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C10orf128 Gene

protein-coding   GIFtS: 36
GCID: GC10M050362          (predicted)

Chromosome 10 Open Reading Frame 128

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 10 Open Reading Frame 1281 2
Putative Uncharacterized Protein C10orf1282

External Ids:    HGNC: 272741   Entrez Gene: 1703712   Ensembl: ENSG000002041617   UniProtKB: Q5T2923   

Export aliases for C10orf128 gene to outside databases

Previous GC identifers: GC10M049707 GC10M050033 GC10M044628


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C10orf128 Gene:
C10orf128 (chromosome 10 open reading frame 128) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C10orf128 gene promoter:
         STAT5B   HOXA9B   HOXA9   SREBP-1c   CUTL1   SREBP-1b   C/EBPalpha   SREBP-1a   Meis-1a   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C10orf128

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C10orf128


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.23

C10orf128 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C10orf128 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M050362:  view genomic region     (about GC identifiers)

Start:
50,362,773 bp from pter      End:
50,396,630 bp from pter
Size:
33,858 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CJ128_HUMAN, Q5T292 (See protein sequence)
Recommended Name: Putative uncharacterized protein C10orf128 precursor  
Size: 105 amino acids; 11325 Da
Secondary accessions: A6XND2 Q5T289 Q5T291
Alternative splicing: 4 isoforms:  Q5T292-1   Q5T292-2   Q5T292-3   Q5T292-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C10orf128: NX_Q5T292

Explore proteomics data for C10orf128 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C10orf128 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001010863.1  NP_001275669.1  NP_001275670.1  NP_001275671.1  NP_001275672.1  

    ENSEMBL proteins: 
     ENSP00000432859   ENSP00000363268   ENSP00000417246   ENSP00000395067   ENSP00000363263  
     ENSP00000363266  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5T292


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for C10orf128

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CJ128_HUMAN, Q5T292: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with C10orf128           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C10orf128
    Interactions:

        Search GeneGlobe Interaction Network for C10orf128

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C10orf128 (CJ128)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C10orf128 gene (5 alternative transcripts): 
    NM_001010863.2  NM_001288740.1  NM_001288741.1  NM_001288742.1  NM_001288743.1  

    Unigene Cluster for C10orf128:

    Chromosome 10 open reading frame 128
    Hs.385493  [show with all ESTs]
    Unigene Representative Sequence: BC047724
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374156(uc001jhl.4) ENST00000374153(uc001jhn.4) ENST00000488276
    ENST00000474718 ENST00000453436 ENST00000374148(uc001jho.4) ENST00000470884
    ENST00000374151(uc010qgo.2)
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    Additional mRNA sequence: 

    AK303891.1 AL832399.1 BC031641.1 BC037922.2 BC042857.1 BC047724.1 BC104438.1 BC104439.1 
    DQ884399.1 

    8 DOTS entries:

    DT.40114455  DT.95366537  DT.121279313  DT.95150966  DT.100019575  DT.121279280  DT.409502  DT.92438315 

    Selected AceView cDNA sequences (see all 64):

    AJ346402 BM728295 CR618023 AI192391 BU145920 AA039928 CR607332 BX104589 
    CA406806 BM972773 BC031641 AW170228 BQ716090 AL832399 CR624206 AI301837 
    CB530036 AW241161 BI544247 BI544323 BI011006 AI038938 BQ575844 AA214559 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    C10orf128 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    C10orf128 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C10orf128 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.385493
        Custom PCR Arrays for C10orf128
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for C10orf128 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1810011H11Rik1 , 5 RIKEN cDNA 1810011H11 gene1, 5 77.3(n)1
    75.53(a)1
      14 (19.40 cM)5
    690691  NM_001163616.11  NP_001157088.11 
     327859635 


    ENSEMBL Gene Tree for C10orf128 (if available)
    TreeFam Gene Tree for C10orf128 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C10orf128 (see all 954)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727850931,2
    C,F--50363403(+) CGATAG/AGGCTA 1 -- ds50016Minor allele frequency- A:0.13WA NA CSA 246
    rs70810971,2
    C,F,A--50363454(+) CTTCAC/AATAGT 1 -- ds5001 ese36Minor allele frequency- A:0.17WA NA EA 364
    rs1465519991,2
    --50363460(+) ATAGTA/CCATCT 1 -- ds50010--------
    rs37507431,2
    C,H--50363508(-) TAGAAC/TGATTA 1 -- ds50015Minor allele frequency- T:0.01EA NS 1902
    rs38337331,2
    C--50363546(-) TACAC-/ACTGCCA 1 -- ds50010--------
    rs1875239341,2
    --50363567(+) GTGTTC/GGGTCG 1 -- ds50010--------
    rs1390822681,2
    --50363613(+) TTCCAC/TGGACA 1 -- ds50010--------
    rs1917683431,2
    --50363614(+) TCCACA/GGACAT 1 -- ds50010--------
    rs111010001,2
    C,F--50363730(+) CAGTCC/TGTTTC 1 -- ds5001 ese31Minor allele frequency- T:0.05WA 118
    rs1828186071,2
    --50363731(+) AGTCCA/GTTTCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for C10orf128 (50362773 - 50396630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for C10orf128:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736496CNV Deletion23290073
    nsv895365CNV Loss21882294
    nsv895369CNV Gain21882294
    nsv895375CNV Gain21882294
    nsv7203OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with C10orf128           About GenesLikeMe

    Genetic Association Database (GAD): C10orf128

    Export disorders for C10orf128 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C10orf128 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C10orf128)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)4 Lunetta K.L....Murabito J.M. (BMC Med. Genet. 2007)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 170371 HGNC: 27274 AceView: C10orf128 Ensembl:ENSG00000204161 euGenes: HUgn170371
    ECgene: C10orf128 H-InvDB: C10orf128

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C10orf128 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C10orf128 gene:
    Search GeneIP for patents involving C10orf128

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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