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C10orf128 Gene

protein-coding GIFtS: 37

GC10M050033

chromosome 10 open reading frame 128
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
Em:AC084727.5 ^¹
OTTHUMP00000019575 ^²

Descriptions
chromosome 10 open reading frame 128 ^²
hypothetical protein LOC170371 ^²

External Ids
HGNC: 27274¹
Entrez Gene: 170371²
UniProtKB: Q5T292³
Ensembl: ENSG00000204161⁷

Search outside databases for aliases for C10orf128 gene

Previous GC identifer: GC10M049707

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C10orf128 gene

Entrez Gene cytogenetic band: 10q11.22 Ensembl cytogenetic band: 10q11.22 HGNC cytogenetic band: 10q11.23

C10orf128 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M050033: (about GC identifiers)

Start:	50,032,781 bp from pter
End:	50,066,442 bp from pter
Size:	33,662 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_017696.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CJ128_HUMAN, Q5T292 (See protein sequence)

Recommended Name: Putative uncharacterized protein C10orf128 precursor

Size: 105 amino acids; 11325 Da

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: A6XND2 Q5T289 Q5T291

Alternative splicing: 4 isoforms: Q5T292-1 Q5T292-2 Q5T292-3 Q5T292-4

REFSEQ proteins: NP_001010863.1

ENSEMBL proteins:

ENSP00000363263 ENSP00000363271 ENSP00000363266 ENSP00000363268 ENSP00000363264 ENSP00000382325

Human Recombinant Proteins

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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for C10orf128:

	Browse Antibodies Central at Invitrogen
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	Search Novus for antibodies for C10orf128

Assays for C10orf128:

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	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5T292

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf128)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Applied Biosystems Silencer® siRNAs for C10orf128

Sigma-Aldrich siRNA for C10orf128

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010863
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010863
untagged cDNA clone in CMV expression vector: NM_001010863

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001010863

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C10orf128

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C10orf128)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Sigma-Aldrich siRNA for C10orf128

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001010863

REFSEQ mRNAs for C10orf128 gene:

NM_001010863.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001010863

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001010863
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001010863
                                 untagged cDNA clone in CMV expression vector: NM_001010863

Additional cDNA sequence:

AK303891.1 AL832399.1 BC031641.1 BC037922.2 BC042857.1 BC047724.1 BC104438.1 BC104439.1

CR607332.1 CR618023.1 CR624206.1 DQ884399.1

8 DOTS entries:

DT.40114455 DT.95366537 DT.121279313 DT.95150966 DT.92438315 DT.100019575 DT.121279280 DT.409502

24/64 AceView cDNA sequences (see all 64 ):

BU145920 AL832399 AI301837 CB530036 BC031641 BX104589 AJ346402 CR624206

BM728295 AW170228 CA406806 AI192391 BM972773 CR618023 BQ716090 AA039928

CR607332 AA213418 AA975363 AL574720 AL523001 BI826093 BC047724 CA396219

highest scoring ESTs for C10orf128:

AA214559 BC037922 BC042857 BC047724 BI544247 BI544323 BM921158 CA396219 AA039928 AA041552

Unigene Cluster for C10orf128:

Chromosome 10 open reading frame 128

Hs.385493 [show with all ESTs]

Unigene Representative Sequence: BC047724

GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations:

ENST00000374148 ENST00000374156 ENST00000374151 ENST00000374153 ENST00000374149 ENST00000399393

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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C10orf128 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C10orf128

¹ / ² / ³

4 probe-sets matching C10orf128 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54479_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA214559	0.80	1.00	0.91	1
228372_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW204712	0.60	1.00	0.82	1
228372_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1561890_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks C10orf128 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.385493

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for C10orf128 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC736514¹	--	hypothetical protein LOC736514	89.38(n) 86.81(a)	736514 XM_001138495.1 XP_001138495.1
cow (Bos taurus)	LOC783944¹	--	hypothetical LOC783944	79.63(n) 68.89(a)	783944 XM_001251638.1 XP_001251639.1
rat (Rattus norvegicus)	RGD1561145¹	--	similar to novel protein	74.11(n) 69.15(a)	498580 XM_573856.2 XP_573856.2
mouse (Mus musculus)	1810011H11Rik^{1, 5}	14⁵	RIKEN cDNA 1810011H11 gene^{1, 5}	77.3(n)¹ 75.53(a)¹	69069¹ XM_358452.4¹ XP_358452.1¹ AK007434⁵ AK014636⁵ (see all 8)

