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C10orf137 Gene

protein-coding   GIFtS: 50

GC10P127398
chromosome 10 open reading frame 137
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp586F1019 1
EDRF1 1, 2
FLJ21617 1
MGC125705 2
RP11-383C5.6 2
Descriptions
chromosome 10 open reading frame 137 2
erythroid differentiation-related factor 1 2
External Ids
HGNC: 246401
Entrez Gene: 260982
UniProtKB: Q3B7T13
Ensembl: ENSG000001079387
Search outside databases for aliases for C10orf137 gene

Previous GC identifer: GC10P126983

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1
Function: Transcription factor involved in erythroid differentiation. Involved in transcriptional
activation of the globin gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf137 gene  

Entrez Gene cytogenetic band: 10q26.13-q26.2   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.2

C10orf137 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P127398:     (about GC identifiers)

Start:
127,398,074 bp from pter
End:
127,442,702 bp from pter
Size:
44,629 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000010.9  NT_035040.4  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1 (See protein sequence)
Recommended Name: Erythroid differentiation-related factor 1  
Size: 1238 amino acids; 138528 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=CAH73214.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RC65 Q3KR40 Q4G190 Q5VZQ4 Q8IZ74 Q9Y3W4
Alternative splicing: 5 isoforms:  Q3B7T1-1   Q3B7T1-2   Q3B7T1-3   Q3B7T1-4   Q3B7T1-5   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_056423.2  

    ENSEMBL proteins: 
    ENSP00000336727 ENSP00000376491 ENSP00000349244 ENSP00000357805 ENSP00000357803 ENSP00000357802 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (C10orf137)
    Human Recombinant Proteins from Abnova (C10orf137)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for C10orf137: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (C10orf137), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (C10orf137)
    Novus Biologicals Antibody for C10orf137

    Assays for C10orf137: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q3B7T1

    UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1
    Similarity: Contains 2 TPR repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (C10orf137)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015608

                  Applied Biosystems Silencer® siRNAs for C10orf137

                  Sigma-Aldrich siRNA for C10orf137  
                         Sigma-Aldrich shRNA for C10orf137  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for C10orf137
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015608
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015608
                                     untagged cDNA clones in CMV expression vector (see all 4): BC026172 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_015608

    UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1
    Function: Transcription factor involved in erythroid differentiation. Involved in transcriptional
    activation of the globin gene

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/7 Interacting proteins for C10orf137 (ENSP000003367273) via UniProtKB, MINT, and/or STRING (see all 7 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCENSP000003672073STRING (score=.866)
    CSF2RAENSP000003709203STRING (score=.82)
    CSF2RBENSP000002628253STRING (score=.82)
    IL6RENSP000003574703STRING (score=.803)
    IL6STENSP000003387993STRING (score=.803)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for C10orf137

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (C10orf137)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015608

                  Sigma-Aldrich siRNA for C10orf137  
                         Sigma-Aldrich shRNA for C10orf137  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_015608  

    REFSEQ mRNAs for C10orf137 gene: 

    NM_015608.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_015608  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015608
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015608
                                     untagged cDNA clones in CMV expression vector (see all 4): BC026172 

    Additional cDNA sequence: 

    AF040247.1 AK025270.1 AK091507.1 AK314958.1 AL050102.1 BC016903.1 BC026172.1 BC028715.2 
    BC029650.1 BC105929.1 BC107479.1 BC107896.1 

    15 DOTS entries:

    DT.121234714  DT.86846996  DT.100764065  DT.101955573  DT.121234727  DT.86846995  DT.86845871  DT.75134901 
    DT.97763816  DT.121234690  DT.40280152  DT.65286943  DT.91675497  DT.97825617  DT.316242 

    24/130 AceView cDNA sequences (see all 130 ):

    BM673102 AK091507 CA418184 NM_015608 BC029650 AA332074 AA806179 AW069820 
    AL050102 AK025270 AI417806 AA635514 AI963607 BC026172 AI569590 T52121 
    AI656419 BF223246 AI222978 CA306504 CA312204 BX648348 BC028715 AA282087 

    highest scoring ESTs for C10orf137:

    AL050102 AA046262 AA046340 AA196633 AA282087 AA411700 AA501413 AA635514 AA700212 AA805086 

    Unigene Cluster for C10orf137:

    Chromosome 10 open reading frame 137
    Hs.468688  [show with all ESTs]
    Unigene Representative Sequence: NM_015608


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf137 (see all 10 )

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
    SP1:                                                                                                                                -                       -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                  -                                                         
    SP5:                                                                                                  -                                                         

