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GOLGA7B Gene

protein-coding   GIFtS: 38

GC10P099599
golgi autoantigen, golgin subfamily a, 7B
(Previous names: chromosome 10 open reading frame 133, chromosome 10 open reading frame 132 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: C10orf133, C10orf132)
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Aliases &
Descriptions
for GOLGA7B

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
C10orf132 2, 3
C10orf133 2, 3
MGC131701 2
OTTHUMP00000020232 2
bA451M19.3 1, 2
bA459F3.4 1, 2
Descriptions
chromosome 10 open reading frame 132 1
chromosome 10 open reading frame 133 1
golgi autoantigen, golgin subfamily a, 7B 2
golgi autoantigen-like 2
External Ids
HGNC: 316681
Entrez Gene: 4016472
UniProtKB: Q2TAP03
Ensembl: ENSG000001552657
Search outside databases for aliases for GOLGA7B gene

Summaries
for GOLGA7B

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GOG7B_HUMAN, Q2TAP0
Function: May be involved in protein transport from Golgi to cell surface (By similarity)

Genomic Location
for GOLGA7B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.2   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24.2

GOLGA7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P099599:     (about GC identifiers)

Start:
 99,599,986 bp from pter
End:
 99,617,772 bp from pter
Size:
 17,787 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  

Proteins
for GOLGA7B

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: GOG7B_HUMAN, Q2TAP0 (See protein sequence)
Recommended Name: Golgin subfamily A member 7B  
Size: 167 amino acids; 18335 Da
Subcellular location: Golgi apparatus membrane; Lipid-anchor (By similarity)
Secondary accessions: Q5T4F5

REFSEQ proteins: NP_001010917.1  

ENSEMBL proteins: 
ENSP00000359634 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (C10ORF132)
Browse Abnova for Human Recombinant Proteins
              OriGene Purified Recombinant Human Protein: GOLGA7B 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000139 Golgi membrane IEA--
GO:0005794 Golgi apparatus IEA--
GO:0016020 membrane IEA--
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Antibodies for GOLGA7B: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for GOLGA7B
Browse R&D Systems for Antibodies
Antibodies from Abcam (C10ORF132), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for GOLGA7B

Assays for GOLGA7B: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for GOLGA7B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR019383 Golgin_A_7/ERF4


   GeneDecks  GOLGA7B for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q2TAP0

ProtoNet protein and cluster: Q2TAP0

UniProtKB/Swiss-Prot: GOG7B_HUMAN, Q2TAP0
Similarity: Belongs to the ERF4 family

Gene Function
for GOLGA7B

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (GOLGA7B)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001010917

              Applied Biosystems Silencer® siRNAs for GOLGA7B

              Sigma-Aldrich siRNA for GOLGA7B  
                     Sigma-Aldrich shRNA for GOLGA7B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010917
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010917
                                 untagged cDNA clone in CMV expression vector: NM_001010917 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001010917

UniProtKB/Swiss-Prot: GOG7B_HUMAN, Q2TAP0
Function: May be involved in protein transport from Golgi to cell surface (By similarity)

Pathways & Interactions
for GOLGA7B

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for GOLGA7B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GOLGA7B

Transcripts
for GOLGA7B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (GOLGA7B)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001010917

              Sigma-Aldrich siRNA for GOLGA7B  
                     Sigma-Aldrich shRNA for GOLGA7B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001010917  

REFSEQ mRNAs for GOLGA7B gene: 

NM_001010917.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001010917  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010917
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010917
                                 untagged cDNA clone in CMV expression vector: NM_001010917 

Additional cDNA sequence: 

BC008047.2 BC020255.1 BC110810.1 

4 DOTS entries:

DT.400577  DT.100746864  DT.102820708  DT.423813 

24/78 AceView cDNA sequences (see all 78 ):

BM931682 BU950363 CA308047 F11306 BQ719590 Z44357 AI821050 AK125454 
BQ187313 BM718482 AI952033 T09440 BQ214386 BM709434 BG678654 BG767141 
R60252 BX282404 BQ950672 T09172 AI917468 BE384574 BI754792 BM083452 

Unigene Cluster for GOLGA7B:

