarity: Contains 2 TPR repeats |
Function
for C10orf137 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1Function: Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of theglobin gene
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C10orf137 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf137 |
1 GenomeRNAi human phenotype for C10orf137:
|
Pathways & Interactions
for C10orf137 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C10orf137
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/9 Interacting proteins for C10orf137 (Q3B7T12, 3 ENSP000003367274) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
C10orf137 for ontologies About GeneDecksing
|
Drugs & Compounds
for C10orf137 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C10orf137
Search CenterWatch for drugs/clinical trials and news about C10orf137 / EDRF1
|
Transcripts
for C10orf137 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C10orf137 gene (3 alternative transcripts): NM_001202438.1 NM_015608.2 NM_030897.1 Unigene Cluster for C10orf137: Chromosome 10 open reading frame 137 Hs.468688 [show with all ESTs]Unigene Representative Sequence: NM_00120243813 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000419769 ENST00000481600(uc001lip.1) ENST00000356792 ENST00000368815
ENST00000525091(uc001lin.3) ENST00000337623(uc001liq.1 uc001lio.1 uc001lis.1)
ENST00000530795 ENST00000368813(uc001lir.3) ENST00000469725 ENST00000525524
ENST00000527655 ENST00000368812(uc001lit.1) ENST00000525358
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C10orf137 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C10orf137 (see all 3)
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Additional cDNA sequence: AF040247.1 AK025270.1 AK091507.1 AK314958.1 AL050102.1 BC016903.1 BC026172.1 BC028715.2 BC029650.1 BC105929.1 BC107479.1 BC107896.1 15 DOTS entries: DT.121234714 DT.86846996 DT.100764065 DT.101955573 DT.86846995 DT.121234727 DT.86845871 DT.97763816 DT.121234690 DT.65286943 DT.75134901 DT.91675497 DT.97825617 DT.316242 DT.40280152 24/130 AceView cDNA sequences (see all 130): AA913250 AX747027 T52121 AL050102 NM_015608 AA806179 BC026172 CA418184 AA332074 BM995419 BX648348 BC028715 AA282087 BQ440845 CA312204 CA430249 AI656419 F11521 BC029650 BF223246 AI222978 F11522 CA306504 AI569590
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf137 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | · | 22c |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C10orf137
|
Expression
for C10orf137 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C10orf137 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTGAAAGG
About this image
See C10orf137 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C10orf137
SOURCE GeneReport for Unigene cluster: Hs.468688
SABiosciences Custom PCR Arrays for C10orf137
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C10orf137
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf137 |
Orthologs
for C10orf137 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for C10orf137 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for C10orf137 (if available)
TreeFam Gene Tree for C10orf137 (if available) |
Paralogs
for C10orf137 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C10orf137 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C10orf137 (127408084 - 127452712 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C10orf137: --
Human Gene Mutation Database (HGMD): C10orf137
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C10orf137 |
|
Disorders
/ Diseases
for C10orf137 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C10orf137 for disorders About GeneDecksing
2  diseases for C10orf137: About MalaCardsfamilial colorectal cancer colorectal cancer
Human Genome Epidemiology (HuGE) Navigator: C10orf137 (3 documents)
Export disorders for C10orf137 gene to outside databases
|
Publications
for C10orf137 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C10orf137 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with C10orf137) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel erythroid differentiation related gene EDRF1 upregulating globin gene expression in HEL cells. (PubMed id 12609092)1, 2, 9 Wang D.... Shen B. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
|
External Searches for C10orf137 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C10orf137 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C10orf137 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C10orf137 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C10orf137 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C10orf137 gene:
Search GeneIP for patents involving C10orf137
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C10orf137 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | |  |  |  |  | | | | |
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 | | | C10orf137 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C10orf137 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C10orf137 |
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