    ExUns: 17b ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22a · 22b · 22c
    SP1:                    -                                             
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  

    About this scheme

    ECgene alternative splicing isoforms for C10orf137

    6 Ensembl transcripts including schematic representations:
    ENST00000337623  ENST00000392732  ENST00000356792  ENST00000368815  ENST00000368813  ENST00000368812  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    C10orf137 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for C10orf137

    1 / 2 / 3

    7 probe-sets matching C10orf137 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    34269_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AL050102 1.00 1.00 1.00 1

    213410_at2, 3 U133-A 1 1.00 1.00 -- -- AL050102 1.00 1.00 1.00 1

    215072_x_at2, 3 U133-A 70 1.00 0.91 -- -- AK025270 0.60 1.00 0.82 1

    208115_x_at2, 3 U133-A 70 1.00 0.91 -- -- NM_030897 0.20 1.00 0.72 1

    213410_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    215072_x_at2 U133Plus2 70 1.00 0.91 -- -- -- -- -- -- --

    208115_x_at2 U133Plus2 70 1.00 0.91 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTCTGAAAGG

    SOURCE GeneReport for Unigene cluster: Hs.468688

    Expression variation in blood from EXPOLDB for C10orf137

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for C10orf137 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4778621   -- similar to erythroid differentiation-related factor more 91.52(n)
    96.23(a)
    477862  XM_535054.2  XP_535054.2 
    chimpanzee
    (Pan troglodytes)
    LOC7361161   -- erythroid differentiation-related factor 1 99.53(n)
    99.92(a)
    736116  XM_001137992.1  XP_001137992.1 
    cow
    (Bos taurus)
    LOC5340651   -- similar to erythroid differentiation-related factor more 90.14(n)
    95.25(a)
    534065  XM_864253.2  XP_869346.1 
    rat
    (Rattus norvegicus)
    RGD13068201   -- similar to erythroid differentiation-related factor more 87.74(n)
    93.84(a)
    309069  XM_219414.4  XP_219414.4 
    mouse
    (Mus musculus)
    2700050L05Rik1, 5 75
    RIKEN cDNA 2700050L05 gene1, 5 87.58(n)1
    93.51(a)1
    2147641  NM_178115.31  NP_835216.21 
     AA2097995  AI1817645  (see all 19)
    About this table        Species with no ortholog for C10orf137

    ENSEMBL Gene Tree for C10orf137
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/154 NCBI SNPs in C10orf137 are shown (see all 154 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 114)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs22968301,2
    C,F,H127442530(-) AGCTCG/ATCTTT 1 -- ut31 ese312Minor allele frequency- A:0.10EA NA EU WA 2456
    rs22968311,2
    C,F,H127442044(-) GGACAC/TGGCTC 1 -- ut31 ese35Minor allele frequency- T:0.11EA EU WA 1908
    rs171535101,2
    C,F,H127431429(+) AGCACG/ACATTC 1 T/A mis112Minor allele frequency- A:0.15NA EU EA WA 1052
    rs283813371,2
    F127443189(-) AATTCG/TGCTTA 1 -- ng315Minor allele frequency- T:0.01NS 176
    --
    rs171534811,2
    F127414343(+) AGTGAT/CGAAAA 1 D/D syn11Minor allele frequency- C:0.02EU 94
    rs109014211,2
    A,C,F,H127422249(+) AGGTTG/ATAAGT 1 -- int111Minor allele frequency- A:0.36NA EU EA WA 922
    rs65977261,2
    A,C,F,H127428415(+) ATTCAA/TTCGGC 1 -- int17Minor allele frequency- T:0.09EU EA WA NA 558
    rs37401811,2
    A,C,F,H127416420(-) ACATAC/TTGTTT 1 -- int114Minor allele frequency- T:0.29EA NS NA EU WA 2250
    rs98043561,2
    A,C,F,H127400736(+) AAATAC/TCATTT 1 -- int16Minor allele frequency- T:0.39EU EA WA NA 586
    rs112446261,2
    A,C,F,H127415049(+) TCCCTG/ATGATT 1 -- int111Minor allele frequency- A:0.39EU EA WA NA 980
    About this table

    HapMap Linkage Disequilibrium images for C10orf137 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    8 PubMed articles for C10orf137 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 26098 HGNC: 24640 AceView: C10orf137 Ensembl:ENSG00000107938 euGenes: HUgn26098
    ECgene: C10orf137 H-InvDB: C10orf137
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for C10orf137:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for C10orf137 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for C10orf137 Browse small molecules at Sigma-Aldrich
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     Antibodies for C10orf137

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