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C10orf134 Gene

protein-coding   GIFtS: 34

GC10P118598
chromosome 10 open reading frame 134
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for C10orf134

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZP781N1041 2
Em:AC023283.3 1
Descriptions
chromosome 10 open reading frame 134 2
External Ids
HGNC: 316701
Entrez Gene: 3877122
UniProtKB: A6NNW63
Ensembl: ENSG000001883167
Search outside databases for aliases for C10orf134 gene

Previous GC identifer: GC10U900549

Summaries
for C10orf134

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for C10orf134

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q26

C10orf134 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P118598:     (about GC identifiers)

Start:
 118,598,662 bp from pter
End:
 118,661,287 bp from pter
Size:
 62,626 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  

Proteins
for C10orf134

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: ENOLL_HUMAN, A6NNW6 (See protein sequence)
Recommended Name: Enolase-like protein ENSP00000345555  
Size: 628 amino acids; 68821 Da

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2




    • ENSEMBL proteins: 
    ENSP00000345555 ENSP00000387194 ENSP00000358208 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for C10orf134: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
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    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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    Search Novus for antibodies for C10orf134

    Assays for C10orf134: 
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    Protein Domains/
    Families
    for C10orf134

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR000941 Enolase


       GeneDecks  C10orf134 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry A6NNW6

    ProtoNet protein and cluster: A6NNW6

    UniProtKB/Swiss-Prot: ENOLL_HUMAN, A6NNW6
    Similarity: Belongs to the enolase family

    Gene Function
    for C10orf134

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (C10orf134)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Applied Biosystems Silencer® siRNAs for C10orf134

                  Sigma-Aldrich siRNA for C10orf134  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                    Browse Origene for untagged/tagged cDNA clones in CMV expression vector

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                    Browse Origene genome-wide validated SYBR primer pairs

    Pathways & Interactions
    for C10orf134

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  C10orf134  (Your Favorite Gene powered by Ingenuity) 
     Glycolysis/Gluconeogenesis
     Phenylalanine, Tyrosine and Tryptophan Biosynthesis

       GeneDecks  C10orf134 for the pathways selected above  
    About GeneDecksing

      --

    Drugs & Compounds
    for C10orf134

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for C10orf134

    Transcripts
    for C10orf134

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (C10orf134)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Sigma-Aldrich siRNA for C10orf134  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    XM_370577  

                    Browse Origene for untagged/tagged cDNA clones in CMV expression vector

    Additional cDNA sequence: 

    BX647301.1 XM_370577.6 

    5 DOTS entries:

    DT.121266216  DT.40305752  DT.86842280  DT.40219214  DT.40258166 

    6 AceView cDNA sequences:

    BX647301 CB306434 AW340603 BM982317 M85414 AA811493 

    Unigene Cluster for C10orf134:

    Chromosome 10 open reading frame 134
    Hs.696001  [show with all ESTs]
    Unigene Representative Sequence: XM_370577


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000341276  ENST00000409522  ENST00000369207  

    Expression
    for C10orf134

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
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    C10orf134 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for C10orf134

    1Data from GNF BioGPS
        About these images

    About these images

    CGAP SAGE TAG: TCTGTGCTGA

    SOURCE GeneReport for Unigene cluster: Hs.696001

    Orthologs
    for C10orf134

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for C10orf134 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LOC4778321   -- similar to enolase 2 84.65(n)
    80.51(a)    		 477832  XM_535025.2  XP_535025.2 
    chimpanzee
    (Pan troglodytes)    		 LOC7422151   -- hypothetical protein LOC742215 95.72(n)
    95.05(a)    		 742215  XM_001145271.1  XP_001145271.1 
    rat
    (Rattus norvegicus)    		 RGD13083331   -- similar to enolase (46.6 kD) (2J223) 78.88(n)
    73.78(a)    		 292138  XM_214733.4  XP_214733.4 
    mouse
    (Mus musculus)    		 6430537H07Rik1, 5 195
    		 RIKEN cDNA 6430537H07 gene1, 5 78.75(n)1
    73.98(a)1    		 2262651  NM_178689.31  NP_848804.11 
     AK0323955  AK0766825  (see all 9)
    chicken
    (Gallus gallus)    		 LOC4239181   -- similar to RIKEN cDNA 6430537H07 gene 60.35(n)
    47.39(a)    		 423918  XM_421780.2  XP_421780.2 
    About this table        Species with no ortholog for C10orf134

    ENSEMBL Gene Tree for C10orf134

    Paralogs
    for C10orf134

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for C10orf134 gene
    ENSG000002158092  ENO12  

    SNPs/Variants
    for C10orf134

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/171 NCBI SNPs in C10orf134 are shown (see all 171 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 50)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs24498071,2
    		A,C,F,H118632067(+) TAAAAG/TGGTTA 1 -- ut314Minor allele frequency- T:0.05EU EA WA 414
    rs10235511,2
    		A,C,F,H118597287(+) GGTTAT/CAGGGT 1 -- ng514Minor allele frequency- C:0.40EU EA WA 412
    rs10235501,2
    		A,C,F,H118597218(+) aatgaT/Cgctgc 1 -- ng514Minor allele frequency- C:0.43EU EA WA 398
    rs10235521,2
    		A,C,F,H118597569(+) AGGTGA/GAATGG 1 -- ng517Minor allele frequency- G:0.40NA EA EU WA 612
    rs10235491,2
    		A,C,F,H118596800(+) CATCAA/GTTCCC 1 -- ng518Minor allele frequency- G:0.44MN EU EA WA NA 740
    rs94212461,2
    		A,C,F,H118598092(+) CCGCCC/TACTCC 1 -- ng5111Minor allele frequency- T:0.40EU EA WA NA 958
    --
    rs24293651,2
    		A,C,H118631869(+) CATACT/CACAGC 1 -- ut31 ese34Minor allele frequency- C:0.00EU EA WA 396
    --
    rs111978431,2
    		C,F,H118631386(+) ATGTGG/TATTTT 1 -- ut31 ese312Minor allele frequency- T:0.14EU EA WA NA 1040
    --
    rs170953371,2
    		F118598924(+) TAAAAG/AGGAAC 1 -- ut513Minor allele frequency- A:0.01NA 140
    --
    rs79206381,2
    		H118631802(+) AGTATA/CAATGA 1 -- ut314Minor allele frequency- C:0.00EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for C10orf134 (up to first 250kb)

    Disorders & Mutations
    for C10orf134

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for C10orf134

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for C10orf134

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		1 PubMed article for C10orf134 gene:

    Search for C10orf134

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C10orf134

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 387712 HGNC: 31670 AceView: LOC387712 Ensembl:ENSG00000188316 euGenes: HUgn387712
    ECgene: C10orf134 H-InvDB: C10orf134

    Other Databases showing C10orf134

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing C10orf134

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for C10orf134

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for C10orf134

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for C10orf134:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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     Predesigned and custom siRNAs for C10orf134 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for C10orf134

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