Golgi autoantigen, golgin subfamily a, 7B
Hs.567524  [show with all ESTs]
Unigene Representative Sequence: NM_001010917


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000370602  

Expression
for GOLGA7B

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GOLGA7B expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for GOLGA7B

1 / 2

3 probe-sets matching GOLGA7B gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

90036_at2 U95-E 1 1.00 1.00 1.00 1.00 -- -- -- -- --

228068_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

228068_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGAGGGCTGG

SOURCE GeneReport for Unigene cluster: Hs.567524

Orthologs
for GOLGA7B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for GOLGA7B gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
cow
(Bos taurus)		 GOLGA7B1   -- golgi autoantigen, golgin subfamily a, 7B 94.41(n)
98.2(a)		 767832  NM_001076954.1  NP_001070422.1 
rat
(Rattus norvegicus)		 Golga7b1   -- golgi autoantigen, golgin subfamily a, 7B 91.22(n)
98.2(a)		 309378  XM_219889.4  XP_219889.4 
mouse
(Mus musculus)		 Golga7b1, 5 195
 golgi autoantigen, golgin subfamily a, 7B1, 5 91.22(n)1
98.8(a)1		 711461  NM_027694.11  NP_081970.11 
 AI8399345  AK0168505  (see all 9)
zebrafish
(Danio rerio)		 LOC5655901   -- similar to Uncharacterized protein C10orf132 75.37(n)
84.08(a)		 565590  XM_688859.2  XP_693951.2 
fruit fly
(Drosophila melanogaster)		 CG54471   -- CG5447 60.56(n)
55.83(a)		 43192  NM_143221.2  NP_651478.1 
About this table        Species with no ortholog for GOLGA7B

ENSEMBL Gene Tree for GOLGA7B

Paralogs
for GOLGA7B

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for GOLGA7B gene
GOLGA72  

SNPs/Variants
for GOLGA7B

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/50 NCBI SNPs in GOLGA7B are shown (see all 50 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 51)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs14170011,2
A,C,F,H99610122(+) tttttC/Tttttc 1 -- int1 trp34Minor allele frequency- T:0.46EU EA WA 418
rs125696271,2
A,C,F,H99606542(+) tgtctC/Tactgt 1 -- int18Minor allele frequency- T:0.07EU EA WA 822
rs111894121,2
A,C,F,H99601703(+) CGCATG/AAGTGA 1 -- int112Minor allele frequency- A:0.30EU EA WA 1256
rs118194761,2
A,C,F,H99601583(+) CTCTAT/GGTCAA 1 -- int18Minor allele frequency- G:0.15EU EA WA 836
rs79112921,2
F,H99609643(+) GGATGA/GTACAG 1 -- int14Minor allele frequency- G:0.02EU EA WA 420
--
rs14170001,2
A,C99610117(+) ggtctC/Tttttt 1 -- int1 trp30--------
rs44394511,2
H99603529(+) TTTCAG/CAGCAT 1 -- int14Minor allele frequency- C:0.00EU EA WA 418
rs127806421,2
H99600385(+) TTGGAG/AACGCG 1 -- int11Minor allele frequency- A:0.00WA 120
--
rs616402411,2
--99599358(+) GGGCGA/GGGGAG 1 -- ng510--------
--
rs127794561,2
--99600025(+) CCCCGC/GGACAG 1 -- ut51 ese30--------
About this table

HapMap Linkage Disequilibrium images for GOLGA7B (up to first 250kb)

Disorders & Mutations
for GOLGA7B

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for GOLGA7B

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for GOLGA7B

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

3 PubMed articles for GOLGA7B gene:

Search for GOLGA7B

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing GOLGA7B

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 401647 HGNC: 31668 AceView: C10orf132 Ensembl:ENSG00000155265 euGenes: HUgn401647
ECgene: GOLGA7B H-InvDB: GOLGA7B

Other Databases showing GOLGA7B

(According to HUGE)
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   --

Specialized Databases showing GOLGA7B

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for GOLGA7B

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for GOLGA7B

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for GOLGA7B:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for GOLGA7B-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for GOLGA7B Antibodies for GOLGA7B
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for GOLGA7B Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
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 Antibodies (C10ORF132)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for GOLGA7B




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for GOLGA7B

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