About this table Species with no ortholog for C10orf128

ENSEMBL Gene Tree for C10orf128

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/235 NCBI SNPs in C10orf128 are shown (see all 235 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 129)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10857438^1,2	A,C,F,H	50067687(+)	`CCCCTC/TAGGCT`	1	--	ng3¹		1		WA	120
	rs12257132^1,2	C,F,H	50043838(+)	`TTAGCG/AGGATG`	1	L/P	mis¹		8		EU EA WA	840
	rs12257188^1,2	F,H	50068040(+)	`ATTTCA/CCTTTC`	1	--	ng3¹ tfbs³		4		EU EA WA	416
--	rs7081097^1,2	A,C	50033460(+)	`CTTCAA/CATAGT`	1	--	ng5¹ ese³		0	--	--	--	--
	rs17009534^1,2	F,H	50066394(+)	`CTGGCG/ACTCTG`	1	--	ut5¹ ese³		7		NA EU EA WA	536
	rs3750743^1,2	H	50033514(-)	`TAGAAC/TGATTA`	1	--	ng5¹		5		EA EU WA	1902
	rs2725180^1,2	A,C,F,H,O	50039401(-)	`GAAAAT/CGGTTT`	1	--	int¹		16		EA NA EU WA	1474
	rs1962336^1,2	A,C,F,H,O	50063019(-)	`AACACG/ATTGCA`	1	--	int¹		13		MN EU EA WA NA	1180
	rs2003044^1,2	A,C,F,H,O	50042353(-)	`GACCTG/AGGATG`	1	--	int¹		5		MN EU EA WA	602
	rs2002332^1,2	A,C,F,O	50052352(+)	`CTCCAA/CGGGGC`	1	--	int¹		4		EA NA	208

About this table

HapMap Linkage Disequilibrium images for C10orf128 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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4 PubMed articles for C10orf128 gene:

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)⁴ Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 170371	HGNC: 27274	AceView: C10orf128	Ensembl:ENSG00000204161	euGenes: HUgn170371
ECgene: C10orf128	H-InvDB: C10orf128

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for C10orf128
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for C10orf128:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C10orf128-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for C10orf128		Browse antibodies at Sigma-Aldrich
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C10orf128 Gene

protein-coding GIFtS: 37

Aliases &
Descriptions
for C10orf128

Summaries
for C10orf128

Genomic Location
for C10orf128

Proteins
for C10orf128

Protein Domains/
Families
for C10orf128

Gene Function
for C10orf128

Pathways & Interactions
for C10orf128

Drugs & Compounds
for C10orf128

Transcripts
for C10orf128

Expression
for C10orf128

Orthologs
for C10orf128

Paralogs
for C10orf128

SNPs/Variants
for C10orf128

Disorders & Mutations
for C10orf128

Medical News
for C10orf128

Publications
for C10orf128

Search for C10orf128

Genome Databases showing C10orf128

Other Databases showing C10orf128

Specialized Databases showing C10orf128

Licensable Technologies
for C10orf128

Services
for C10orf128

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C10orf128 Gene

protein-coding GIFtS: 37

Aliases & Descriptionsfor C10orf128

Summariesfor C10orf128

Genomic Locationfor C10orf128

Proteinsfor C10orf128

Protein Domains/Familiesfor C10orf128

Gene Functionfor C10orf128

Pathways & Interactionsfor C10orf128

Drugs & Compoundsfor C10orf128

Transcriptsfor C10orf128

Expression for C10orf128

Orthologsfor C10orf128

Paralogsfor C10orf128

SNPs/Variantsfor C10orf128

Disorders & Mutationsfor C10orf128

Medical Newsfor C10orf128

Publicationsfor C10orf128

Search for C10orf128

Genome Databases showing C10orf128

Other Databases showing C10orf128

Specialized Databases showing C10orf128

Licensable Technologiesfor C10orf128

Servicesfor C10orf128

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C10orf128

Summaries
for C10orf128

Genomic Location
for C10orf128

Proteins
for C10orf128

Protein Domains/
Families
for C10orf128

Gene Function
for C10orf128

Pathways & Interactions
for C10orf128

Drugs & Compounds
for C10orf128

Transcripts
for C10orf128

Expression
for C10orf128

Orthologs
for C10orf128

Paralogs
for C10orf128

SNPs/Variants
for C10orf128

Disorders & Mutations
for C10orf128

Medical News
for C10orf128

Publications
for C10orf128

Licensable Technologies
for C10orf128

Services
for C10orf128