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C10orf136 Gene

protein-coding   GIFtS: 31

GC10P043660
chromosome 10 open reading frame 136
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
bA168P8.1 1, 2
Descriptions
chromosome 10 open reading frame 136 2
External Ids
HGNC: 316571
Entrez Gene: 4142602
UniProtKB: Q5W0B83
Ensembl: ENSG000002041877
Search outside databases for aliases for C10orf136 gene

Previous GC identifer: GC10U900545

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the C10orf136 gene  

Entrez Gene cytogenetic band: 10q11.21   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.21

C10orf136 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P043660:     (about GC identifiers)

Start:
43,660,760 bp from pter
End:
43,666,076 bp from pter
Size:
5,317 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000010.9  NT_033985.6  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ136_HUMAN, Q5W0B8 (See protein sequence)
Recommended Name: Putative uncharacterized protein C10orf136  
Size: 63 amino acids; 6775 Da
Sequence caution: Sequence=CAH70844.1; Type=Erroneous gene model prediction;



ENSEMBL proteins: 
ENSP00000386475 ENSP00000363554 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for C10orf136: 
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Search Novus for antibodies for C10orf136

Assays for C10orf136: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
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Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5W0B8

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for C10orf136

              Sigma-Aldrich siRNA for C10orf136  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                Browse Origene genome-wide validated SYBR primer pairs

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf136

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Sigma-Aldrich siRNA for C10orf136  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

XM_926383  

                Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Additional cDNA sequence: 

BC017939.1 XM_926383.3 

1 DOTS entry:

DT.95331432 

highest scoring ESTs for C10orf136:

BC017939 BF670044 AW613725 XM_926383 

Unigene Cluster for C10orf136:

Chromosome 10 open reading frame 136
Hs.351856  [show with all ESTs]
Unigene Representative Sequence: BC017939


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000409928  ENST00000374432  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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C10orf136 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for C10orf136

1 / 2

1 probe-set matching C10orf136 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1560851_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TGTAGGTCCA

SOURCE GeneReport for Unigene cluster: Hs.351856
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for C10orf136 gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
LOC7458561   -- hypothetical protein LOC745856 98.41(n)
96.83(a)
745856  XM_001152261.1  XP_001152261.1 
About this table        Species with no ortholog for C10orf136

ENSEMBL Gene Tree for C10orf136
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/40 NCBI SNPs in C10orf136 are shown (see all 40 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 38)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs12548461,2
A,C,F,H43666100(+) TATATA/GTACAC 1 -- ng319Minor allele frequency- G:0.04MN EU EA WA 1006
rs16752911,2
C,F,H,O43659321(+) AAATTC/TTGAGT 1 -- ng5113Minor allele frequency- T:0.13MN EU EA WA 1440
rs112387381,2
A43659424(+) GGAGAA/GAACAT 1 -- ng51 trp30--------
--
rs415314441,2
F43659191(+) GTTGGG/AATCGG 1 -- ng514Minor allele frequency- A:0.05EU EA WA 418
rs7487151,2
A,C,F,H,O43663093(-) ATCACG/ATAACC 1 -- int111Minor allele frequency- A:0.31NA EA EU WA 1075
rs107935031,2
A,C,F,H43664744(+) AGGGTC/TGGTGA 1 -- int112Minor allele frequency- N:0.00EU EA WA NA 1052
rs49487851,2
A,C,F,H43660871(+) TTCCTG/ATCCAG 1 -- int18Minor allele frequency- A:0.33EU EA WA 838
rs108999221,2
A,C,F,H43661970(+) CTGAAA/GAGACG 1 -- int14Minor allele frequency- G:0.41EU EA WA 418
rs171544991,2
F,H43663937(+) CCTATG/CGTTCG 1 -- int17Minor allele frequency- C:0.04NA EU EA WA 560
rs127843361,2
H43664077(+) TAATTT/ATTTAT 1 -- int14Minor allele frequency- A:0.00EU EA WA 368
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HapMap Linkage Disequilibrium images for C10orf136 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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3 PubMed articles for C10orf136 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 414260 HGNC: 31657 Ensembl:ENSG00000204187 euGenes: HUgn414260 ECgene: C10orf136
H-InvDB: C10orf136
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for C10orf136:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
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 Predesigned and custom siRNAs for C10orf136 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for C10orf136

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