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Aliases & Descriptions for C10orf137
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp586F1019 1 | | EDRF1 1, 2 | | FLJ21617 1 | | MGC125705 2 | | RP11-383C5.6 2 |
| | | Descriptions |
|---|
| chromosome 10 open reading frame 137 2 | | erythroid differentiation-related factor 1 2 |
|
| | Search outside databases for aliases for C10orf137 genePrevious GC identifer: GC10P126983 |
Summaries for C10orf137(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1Function: Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene |
Genomic Location for C10orf137
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the C10orf137 gene 
Entrez Gene cytogenetic band: 10q26.13-q26.2 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q26.2C10orf137 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P127398:
(about GC identifiers)
Start:
|
127,398,074 bp from pter |
End:
|
127,442,702 bp from pter |
Size:
|
44,629 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_035040.4
| Proteins for C10orf137
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1 (See
protein sequence)Recommended Name: Erythroid differentiation-related factor 1 Size: 1238 amino acids; 138528 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=CAH73214.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RC65 Q3KR40 Q4G190 Q5VZQ4 Q8IZ74 Q9Y3W4Alternative splicing: 5 isoforms: Q3B7T1-1 Q3B7T1-2 Q3B7T1-3 Q3B7T1-4 Q3B7T1-5 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056423.2
ENSEMBL proteins: ENSP00000336727 ENSP00000376491 ENSP00000349244 ENSP00000357805 ENSP00000357803 ENSP00000357802
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for C10orf137: Assays for C10orf137: | Protein
Domains/ Families for C10orf137(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q3B7T1 UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1Similarity: Contains 2 TPR repeats | Gene Function for C10orf137
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015608
Applied Biosystems Silencer® siRNAs for C10orf137
Sigma-Aldrich siRNA for C10orf137  Sigma-Aldrich shRNA for C10orf137  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015608                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015608                                  untagged cDNA clones in CMV expression vector (see all 4): BC026172 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015608
UniProtKB/Swiss-Prot: EDRF1_HUMAN, Q3B7T1Function: Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene | Pathways & Interactions for C10orf137
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/7 Interacting proteins for C10orf137 (ENSP000003367273) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for C10orf137(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for C10orf137
|
Transcripts for C10orf137(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015608
Sigma-Aldrich siRNA for C10orf137  Sigma-Aldrich shRNA for C10orf137  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015608 REFSEQ mRNAs for C10orf137 gene: NM_015608.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015608               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015608                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015608                                  untagged cDNA clones in CMV expression vector (see all 4): BC026172  Additional cDNA sequence: AF040247.1 AK025270.1 AK091507.1 AK314958.1 AL050102.1 BC016903.1 BC026172.1 BC028715.2 BC029650.1 BC105929.1 BC107479.1 BC107896.1 15 DOTS entries: DT.121234714 DT.86846996 DT.100764065 DT.101955573 DT.121234727 DT.86846995 DT.86845871 DT.75134901 DT.97763816 DT.121234690 DT.40280152 DT.65286943 DT.91675497 DT.97825617 DT.316242 24/130 AceView cDNA sequences (see all 130
):BM673102 AK091507 CA418184 NM_015608 BC029650 AA332074 AA806179 AW069820 AL050102 AK025270 AI417806 AA635514 AI963607 BC026172 AI569590 T52121 AI656419 BF223246 AI222978 CA306504 CA312204 BX648348 BC028715 AA282087
highest scoring ESTs for C10orf137:AL050102 AA046262 AA046340 AA196633 AA282087 AA411700 AA501413 AA635514 AA700212 AA805086 Unigene Cluster for C10orf137: Chromosome 10 open reading frame 137 Hs.468688 [show with all ESTs]Unigene Representative Sequence: NM_015608
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for C10orf137 (see all 10
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | · | 22c | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for C10orf137
6 Ensembl transcripts including schematic representations: ENST00000337623
ENST00000392732
ENST00000356792
ENST00000368815
ENST00000368813
ENST00000368812
|
Expression for C10orf137
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| C10orf137 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for C10orf137
1 / 2 / 3 7 probe-sets matching C10orf137 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTCTGAAAGG
SOURCE GeneReport for Unigene cluster: Hs.468688
Expression variation in blood from EXPOLDB for C10orf137 |
Orthologs for C10orf137
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for C10orf137 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for C10orf137
ENSEMBL Gene Tree for C10orf137 | Paralogs for C10orf137(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for C10orf137(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for C10orf137 (up to first 250kb)
|
Disorders & Mutations for C10orf137
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for C10orf137(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for C10orf137 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for C10orf137 gene: |
Search for C10orf137
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing C10orf137
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing C10orf137
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C10orf137(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for C10orf137(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for C10orf137:

|
GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
|